| Definition | Burkholderia phymatum STM815 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010622 |
| Length | 3,479,187 |
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The map label for this gene is pbpC [H]
Identifier: 186475706
GI number: 186475706
Start: 1045320
End: 1047677
Strand: Reverse
Name: pbpC [H]
Synonym: Bphy_0941
Alternate gene names: 186475706
Gene position: 1047677-1045320 (Counterclockwise)
Preceding gene: 186475707
Following gene: 186475705
Centisome position: 30.11
GC content: 69.17
Gene sequence:
>2358_bases ATGCGAGCATCCACGAAAGCGATGAACTGCGATGCTCCCCTCGCGCGGCGCGGGTTCGTTGCGTTCGTGCGCATCGTGCG CATCGTGCTTTGTATTTTATGGGTCGGCGAACCGCTCGCGGCGCACGCACTGCCGACCTTCGACGACGTCCGCACGCAAT GGCGCAGCTCCGACTGGCTGCTGCTGTCTCGCGACGGGGTGCCGCTGCAGCGTACGCGTATCGACCGGACCGAGCGGCGC GGCGACTGGGTCGCGCTCGCGGATGTGTCGCCCGCGCTGCGCGAAGCGATCGTCGTGTCGGAGGACAAGCGCTTCTACGA GCATAGCGGCGTCGACTGGCGCGGCGCCGCGGCGGCTGCATGGGCGAACCTGTGGAACACGCGCACGCGCGGCGCGTCTA CCGTCACGATGCAGCTGACGGGCCTGCTCAACGACGACCGCGAACGGTCTGGGCAGCGTTCGATCGCGCAGAAGGCCAAT CAGGCCGTGAGCGCGCTGTGGCTCGAACACGCGTGGCGCAAGGACCAGATTCTCGAAGCCTATCTGAACCTCGTGCCGTT TCGCGGCGAGACGATCGGCCTGTCGGCGCTGTCGATCACGCTGTTCGGCAAGGCGCCATCCGGTCTCGACGAGCGCGAGG CCGCCATCGCCGCCGCGTTGATCCGTGCGCCGAATGCGTCGTACGCGAAGGTCGGCGAGCGCGCGTGCCGGATCCTGCGC GACATGCAGGCACCCGAACGCTGTGCCCGTCTCGCCGCTTTCGTTCAGCTCGCGTTCGCGCGCCCTGCTCCCGTGCTGCT GTCCGTCTCCCCCGATGCGCCGATTCTCGCGCCGCACCTCGCGCGCCGCATCGCGAGCGAAACGCATCCCGTAGCGGGCG CGCGCGTGACCAGCACGCTCGACGCGAAGCTGCAGCGTTTCGCCAGCGACACGCTCACGCGCACGCTCGTCGAACTCAAT GCGCCCGCGCATCCGCGCAATGTCCACGACGGCGCCATCGTCGTGCTCGACAATGCGACGGGCGAAGTACTCGCATGGGT CGGCTCGTCGGGCGCGCTGTCGGACGCGCGCGATGTCGATGCCGTGCTCGCGCGCCGCCAGGCCGGATCGACGCTCAAGC CGTTCCTGTATGCGCAGGCCATCGACGAACGGCGGCTCACCACGGCGTCGCTGCTCGACGACGCGCCGCTCGATCTTCCG GCAGGCGGCGGCCTCTACATACCGCAGAACTACGACAAGGACTTCAAGGGCTGGGTGAGCGTGCGCACAGCGCTTGGCTC GTCGCTGAACGTGCCCGCCGTGCGCACGCTGGTGATGCTCACGCCGCACCGCTTCGCGAAAACGTTGACCGCGCTCGGCT TGCCGCTCGACCAAAGCGGAGACTACTACGGCTATTCGCTCGCGTTAGGCAGCGCGGACGTGACCCTGCTGTCGCTGACC AATGCGTATCGCGCGCTGGCAAATGGCGGCGTCGCCGCGCCGACCGTCGATGTCGTGCGACGCCCGCTCTCGCCTGCGGC ACAGCAACGCGTGTTCAGCAGCGATGCGAGCTACATCATCGCGACAGTGCTGTCGGACAACAACGCGCGCACGCGCACGT TCGGCTTCGACAGCCCGCTCGCGACGCGCTTTTTCTCGGCAGTGAAGACGGGCACCAGCAAGGATATGCGCGACAACTGG ACGGTCGGCTATACGTCGCGCTACACGGTCGGCGTGTGGGTCGGCAACGCGGACGGCCAGCCGATGTGGGACGTGTCCGG CGTCACGGGCGCCGCGCCCATCTGGGCGGCCGTCGTCGGTTATCTGCACCGGCGCGTGCCGAGCGTCGCGCCGCGCGCGC CTGCGGGCGTCGTGCAAACGCGCGTCACCTTCGACGGCAATATCGAGCCCGCACGCAACGAGTGGTTTGTCAGCGGCACC CAAACGCCTATCGTGGGGCTTGCCGCGAATGCCGGGCCGGCGGATCGCGCGCCCGCCGTCTCACGCGTAACAACGCCAGG GCGGGCGATGTCATCGGCAAACGCCGCACCGCGCATCGCTTCCCCCACGGACGGCACGCTGTTCGCGCTCGATCCCGACA TCCCCGCCGCGCGCCAGCGCATCGTGTTCGAGCGCGCGAGCGGCTCGTCCTCGCGCAGCCGCTGGCGACTCGACGGCAAG CCGCTCGGCGGCGACGAGCGCGTGCTGTGGCTGCCGTGGCCCGGGCGCCATGTGCTCGAACTCGTCGACGCGGACGGCAT GAGCGCCGATTCGGTGCATTTCGACGTCCGCGGTGCGACGGCGCGCGAGACCGCGTTGCCGGGCGGTACGAAATCCGACA CACCGCACCACGGCGTCACGCCATCCAACGCCCGCTGA
Upstream 100 bases:
>100_bases TCGAAGCGCTCTACGCGCCGTCGACCTTCGGTGTGCTGCCGAATGCGCCCGTCGTCGTGAAACCCGTGGCGGCCGCTGTG AAGTGACAGGAAGTTACGCG
Downstream 100 bases:
>100_bases GATCCGCTGCGCCCGACCGCACAGCGATCGCGCAGAAGCTTTAAATTTGGTGAGCCTGCATTGTGTTGTCACGATTCAAA CGGTATAAATCGCCCGATTC
Product: penicillin-binding protein 1C
Products: NA
Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]
Number of amino acids: Translated: 785; Mature: 785
Protein sequence:
>785_residues MRASTKAMNCDAPLARRGFVAFVRIVRIVLCILWVGEPLAAHALPTFDDVRTQWRSSDWLLLSRDGVPLQRTRIDRTERR GDWVALADVSPALREAIVVSEDKRFYEHSGVDWRGAAAAAWANLWNTRTRGASTVTMQLTGLLNDDRERSGQRSIAQKAN QAVSALWLEHAWRKDQILEAYLNLVPFRGETIGLSALSITLFGKAPSGLDEREAAIAAALIRAPNASYAKVGERACRILR DMQAPERCARLAAFVQLAFARPAPVLLSVSPDAPILAPHLARRIASETHPVAGARVTSTLDAKLQRFASDTLTRTLVELN APAHPRNVHDGAIVVLDNATGEVLAWVGSSGALSDARDVDAVLARRQAGSTLKPFLYAQAIDERRLTTASLLDDAPLDLP AGGGLYIPQNYDKDFKGWVSVRTALGSSLNVPAVRTLVMLTPHRFAKTLTALGLPLDQSGDYYGYSLALGSADVTLLSLT NAYRALANGGVAAPTVDVVRRPLSPAAQQRVFSSDASYIIATVLSDNNARTRTFGFDSPLATRFFSAVKTGTSKDMRDNW TVGYTSRYTVGVWVGNADGQPMWDVSGVTGAAPIWAAVVGYLHRRVPSVAPRAPAGVVQTRVTFDGNIEPARNEWFVSGT QTPIVGLAANAGPADRAPAVSRVTTPGRAMSSANAAPRIASPTDGTLFALDPDIPAARQRIVFERASGSSSRSRWRLDGK PLGGDERVLWLPWPGRHVLELVDADGMSADSVHFDVRGATARETALPGGTKSDTPHHGVTPSNAR
Sequences:
>Translated_785_residues MRASTKAMNCDAPLARRGFVAFVRIVRIVLCILWVGEPLAAHALPTFDDVRTQWRSSDWLLLSRDGVPLQRTRIDRTERR GDWVALADVSPALREAIVVSEDKRFYEHSGVDWRGAAAAAWANLWNTRTRGASTVTMQLTGLLNDDRERSGQRSIAQKAN QAVSALWLEHAWRKDQILEAYLNLVPFRGETIGLSALSITLFGKAPSGLDEREAAIAAALIRAPNASYAKVGERACRILR DMQAPERCARLAAFVQLAFARPAPVLLSVSPDAPILAPHLARRIASETHPVAGARVTSTLDAKLQRFASDTLTRTLVELN APAHPRNVHDGAIVVLDNATGEVLAWVGSSGALSDARDVDAVLARRQAGSTLKPFLYAQAIDERRLTTASLLDDAPLDLP AGGGLYIPQNYDKDFKGWVSVRTALGSSLNVPAVRTLVMLTPHRFAKTLTALGLPLDQSGDYYGYSLALGSADVTLLSLT NAYRALANGGVAAPTVDVVRRPLSPAAQQRVFSSDASYIIATVLSDNNARTRTFGFDSPLATRFFSAVKTGTSKDMRDNW TVGYTSRYTVGVWVGNADGQPMWDVSGVTGAAPIWAAVVGYLHRRVPSVAPRAPAGVVQTRVTFDGNIEPARNEWFVSGT QTPIVGLAANAGPADRAPAVSRVTTPGRAMSSANAAPRIASPTDGTLFALDPDIPAARQRIVFERASGSSSRSRWRLDGK PLGGDERVLWLPWPGRHVLELVDADGMSADSVHFDVRGATARETALPGGTKSDTPHHGVTPSNAR >Mature_785_residues MRASTKAMNCDAPLARRGFVAFVRIVRIVLCILWVGEPLAAHALPTFDDVRTQWRSSDWLLLSRDGVPLQRTRIDRTERR GDWVALADVSPALREAIVVSEDKRFYEHSGVDWRGAAAAAWANLWNTRTRGASTVTMQLTGLLNDDRERSGQRSIAQKAN QAVSALWLEHAWRKDQILEAYLNLVPFRGETIGLSALSITLFGKAPSGLDEREAAIAAALIRAPNASYAKVGERACRILR DMQAPERCARLAAFVQLAFARPAPVLLSVSPDAPILAPHLARRIASETHPVAGARVTSTLDAKLQRFASDTLTRTLVELN APAHPRNVHDGAIVVLDNATGEVLAWVGSSGALSDARDVDAVLARRQAGSTLKPFLYAQAIDERRLTTASLLDDAPLDLP AGGGLYIPQNYDKDFKGWVSVRTALGSSLNVPAVRTLVMLTPHRFAKTLTALGLPLDQSGDYYGYSLALGSADVTLLSLT NAYRALANGGVAAPTVDVVRRPLSPAAQQRVFSSDASYIIATVLSDNNARTRTFGFDSPLATRFFSAVKTGTSKDMRDNW TVGYTSRYTVGVWVGNADGQPMWDVSGVTGAAPIWAAVVGYLHRRVPSVAPRAPAGVVQTRVTFDGNIEPARNEWFVSGT QTPIVGLAANAGPADRAPAVSRVTTPGRAMSSANAAPRIASPTDGTLFALDPDIPAARQRIVFERASGSSSRSRWRLDGK PLGGDERVLWLPWPGRHVLELVDADGMSADSVHFDVRGATARETALPGGTKSDTPHHGVTPSNAR
Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]
COG id: COG4953
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1788867, Length=612, Percent_Identity=33.4967320261438, Blast_Score=229, Evalue=4e-61, Organism=Escherichia coli, GI1786343, Length=575, Percent_Identity=27.304347826087, Blast_Score=135, Evalue=1e-32, Organism=Escherichia coli, GI87082258, Length=325, Percent_Identity=25.8461538461538, Blast_Score=85, Evalue=2e-17, Organism=Escherichia coli, GI1789601, Length=171, Percent_Identity=34.5029239766082, Blast_Score=70, Evalue=7e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011815 - InterPro: IPR009647 - InterPro: IPR001460 [H]
Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-
Molecular weight: Translated: 84501; Mature: 84501
Theoretical pI: Translated: 10.05; Mature: 10.05
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRASTKAMNCDAPLARRGFVAFVRIVRIVLCILWVGEPLAAHALPTFDDVRTQWRSSDWL CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCCCEE LLSRDGVPLQRTRIDRTERRGDWVALADVSPALREAIVVSEDKRFYEHSGVDWRGAAAAA EEECCCCCHHHHHCCHHHCCCCEEEEECCCHHHHHHEEECCCHHHHHHCCCCCCCHHHHH WANLWNTRTRGASTVTMQLTGLLNDDRERSGQRSIAQKANQAVSALWLEHAWRKDQILEA HHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH YLNLVPFRGETIGLSALSITLFGKAPSGLDEREAAIAAALIRAPNASYAKVGERACRILR HHHHCCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH DMQAPERCARLAAFVQLAFARPAPVLLSVSPDAPILAPHLARRIASETHPVAGARVTSTL HCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHH DAKLQRFASDTLTRTLVELNAPAHPRNVHDGAIVVLDNATGEVLAWVGSSGALSDARDVD HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHHHH AVLARRQAGSTLKPFLYAQAIDERRLTTASLLDDAPLDLPAGGGLYIPQNYDKDFKGWVS HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHH VRTALGSSLNVPAVRTLVMLTPHRFAKTLTALGLPLDQSGDYYGYSLALGSADVTLLSLT HHHHHCCCCCCHHHHHHEEECCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCEEEEEHH NAYRALANGGVAAPTVDVVRRPLSPAAQQRVFSSDASYIIATVLSDNNARTRTFGFDSPL HHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCHH ATRFFSAVKTGTSKDMRDNWTVGYTSRYTVGVWVGNADGQPMWDVSGVTGAAPIWAAVVG HHHHHHHHHCCCCCCCCCCCEEEECCEEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHH YLHRRVPSVAPRAPAGVVQTRVTFDGNIEPARNEWFVSGTQTPIVGLAANAGPADRAPAV HHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCCC SRVTTPGRAMSSANAAPRIASPTDGTLFALDPDIPAARQRIVFERASGSSSRSRWRLDGK CCCCCCCHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHEEEEECCCCCCCCEEEECCC PLGGDERVLWLPWPGRHVLELVDADGMSADSVHFDVRGATARETALPGGTKSDTPHHGVT CCCCCCEEEEECCCCHHHHHEECCCCCCCCCEEEEECCCCCHHHCCCCCCCCCCCCCCCC PSNAR CCCCC >Mature Secondary Structure MRASTKAMNCDAPLARRGFVAFVRIVRIVLCILWVGEPLAAHALPTFDDVRTQWRSSDWL CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCCCEE LLSRDGVPLQRTRIDRTERRGDWVALADVSPALREAIVVSEDKRFYEHSGVDWRGAAAAA EEECCCCCHHHHHCCHHHCCCCEEEEECCCHHHHHHEEECCCHHHHHHCCCCCCCHHHHH WANLWNTRTRGASTVTMQLTGLLNDDRERSGQRSIAQKANQAVSALWLEHAWRKDQILEA HHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH YLNLVPFRGETIGLSALSITLFGKAPSGLDEREAAIAAALIRAPNASYAKVGERACRILR HHHHCCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH DMQAPERCARLAAFVQLAFARPAPVLLSVSPDAPILAPHLARRIASETHPVAGARVTSTL HCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHH DAKLQRFASDTLTRTLVELNAPAHPRNVHDGAIVVLDNATGEVLAWVGSSGALSDARDVD HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHHHH AVLARRQAGSTLKPFLYAQAIDERRLTTASLLDDAPLDLPAGGGLYIPQNYDKDFKGWVS HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHH VRTALGSSLNVPAVRTLVMLTPHRFAKTLTALGLPLDQSGDYYGYSLALGSADVTLLSLT HHHHHCCCCCCHHHHHHEEECCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCEEEEEHH NAYRALANGGVAAPTVDVVRRPLSPAAQQRVFSSDASYIIATVLSDNNARTRTFGFDSPL HHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCHH ATRFFSAVKTGTSKDMRDNWTVGYTSRYTVGVWVGNADGQPMWDVSGVTGAAPIWAAVVG HHHHHHHHHCCCCCCCCCCCEEEECCEEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHH YLHRRVPSVAPRAPAGVVQTRVTFDGNIEPARNEWFVSGTQTPIVGLAANAGPADRAPAV HHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCCC SRVTTPGRAMSSANAAPRIASPTDGTLFALDPDIPAARQRIVFERASGSSSRSRWRLDGK CCCCCCCHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHEEEEECCCCCCCCEEEECCC PLGGDERVLWLPWPGRHVLELVDADGMSADSVHFDVRGATARETALPGGTKSDTPHHGVT CCCCCCEEEEECCCCHHHHHEECCCCCCCCCEEEEECCCCCHHHCCCCCCCCCCCCCCCC PSNAR CCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10542235; 9205837; 9278503; 9841666 [H]