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The map label for this gene is folP-A [H]

Identifier: 186475645

GI number: 186475645

Start: 984031

End: 984873

Strand: Direct

Name: folP-A [H]

Synonym: Bphy_0880

Alternate gene names: 186475645

Gene position: 984031-984873 (Clockwise)

Preceding gene: 186475644

Following gene: 186475646

Centisome position: 28.28

GC content: 63.7

Gene sequence:

>843_bases
ATGCAATGCGGCCGGTTTACGTTCACGTTCGAACGTCCGCTCGTGATGGGCATCTTGAACGTCACGCCCGACTCCTTTTC
CGATGGCGGCCTGTACGCGGATCCGGGCAAGGCGCGGCTGCAGGCGGAGAGGCTATTGGCGGAAGGCGCCGATATCATCG
ATATCGGCGGCGAGTCGACCCGGCCAGGGGCGCCACCTGTGCCCTTGGCCGAGGAACTGGAGCGGGTGATTCCGCTCGTC
AAGGAACTGAGCGACGCAGGCATTCCGGTGTCCGTCGACACGTACAAGCCCGAAGTGATGCGTCATGCGCTGGCGGCGGG
CGCTGATCTGATTAATGATATTTGGGGCTTCAGGATGCCCGGCGCGATCGATGCGGTGCGCGACAGCCAATGCGGCTTGT
GCGTGATGCACATGCTGGGCGAACCGCAGACGATGCAGGTCGGCGAGCCGGTCTACGGGGACGTCGTTGTCGACATACGC
GCCTTTCTGGAAGAACGTGTCGCTACGATGATAAAGGCCGGTGTTGCGAAAAATCGCGTCAGCGTCGATCCGGGCTTCGG
ATTTGGCAAGACGGTCGAGCATAATTACGCGCTGCTCGCCCACTTGCCTGAGACATCGCCGGTTGTCGGCACGCCGCTGC
CGATTCTCGCTGGCATGTCGCGCAAATCGATGCTCGGGGCCGTCGTGAACCGGCCTGCGCCGGAAAGGGTGGCAGCAAGC
ATTGCAGCCGCCGTGTGCGCGGCTGAACGGGGGGCAGCGATCATCCGCGTGCACGATGTGGCGCAGACGGTGGATGCACT
GAAAGTATGGGTGGCGACGCGCGACGCAGCGCGGCGCGCCTGA

Upstream 100 bases:

>100_bases
ATCGCGATGAAGTCGCGGTATGTCCTGAATCCATTGCTTTTCGTCTTAGCCTATTCTCGTGCCCAACTTTTACTCTCCGC
CTTATCCGATTGCCGAACCG

Downstream 100 bases:

>100_bases
TCTCCACGCTTGGGAGGAAAATTCCAATATGGCACGTCGGTATTTCGGAACGGACGGGATTCGTGGCAAGGTCGGCGATC
CGCCGATCACGCCGGACTTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MQCGRFTFTFERPLVMGILNVTPDSFSDGGLYADPGKARLQAERLLAEGADIIDIGGESTRPGAPPVPLAEELERVIPLV
KELSDAGIPVSVDTYKPEVMRHALAAGADLINDIWGFRMPGAIDAVRDSQCGLCVMHMLGEPQTMQVGEPVYGDVVVDIR
AFLEERVATMIKAGVAKNRVSVDPGFGFGKTVEHNYALLAHLPETSPVVGTPLPILAGMSRKSMLGAVVNRPAPERVAAS
IAAAVCAAERGAAIIRVHDVAQTVDALKVWVATRDAARRA

Sequences:

>Translated_280_residues
MQCGRFTFTFERPLVMGILNVTPDSFSDGGLYADPGKARLQAERLLAEGADIIDIGGESTRPGAPPVPLAEELERVIPLV
KELSDAGIPVSVDTYKPEVMRHALAAGADLINDIWGFRMPGAIDAVRDSQCGLCVMHMLGEPQTMQVGEPVYGDVVVDIR
AFLEERVATMIKAGVAKNRVSVDPGFGFGKTVEHNYALLAHLPETSPVVGTPLPILAGMSRKSMLGAVVNRPAPERVAAS
IAAAVCAAERGAAIIRVHDVAQTVDALKVWVATRDAARRA
>Mature_280_residues
MQCGRFTFTFERPLVMGILNVTPDSFSDGGLYADPGKARLQAERLLAEGADIIDIGGESTRPGAPPVPLAEELERVIPLV
KELSDAGIPVSVDTYKPEVMRHALAAGADLINDIWGFRMPGAIDAVRDSQCGLCVMHMLGEPQTMQVGEPVYGDVVVDIR
AFLEERVATMIKAGVAKNRVSVDPGFGFGKTVEHNYALLAHLPETSPVVGTPLPILAGMSRKSMLGAVVNRPAPERVAAS
IAAAVCAAERGAAIIRVHDVAQTVDALKVWVATRDAARRA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=271, Percent_Identity=48.7084870848708, Blast_Score=247, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6324073, Length=310, Percent_Identity=29.6774193548387, Blast_Score=113, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29772; Mature: 29772

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQCGRFTFTFERPLVMGILNVTPDSFSDGGLYADPGKARLQAERLLAEGADIIDIGGEST
CCCCCEEEEECCCCEEHEECCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCEEEECCCCC
RPGAPPVPLAEELERVIPLVKELSDAGIPVSVDTYKPEVMRHALAAGADLINDIWGFRMP
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
GAIDAVRDSQCGLCVMHMLGEPQTMQVGEPVYGDVVVDIRAFLEERVATMIKAGVAKNRV
CHHHHHCCCCCCHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCE
SVDPGFGFGKTVEHNYALLAHLPETSPVVGTPLPILAGMSRKSMLGAVVNRPAPERVAAS
ECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCHHHHHHH
IAAAVCAAERGAAIIRVHDVAQTVDALKVWVATRDAARRA
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQCGRFTFTFERPLVMGILNVTPDSFSDGGLYADPGKARLQAERLLAEGADIIDIGGEST
CCCCCEEEEECCCCEEHEECCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCEEEECCCCC
RPGAPPVPLAEELERVIPLVKELSDAGIPVSVDTYKPEVMRHALAAGADLINDIWGFRMP
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
GAIDAVRDSQCGLCVMHMLGEPQTMQVGEPVYGDVVVDIRAFLEERVATMIKAGVAKNRV
CHHHHHCCCCCCHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCE
SVDPGFGFGKTVEHNYALLAHLPETSPVVGTPLPILAGMSRKSMLGAVVNRPAPERVAAS
ECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCHHHHHHH
IAAAVCAAERGAAIIRVHDVAQTVDALKVWVATRDAARRA
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]