Click here to switch to the map view.

The map label for this gene is rnc [H]

Identifier: 186475606

GI number: 186475606

Start: 940073

End: 941398

Strand: Direct

Name: rnc [H]

Synonym: Bphy_0841

Alternate gene names: 186475606

Gene position: 940073-941398 (Clockwise)

Preceding gene: 186475605

Following gene: 186475607

Centisome position: 27.02

GC content: 65.76

Gene sequence:

>1326_bases
ATGCGCCCGCGTTATACTCTGCACATGCCCCTATCTCCGTTGGAAAGCCGTTTGCGCTACGAATTTCGCAATGCGGAATT
GTTGCGACAGGCTTTAACTCACCGCAGTCACAGTGCCACGCATAATGAGCGGCTGGAATTTCTCGGCGATTCCGTTCTGA
ACTGCGCGGTGGCCGCGCTTTTGTTCCAACGTTTCGGGAAGCTGGACGAGGGTGATCTGTCCCGCGTTCGCGCCAATCTC
GTCAAACAGCAGTCGCTGTATGAGATTGCTCAGGCGCTGAATATCTCCGAGGGACTGCGGCTCGGCGAAGGCGAATTGCG
CAGCGGCGGCTTCCGCCGTCCGTCCATTCTGGCCGATACCCTGGAAGCCATTCTGGGCGCAATCTTCCTCGACGGCGGTT
TTGACGCGGCGCAAACGGTCATCAAGCGGCTCTACGTGCCGATTCTCGATCACATTGATCCGCGCACGCTCGGCAAGGAC
GCCAAAACGCTGCTGCAGGAATACCTGCAGGGTCACAAGATTCCCCTGCCGACCTACACCGTCGTCGCCACGCATGGTGC
GGCACACAATCAGCAGTTCGAGGTGGAGTGCACGGTGCCCAAGCTGGACGTGAAAGTGTCCGGTTCAGGCGCTAGCCGTC
GCGCGGCCGAGCAGGCTGCGGCGAAAAAGGCGCTCGACGAGGTGATGGCTGCGGCGCCTGCCGTAGTATCCAAGACCAAG
CGCTCGAAGGGCGCTCGCGCGACCAGGCAGGAAGCCGAAATCGTGCCGGGCGTGACGGGCGTGCAGGCTGCGCTCGATCT
GCGGGCGCCCGACAGCCGCAGGGCCGAACGCGCGTCACGGGCCGAGGCGAAACCGGTGGGGCCGGAGGTGCCGTCGGCTG
CACAGGCGGCTGCCGGCGCGCCGCTCGCCGTCATCCGCGCAGCGCATGTGGAATATAGCCAGGACGTTGGGGGCGGCGAC
AAGGCCGATCGCGGCGAGAAGGGCGAGCGGCCGGCGCGGATCGCGGACCGCGCTGCAGCCGAGAAAGTCGCGCAGGAAAA
GAGCGCGGACCGACCGGAAGCGGCGCTGAAGCCGGTCGAGCGTCAAACCGAGCGTCAGCAGGGCGCGGATAAGCCCGACG
CGCAGTCGCGCGCAGCGGACAAAGCCCCCGACAAGGCGGTGGACAAACCTGCTGACAAGCCCGCCGAAAAACCCGACACC
AACGCCCGCAGCGCAGACAAACCCGCGTCCCGCGCTCGCGAGGCCGCGCCCGGCACAAGCACGGGCGATCTCGAACCCGG
CGTCGCCGGCGCGGTGCATACCCGCGTGGCCGATGCCGGTCATTGA

Upstream 100 bases:

>100_bases
CGTGCATTCCATGCGGCGTGTTATCACGCTACTTTAAGAACGCGCGGTAACATCGCTACAACACGCTTTTTCGGCGCCGG
GGCCGCGTTTCCGCCCCGTG

Downstream 100 bases:

>100_bases
ACGCAATATCACGTGAATGCGCGCTCGATGATGCGCGCCCACCCGAACCTGCCGTAGTACGAATATGAACGCTTCCACTC
CCACTGGTTTCCGCTGCGGC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MRPRYTLHMPLSPLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANL
VKQQSLYEIAQALNISEGLRLGEGELRSGGFRRPSILADTLEAILGAIFLDGGFDAAQTVIKRLYVPILDHIDPRTLGKD
AKTLLQEYLQGHKIPLPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPAVVSKTK
RSKGARATRQEAEIVPGVTGVQAALDLRAPDSRRAERASRAEAKPVGPEVPSAAQAAAGAPLAVIRAAHVEYSQDVGGGD
KADRGEKGERPARIADRAAAEKVAQEKSADRPEAALKPVERQTERQQGADKPDAQSRAADKAPDKAVDKPADKPAEKPDT
NARSADKPASRAREAAPGTSTGDLEPGVAGAVHTRVADAGH

Sequences:

>Translated_441_residues
MRPRYTLHMPLSPLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANL
VKQQSLYEIAQALNISEGLRLGEGELRSGGFRRPSILADTLEAILGAIFLDGGFDAAQTVIKRLYVPILDHIDPRTLGKD
AKTLLQEYLQGHKIPLPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPAVVSKTK
RSKGARATRQEAEIVPGVTGVQAALDLRAPDSRRAERASRAEAKPVGPEVPSAAQAAAGAPLAVIRAAHVEYSQDVGGGD
KADRGEKGERPARIADRAAAEKVAQEKSADRPEAALKPVERQTERQQGADKPDAQSRAADKAPDKAVDKPADKPAEKPDT
NARSADKPASRAREAAPGTSTGDLEPGVAGAVHTRVADAGH
>Mature_441_residues
MRPRYTLHMPLSPLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANL
VKQQSLYEIAQALNISEGLRLGEGELRSGGFRRPSILADTLEAILGAIFLDGGFDAAQTVIKRLYVPILDHIDPRTLGKD
AKTLLQEYLQGHKIPLPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPAVVSKTK
RSKGARATRQEAEIVPGVTGVQAALDLRAPDSRRAERASRAEAKPVGPEVPSAAQAAAGAPLAVIRAAHVEYSQDVGGGD
KADRGEKGERPARIADRAAAEKVAQEKSADRPEAALKPVERQTERQQGADKPDAQSRAADKAPDKAVDKPADKPAEKPDT
NARSADKPASRAREAAPGTSTGDLEPGVAGAVHTRVADAGH

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=265, Percent_Identity=26.7924528301887, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI155030234, Length=265, Percent_Identity=26.7924528301887, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=52.4271844660194, Blast_Score=218, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17506883, Length=197, Percent_Identity=30.4568527918782, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=197, Percent_Identity=30.4568527918782, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323895, Length=97, Percent_Identity=32.9896907216495, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137682, Length=233, Percent_Identity=28.755364806867, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 47135; Mature: 47135

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPRYTLHMPLSPLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAAL
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LFQRFGKLDEGDLSRVRANLVKQQSLYEIAQALNISEGLRLGEGELRSGGFRRPSILADT
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LEAILGAIFLDGGFDAAQTVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIPLPTYT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCCCEE
VVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPAVVSKTK
EEEECCCCCCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSKGARATRQEAEIVPGVTGVQAALDLRAPDSRRAERASRAEAKPVGPEVPSAAQAAAGA
HHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCC
PLAVIRAAHVEYSQDVGGGDKADRGEKGERPARIADRAAAEKVAQEKSADRPEAALKPVE
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
RQTERQQGADKPDAQSRAADKAPDKAVDKPADKPAEKPDTNARSADKPASRAREAAPGTS
HHHHHHHCCCCCCHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
TGDLEPGVAGAVHTRVADAGH
CCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MRPRYTLHMPLSPLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAAL
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LFQRFGKLDEGDLSRVRANLVKQQSLYEIAQALNISEGLRLGEGELRSGGFRRPSILADT
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LEAILGAIFLDGGFDAAQTVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIPLPTYT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCCCEE
VVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPAVVSKTK
EEEECCCCCCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSKGARATRQEAEIVPGVTGVQAALDLRAPDSRRAERASRAEAKPVGPEVPSAAQAAAGA
HHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCC
PLAVIRAAHVEYSQDVGGGDKADRGEKGERPARIADRAAAEKVAQEKSADRPEAALKPVE
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
RQTERQQGADKPDAQSRAADKAPDKAVDKPADKPAEKPDTNARSADKPASRAREAAPGTS
HHHHHHHCCCCCCHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
TGDLEPGVAGAVHTRVADAGH
CCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]