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The map label for this gene is fabF [H]

Identifier: 186475597

GI number: 186475597

Start: 930949

End: 932235

Strand: Direct

Name: fabF [H]

Synonym: Bphy_0832

Alternate gene names: 186475597

Gene position: 930949-932235 (Clockwise)

Preceding gene: 186475596

Following gene: 186475598

Centisome position: 26.76

GC content: 62.08

Gene sequence:

>1287_bases
GTGCGCTCCTGTGGCTTTTGTTTTGTCATCTATGGAAAAGGGGTTACCGTGAGCCGTCGTCGTGTTGTTGTTACAGGCCT
GGGGCTTATTTCGCCTGTTGGCAATAATGTTGCCGACGGCTGGGCCAATCTGGTCGCCGGCAAGTCTGGCATCGCCAACA
TCACGAAGTTCGACGCGTCGAACTTCTCCACACGTTTCGCCGGTGAGGTGAAGGGCTTCAACATTGAAGACTACATCGCC
GGCAAGGAAGCGCGCCATATGGATACGTTCATCCATTACGGCGTGGCTGCCGGCATCCAGGCGATGCAGGACAGCGGCCT
CGAAATCACCGATGCGAACTCGGAACGCGTTGGCGTCGTGGTCGGTTCGGGCATCGGCGGCCTGCCAATGATCGAAGTCA
CGCAGACGGAACTGCTGAATCGCGGCCCGCGCCGGATTTCGCCGTTCTTCGTGCCGGCGTCGATCATCAACATGATCTCC
GGTCATCTGTCGATCAAGTTCGGCCTGAAGGGTCCGAACCTGTCGATGGTGACGGCTTGTACGACGGGTCTGCATTGCAT
CGGCGAGGCATCGCGTCTGATCGAGTACGGCGACGCCGACGTGATGATCGCGGGCGGCGCGGAATCGACCGTTTCGCCCC
TCGGCATCGGCGGCTTCGCGGCGGCGCGCGCGCTGTCGCAGCGTAACGACGATCCGGCGACGGCGAGCCGTCCTTGGGAC
AAGGACCGCGACGGTTTCGTGCTCGGCGAGGGTGCGGGCGTGATGGTGCTCGAAGAGTACGAACATGCGAAGGCGCGCGG
CGCGAAGATCTACGCGGAAGTCGGCGGTTACGGCATGAGCGGCGACGCGTATCACATGACGGCCCCGCTCGAAGACGGCG
ACGGCGCACGCCGCTGCATGATCGCAGCGATGAAGAACGCTGGCGTCAACCCCGATTCGGTGAATTACCTGAACGCGCAC
GGCACCTCGACGCCGCTCGGCGACCTCGCCGAAACCACGGGCATCAAGCGCGCATTCGGCGATCACTCGAAGAAGATCGT
CGTAAATTCGACAAAGTCGATGACGGGTCACCTGCTGGGCGGTGCGGGCGGTCTGGAGTCCGTGTTCACGGTCCTGGCTG
TGCATCACCAGGTGTCGCCGCCGACCATCAACATCTTCAACCAGGATCCGGAATGCGATCTCGACTACTGCGCCAACACG
GCGCGGGAGATGAAGATCGACGTCGCGCTGAAGAACTCGTTCGGGTTCGGCGGCACGAACGGCACGCTGGTTTTCAAGCG
CGCCTGA

Upstream 100 bases:

>100_bases
TCTGGCGTTGCCGCCAGTGCACCGGTCAGCGTATTCGTCAGCGCCCTGGTCAGCACGATCGTCAGGTTAAACAGCCACAG
GGCACACAGGGCGCTTTCCT

Downstream 100 bases:

>100_bases
TCGCTTGACGGCGGCATCCTCGCGGCCGGCTGAGCCGGCTCACGCGCCCGCTCCCGCTCCCGCATTAATCGGCGGACCCT
CGCAACGCATTGCGCTGCGG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MRSCGFCFVIYGKGVTVSRRRVVVTGLGLISPVGNNVADGWANLVAGKSGIANITKFDASNFSTRFAGEVKGFNIEDYIA
GKEARHMDTFIHYGVAAGIQAMQDSGLEITDANSERVGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMIS
GHLSIKFGLKGPNLSMVTACTTGLHCIGEASRLIEYGDADVMIAGGAESTVSPLGIGGFAAARALSQRNDDPATASRPWD
KDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVGGYGMSGDAYHMTAPLEDGDGARRCMIAAMKNAGVNPDSVNYLNAH
GTSTPLGDLAETTGIKRAFGDHSKKIVVNSTKSMTGHLLGGAGGLESVFTVLAVHHQVSPPTINIFNQDPECDLDYCANT
AREMKIDVALKNSFGFGGTNGTLVFKRA

Sequences:

>Translated_428_residues
MRSCGFCFVIYGKGVTVSRRRVVVTGLGLISPVGNNVADGWANLVAGKSGIANITKFDASNFSTRFAGEVKGFNIEDYIA
GKEARHMDTFIHYGVAAGIQAMQDSGLEITDANSERVGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMIS
GHLSIKFGLKGPNLSMVTACTTGLHCIGEASRLIEYGDADVMIAGGAESTVSPLGIGGFAAARALSQRNDDPATASRPWD
KDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVGGYGMSGDAYHMTAPLEDGDGARRCMIAAMKNAGVNPDSVNYLNAH
GTSTPLGDLAETTGIKRAFGDHSKKIVVNSTKSMTGHLLGGAGGLESVFTVLAVHHQVSPPTINIFNQDPECDLDYCANT
AREMKIDVALKNSFGFGGTNGTLVFKRA
>Mature_428_residues
MRSCGFCFVIYGKGVTVSRRRVVVTGLGLISPVGNNVADGWANLVAGKSGIANITKFDASNFSTRFAGEVKGFNIEDYIA
GKEARHMDTFIHYGVAAGIQAMQDSGLEITDANSERVGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMIS
GHLSIKFGLKGPNLSMVTACTTGLHCIGEASRLIEYGDADVMIAGGAESTVSPLGIGGFAAARALSQRNDDPATASRPWD
KDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVGGYGMSGDAYHMTAPLEDGDGARRCMIAAMKNAGVNPDSVNYLNAH
GTSTPLGDLAETTGIKRAFGDHSKKIVVNSTKSMTGHLLGGAGGLESVFTVLAVHHQVSPPTINIFNQDPECDLDYCANT
AREMKIDVALKNSFGFGGTNGTLVFKRA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=421, Percent_Identity=47.2684085510689, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=54.7945205479452, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI41872631, Length=435, Percent_Identity=25.2873563218391, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=60.9223300970874, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=40.1937046004843, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=37.1980676328502, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=40.9090909090909, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI212642053, Length=418, Percent_Identity=24.6411483253589, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=418, Percent_Identity=23.9234449760766, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=36.7713004484305, Blast_Score=274, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24644341, Length=440, Percent_Identity=44.3181818181818, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI19920632, Length=389, Percent_Identity=25.4498714652956, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221330659, Length=389, Percent_Identity=25.4498714652956, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=23.3644859813084, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45004; Mature: 45004

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSCGFCFVIYGKGVTVSRRRVVVTGLGLISPVGNNVADGWANLVAGKSGIANITKFDAS
CCCCEEEEEEECCCEEEECCEEEEEECCHHCCCCCCHHHHHHHHHCCCCCCCCEEEECCC
NFSTRFAGEVKGFNIEDYIAGKEARHMDTFIHYGVAAGIQAMQDSGLEITDANSERVGVV
CCCEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEE
VGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLSMVTAC
EECCCCCCCEEEEHHHHHHCCCCCCCCCEEEHHHHHHHHCCCEEEEEECCCCCCEEEEEH
TTGLHCIGEASRLIEYGDADVMIAGGAESTVSPLGIGGFAAARALSQRNDDPATASRPWD
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
KDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVGGYGMSGDAYHMTAPLEDGDGARRCM
CCCCCEEEECCCCEEEEECCHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCCHHHHH
IAAMKNAGVNPDSVNYLNAHGTSTPLGDLAETTGIKRAFGDHSKKIVVNSTKSMTGHLLG
HHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHCHHHHHCCCCCEEEEECCCCCCEEEEC
GAGGLESVFTVLAVHHQVSPPTINIFNQDPECDLDYCANTAREMKIDVALKNSFGFGGTN
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHCCCCHHEEEEEEEECCCCCCCCC
GTLVFKRA
CEEEEEEC
>Mature Secondary Structure
MRSCGFCFVIYGKGVTVSRRRVVVTGLGLISPVGNNVADGWANLVAGKSGIANITKFDAS
CCCCEEEEEEECCCEEEECCEEEEEECCHHCCCCCCHHHHHHHHHCCCCCCCCEEEECCC
NFSTRFAGEVKGFNIEDYIAGKEARHMDTFIHYGVAAGIQAMQDSGLEITDANSERVGVV
CCCEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEE
VGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLSMVTAC
EECCCCCCCEEEEHHHHHHCCCCCCCCCEEEHHHHHHHHCCCEEEEEECCCCCCEEEEEH
TTGLHCIGEASRLIEYGDADVMIAGGAESTVSPLGIGGFAAARALSQRNDDPATASRPWD
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
KDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVGGYGMSGDAYHMTAPLEDGDGARRCM
CCCCCEEEECCCCEEEEECCHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCCHHHHH
IAAMKNAGVNPDSVNYLNAHGTSTPLGDLAETTGIKRAFGDHSKKIVVNSTKSMTGHLLG
HHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHCHHHHHCCCCCEEEEECCCCCCEEEEC
GAGGLESVFTVLAVHHQVSPPTINIFNQDPECDLDYCANTAREMKIDVALKNSFGFGGTN
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHCCCCHHEEEEEEEECCCCCCCCC
GTLVFKRA
CEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]