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The map label for this gene is fabH

Identifier: 186475593

GI number: 186475593

Start: 927426

End: 928415

Strand: Direct

Name: fabH

Synonym: Bphy_0828

Alternate gene names: 186475593

Gene position: 927426-928415 (Clockwise)

Preceding gene: 186475592

Following gene: 186475594

Centisome position: 26.66

GC content: 63.33

Gene sequence:

>990_bases
ATGGCTCAATCCACTACCTATTCCCGCGTGCTGGGCACGGGCAGCTATCTGCCGCCCAACCGCGTTTCCAATCAGGATCT
GGCCGCTCGTCTCGCGAAGCAGGGAATCGAGACGAGCGACGAATGGATCGTGGCCCGCACGGGCATCCACGCGCGCCACT
TCGCCGAACCTGACGTCACGACCAGCGACCTCGCACTGATCGCGTCGCAACGGGCGATCGAAGCCGCCGATGTCGATCCG
CAGGCCATCGATCTGATCATCGTCGCCACGTCGACGCCGGACTTCGTGTTTCCGAGCACAGCCTGCCTGCTGCAGAACAA
GCTGGGCATCAAGAACAACGGCGCCGCGTTCGACGTGCAGGCCGTGTGCTCAGGTTTTGCCTATGCCGTTGCGACGGCTG
ACAGCTTCATTCGAAGCGGGCAACATCGTACTGCGTTGGTGGTCGGGGCTGAAACGTTCTCGCGCATTCTCGATTTCAAC
GACCGCACCACGTGCGTGCTGTTTGGCGATGGCGCGGGCGCCGTCGTCCTGCAGGCATCGGACGAGCCGGGCGTACTGGC
AAGCGCGTTGCACGCGGACGGCAGTCATTCGAACATTCTCTGCACGCCGGGCAACGTGAACGGCGGCATCGTGCAAGGCA
GTGCGTTCCTGCACATGGACGGGCAGGCGGTGTTCAAGTTGGCTGTCAACGTGCTGGAAAAAGTCGCGGTCGAGGCGCTG
CAGAAAGCCGATCTTCAACCCGAACAGATCGACTGGCTGATTCCGCACCAGGCCAACATCCGCATCATGCAGAGCACGTG
CCGCAAGCTCGGCCTGCCGCAGGAGCGGATGGTCGTCACAGTGCACGAGCACGGCAACACGTCGGCGGCGTCGATTCCGC
TCGCGCTCGATGTCGCGGTCCGCGACGGACGCATCCAGCGGGGCCATAACGTGCTGATCGAAGGCGTCGGCGGCGGCTTT
ACATGGGGCGCATCGGTCATCCGTTACTGA

Upstream 100 bases:

>100_bases
CAGGCGGGCCGGGTTCCGCGAGCCAGATGGCTAGCCCGATCGCAGGTCCGGTTTCTGGCCAGCCGGCCGAGCCCTACAGC
GCACAATCCTCGAAGGCATA

Downstream 100 bases:

>100_bases
TGGCCGCGCGCAGCGGCGCCAGACGCCGCTTCAAGCCGTAGCGCACGCCATGCGTGCATCACGCACATTTGAACTCATCG
AATTGGGGACGATATGAAAT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MAQSTTYSRVLGTGSYLPPNRVSNQDLAARLAKQGIETSDEWIVARTGIHARHFAEPDVTTSDLALIASQRAIEAADVDP
QAIDLIIVATSTPDFVFPSTACLLQNKLGIKNNGAAFDVQAVCSGFAYAVATADSFIRSGQHRTALVVGAETFSRILDFN
DRTTCVLFGDGAGAVVLQASDEPGVLASALHADGSHSNILCTPGNVNGGIVQGSAFLHMDGQAVFKLAVNVLEKVAVEAL
QKADLQPEQIDWLIPHQANIRIMQSTCRKLGLPQERMVVTVHEHGNTSAASIPLALDVAVRDGRIQRGHNVLIEGVGGGF
TWGASVIRY

Sequences:

>Translated_329_residues
MAQSTTYSRVLGTGSYLPPNRVSNQDLAARLAKQGIETSDEWIVARTGIHARHFAEPDVTTSDLALIASQRAIEAADVDP
QAIDLIIVATSTPDFVFPSTACLLQNKLGIKNNGAAFDVQAVCSGFAYAVATADSFIRSGQHRTALVVGAETFSRILDFN
DRTTCVLFGDGAGAVVLQASDEPGVLASALHADGSHSNILCTPGNVNGGIVQGSAFLHMDGQAVFKLAVNVLEKVAVEAL
QKADLQPEQIDWLIPHQANIRIMQSTCRKLGLPQERMVVTVHEHGNTSAASIPLALDVAVRDGRIQRGHNVLIEGVGGGF
TWGASVIRY
>Mature_328_residues
AQSTTYSRVLGTGSYLPPNRVSNQDLAARLAKQGIETSDEWIVARTGIHARHFAEPDVTTSDLALIASQRAIEAADVDPQ
AIDLIIVATSTPDFVFPSTACLLQNKLGIKNNGAAFDVQAVCSGFAYAVATADSFIRSGQHRTALVVGAETFSRILDFND
RTTCVLFGDGAGAVVLQASDEPGVLASALHADGSHSNILCTPGNVNGGIVQGSAFLHMDGQAVFKLAVNVLEKVAVEALQ
KADLQPEQIDWLIPHQANIRIMQSTCRKLGLPQERMVVTVHEHGNTSAASIPLALDVAVRDGRIQRGHNVLIEGVGGGFT
WGASVIRY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=323, Percent_Identity=49.2260061919505, Blast_Score=319, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_BURP8 (B2JFI9)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001857063.1
- ProteinModelPortal:   B2JFI9
- SMR:   B2JFI9
- GeneID:   6242326
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_0828
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- ProtClustDB:   PRK09352
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34905; Mature: 34774

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: ACT_SITE 123-123 ACT_SITE 256-256 ACT_SITE 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQSTTYSRVLGTGSYLPPNRVSNQDLAARLAKQGIETSDEWIVARTGIHARHFAEPDVT
CCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHCCCCCCC
TSDLALIASQRAIEAADVDPQAIDLIIVATSTPDFVFPSTACLLQNKLGIKNNGAAFDVQ
HHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCEEEHH
AVCSGFAYAVATADSFIRSGQHRTALVVGAETFSRILDFNDRTTCVLFGDGAGAVVLQAS
HHHCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEEEC
DEPGVLASALHADGSHSNILCTPGNVNGGIVQGSAFLHMDGQAVFKLAVNVLEKVAVEAL
CCCCHHHHHHHCCCCCCEEEEECCCCCCCEEECEEEEEECCHHHHHHHHHHHHHHHHHHH
QKADLQPEQIDWLIPHQANIRIMQSTCRKLGLPQERMVVTVHEHGNTSAASIPLALDVAV
HHCCCCHHHEEEECCCCCCEEEHHHHHHHHCCCCHHEEEEEEECCCCCCEECEEEEEEEE
RDGRIQRGHNVLIEGVGGGFTWGASVIRY
ECCCEECCCEEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure 
AQSTTYSRVLGTGSYLPPNRVSNQDLAARLAKQGIETSDEWIVARTGIHARHFAEPDVT
CCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHCCCCCCC
TSDLALIASQRAIEAADVDPQAIDLIIVATSTPDFVFPSTACLLQNKLGIKNNGAAFDVQ
HHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCEEEHH
AVCSGFAYAVATADSFIRSGQHRTALVVGAETFSRILDFNDRTTCVLFGDGAGAVVLQAS
HHHCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEEEC
DEPGVLASALHADGSHSNILCTPGNVNGGIVQGSAFLHMDGQAVFKLAVNVLEKVAVEAL
CCCCHHHHHHHCCCCCCEEEEECCCCCCCEEECEEEEEECCHHHHHHHHHHHHHHHHHHH
QKADLQPEQIDWLIPHQANIRIMQSTCRKLGLPQERMVVTVHEHGNTSAASIPLALDVAV
HHCCCCHHHEEEECCCCCCEEEHHHHHHHHCCCCHHEEEEEEECCCCCCEECEEEEEEEE
RDGRIQRGHNVLIEGVGGGFTWGASVIRY
ECCCEECCCEEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA