Click here to switch to the map view.

The map label for this gene is moaA [H]

Identifier: 186475582

GI number: 186475582

Start: 915108

End: 916220

Strand: Reverse

Name: moaA [H]

Synonym: Bphy_0817

Alternate gene names: 186475582

Gene position: 916220-915108 (Counterclockwise)

Preceding gene: 186475583

Following gene: 186475581

Centisome position: 26.33

GC content: 64.87

Gene sequence:

>1113_bases
ATGTCCCGACGCATCATTCCTGTTGCCGACGTCAGCGCGGTTCCCGACGTCGCCGGTCCTGCCCGGACCCCACGCGGCGA
ATTGACCGATACGCTGTCGCGCCCGTTGCGCGATCTGCGTATTTCGGTGACGGACCGCTGCAACTTCCGGTGCGTCTACT
GCATGCCGCGCGCCGTGTTCGGCAAGGACTATCCGTTTCTGCCGCACAGTGCGCTGCTGACCTTCGAGGAGATCGAGCGG
CTCGCGGCAATATTCGTCGCGCATGGCGTCGAAAAGATCCGTCTGACGGGCGGCGAACCGCTGCTGCGCAAGAATCTCGA
ATTTCTGATCGAGCGCCTGGCGCGTATGACAACGGCGGCAGGCAAGCCGCTTGACCTGACGCTCACGACCAACGGCTCGC
TGCTCGCCCGCAAAGCGCGCAGCCTGAAAGATGCCGGGCTCAACCGCGTCACCGTAAGCCTCGATGCGCTTGACGACGCG
TTATTTCGCCGCATGAACGACGCCGATTTCGCGGTGAGCGATGTGCTCCACGGCATTGAAGTCGCGCAATCGGTTGGGCT
TGCGCCACTGAAGGTGAACATGGTGGTCAAACGCGGCACGAATGACAGCGAAATCGTGCCGCTGGCGCGGCATTTCAAAG
GCTCGGGCGTCGTGCTGCGGTTTATCGAATACATGGACGTCGGCACGTCGAACGGCTGGAACATGACGGAAGTGCTGCCG
TCGGCGGACGTGGTCGCGCGCATCAGCGAGCACTTCCCGCTGTCGCCCCTCGAAGCGCACAGCGCCGCCGAAACCGCCCA
GCGCTGGGGTTACGCGGACGGCAGCGGCGAAGTCGGCGTGATCTCCAGCGTGACGCGGGCATTCTGTGGCGACTGCACGC
GCGCGCGGTTGTCGACGGAAGGCAAAGTCTATCTGTGCCTGTTCGCGTCGTCGGGTCACGACCTGCGCGCGCTCGTGCGC
AACGGCACGAGCGACGCAGGCATCGCCACCGCCATCGCCAATATGTGGCACGCGCGCGGTGACCGTTACTCGCAGCTGCG
CGGCAGTGCGAGCACGGCGGCAAAGACGGCGACGCAAGTGCGGCGCGTCGAGATGTCGTACATCGGCGGCTGA

Upstream 100 bases:

>100_bases
CCGTCAACATGGATACGCGCGTGATATACCGCGCGTTCGCCCTACTGTGACGGAATGGGCCTTCCGTTAGAATGAAGTCT
GATATTCGAAATATGTGACC

Downstream 100 bases:

>100_bases
GTTCGTCGTCCTCGCATGACAGTGACGCGCGACGACATCACCGGCCTGCTCCTCGCGGGTGGGCGCGGCATGCGCATGGG
CGGCGCCGACAAAGGCCTGC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSRRIIPVADVSAVPDVAGPARTPRGELTDTLSRPLRDLRISVTDRCNFRCVYCMPRAVFGKDYPFLPHSALLTFEEIER
LAAIFVAHGVEKIRLTGGEPLLRKNLEFLIERLARMTTAAGKPLDLTLTTNGSLLARKARSLKDAGLNRVTVSLDALDDA
LFRRMNDADFAVSDVLHGIEVAQSVGLAPLKVNMVVKRGTNDSEIVPLARHFKGSGVVLRFIEYMDVGTSNGWNMTEVLP
SADVVARISEHFPLSPLEAHSAAETAQRWGYADGSGEVGVISSVTRAFCGDCTRARLSTEGKVYLCLFASSGHDLRALVR
NGTSDAGIATAIANMWHARGDRYSQLRGSASTAAKTATQVRRVEMSYIGG

Sequences:

>Translated_370_residues
MSRRIIPVADVSAVPDVAGPARTPRGELTDTLSRPLRDLRISVTDRCNFRCVYCMPRAVFGKDYPFLPHSALLTFEEIER
LAAIFVAHGVEKIRLTGGEPLLRKNLEFLIERLARMTTAAGKPLDLTLTTNGSLLARKARSLKDAGLNRVTVSLDALDDA
LFRRMNDADFAVSDVLHGIEVAQSVGLAPLKVNMVVKRGTNDSEIVPLARHFKGSGVVLRFIEYMDVGTSNGWNMTEVLP
SADVVARISEHFPLSPLEAHSAAETAQRWGYADGSGEVGVISSVTRAFCGDCTRARLSTEGKVYLCLFASSGHDLRALVR
NGTSDAGIATAIANMWHARGDRYSQLRGSASTAAKTATQVRRVEMSYIGG
>Mature_369_residues
SRRIIPVADVSAVPDVAGPARTPRGELTDTLSRPLRDLRISVTDRCNFRCVYCMPRAVFGKDYPFLPHSALLTFEEIERL
AAIFVAHGVEKIRLTGGEPLLRKNLEFLIERLARMTTAAGKPLDLTLTTNGSLLARKARSLKDAGLNRVTVSLDALDDAL
FRRMNDADFAVSDVLHGIEVAQSVGLAPLKVNMVVKRGTNDSEIVPLARHFKGSGVVLRFIEYMDVGTSNGWNMTEVLPS
ADVVARISEHFPLSPLEAHSAAETAQRWGYADGSGEVGVISSVTRAFCGDCTRARLSTEGKVYLCLFASSGHDLRALVRN
GTSDAGIATAIANMWHARGDRYSQLRGSASTAAKTATQVRRVEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=343, Percent_Identity=34.6938775510204, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI22027536, Length=343, Percent_Identity=34.6938775510204, Blast_Score=188, Evalue=7e-48,
Organism=Escherichia coli, GI1786999, Length=311, Percent_Identity=33.1189710610932, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17561210, Length=324, Percent_Identity=33.641975308642, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI32566331, Length=336, Percent_Identity=32.1428571428571, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32566329, Length=317, Percent_Identity=32.4921135646688, Blast_Score=170, Evalue=9e-43,
Organism=Drosophila melanogaster, GI28574490, Length=294, Percent_Identity=37.4149659863946, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI28574488, Length=294, Percent_Identity=37.4149659863946, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 40160; Mature: 40029

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRIIPVADVSAVPDVAGPARTPRGELTDTLSRPLRDLRISVTDRCNFRCVYCMPRAVF
CCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEECCHHHH
GKDYPFLPHSALLTFEEIERLAAIFVAHGVEKIRLTGGEPLLRKNLEFLIERLARMTTAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
GKPLDLTLTTNGSLLARKARSLKDAGLNRVTVSLDALDDALFRRMNDADFAVSDVLHGIE
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHH
VAQSVGLAPLKVNMVVKRGTNDSEIVPLARHFKGSGVVLRFIEYMDVGTSNGWNMTEVLP
HHHHCCCCEEEEEEEEECCCCCCCEEHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
SADVVARISEHFPLSPLEAHSAAETAQRWGYADGSGEVGVISSVTRAFCGDCTRARLSTE
CHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCC
GKVYLCLFASSGHDLRALVRNGTSDAGIATAIANMWHARGDRYSQLRGSASTAAKTATQV
CCEEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHH
RRVEMSYIGG
HHHHHHHCCC
>Mature Secondary Structure 
SRRIIPVADVSAVPDVAGPARTPRGELTDTLSRPLRDLRISVTDRCNFRCVYCMPRAVF
CCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEECCHHHH
GKDYPFLPHSALLTFEEIERLAAIFVAHGVEKIRLTGGEPLLRKNLEFLIERLARMTTAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
GKPLDLTLTTNGSLLARKARSLKDAGLNRVTVSLDALDDALFRRMNDADFAVSDVLHGIE
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHH
VAQSVGLAPLKVNMVVKRGTNDSEIVPLARHFKGSGVVLRFIEYMDVGTSNGWNMTEVLP
HHHHCCCCEEEEEEEEECCCCCCCEEHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
SADVVARISEHFPLSPLEAHSAAETAQRWGYADGSGEVGVISSVTRAFCGDCTRARLSTE
CHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCC
GKVYLCLFASSGHDLRALVRNGTSDAGIATAIANMWHARGDRYSQLRGSASTAAKTATQV
CCEEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHH
RRVEMSYIGG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]