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The map label for this gene is hldD [H]

Identifier: 186475517

GI number: 186475517

Start: 848702

End: 849694

Strand: Direct

Name: hldD [H]

Synonym: Bphy_0752

Alternate gene names: 186475517

Gene position: 848702-849694 (Clockwise)

Preceding gene: 186475516

Following gene: 186475518

Centisome position: 24.39

GC content: 61.03

Gene sequence:

>993_bases
ATGACCCTCATCGTCACCGGCGCGGCTGGTTTTATCGGCAGCAATCTCGTCAAGGCGCTCAACGAGCGCGGCGAAGACGG
CATCATCGCCGTCGACAATCTGACGCGCGCCGACAAGTTCAAGAATCTCGTCGACTGTGAAATCGATGACTATCTCGACA
AGACGGAATTCGTCGAGCGCTTTGCGCGCGGCGACTTCGGCAAGGTGCGCGCGATTTTCCATGAGGGTGCCTGTTCGGAC
ACGATGGAAACCGACGGCCGCTACATGATGGATAACAACTTCCGCTATAGCCGCGCGGTGCTCGATGCGTGTCTCGCGCA
GGGCGTGCAATTTCTGTACGCGTCGTCGGCGGCGACTTATGGCGGCTCGACGCGCTTCGTCGAAGAGCGCGAGGTCGAGG
CGCCGCTGAATGTATACGGCTATTCGAAGTTCCTGTTCGATCAGGTGATCCGGCGCGTGCTGCCCACCGCGAAGAGCCAG
ATTGCGGGCTTTCGCTACTTCAACGTGTACGGGCCGCGCGAATCGCACAAGGCACGCATGGCTTCCGTCGCGTTTCACAA
CTTCAACCAGTTCCGCGCTGAAGGGAAAGTCAAGCTCTTCGGCGAGTACAACGGCTACGCAGCAGGCGAACAGACGCGCG
ACTTCGTCTCCGTCGAAGACCTGGTGAAGGTGAATCTGCACTTCTTCGATCATCCGGAGAAGTCGGGCATCTTCAATCTC
GGCAGCGGGCGTGCGCAGCCGTTCAATGACATCGCGTCGACGGTGGTCAACGCGCTGCGTGCGCTCGACGGCGAGCCGGC
GTTGTCGCTCGCTGAGCTGGTGCAGCGCGGGTTGATCGAGTACATCCCGTTCCCCGACGCGTTGCGCGGCAAGTATCAGT
GCTTCACGCAAGCCGACCTGACGAAGCTGCGCGCAGCGGGCTACGACGCGCCGTTCCTGACGGTGCAGGAAGGCGTCGAT
CGTTACGTGCGTTGGCTATCCGGCCAGGTGTAA

Upstream 100 bases:

>100_bases
CGACGAACTCTTTCACTGATGCCCGCGCGCGCCCGTTTCATCGCGTGGCGCGCGGCGGTTCATCTGCGCATCCGTTGACT
CACATCACTGCAGGACGACC

Downstream 100 bases:

>100_bases
ATCGTTCGTACGCCTCTCTACACTGGGGTCTCCTGGTCGGTGATCGTCACTGGCCGGTGTTTCAGGGAGATCCCATATGC
TCAAAAAAATCTTCGTCACG

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTLIVTGAAGFIGSNLVKALNERGEDGIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVERFARGDFGKVRAIFHEGACSD
TMETDGRYMMDNNFRYSRAVLDACLAQGVQFLYASSAATYGGSTRFVEEREVEAPLNVYGYSKFLFDQVIRRVLPTAKSQ
IAGFRYFNVYGPRESHKARMASVAFHNFNQFRAEGKVKLFGEYNGYAAGEQTRDFVSVEDLVKVNLHFFDHPEKSGIFNL
GSGRAQPFNDIASTVVNALRALDGEPALSLAELVQRGLIEYIPFPDALRGKYQCFTQADLTKLRAAGYDAPFLTVQEGVD
RYVRWLSGQV

Sequences:

>Translated_330_residues
MTLIVTGAAGFIGSNLVKALNERGEDGIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVERFARGDFGKVRAIFHEGACSD
TMETDGRYMMDNNFRYSRAVLDACLAQGVQFLYASSAATYGGSTRFVEEREVEAPLNVYGYSKFLFDQVIRRVLPTAKSQ
IAGFRYFNVYGPRESHKARMASVAFHNFNQFRAEGKVKLFGEYNGYAAGEQTRDFVSVEDLVKVNLHFFDHPEKSGIFNL
GSGRAQPFNDIASTVVNALRALDGEPALSLAELVQRGLIEYIPFPDALRGKYQCFTQADLTKLRAAGYDAPFLTVQEGVD
RYVRWLSGQV
>Mature_329_residues
TLIVTGAAGFIGSNLVKALNERGEDGIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVERFARGDFGKVRAIFHEGACSDT
METDGRYMMDNNFRYSRAVLDACLAQGVQFLYASSAATYGGSTRFVEEREVEAPLNVYGYSKFLFDQVIRRVLPTAKSQI
AGFRYFNVYGPRESHKARMASVAFHNFNQFRAEGKVKLFGEYNGYAAGEQTRDFVSVEDLVKVNLHFFDHPEKSGIFNLG
SGRAQPFNDIASTVVNALRALDGEPALSLAELVQRGLIEYIPFPDALRGKYQCFTQADLTKLRAAGYDAPFLTVQEGVDR
YVRWLSGQV

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=327, Percent_Identity=56.2691131498471, Blast_Score=350, Evalue=6e-98,
Organism=Saccharomyces cerevisiae, GI6319493, Length=274, Percent_Identity=26.6423357664234, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36908; Mature: 36777

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIVTGAAGFIGSNLVKALNERGEDGIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVER
CEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCHHHHCCHHHHHHH
FARGDFGKVRAIFHEGACSDTMETDGRYMMDNNFRYSRAVLDACLAQGVQFLYASSAATY
HHCCCHHHHHHHHHCCCCCCCHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GGSTRFVEEREVEAPLNVYGYSKFLFDQVIRRVLPTAKSQIAGFRYFNVYGPRESHKARM
CCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHH
ASVAFHNFNQFRAEGKVKLFGEYNGYAAGEQTRDFVSVEDLVKVNLHFFDHPEKSGIFNL
HHHHHHHHHHHHCCCCEEEEECCCCEECCCHHHHHHHHHHHHHHHEEEECCCCCCCCEEC
GSGRAQPFNDIASTVVNALRALDGEPALSLAELVQRGLIEYIPFPDALRGKYQCFTQADL
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
TKLRAAGYDAPFLTVQEGVDRYVRWLSGQV
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLIVTGAAGFIGSNLVKALNERGEDGIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVER
EEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCHHHHCCHHHHHHH
FARGDFGKVRAIFHEGACSDTMETDGRYMMDNNFRYSRAVLDACLAQGVQFLYASSAATY
HHCCCHHHHHHHHHCCCCCCCHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GGSTRFVEEREVEAPLNVYGYSKFLFDQVIRRVLPTAKSQIAGFRYFNVYGPRESHKARM
CCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHH
ASVAFHNFNQFRAEGKVKLFGEYNGYAAGEQTRDFVSVEDLVKVNLHFFDHPEKSGIFNL
HHHHHHHHHHHHCCCCEEEEECCCCEECCCHHHHHHHHHHHHHHHEEEECCCCCCCCEEC
GSGRAQPFNDIASTVVNALRALDGEPALSLAELVQRGLIEYIPFPDALRGKYQCFTQADL
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHH
TKLRAAGYDAPFLTVQEGVDRYVRWLSGQV
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA