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The map label for this gene is gyrA [H]

Identifier: 186475503

GI number: 186475503

Start: 832056

End: 834635

Strand: Direct

Name: gyrA [H]

Synonym: Bphy_0738

Alternate gene names: 186475503

Gene position: 832056-834635 (Clockwise)

Preceding gene: 186475498

Following gene: 186475504

Centisome position: 23.92

GC content: 60.97

Gene sequence:

>2580_bases
ATGCGCCGCTCGTATATCGAGTACGCGATGAGCGTGATCGTAGGGCGCGCCCTTCCCGATGTCCGCGATGGCCTGAAGCC
GGTGCACCGGCGCGTGCTGTACGCCATGCACGAGCTGAACAACGACTGGAATCGGGCGTACAAGAAGTCGGCACGTATCG
TCGGCGATGTGATCGGTAAGTACCATCCGCACGGTGATTCGGCTGTATACGACACGATTGTCCGCATGGCGCAGGATTTT
TCGCTGCGCTACATGCTCGTCGATGGACAAGGCAATTTCGGGTCGGTCGACGGCGACAACGCCGCGGCGATGCGTTACAC
CGAAATACGCATGGCGAAGATCGGCCACGAACTGCTCGCCGACATCGACAAGGAAACAGTCGATTTCCAGCCCAACTACG
ACGGCAGCGAAAACGAGCCGTCCATTCTGCCTGCACGCATTCCGAACCTGCTGATCAACGGCTCGTCGGGCATTGCCGTC
GGCATGGCGACCAACATTCCGCCGCACAATCTGAGCGAAATCGTCGACGCCTGCCACCACCTGCTGAAGAACCCGGAAGC
GTCGATCGACGAGCTGATCGAGATCGTGCCGGCGCCCGACTTCCCGACGGCGGGGATCATCTACGGCGTCGCTGGCGTGC
GCGACGGCTACCGCACGGGGCGCGGGCGCGTCGTGATGCGCGCCGCCACGCACTTCGAAGAGATTGATCGCGGCCAACGC
ATGGCGATCATCGTCGACGAGCTGCCGTATCAGGTGAACAAGCGTTCGCTGCTCGAGCGTATCGCCGAACTGGTGAATGA
GAAAAAGCTGGAAGGCATTTCGGACATTCGCGACGAATCCGACAAGAGTGGTATGCGCGTCGTGATCGAACTTAAGCGCG
GCGAAGTGCCCGAGGTCATTCTTAACAATCTGTACAAGGCAACGCAGCTCCAGGACACGTTCGGCATGAACATGGTCGCG
CTCGTCGACGGCCAGCCGAAGCTGCTGAACCTGAAGGAAATGCTCTCGCATTTCCTGTCGCACCGTCGCGAGGTGCTGAC
ACGGCGCACTGTATACGAACTGCGCAAGGCGCGCGAACGCGGCCATGTGCTCGAAGGCCTCGCCGTCGCGCTCGCCAACA
TCGACGACTTCATCGCGATCATCAAGGCAGCGCCTACGCCGCCCATTGCGAAGCAGGAGTTGATGGACCGTTCGTGGGAT
TCATCGATCGTGCGCGAAATGCTGCAGCGCGCAGAAACCGACAACGCGACGTCCGGCGGCCGCGCCGCGTATCGTCCGGA
AGGATTGAACCCGGCGTACGGCATGCAGGCCGACGGTCTGTACCGTCTGTCTGACACGCAGGCGCAGGAAATCCTGCAGA
TGCGTCTGCAGCGCCTGACGGGTCTGGAGCAGGACAAGATCATCGGCGAGTACCGCGACGTGATGGCGCAGATCGCCGAC
CTGCTGGACATTCTGGCGCGCCCGGAGCGTATAACTTCCATCATCTTCGACGAACTCACCACGATCAAGAGCGAATTTGG
CGACGAGCGCCGCTCGAAGATCGAGATGAACGCAACCGAGCTGAACACGGAAGACCTCATCACGCCGCAGGACATGGTCG
TGACGATGTCGCACTCCGGTTACGTGAAATCGCAGCCGTTGTCGGAATATCGCGCCCAGAAGCGCGGAGGTCGCGGCAAA
CAGGCGACACAGATGAAGGAAGACGATTGGATCGACACGCTCTTCATCGCGAACACGCACGATCACATCCTCTGCTTCTC
GAACCGCGGCCGTGTTTACTGGCTGAAGGTTTACGAAGTACCGCAGGGCTCGCGCAATTCGCGCGGCCGTCCGATCGTCA
ATATGTTCCCGCTGCAGGAGGGCGAGAAGATTACGGTCGTGCTGCCCGTGAAGGAATTTTCGGCGGACAAGTTCGTTTTT
ATGGCGACGGCGCTCGGCACCGTCAAGAAGACGCCGCTCGAAGCGTTCAGTCGTCCGCTGAAGAAGGGCATCATCGCGGT
CGGTCTGGATGATGGCGACTACCTGATCGGCGCGGCTATCACAGATGGCGAGCATGATGTGATGCTGTTCTCGGACTCGG
GCAAAGCGGTGCGCTTCGACGAGAACGACGTTCGTCCGATGGGCCGTGAAGCGCGCGGCGTGCGCGGCATGCAGCTCGAA
GACGGCCAGAGTGTGATCGCACTACTGGTGGCGGGCGACGAGCAGCAGTCGGTGCTGACGGCAACGGAAAACGGCTACGG
CAAGCGCACCCCGATCACCGAGTACACGCGTCATGGCCGCGGCACGAAGGGCATGATCGCGATCCAGACGTCCGAGCGCA
ACGGCAAGGTCGTCGCCGCGACACTGGTCGACCCGGAAGCGCAGATCATGCTGATCACCAACACGGGCGTGCTGATCCGC
ACGCGCGTGTCAGAAATTCGAGAAATGGGCCGTGCAACGCAAGGTGTTACACTCATCAGCCTTGATGAAGGCACCAAGCT
TTCCGGTCTGCAACAGATTGCCGAAGCGGAAGCTGACGTGGACGGCGACGCCGACCTGCCTGCAGACGAAGCAGGCGGCG
ATGAAAGCGAAGCGTCGTAG

Upstream 100 bases:

>100_bases
GAGGTGAAGAACGCGTTTCCCTCATCGTCTTCGCGCGTAAACGATACGGACAATGGATCAATTCGCCAAAGAGACTCTAC
CAATCTCCCTAGAGGAGGAA

Downstream 100 bases:

>100_bases
TCTGCCTCGAAGCTTCTCAAGTAATGCGGAAAGCCGCGCGGGCATTCCGCGCGCATCGGGACTGATGCGCCGCTTGCGCG
GTGAAGCACCCAGATTAATT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 859; Mature: 859

Protein sequence:

>859_residues
MRRSYIEYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWNRAYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQDF
SLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFQPNYDGSENEPSILPARIPNLLINGSSGIAV
GMATNIPPHNLSEIVDACHHLLKNPEASIDELIEIVPAPDFPTAGIIYGVAGVRDGYRTGRGRVVMRAATHFEEIDRGQR
MAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVILNNLYKATQLQDTFGMNMVA
LVDGQPKLLNLKEMLSHFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDDFIAIIKAAPTPPIAKQELMDRSWD
SSIVREMLQRAETDNATSGGRAAYRPEGLNPAYGMQADGLYRLSDTQAQEILQMRLQRLTGLEQDKIIGEYRDVMAQIAD
LLDILARPERITSIIFDELTTIKSEFGDERRSKIEMNATELNTEDLITPQDMVVTMSHSGYVKSQPLSEYRAQKRGGRGK
QATQMKEDDWIDTLFIANTHDHILCFSNRGRVYWLKVYEVPQGSRNSRGRPIVNMFPLQEGEKITVVLPVKEFSADKFVF
MATALGTVKKTPLEAFSRPLKKGIIAVGLDDGDYLIGAAITDGEHDVMLFSDSGKAVRFDENDVRPMGREARGVRGMQLE
DGQSVIALLVAGDEQQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVDPEAQIMLITNTGVLIR
TRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEADVDGDADLPADEAGGDESEAS

Sequences:

>Translated_859_residues
MRRSYIEYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWNRAYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQDF
SLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFQPNYDGSENEPSILPARIPNLLINGSSGIAV
GMATNIPPHNLSEIVDACHHLLKNPEASIDELIEIVPAPDFPTAGIIYGVAGVRDGYRTGRGRVVMRAATHFEEIDRGQR
MAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVILNNLYKATQLQDTFGMNMVA
LVDGQPKLLNLKEMLSHFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDDFIAIIKAAPTPPIAKQELMDRSWD
SSIVREMLQRAETDNATSGGRAAYRPEGLNPAYGMQADGLYRLSDTQAQEILQMRLQRLTGLEQDKIIGEYRDVMAQIAD
LLDILARPERITSIIFDELTTIKSEFGDERRSKIEMNATELNTEDLITPQDMVVTMSHSGYVKSQPLSEYRAQKRGGRGK
QATQMKEDDWIDTLFIANTHDHILCFSNRGRVYWLKVYEVPQGSRNSRGRPIVNMFPLQEGEKITVVLPVKEFSADKFVF
MATALGTVKKTPLEAFSRPLKKGIIAVGLDDGDYLIGAAITDGEHDVMLFSDSGKAVRFDENDVRPMGREARGVRGMQLE
DGQSVIALLVAGDEQQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVDPEAQIMLITNTGVLIR
TRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEADVDGDADLPADEAGGDESEAS
>Mature_859_residues
MRRSYIEYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWNRAYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQDF
SLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFQPNYDGSENEPSILPARIPNLLINGSSGIAV
GMATNIPPHNLSEIVDACHHLLKNPEASIDELIEIVPAPDFPTAGIIYGVAGVRDGYRTGRGRVVMRAATHFEEIDRGQR
MAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVILNNLYKATQLQDTFGMNMVA
LVDGQPKLLNLKEMLSHFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDDFIAIIKAAPTPPIAKQELMDRSWD
SSIVREMLQRAETDNATSGGRAAYRPEGLNPAYGMQADGLYRLSDTQAQEILQMRLQRLTGLEQDKIIGEYRDVMAQIAD
LLDILARPERITSIIFDELTTIKSEFGDERRSKIEMNATELNTEDLITPQDMVVTMSHSGYVKSQPLSEYRAQKRGGRGK
QATQMKEDDWIDTLFIANTHDHILCFSNRGRVYWLKVYEVPQGSRNSRGRPIVNMFPLQEGEKITVVLPVKEFSADKFVF
MATALGTVKKTPLEAFSRPLKKGIIAVGLDDGDYLIGAAITDGEHDVMLFSDSGKAVRFDENDVRPMGREARGVRGMQLE
DGQSVIALLVAGDEQQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVDPEAQIMLITNTGVLIR
TRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEADVDGDADLPADEAGGDESEAS

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=26.4797507788162, Blast_Score=92, Evalue=3e-18,
Organism=Homo sapiens, GI19913408, Length=357, Percent_Identity=25.7703081232493, Blast_Score=90, Evalue=9e-18,
Organism=Escherichia coli, GI1788562, Length=844, Percent_Identity=60.4265402843602, Blast_Score=1034, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=717, Percent_Identity=35.2859135285914, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=494, Percent_Identity=24.8987854251012, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=380, Percent_Identity=25.5263157894737, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=364, Percent_Identity=25.2747252747253, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=27.3775216138329, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136538, Length=348, Percent_Identity=26.7241379310345, Blast_Score=90, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 95420; Mature: 95420

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSYIEYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWNRAYKKSARIVGDVIGK
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
YHPHGDSAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLA
CCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
DIDKETVDFQPNYDGSENEPSILPARIPNLLINGSSGIAVGMATNIPPHNLSEIVDACHH
HCCCHHCCCCCCCCCCCCCCCEECCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHH
LLKNPEASIDELIEIVPAPDFPTAGIIYGVAGVRDGYRTGRGRVVMRAATHFEEIDRGQR
HHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHCCCCE
MAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVI
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEECCCCCHHHH
LNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEMLSHFLSHRREVLTRRTVYELRKARER
HHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHVLEGLAVALANIDDFIAIIKAAPTPPIAKQELMDRSWDSSIVREMLQRAETDNATSGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
RAAYRPEGLNPAYGMQADGLYRLSDTQAQEILQMRLQRLTGLEQDKIIGEYRDVMAQIAD
CCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LLDILARPERITSIIFDELTTIKSEFGDERRSKIEMNATELNTEDLITPQDMVVTMSHSG
HHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHEEEECHHHCCHHHCCCCCCEEEEEECCC
YVKSQPLSEYRAQKRGGRGKQATQMKEDDWIDTLFIANTHDHILCFSNRGRVYWLKVYEV
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCEEEEEEEEC
PQGSRNSRGRPIVNMFPLQEGEKITVVLPVKEFSADKFVFMATALGTVKKTPLEAFSRPL
CCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEHHHHHHHCCHHHHHHHHH
KKGIIAVGLDDGDYLIGAAITDGEHDVMLFSDSGKAVRFDENDVRPMGREARGVRGMQLE
HCCEEEEEECCCCEEEEEEEECCCCCEEEECCCCCEEEECCCCCCCCCHHHCCCCCCEEC
DGQSVIALLVAGDEQQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAA
CCCEEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCEEEE
TLVDPEAQIMLITNTGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEADV
EEECCCCEEEEEECCCEEEEHHHHHHHHHCCHHCCEEEEEECCCCCHHHHHHHHHHHCCC
DGDADLPADEAGGDESEAS
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRSYIEYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWNRAYKKSARIVGDVIGK
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
YHPHGDSAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLA
CCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
DIDKETVDFQPNYDGSENEPSILPARIPNLLINGSSGIAVGMATNIPPHNLSEIVDACHH
HCCCHHCCCCCCCCCCCCCCCEECCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHH
LLKNPEASIDELIEIVPAPDFPTAGIIYGVAGVRDGYRTGRGRVVMRAATHFEEIDRGQR
HHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHCCCCE
MAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVI
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEECCCCCHHHH
LNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEMLSHFLSHRREVLTRRTVYELRKARER
HHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHVLEGLAVALANIDDFIAIIKAAPTPPIAKQELMDRSWDSSIVREMLQRAETDNATSGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
RAAYRPEGLNPAYGMQADGLYRLSDTQAQEILQMRLQRLTGLEQDKIIGEYRDVMAQIAD
CCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LLDILARPERITSIIFDELTTIKSEFGDERRSKIEMNATELNTEDLITPQDMVVTMSHSG
HHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHEEEECHHHCCHHHCCCCCCEEEEEECCC
YVKSQPLSEYRAQKRGGRGKQATQMKEDDWIDTLFIANTHDHILCFSNRGRVYWLKVYEV
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCEEEEEEEEC
PQGSRNSRGRPIVNMFPLQEGEKITVVLPVKEFSADKFVFMATALGTVKKTPLEAFSRPL
CCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEHHHHHHHCCHHHHHHHHH
KKGIIAVGLDDGDYLIGAAITDGEHDVMLFSDSGKAVRFDENDVRPMGREARGVRGMQLE
HCCEEEEEECCCCEEEEEEEECCCCCEEEECCCCCEEEECCCCCCCCCHHHCCCCCCEEC
DGQSVIALLVAGDEQQSVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAA
CCCEEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCEEEE
TLVDPEAQIMLITNTGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEADV
EEECCCCEEEEEECCCEEEEHHHHHHHHHCCHHCCEEEEEECCCCCHHHHHHHHHHHCCC
DGDADLPADEAGGDESEAS
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]