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The map label for this gene is guaD [H]

Identifier: 186475474

GI number: 186475474

Start: 795644

End: 796969

Strand: Reverse

Name: guaD [H]

Synonym: Bphy_0709

Alternate gene names: 186475474

Gene position: 796969-795644 (Counterclockwise)

Preceding gene: 186475475

Following gene: 186475472

Centisome position: 22.91

GC content: 64.48

Gene sequence:

>1326_bases
ATGACTCAAACAGCTTTTCGCGCGCACCTGCTGACGTTCAACGGCGATCCTGCGCAATCGTCCAACGCTGCAGTGTTCAA
CGAAGACGGCCTTTTGATCGTCGAAGACGGACATGTCGTCGCGGCGGGTGCGCATGCATCCGTCGCTGCACAGCTCGCAC
CTGGGACGCAGGTGATCGAGATGCGCGACAAGCTGATCGTCCCCGGTTTCATCGACACGCATATCCATTTCCCGCAGACG
GACATGATTGCGTCGCCCGCGCCGGGTCTGCTGCCGTGGCTCGACACGTACACGTTCCCAACCGAGCGCGGTTTCAGCGA
AGCCGCCGTCGCAGAGGACACGGCGCGCTTTTTCATCGACGAGCTGCTCGCGAACGGTACGACGACGGCGCTCGTCTACT
GCACAGTGCACAAGCAATCGGCCGATGCGCTGTTCACGCAAGCGCAGCGCCGCAATGTGCGGATGATCGGCGGCAAGGTG
CTGATGGATCGCAACTGCCCCGAGTTTCTGCGCGACACCGCGCAATCGGGCTACGACGATAGCGCCGAGCTGATCGCGCG
CTGGCACGACAACGGGCGGCAGATGTACGCGCTAACGCCGCGCTTCGCGCCGACCTCGACGCAAGCGCAGCTCGAAGCGA
CGGGTGCGCTCGCGAAGCTGCATCCCGACGTGTTCATCCAGACCCACGTCGCGGAGAATCATGACGAAGTGAAGTGGGTG
GCGAGCCTGTTCCCCGGCCATCGCAGCTATCTCGACATCTACGATCACTATGGTCTGTTGCGGCCGCGCGCCGTGTACGG
GCACTGCATTCACCTCGACACCGAGGACCGGCGACGGATGGCGCAAACGAGCGCCGTCGCGGCACACTGCCCGACGTCGA
ACCTGTTTCTCGGCAGCGGACTGTTCGATTTCGACAAGGCGATCGAGTCGGGCATGCCTGTCGCGCTCGCCACCGACGTC
GGCGGCGGCACGTCGTTCTCGATGCTGCAAACGATGAATGAAGCGCACAAGGTCGCGCGTCTTGGCGGGCATCATCTGAC
GGCGACGCGCATGTTCTGGCTGGCGACGGCGGGCGCTGCCGAAGCGCTCGATCTCGGCGACAAGATCGGCACGCTCAAGC
CGAAAGCGGAGGCAGACTTCGTGGTGCTCGATCCACGCGCGACGCCGCTGCTCGCGCGGCGCACTGCGCGCACCGAGACG
CTGGAGGAACTGCTGTTCGCGTTCGCGCTACTGGGCGACGATCGCGCCGTGTATGAGACGTATGCAGCGGGGCAGCGTGT
GCATCGACGTGACGATACGGTGGGGAAGGCGCGGATCGCGGCCTGA

Upstream 100 bases:

>100_bases
CGTTCGTCACGCCCGCGCAGCGCGATGCGATGATCGCGAAACTCGATGCGCACTGGCGCGCATCTGCCTGATTCTTACCC
GTTCGGAGACGGTTTCACTC

Downstream 100 bases:

>100_bases
TTTTTTAGCGTGCGGCGGGTGGTTTTTTTGCTGGCGTTATGTTCGGTCGCTGCGCGTTGTTTTTTTTCTGGCAGCGAAAC
GCAACCCGGATGCCGGCGAA

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTQTAFRAHLLTFNGDPAQSSNAAVFNEDGLLIVEDGHVVAAGAHASVAAQLAPGTQVIEMRDKLIVPGFIDTHIHFPQT
DMIASPAPGLLPWLDTYTFPTERGFSEAAVAEDTARFFIDELLANGTTTALVYCTVHKQSADALFTQAQRRNVRMIGGKV
LMDRNCPEFLRDTAQSGYDDSAELIARWHDNGRQMYALTPRFAPTSTQAQLEATGALAKLHPDVFIQTHVAENHDEVKWV
ASLFPGHRSYLDIYDHYGLLRPRAVYGHCIHLDTEDRRRMAQTSAVAAHCPTSNLFLGSGLFDFDKAIESGMPVALATDV
GGGTSFSMLQTMNEAHKVARLGGHHLTATRMFWLATAGAAEALDLGDKIGTLKPKAEADFVVLDPRATPLLARRTARTET
LEELLFAFALLGDDRAVYETYAAGQRVHRRDDTVGKARIAA

Sequences:

>Translated_441_residues
MTQTAFRAHLLTFNGDPAQSSNAAVFNEDGLLIVEDGHVVAAGAHASVAAQLAPGTQVIEMRDKLIVPGFIDTHIHFPQT
DMIASPAPGLLPWLDTYTFPTERGFSEAAVAEDTARFFIDELLANGTTTALVYCTVHKQSADALFTQAQRRNVRMIGGKV
LMDRNCPEFLRDTAQSGYDDSAELIARWHDNGRQMYALTPRFAPTSTQAQLEATGALAKLHPDVFIQTHVAENHDEVKWV
ASLFPGHRSYLDIYDHYGLLRPRAVYGHCIHLDTEDRRRMAQTSAVAAHCPTSNLFLGSGLFDFDKAIESGMPVALATDV
GGGTSFSMLQTMNEAHKVARLGGHHLTATRMFWLATAGAAEALDLGDKIGTLKPKAEADFVVLDPRATPLLARRTARTET
LEELLFAFALLGDDRAVYETYAAGQRVHRRDDTVGKARIAA
>Mature_440_residues
TQTAFRAHLLTFNGDPAQSSNAAVFNEDGLLIVEDGHVVAAGAHASVAAQLAPGTQVIEMRDKLIVPGFIDTHIHFPQTD
MIASPAPGLLPWLDTYTFPTERGFSEAAVAEDTARFFIDELLANGTTTALVYCTVHKQSADALFTQAQRRNVRMIGGKVL
MDRNCPEFLRDTAQSGYDDSAELIARWHDNGRQMYALTPRFAPTSTQAQLEATGALAKLHPDVFIQTHVAENHDEVKWVA
SLFPGHRSYLDIYDHYGLLRPRAVYGHCIHLDTEDRRRMAQTSAVAAHCPTSNLFLGSGLFDFDKAIESGMPVALATDVG
GGTSFSMLQTMNEAHKVARLGGHHLTATRMFWLATAGAAEALDLGDKIGTLKPKAEADFVVLDPRATPLLARRTARTETL
EELLFAFALLGDDRAVYETYAAGQRVHRRDDTVGKARIAA

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=419, Percent_Identity=31.980906921241, Blast_Score=200, Evalue=3e-51,
Organism=Escherichia coli, GI1789249, Length=416, Percent_Identity=49.0384615384615, Blast_Score=435, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319963, Length=406, Percent_Identity=29.5566502463054, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24643849, Length=434, Percent_Identity=31.5668202764977, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48186; Mature: 48055

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTAFRAHLLTFNGDPAQSSNAAVFNEDGLLIVEDGHVVAAGAHASVAAQLAPGTQVIE
CCCCCEEEEEEEECCCCCCCCCCEEEECCCEEEEECCEEEEECCCHHHHEECCCCCEEEE
MRDKLIVPGFIDTHIHFPQTDMIASPAPGLLPWLDTYTFPTERGFSEAAVAEDTARFFID
ECCCEECCCEECCCEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
ELLANGTTTALVYCTVHKQSADALFTQAQRRNVRMIGGKVLMDRNCPEFLRDTAQSGYDD
HHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCEEEECCEEEECCCCHHHHHHHHHCCCCC
SAELIARWHDNGRQMYALTPRFAPTSTQAQLEATGALAKLHPDVFIQTHVAENHDEVKWV
HHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHCCHHHCCCCEEEEEECCCCCHHHHHH
ASLFPGHRSYLDIYDHYGLLRPRAVYGHCIHLDTEDRRRMAQTSAVAAHCPTSNLFLGSG
HHHCCCCCHHHHHHHHCCCCCCHHHEEEEEEECCHHHHHHHHHHHHEEECCCCCEEEECC
LFDFDKAIESGMPVALATDVGGGTSFSMLQTMNEAHKVARLGGHHLTATRMFWLATAGAA
CHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHEEEEEECCCH
EALDLGDKIGTLKPKAEADFVVLDPRATPLLARRTARTETLEELLFAFALLGDDRAVYET
HHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YAAGQRVHRRDDTVGKARIAA
HHHHHHHHHCCCCCCCEEECC
>Mature Secondary Structure 
TQTAFRAHLLTFNGDPAQSSNAAVFNEDGLLIVEDGHVVAAGAHASVAAQLAPGTQVIE
CCCCEEEEEEEECCCCCCCCCCEEEECCCEEEEECCEEEEECCCHHHHEECCCCCEEEE
MRDKLIVPGFIDTHIHFPQTDMIASPAPGLLPWLDTYTFPTERGFSEAAVAEDTARFFID
ECCCEECCCEECCCEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
ELLANGTTTALVYCTVHKQSADALFTQAQRRNVRMIGGKVLMDRNCPEFLRDTAQSGYDD
HHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCEEEECCEEEECCCCHHHHHHHHHCCCCC
SAELIARWHDNGRQMYALTPRFAPTSTQAQLEATGALAKLHPDVFIQTHVAENHDEVKWV
HHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHCCHHHCCCCEEEEEECCCCCHHHHHH
ASLFPGHRSYLDIYDHYGLLRPRAVYGHCIHLDTEDRRRMAQTSAVAAHCPTSNLFLGSG
HHHCCCCCHHHHHHHHCCCCCCHHHEEEEEEECCHHHHHHHHHHHHEEECCCCCEEEECC
LFDFDKAIESGMPVALATDVGGGTSFSMLQTMNEAHKVARLGGHHLTATRMFWLATAGAA
CHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHEEEEEECCCH
EALDLGDKIGTLKPKAEADFVVLDPRATPLLARRTARTETLEELLFAFALLGDDRAVYET
HHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YAAGQRVHRRDDTVGKARIAA
HHHHHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]