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The map label for this gene is fabB [H]

Identifier: 186475469

GI number: 186475469

Start: 791166

End: 792392

Strand: Direct

Name: fabB [H]

Synonym: Bphy_0704

Alternate gene names: 186475469

Gene position: 791166-792392 (Clockwise)

Preceding gene: 186475468

Following gene: 186475470

Centisome position: 22.74

GC content: 67.32

Gene sequence:

>1227_bases
ATGACGCGTGTGCAAGGCATGCAGCGCGTCGTCGTCACGGGCATGGGCATCGTGTCGTGCATCGGCAATACGCTCGACGA
CGTCAGCGCTGCGCTGCGTGAAGGACGCAGCGGCATCACGCATGTCGATGCGTGGCGCGAGCGCGGCTTCGGCACCCAGG
TCGCGGGTGTCGCGTCGGTGGACGGCGAGCCGCCATTCGATCGCAAGCTTGAACGATTCATGGGCGATACCGCGCGCTTC
GCGTGCCACGCGGCGCGCAAGGCCATCGACGACGCAGGTCTCGATATCGCCGCGCTGCGTTCGCATCACGTCGGTGCCGT
GCTCGGCTCGGGTGTCGGCACGATGTCGGCGTATGACGCGGCGATGGCCGTCGCGAACACGCGCGGTGTCGAGAAAACGC
CGCCGTACACGGTGCCGCAGGCGATGAGCAGCACCGCCTCCGCGAACGTCGCGCAGGTGTTCGGCATCGAGGGCGTCACG
TATTCGCCGTCGTCGGCGTGCACGACGTCGGCGCTCGCGATCGGCCAGGCCATGCAGCTGATTCAAACGGGACGTCAACG
GATCGTTCTCGCAGGTGGCAGCGAATGCCTGCACGACAACATGACGCTGATGTTCGACGCGATGCATGCGCTGTCGCGCC
GCTTCAACGACACGCCCGCCAGCGCCTCGCGACCTTACGATACGGCGCGCGACGGCTTCGTGATCGCAGCGGGCGGCGGC
GTGCTCGTGCTCGAAGCGCTCGATCATGCGCTCGCACGCGGCGCGCGCATCTATGCGGAGCTGACGGGGTTCGGCCACTG
CACGGACGGCGCGGGCATGGTGTCGCCGCACGCGCCGGGCATCGCGCGCGCAATGCAGGTTGCGCTCGACGAAGCGGGCG
CGCGTCCCGATTACGTGAATGCGCACGCGCCGTCGACGCCGCTCGGCGACATCGAGGAACTGCGCGCGCTGCAAACGGTG
TTCGGTTTGGACGTGCCGCCGTTTTCGTCGACGAAGGGGCTGACGGGGCATCCCCTCGGCGCATGCGGGGCGCATGAGGC
GATCTACACGCTGCTCATGATGCGCGACGGTTTTATCGCAGGGACGGTGGGCATCGAACAGATCGAGCCGCTCGCACAAC
AACTGCCGCTGGTGCAGGCCACGCGCGAAGCGAGGATCGATCGCGCGTTGTCGGTGTCGTTCGGTTTCGGGGGGAGTTGC
GCGAGCCTGATGTTTGCCAGGATTTGA

Upstream 100 bases:

>100_bases
ACATTCGAGGCGAGGCACGCGCGATCGATGCCGAATACGTGATGAGCAATAACTTCGCGTTTGGGGGCATCAACACGTCG
CTGATTTTCAGGCGCGTTCG

Downstream 100 bases:

>100_bases
AACGTAGTACGCACAATCAACAACGAGAAAGGGAATACGAAGAATGAAGACCAGAATCGCAATGGGGTTGGTGGCGGCCG
TCGTGCTGACGCAGGCGGGC

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MTRVQGMQRVVVTGMGIVSCIGNTLDDVSAALREGRSGITHVDAWRERGFGTQVAGVASVDGEPPFDRKLERFMGDTARF
ACHAARKAIDDAGLDIAALRSHHVGAVLGSGVGTMSAYDAAMAVANTRGVEKTPPYTVPQAMSSTASANVAQVFGIEGVT
YSPSSACTTSALAIGQAMQLIQTGRQRIVLAGGSECLHDNMTLMFDAMHALSRRFNDTPASASRPYDTARDGFVIAAGGG
VLVLEALDHALARGARIYAELTGFGHCTDGAGMVSPHAPGIARAMQVALDEAGARPDYVNAHAPSTPLGDIEELRALQTV
FGLDVPPFSSTKGLTGHPLGACGAHEAIYTLLMMRDGFIAGTVGIEQIEPLAQQLPLVQATREARIDRALSVSFGFGGSC
ASLMFARI

Sequences:

>Translated_408_residues
MTRVQGMQRVVVTGMGIVSCIGNTLDDVSAALREGRSGITHVDAWRERGFGTQVAGVASVDGEPPFDRKLERFMGDTARF
ACHAARKAIDDAGLDIAALRSHHVGAVLGSGVGTMSAYDAAMAVANTRGVEKTPPYTVPQAMSSTASANVAQVFGIEGVT
YSPSSACTTSALAIGQAMQLIQTGRQRIVLAGGSECLHDNMTLMFDAMHALSRRFNDTPASASRPYDTARDGFVIAAGGG
VLVLEALDHALARGARIYAELTGFGHCTDGAGMVSPHAPGIARAMQVALDEAGARPDYVNAHAPSTPLGDIEELRALQTV
FGLDVPPFSSTKGLTGHPLGACGAHEAIYTLLMMRDGFIAGTVGIEQIEPLAQQLPLVQATREARIDRALSVSFGFGGSC
ASLMFARI
>Mature_407_residues
TRVQGMQRVVVTGMGIVSCIGNTLDDVSAALREGRSGITHVDAWRERGFGTQVAGVASVDGEPPFDRKLERFMGDTARFA
CHAARKAIDDAGLDIAALRSHHVGAVLGSGVGTMSAYDAAMAVANTRGVEKTPPYTVPQAMSSTASANVAQVFGIEGVTY
SPSSACTTSALAIGQAMQLIQTGRQRIVLAGGSECLHDNMTLMFDAMHALSRRFNDTPASASRPYDTARDGFVIAAGGGV
LVLEALDHALARGARIYAELTGFGHCTDGAGMVSPHAPGIARAMQVALDEAGARPDYVNAHAPSTPLGDIEELRALQTVF
GLDVPPFSSTKGLTGHPLGACGAHEAIYTLLMMRDGFIAGTVGIEQIEPLAQQLPLVQATREARIDRALSVSFGFGGSCA
SLMFARI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=34.3675417661098, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI223972627, Length=139, Percent_Identity=40.2877697841727, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI41872631, Length=351, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=47.6543209876543, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=38.1067961165049, Blast_Score=216, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=32.4582338902148, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=37.0786516853933, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI212642053, Length=349, Percent_Identity=25.214899713467, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17550940, Length=269, Percent_Identity=24.907063197026, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=32.1428571428571, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6325025, Length=183, Percent_Identity=30.0546448087432, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=36.4285714285714, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI221330659, Length=345, Percent_Identity=25.5072463768116, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19920632, Length=345, Percent_Identity=25.5072463768116, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24581345, Length=408, Percent_Identity=22.7941176470588, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42589; Mature: 42458

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVQGMQRVVVTGMGIVSCIGNTLDDVSAALREGRSGITHVDAWRERGFGTQVAGVASV
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEC
DGEPPFDRKLERFMGDTARFACHAARKAIDDAGLDIAALRSHHVGAVLGSGVGTMSAYDA
CCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHCCCCHHHHHHH
AMAVANTRGVEKTPPYTVPQAMSSTASANVAQVFGIEGVTYSPSSACTTSALAIGQAMQL
HHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
IQTGRQRIVLAGGSECLHDNMTLMFDAMHALSRRFNDTPASASRPYDTARDGFVIAAGGG
HHCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCC
VLVLEALDHALARGARIYAELTGFGHCTDGAGMVSPHAPGIARAMQVALDEAGARPDYVN
CHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
AHAPSTPLGDIEELRALQTVFGLDVPPFSSTKGLTGHPLGACGAHEAIYTLLMMRDGFIA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEE
GTVGIEQIEPLAQQLPLVQATREARIDRALSVSFGFGGSCASLMFARI
ECCCHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
TRVQGMQRVVVTGMGIVSCIGNTLDDVSAALREGRSGITHVDAWRERGFGTQVAGVASV
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEC
DGEPPFDRKLERFMGDTARFACHAARKAIDDAGLDIAALRSHHVGAVLGSGVGTMSAYDA
CCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHCCCCHHHHHHH
AMAVANTRGVEKTPPYTVPQAMSSTASANVAQVFGIEGVTYSPSSACTTSALAIGQAMQL
HHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
IQTGRQRIVLAGGSECLHDNMTLMFDAMHALSRRFNDTPASASRPYDTARDGFVIAAGGG
HHCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCC
VLVLEALDHALARGARIYAELTGFGHCTDGAGMVSPHAPGIARAMQVALDEAGARPDYVN
CHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
AHAPSTPLGDIEELRALQTVFGLDVPPFSSTKGLTGHPLGACGAHEAIYTLLMMRDGFIA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEE
GTVGIEQIEPLAQQLPLVQATREARIDRALSVSFGFGGSCASLMFARI
ECCCHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]