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The map label for this gene is fabF [H]

Identifier: 186475468

GI number: 186475468

Start: 789943

End: 791169

Strand: Direct

Name: fabF [H]

Synonym: Bphy_0703

Alternate gene names: 186475468

Gene position: 789943-791169 (Clockwise)

Preceding gene: 186475467

Following gene: 186475469

Centisome position: 22.7

GC content: 65.28

Gene sequence:

>1227_bases
ATGAAGCGTGTCGTCATTACGGGCATGGGCGGCGTCACGGCGCTCGGCAGCCGCTGGGACGAGATCGAAGCGGCACTGAA
GGCAGGCCGCAACGCGGTGCGGCGCATGCCGGACTGGGATTACTTCGAGTCGCTGCATACGCGTCTCGCGGCGCCGCTGC
CTGGGTTCGCTCAACCCGCCGACTGGCCGCGCAAGAAGACGCGCTCGATGGGCAGGGTATCGATGTACGCGGTGCGCGCG
AGCGAACTCGCGCTCGCCGATGCGGGTTTCGCGGGGGACGAGTCGATCAGCGACGGCCGCATGGGCGTCGCATACGGCTC
GTCGTCGGGTTCCGTCGAACCGATCCGCGCATTCGGCACGATGCTCGAATCGGGTTCGATGACCGACGTCACGTCGAACA
GCTACGTGCAGATGATGCCGCACACGACGGCCGTCAACGTGAGCCTCTTCTGGGATCTGAAGGGGCGTATCGTGCCGACC
TCGTCGGCATGTGCGTCGGGCAGCCAGGCAATCGGCTATGCCTACGAAAATATCGCCATGGGCAAGCAGACGCTCATGCT
CGCGGGCGGCGCGGAAGAACTGTCGGGGCCGGCCGTCGCCGTGTTCGACACGCTGTATGCGACCAGCACGCGCAATGACG
AGCCGCACCTGACGCCGCGTCCGTTCGACGCGAAGCGCGACGGTCTCGTGGTCGGCGAGGGCGCGGCGACGCTCGTGCTC
GAAGAATACGAGCACGCGAAGGCGCGCGGCGCGACGATCCATGCGGAGATCGTCGGCTTCGGCTGCAATTCGGACGGCGC
GCACATGACGCAGCCGACGGCGAGCACGATGGCGCGCGCGATGCAGCTCGCGCTCGAAGACGCAAAGCTCGACGCGAATG
CGATTGCCTATGTGAACGCGCACGGCACGTCGACGGATCGCGGCGACGTGGCGGAGAGCCAGGCCACGGCACGGACTTTC
GGCGAGCGCATGCCGATCTCGTCGCTGAAGAGCTACGTCGGCCATACGCTTGGTGCATGCGGCGCGCTCGAAGCGTGGTG
GACGATCGAAATGATGAAGCGCAACTGGTACGCGCCGACGCTCAATTTGACTGAAGTCGATCCCGCTTGCGCGCCGCTCG
ATTACATTCGAGGCGAGGCACGCGCGATCGATGCCGAATACGTGATGAGCAATAACTTCGCGTTTGGGGGCATCAACACG
TCGCTGATTTTCAGGCGCGTTCGATGA

Upstream 100 bases:

>100_bases
GTCAACCGGCCGAAGTCGCGTCGGTGGTGAGCTTCCTGATGTCGGACGCAGCCTCTTACGTGACGCGCCAGGTAATCGGC
GTCAATGGCGGGATGATCTG

Downstream 100 bases:

>100_bases
CGCGTGTGCAAGGCATGCAGCGCGTCGTCGTCACGGGCATGGGCATCGTGTCGTGCATCGGCAATACGCTCGACGACGTC
AGCGCTGCGCTGCGTGAAGG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKRVVITGMGGVTALGSRWDEIEAALKAGRNAVRRMPDWDYFESLHTRLAAPLPGFAQPADWPRKKTRSMGRVSMYAVRA
SELALADAGFAGDESISDGRMGVAYGSSSGSVEPIRAFGTMLESGSMTDVTSNSYVQMMPHTTAVNVSLFWDLKGRIVPT
SSACASGSQAIGYAYENIAMGKQTLMLAGGAEELSGPAVAVFDTLYATSTRNDEPHLTPRPFDAKRDGLVVGEGAATLVL
EEYEHAKARGATIHAEIVGFGCNSDGAHMTQPTASTMARAMQLALEDAKLDANAIAYVNAHGTSTDRGDVAESQATARTF
GERMPISSLKSYVGHTLGACGALEAWWTIEMMKRNWYAPTLNLTEVDPACAPLDYIRGEARAIDAEYVMSNNFAFGGINT
SLIFRRVR

Sequences:

>Translated_408_residues
MKRVVITGMGGVTALGSRWDEIEAALKAGRNAVRRMPDWDYFESLHTRLAAPLPGFAQPADWPRKKTRSMGRVSMYAVRA
SELALADAGFAGDESISDGRMGVAYGSSSGSVEPIRAFGTMLESGSMTDVTSNSYVQMMPHTTAVNVSLFWDLKGRIVPT
SSACASGSQAIGYAYENIAMGKQTLMLAGGAEELSGPAVAVFDTLYATSTRNDEPHLTPRPFDAKRDGLVVGEGAATLVL
EEYEHAKARGATIHAEIVGFGCNSDGAHMTQPTASTMARAMQLALEDAKLDANAIAYVNAHGTSTDRGDVAESQATARTF
GERMPISSLKSYVGHTLGACGALEAWWTIEMMKRNWYAPTLNLTEVDPACAPLDYIRGEARAIDAEYVMSNNFAFGGINT
SLIFRRVR
>Mature_408_residues
MKRVVITGMGGVTALGSRWDEIEAALKAGRNAVRRMPDWDYFESLHTRLAAPLPGFAQPADWPRKKTRSMGRVSMYAVRA
SELALADAGFAGDESISDGRMGVAYGSSSGSVEPIRAFGTMLESGSMTDVTSNSYVQMMPHTTAVNVSLFWDLKGRIVPT
SSACASGSQAIGYAYENIAMGKQTLMLAGGAEELSGPAVAVFDTLYATSTRNDEPHLTPRPFDAKRDGLVVGEGAATLVL
EEYEHAKARGATIHAEIVGFGCNSDGAHMTQPTASTMARAMQLALEDAKLDANAIAYVNAHGTSTDRGDVAESQATARTF
GERMPISSLKSYVGHTLGACGALEAWWTIEMMKRNWYAPTLNLTEVDPACAPLDYIRGEARAIDAEYVMSNNFAFGGINT
SLIFRRVR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=34.688995215311, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI223972627, Length=175, Percent_Identity=35.4285714285714, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI41872631, Length=276, Percent_Identity=27.1739130434783, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=39.9515738498789, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=36.6265060240964, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=32.5301204819277, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=38.0228136882129, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17550940, Length=288, Percent_Identity=27.7777777777778, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI212642053, Length=277, Percent_Identity=27.0758122743682, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=32.2799097065463, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=34.9282296650718, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI221330659, Length=273, Percent_Identity=25.2747252747253, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19920632, Length=273, Percent_Identity=25.2747252747253, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24581345, Length=277, Percent_Identity=23.826714801444, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43765; Mature: 43765

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVITGMGGVTALGSRWDEIEAALKAGRNAVRRMPDWDYFESLHTRLAAPLPGFAQPA
CCEEEEECCCCHHHHCCCHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
DWPRKKTRSMGRVSMYAVRASELALADAGFAGDESISDGRMGVAYGSSSGSVEPIRAFGT
CCCHHHHHCCCCEEEEEEEHHHHEEECCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHH
MLESGSMTDVTSNSYVQMMPHTTAVNVSLFWDLKGRIVPTSSACASGSQAIGYAYENIAM
HHCCCCCCEECCCCEEEECCCCEEEEEEEEEECCCEEEECCHHHCCCCCHHHHHHHHHHC
GKQTLMLAGGAEELSGPAVAVFDTLYATSTRNDEPHLTPRPFDAKRDGLVVGEGAATLVL
CCEEEEEECCHHHHCCCEEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEE
EEYEHAKARGATIHAEIVGFGCNSDGAHMTQPTASTMARAMQLALEDAKLDANAIAYVNA
HHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEC
HGTSTDRGDVAESQATARTFGERMPISSLKSYVGHTLGACGALEAWWTIEMMKRNWYAPT
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHEEHHCCCCCCC
LNLTEVDPACAPLDYIRGEARAIDAEYVMSNNFAFGGINTSLIFRRVR
CCCCCCCCCCCCHHHHCCCHHEECHHHEEECCEEECCCCHHHEEEECC
>Mature Secondary Structure
MKRVVITGMGGVTALGSRWDEIEAALKAGRNAVRRMPDWDYFESLHTRLAAPLPGFAQPA
CCEEEEECCCCHHHHCCCHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
DWPRKKTRSMGRVSMYAVRASELALADAGFAGDESISDGRMGVAYGSSSGSVEPIRAFGT
CCCHHHHHCCCCEEEEEEEHHHHEEECCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHH
MLESGSMTDVTSNSYVQMMPHTTAVNVSLFWDLKGRIVPTSSACASGSQAIGYAYENIAM
HHCCCCCCEECCCCEEEECCCCEEEEEEEEEECCCEEEECCHHHCCCCCHHHHHHHHHHC
GKQTLMLAGGAEELSGPAVAVFDTLYATSTRNDEPHLTPRPFDAKRDGLVVGEGAATLVL
CCEEEEEECCHHHHCCCEEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEE
EEYEHAKARGATIHAEIVGFGCNSDGAHMTQPTASTMARAMQLALEDAKLDANAIAYVNA
HHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEC
HGTSTDRGDVAESQATARTFGERMPISSLKSYVGHTLGACGALEAWWTIEMMKRNWYAPT
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHEEHHCCCCCCC
LNLTEVDPACAPLDYIRGEARAIDAEYVMSNNFAFGGINTSLIFRRVR
CCCCCCCCCCCCHHHHCCCHHEECHHHEEECCEEECCCCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]