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The map label for this gene is gmk [H]

Identifier: 186475435

GI number: 186475435

Start: 754746

End: 755432

Strand: Direct

Name: gmk [H]

Synonym: Bphy_0669

Alternate gene names: 186475435

Gene position: 754746-755432 (Clockwise)

Preceding gene: 186475434

Following gene: 186475436

Centisome position: 21.69

GC content: 61.86

Gene sequence:

>687_bases
ATGTCCGAACCTAAAGCCGAAGCCAAGCCCGAACCGAAGCGCAATCCGTACGCAGGTGTTTATCCCGGCAACCTGTTCAT
GGTCGTCGCACCGTCGGGCGCGGGCAAGTCGACGCTCGTCAACGCGCTGCTCGCGCGCGACGGAGCGATCCGTCTGTCGA
TCTCGTACACCACGCGCCAGCCGCGTCCGAATGAGCAGGACGGCGAGCACTATCACTTCACGACGGTCGAAGACTTCCTG
CAGCGGCACGACGCAGGGGAGTTTCTCGAGAGCGCGGAAGTGCACGGCAACTACTACGCGACCTCGCGTGTGTGGATCGA
AGAGCAGATGAAAAGCGGCCACGACGTGCTGCTCGAAATCGACTGGCAGGGCGCGCAGCAAGTGAAGAAGCAGTTCCGCA
ATGCCGTCGAGATCTTCATTTTGCCGCCGTCGCTCGAAGCACTCGAAGAGCGTTTGAAAAAGCGCGGCCAGGACGAGCCG
AATGTGATCACGCGACGTCTGCTCGCAGCGGGCAGCGAGATGGCGCACGCCGCGGAAGCGGAGTATGTCGTGATCAACGA
GAACTTCGATCGCGCGCTCGCCGAACTGCAATGCCTCGTGTCGGCCACGCGCTCGCGCTTCGCATCGCAATACGCGCGCC
ATACGAACCTCTTCATGCAACTCGGCATTCACTTGCCGCACGCGTGA

Upstream 100 bases:

>100_bases
GCCGCGAAAGAACTCGCCGATTCGTCGATGACGCTCAAGCTGCTCATCGAACAGATGCGCGAACAAGTACAAAACCTGGA
GTAACGGGAGTCCCACCAGC

Downstream 100 bases:

>100_bases
TACGGGCGAGCTCGCAAGGACATAAGGTAGAATAACCAACATACAGAGAAGGAATTTTCAACATGGCCCGCATTACCGTC
GAAGACTGTCTGAAACAGAT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSEPKAEAKPEPKRNPYAGVYPGNLFMVVAPSGAGKSTLVNALLARDGAIRLSISYTTRQPRPNEQDGEHYHFTTVEDFL
QRHDAGEFLESAEVHGNYYATSRVWIEEQMKSGHDVLLEIDWQGAQQVKKQFRNAVEIFILPPSLEALEERLKKRGQDEP
NVITRRLLAAGSEMAHAAEAEYVVINENFDRALAELQCLVSATRSRFASQYARHTNLFMQLGIHLPHA

Sequences:

>Translated_228_residues
MSEPKAEAKPEPKRNPYAGVYPGNLFMVVAPSGAGKSTLVNALLARDGAIRLSISYTTRQPRPNEQDGEHYHFTTVEDFL
QRHDAGEFLESAEVHGNYYATSRVWIEEQMKSGHDVLLEIDWQGAQQVKKQFRNAVEIFILPPSLEALEERLKKRGQDEP
NVITRRLLAAGSEMAHAAEAEYVVINENFDRALAELQCLVSATRSRFASQYARHTNLFMQLGIHLPHA
>Mature_227_residues
SEPKAEAKPEPKRNPYAGVYPGNLFMVVAPSGAGKSTLVNALLARDGAIRLSISYTTRQPRPNEQDGEHYHFTTVEDFLQ
RHDAGEFLESAEVHGNYYATSRVWIEEQMKSGHDVLLEIDWQGAQQVKKQFRNAVEIFILPPSLEALEERLKKRGQDEPN
VITRRLLAAGSEMAHAAEAEYVVINENFDRALAELQCLVSATRSRFASQYARHTNLFMQLGIHLPHA

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=38.2857142857143, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=38.2857142857143, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=38.2857142857143, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI21361598, Length=190, Percent_Identity=24.2105263157895, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=28.3236994219653, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262118255, Length=173, Percent_Identity=28.3236994219653, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=28.3236994219653, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI262118259, Length=173, Percent_Identity=28.3236994219653, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI38570142, Length=179, Percent_Identity=26.8156424581006, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=48.2587064676617, Blast_Score=194, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI193203132, Length=184, Percent_Identity=34.7826086956522, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=194, Percent_Identity=33.5051546391753, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=37.9120879120879, Blast_Score=125, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21356141, Length=179, Percent_Identity=35.195530726257, Blast_Score=110, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25686; Mature: 25555

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPKAEAKPEPKRNPYAGVYPGNLFMVVAPSGAGKSTLVNALLARDGAIRLSISYTTRQ
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCC
PRPNEQDGEHYHFTTVEDFLQRHDAGEFLESAEVHGNYYATSRVWIEEQMKSGHDVLLEI
CCCCCCCCCEEEEEHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEE
DWQGAQQVKKQFRNAVEIFILPPSLEALEERLKKRGQDEPNVITRRLLAAGSEMAHAAEA
CCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCC
EYVVINENFDRALAELQCLVSATRSRFASQYARHTNLFMQLGIHLPHA
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEPKAEAKPEPKRNPYAGVYPGNLFMVVAPSGAGKSTLVNALLARDGAIRLSISYTTRQ
CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEEEECCC
PRPNEQDGEHYHFTTVEDFLQRHDAGEFLESAEVHGNYYATSRVWIEEQMKSGHDVLLEI
CCCCCCCCCEEEEEHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEE
DWQGAQQVKKQFRNAVEIFILPPSLEALEERLKKRGQDEPNVITRRLLAAGSEMAHAAEA
CCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCC
EYVVINENFDRALAELQCLVSATRSRFASQYARHTNLFMQLGIHLPHA
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA