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The map label for this gene is serS

Identifier: 186475408

GI number: 186475408

Start: 724326

End: 725624

Strand: Direct

Name: serS

Synonym: Bphy_0642

Alternate gene names: 186475408

Gene position: 724326-725624 (Clockwise)

Preceding gene: 186475407

Following gene: 186475409

Centisome position: 20.82

GC content: 62.2

Gene sequence:

>1299_bases
ATGCTTGACATCCAGTTGCTGCGCAAAGACATCGACGGCGTCGCGAAGCGCCTCGCCGATCGCGGCTATATCCTCGACGT
CGCGGCTTTCTCCGCGCTCGAAGCCGAACGCCGCGCCATCCAGACCCGTACCGAAGAGCTGCAGGCAAAGCGCAACAGCC
TGTCGAAGCAGATCGGTGCGATGAAAGGGCGGGGCGAAGACACGTCCGCGGTGATGGCCGAGGTGGGCGGTATCGGCGAC
GAGATGAAGGCGTCGGCAGTGCAACTCGAAGACATCCAGAAGCGCCTGTCGGATCTGCTGCTCGGCGTGCCGAACCTTGC
GCACGAAAGCGTGCCCGTCGGCAACGACGAGGCCGGCAACGTCGAAGTCCGCCGCTGGGGAACGCCGCGCCAGTTCGACT
TCGAGATCAAGGATCACGTCGACGTCGGCACGCCGCTCGGGCTCGATTTCGAAACGGGCGCGAAGCTGTCGGGCGCGCGC
TTCACGCTGCTGCGTGGACAGATTGCGCGTCTGCACCGCGCGCTTGCGCAGTTCATGATCGACACGCACACGCAGCAGCA
CGGCTACACGGAAGTCTATACACCGTATATCGTCAATCCCGAAATCCTGTTCGGCACGGGCCAACTGCCCAAGTTCGCCG
ACGACATGTTCCGCGTCGAAAAGGGCGGCGGCGAAAACACGGTGACGCAATACCTGATCTCGACGTCGGAGATTTCGCTG
ACTAACACGGTGCGCGACAGCATCGTCGACTCGAACGAATTGCCCATCAAGCTGACGGCTCATTCGCCGTGCTTTCGCTC
GGAAGCGGGCTCGTACGGTCGCGACACCCGCGGCATGATCCGTCAGCATCAGTTCGACAAGGTCGAGATGGTGCAGATCG
TGTCGCCCGACACGTCATACGACGCGCTCGAGCAGATGGTCGCGCACGCGGAAGTGATCTTGCAGAAGCTCGAACTGCCG
TATCGTGTCATCACGCTGTGCACCGGCGATATGGGCTTTTCGGCAGCGAAAACGTATGACCTAGAAGTGTGGGTGCCTGC
GCAGAATACCTATCGCGAGATCTCGAGCTGTTCGAACACGGAAGCGTTCCAGGCGCGCCGGATGCAAGCGCGCTTCCGCA
ACGCGCAGGGCAAGCCCGAACTCGTTCATACGCTGAACGGTTCGGGCCTCGCTGTCGGCCGTACACTTGTCGCCGTGCTG
GAGAATTTCCAGAACGCCGATGGCTCGGTGACGGTTCCGGCCGCGCTGCGCCCGTATCTCGGTGGCGTCGATCGACTTGA
AGTGAAGGCGTCTGCCTGA

Upstream 100 bases:

>100_bases
AAGCTGACGCGCTCGTCGCGCCTCACCCGACAATGCCGCCGGCCGGCCGCGGCGGTGCGTTAAAATCGCCCACTCAACCA
ACGAACTGTCGCCCCCACTC

Downstream 100 bases:

>100_bases
GCGTGTTCTGGACCGTCCAAGTTCTTATCGAAGTTTCTGCGAAAAAAACTTGGAAATCGAAAAGAGGTGTTCTATAATCT
TCGTCTCACGCAAGCAACGA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MLDIQLLRKDIDGVAKRLADRGYILDVAAFSALEAERRAIQTRTEELQAKRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAVQLEDIQKRLSDLLLGVPNLAHESVPVGNDEAGNVEVRRWGTPRQFDFEIKDHVDVGTPLGLDFETGAKLSGAR
FTLLRGQIARLHRALAQFMIDTHTQQHGYTEVYTPYIVNPEILFGTGQLPKFADDMFRVEKGGGENTVTQYLISTSEISL
TNTVRDSIVDSNELPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVSPDTSYDALEQMVAHAEVILQKLELP
YRVITLCTGDMGFSAAKTYDLEVWVPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENFQNADGSVTVPAALRPYLGGVDRLEVKASA

Sequences:

>Translated_432_residues
MLDIQLLRKDIDGVAKRLADRGYILDVAAFSALEAERRAIQTRTEELQAKRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAVQLEDIQKRLSDLLLGVPNLAHESVPVGNDEAGNVEVRRWGTPRQFDFEIKDHVDVGTPLGLDFETGAKLSGAR
FTLLRGQIARLHRALAQFMIDTHTQQHGYTEVYTPYIVNPEILFGTGQLPKFADDMFRVEKGGGENTVTQYLISTSEISL
TNTVRDSIVDSNELPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVSPDTSYDALEQMVAHAEVILQKLELP
YRVITLCTGDMGFSAAKTYDLEVWVPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENFQNADGSVTVPAALRPYLGGVDRLEVKASA
>Mature_432_residues
MLDIQLLRKDIDGVAKRLADRGYILDVAAFSALEAERRAIQTRTEELQAKRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAVQLEDIQKRLSDLLLGVPNLAHESVPVGNDEAGNVEVRRWGTPRQFDFEIKDHVDVGTPLGLDFETGAKLSGAR
FTLLRGQIARLHRALAQFMIDTHTQQHGYTEVYTPYIVNPEILFGTGQLPKFADDMFRVEKGGGENTVTQYLISTSEISL
TNTVRDSIVDSNELPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVSPDTSYDALEQMVAHAEVILQKLELP
YRVITLCTGDMGFSAAKTYDLEVWVPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENFQNADGSVTVPAALRPYLGGVDRLEVKASA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=470, Percent_Identity=32.1276595744681, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI8923421, Length=414, Percent_Identity=28.5024154589372, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI225579074, Length=330, Percent_Identity=31.5151515151515, Blast_Score=169, Evalue=3e-42,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=61.1241217798595, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17539260, Length=430, Percent_Identity=31.8604651162791, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17542084, Length=352, Percent_Identity=29.2613636363636, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=406, Percent_Identity=33.4975369458128, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=384, Percent_Identity=29.9479166666667, Blast_Score=182, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24581334, Length=470, Percent_Identity=32.3404255319149, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI17737985, Length=347, Percent_Identity=29.6829971181556, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_BURP8 (B2JEF5)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001856878.1
- ProteinModelPortal:   B2JEF5
- SMR:   B2JEF5
- GeneID:   6242141
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_0642
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47618; Mature: 47618

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 289-289 BINDING 388-388

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDIDGVAKRLADRGYILDVAAFSALEAERRAIQTRTEELQAKRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGRGEDTSAVMAEVGGIGDEMKASAVQLEDIQKRLSDLLLGVPNLAHESVPVGNDEAGN
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRQFDFEIKDHVDVGTPLGLDFETGAKLSGARFTLLRGQIARLHRALAQFMI
EEEEECCCCCEECEEECCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
DTHTQQHGYTEVYTPYIVNPEILFGTGQLPKFADDMFRVEKGGGENTVTQYLISTSEISL
HHCCCCCCCCEECCCEEECCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEE
TNTVRDSIVDSNELPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVSPDTSY
HHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCH
DALEQMVAHAEVILQKLELPYRVITLCTGDMGFSAAKTYDLEVWVPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCCCH
EAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENFQNADGSVTVPAALRPYL
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEECHHHHHHH
GGVDRLEVKASA
CCCCEEEEEECC
>Mature Secondary Structure
MLDIQLLRKDIDGVAKRLADRGYILDVAAFSALEAERRAIQTRTEELQAKRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGRGEDTSAVMAEVGGIGDEMKASAVQLEDIQKRLSDLLLGVPNLAHESVPVGNDEAGN
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRQFDFEIKDHVDVGTPLGLDFETGAKLSGARFTLLRGQIARLHRALAQFMI
EEEEECCCCCEECEEECCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
DTHTQQHGYTEVYTPYIVNPEILFGTGQLPKFADDMFRVEKGGGENTVTQYLISTSEISL
HHCCCCCCCCEECCCEEECCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEE
TNTVRDSIVDSNELPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVSPDTSY
HHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCH
DALEQMVAHAEVILQKLELPYRVITLCTGDMGFSAAKTYDLEVWVPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCCCH
EAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENFQNADGSVTVPAALRPYL
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEECHHHHHHH
GGVDRLEVKASA
CCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA