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The map label for this gene is msrA [H]

Identifier: 186475279

GI number: 186475279

Start: 582616

End: 583167

Strand: Direct

Name: msrA [H]

Synonym: Bphy_0511

Alternate gene names: 186475279

Gene position: 582616-583167 (Clockwise)

Preceding gene: 186475277

Following gene: 186475283

Centisome position: 16.75

GC content: 63.04

Gene sequence:

>552_bases
ATGAGTCAGTCAGTCGAGACCGCCACGCTGGGCGGCGGGTGTTTCTGGTGTCTGGAGGCGGTGTTTCTCGGCGTCGATGG
CGTGACGTCGGTGGAATCGGGGTATGCGGGCGGACAGACCGACAATCCGTCCTACGAGCAGGTGTGTGACGGCAACACGG
GTCACGCGGAAGTCGTGAAGGTGGAATTCGATCCGGCGCGCATCAGCTATCGCGAGGTGCTGGACATTTTCTTTGCGATC
CACGATCCGACGCAGCTTAACCGCCAGGGCAACGATGTCGGCACGCAATACCGGTCGGTGATCTTCACGCACTCCGACGC
GCAGCGCGAGACGGCGCTGCAGGCGATCCGCGAAATCGGCGCCGAAGGCGTCTACGACGGCCAGATCGTCACGCAGGTGC
TGTCGCTCGACGGCAACTACTGGGCCGCCGAGGCCTATCACCAGAACTACTTCGCGCAGCATCCTGATCAAGGCTATTGC
GCGTTCGTCGTCGCGCCGAAGGTGGCGAAGTTCCGGCAGAAGTTCGCGCATCGGATCAAGGCGGGGGCGTGA

Upstream 100 bases:

>100_bases
TGGGCCGGTCGGATGCGGTGAAGAGTGTCCAGGTGACTGCGGCGAGCGGTGCGTTTGTCCTCGAGACGGACGTCGCGGCG
AGCCATTCCAAGGAGCGAGC

Downstream 100 bases:

>100_bases
GCGCGGTTTGATTGGGGGTGTGTCGATGTGAGCGGTGCGAACCCGAGCGGCTGCGCCGTTGTTCGACTACGCGGCTTCGG
CCGCGTTTTCTTTTTGCGCG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MSQSVETATLGGGCFWCLEAVFLGVDGVTSVESGYAGGQTDNPSYEQVCDGNTGHAEVVKVEFDPARISYREVLDIFFAI
HDPTQLNRQGNDVGTQYRSVIFTHSDAQRETALQAIREIGAEGVYDGQIVTQVLSLDGNYWAAEAYHQNYFAQHPDQGYC
AFVVAPKVAKFRQKFAHRIKAGA

Sequences:

>Translated_183_residues
MSQSVETATLGGGCFWCLEAVFLGVDGVTSVESGYAGGQTDNPSYEQVCDGNTGHAEVVKVEFDPARISYREVLDIFFAI
HDPTQLNRQGNDVGTQYRSVIFTHSDAQRETALQAIREIGAEGVYDGQIVTQVLSLDGNYWAAEAYHQNYFAQHPDQGYC
AFVVAPKVAKFRQKFAHRIKAGA
>Mature_182_residues
SQSVETATLGGGCFWCLEAVFLGVDGVTSVESGYAGGQTDNPSYEQVCDGNTGHAEVVKVEFDPARISYREVLDIFFAIH
DPTQLNRQGNDVGTQYRSVIFTHSDAQRETALQAIREIGAEGVYDGQIVTQVLSLDGNYWAAEAYHQNYFAQHPDQGYCA
FVVAPKVAKFRQKFAHRIKAGA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=163, Percent_Identity=43.558282208589, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=43.558282208589, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI208609993, Length=114, Percent_Identity=43.859649122807, Blast_Score=88, Evalue=4e-18,
Organism=Escherichia coli, GI1790665, Length=154, Percent_Identity=41.5584415584416, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=31.2925170068027, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=41.875, Blast_Score=112, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=32.7272727272727, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45553131, Length=159, Percent_Identity=31.4465408805031, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=31.5151515151515, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20076; Mature: 19945

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSVETATLGGGCFWCLEAVFLGVDGVTSVESGYAGGQTDNPSYEQVCDGNTGHAEVVK
CCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEE
VEFDPARISYREVLDIFFAIHDPTQLNRQGNDVGTQYRSVIFTHSDAQRETALQAIREIG
EECCCHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHEEEECCCHHHHHHHHHHHHHC
AEGVYDGQIVTQVLSLDGNYWAAEAYHQNYFAQHPDQGYCAFVVAPKVAKFRQKFAHRIK
CCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHC
AGA
CCC
>Mature Secondary Structure 
SQSVETATLGGGCFWCLEAVFLGVDGVTSVESGYAGGQTDNPSYEQVCDGNTGHAEVVK
CCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEE
VEFDPARISYREVLDIFFAIHDPTQLNRQGNDVGTQYRSVIFTHSDAQRETALQAIREIG
EECCCHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHEEEECCCHHHHHHHHHHHHHC
AEGVYDGQIVTQVLSLDGNYWAAEAYHQNYFAQHPDQGYCAFVVAPKVAKFRQKFAHRIK
CCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHC
AGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]