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The map label for this gene is yddQ [H]

Identifier: 186475244

GI number: 186475244

Start: 540086

End: 540715

Strand: Direct

Name: yddQ [H]

Synonym: Bphy_0476

Alternate gene names: 186475244

Gene position: 540086-540715 (Clockwise)

Preceding gene: 186475242

Following gene: 186475246

Centisome position: 15.52

GC content: 65.08

Gene sequence:

>630_bases
ATGCCCACGCCACGCCGCGCCCTGATCGTCATCGATGTGCAGAACGAGTACGTCACAGGCGACCTGCTGATCGAATACCC
CGACGTGCAGACGTCGCTGTCGAACATCGGCCGGGCAATCGATACGGCGCGCGCCGCGCGGATTCCCGTCGTCGTCGTGC
AGAACTTCGCGCCGGCCGGTTCGCCGGTCTTCGCGCGCGGCAGCGAAGGCGCGCAGCTGCATGCCGTGGTCGCCTCGCGC
CAACACGATCACTATGTCGAGAAAGATCTGCCGAGCGCGTTCACGAACACCGATCTGGCCGGCTGGCTTGCGGCGCATGA
GATCGGCACCCTGACGGTGGTCGGCTACATGACGCATAACTGCGACGCGTCGACGATCGTTCACGCATTGCACATGGGTC
TTGCCGTCGAATTCCTGCACGACGCGACGGGTTCGGTGCCCTATGAGAACAGCGCGGGCTTTGCCAGCGCCGAAGAAATT
CATCGCGTGTACAGCGTCGTGCTGCAATCGCGCTTCGCGGCGGTGGCGAGCACGCAGCAATGGGTGGAGGCCGTGGAGTC
GGGCGGGCAGCTGGAACGCGGCTCGATCTATGCGTCGAACCGGAAGGCGCGCGCGAAGTCTGCCGCGTAA

Upstream 100 bases:

>100_bases
TGTCATGTGGGTCACTGTCGTGCGACGGGCTGACGGCGAACAATGCGCACATCCCGGCTGCACCATCAGCCGCCCGTTTC
AATCATCAAGGAGAGTTGCC

Downstream 100 bases:

>100_bases
GTGAAGCTGGAAGGGTGTCGGGTACGCCGGCGCCCGCACAGCGCATCAGCTGTCCGGGCGAGCCTCGCTCGATCAATGCA
GAGGCAGTGCGCTCAAGCGC

Product: isochorismatase hydrolase

Products: Nicotinate; pyrazinoic acid; NH3 [C]

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MPTPRRALIVIDVQNEYVTGDLLIEYPDVQTSLSNIGRAIDTARAARIPVVVVQNFAPAGSPVFARGSEGAQLHAVVASR
QHDHYVEKDLPSAFTNTDLAGWLAAHEIGTLTVVGYMTHNCDASTIVHALHMGLAVEFLHDATGSVPYENSAGFASAEEI
HRVYSVVLQSRFAAVASTQQWVEAVESGGQLERGSIYASNRKARAKSAA

Sequences:

>Translated_209_residues
MPTPRRALIVIDVQNEYVTGDLLIEYPDVQTSLSNIGRAIDTARAARIPVVVVQNFAPAGSPVFARGSEGAQLHAVVASR
QHDHYVEKDLPSAFTNTDLAGWLAAHEIGTLTVVGYMTHNCDASTIVHALHMGLAVEFLHDATGSVPYENSAGFASAEEI
HRVYSVVLQSRFAAVASTQQWVEAVESGGQLERGSIYASNRKARAKSAA
>Mature_208_residues
PTPRRALIVIDVQNEYVTGDLLIEYPDVQTSLSNIGRAIDTARAARIPVVVVQNFAPAGSPVFARGSEGAQLHAVVASRQ
HDHYVEKDLPSAFTNTDLAGWLAAHEIGTLTVVGYMTHNCDASTIVHALHMGLAVEFLHDATGSVPYENSAGFASAEEIH
RVYSVVLQSRFAAVASTQQWVEAVESGGQLERGSIYASNRKARAKSAA

Specific function: NAD biosynthesis; nicotinamide to NaMN; first step. [C]

COG id: COG1335

COG function: function code Q; Amidases related to nicotinamidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismatase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000868 [H]

Pfam domain/function: PF00857 Isochorismatase [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 22411; Mature: 22280

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPRRALIVIDVQNEYVTGDLLIEYPDVQTSLSNIGRAIDTARAARIPVVVVQNFAPAG
CCCCCEEEEEEECCCCEEECEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
SPVFARGSEGAQLHAVVASRQHDHYVEKDLPSAFTNTDLAGWLAAHEIGTLTVVGYMTHN
CCEEECCCCCCEEEEEECCCCCCHHHHHHCCCHHCCCCHHHHHHHHHCCEEEEEEEEECC
CDASTIVHALHMGLAVEFLHDATGSVPYENSAGFASAEEIHRVYSVVLQSRFAAVASTQQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WVEAVESGGQLERGSIYASNRKARAKSAA
HHHHHHCCCCEECCCEEECCCCCCCCCCC
>Mature Secondary Structure 
PTPRRALIVIDVQNEYVTGDLLIEYPDVQTSLSNIGRAIDTARAARIPVVVVQNFAPAG
CCCCEEEEEEECCCCEEECEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
SPVFARGSEGAQLHAVVASRQHDHYVEKDLPSAFTNTDLAGWLAAHEIGTLTVVGYMTHN
CCEEECCCCCCEEEEEECCCCCCHHHHHHCCCHHCCCCHHHHHHHHHCCEEEEEEEEECC
CDASTIVHALHMGLAVEFLHDATGSVPYENSAGFASAEEIHRVYSVVLQSRFAAVASTQQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WVEAVESGGQLERGSIYASNRKARAKSAA
HHHHHHCCCCEECCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Nicotinamide; pyrazinamide; H2O [C]

Specific reaction: Nicotinamide + H2O = Nicotinate + NH3 pyrazinamide + H2O = pyrazinoic acid + NH3 [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]