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The map label for this gene is apt

Identifier: 186475102

GI number: 186475102

Start: 375110

End: 375676

Strand: Direct

Name: apt

Synonym: Bphy_0333

Alternate gene names: 186475102

Gene position: 375110-375676 (Clockwise)

Preceding gene: 186475101

Following gene: 186475103

Centisome position: 10.78

GC content: 61.73

Gene sequence:

>567_bases
ATGTCTCACGCGCCCGCGAATCGGCCATTCGATCCCGCCGAATACATCAACAGCGAAATTCGTACGGTGCCCGACTGGCC
CCAAGCCGGCGTGCAGTTCCGCGATATCACGCCGCTTCTGCAAAAACCGAAATCGCTGCGCGTGCTGATCGATCTGTTCG
TGCAGCGTTATATCGACCAGAAGCTCGATTACGTGGCCGGTCTCGACGCGCGCGGTTTCATCATCGGGCCGATTCTCGCG
TATGAGCTGAACCTCGGCTTCATTCCGATCCGAAAGATCGGCAAGCTGCCGTTCAGGACGGTGTCCGAATCGTACGAACT
CGAATACGGCTCCGCGACCGTCGAAATTCACGAGGACGCTTGCAAGCCGGGCGACCGGGTCGTGATCGTCGACGATCTGA
TCGCAACGGGCGGGACGATGATGGCGGGCAAGAAGCTGCTCGAACGGTTGGGCGCGACGGTGATCGAAGGCGCGGCGATC
GTCGATCTGCCCGACCTCGGCGGCTCGAAGTTGCTGCGCGGCGCGGGCCTTCCGCTTTTCACCGTCACGTCGTTCGGCGG
CCACTGA

Upstream 100 bases:

>100_bases
GATCACGCGACGCGCTGTTCCCCACGTTTGTCGGACGCGCGCTGCACTCAGGCAACTCACTGGAATTATCAGGGTCCTCA
CAAGCCCGTCTGGAGTCATC

Downstream 100 bases:

>100_bases
TCTCAAACAACGGAGTGTTTGCGCGATGCCCAACTTCCTGCTTTTTCTCGCGACGTCGATAGCGATCACGTTTGCGCCCG
GTCCCGACAATCTGCAGGTT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSHAPANRPFDPAEYINSEIRTVPDWPQAGVQFRDITPLLQKPKSLRVLIDLFVQRYIDQKLDYVAGLDARGFIIGPILA
YELNLGFIPIRKIGKLPFRTVSESYELEYGSATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKKLLERLGATVIEGAAI
VDLPDLGGSKLLRGAGLPLFTVTSFGGH

Sequences:

>Translated_188_residues
MSHAPANRPFDPAEYINSEIRTVPDWPQAGVQFRDITPLLQKPKSLRVLIDLFVQRYIDQKLDYVAGLDARGFIIGPILA
YELNLGFIPIRKIGKLPFRTVSESYELEYGSATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKKLLERLGATVIEGAAI
VDLPDLGGSKLLRGAGLPLFTVTSFGGH
>Mature_187_residues
SHAPANRPFDPAEYINSEIRTVPDWPQAGVQFRDITPLLQKPKSLRVLIDLFVQRYIDQKLDYVAGLDARGFIIGPILAY
ELNLGFIPIRKIGKLPFRTVSESYELEYGSATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKKLLERLGATVIEGAAIV
DLPDLGGSKLLRGAGLPLFTVTSFGGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=176, Percent_Identity=48.8636363636364, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI71773201, Length=127, Percent_Identity=51.9685039370079, Blast_Score=129, Evalue=1e-30,
Organism=Escherichia coli, GI1786675, Length=175, Percent_Identity=48, Blast_Score=176, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17509087, Length=159, Percent_Identity=45.2830188679245, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=176, Percent_Identity=38.0681818181818, Blast_Score=115, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=174, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=41.0404624277457, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_BURP8 (B2JCQ7)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001856572.1
- ProteinModelPortal:   B2JCQ7
- SMR:   B2JCQ7
- GeneID:   6241835
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_0333
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 20519; Mature: 20388

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHAPANRPFDPAEYINSEIRTVPDWPQAGVQFRDITPLLQKPKSLRVLIDLFVQRYIDQ
CCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHH
KLDYVAGLDARGFIIGPILAYELNLGFIPIRKIGKLPFRTVSESYELEYGSATVEIHEDA
HHHHHHCCCCCCEEECCEEEEEECCCEECHHHHCCCCCHHCCCCEEEECCCEEEEEECCC
CKPGDRVVIVDDLIATGGTMMAGKKLLERLGATVIEGAAIVDLPDLGGSKLLRGAGLPLF
CCCCCEEEEEECHHHCCCHHHHHHHHHHHHCHHHHCCEEEEECCCCCCHHHHHCCCCCEE
TVTSFGGH
EECCCCCC
>Mature Secondary Structure 
SHAPANRPFDPAEYINSEIRTVPDWPQAGVQFRDITPLLQKPKSLRVLIDLFVQRYIDQ
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHH
KLDYVAGLDARGFIIGPILAYELNLGFIPIRKIGKLPFRTVSESYELEYGSATVEIHEDA
HHHHHHCCCCCCEEECCEEEEEECCCEECHHHHCCCCCHHCCCCEEEECCCEEEEEECCC
CKPGDRVVIVDDLIATGGTMMAGKKLLERLGATVIEGAAIVDLPDLGGSKLLRGAGLPLF
CCCCCEEEEEECHHHCCCHHHHHHHHHHHHCHHHHCCEEEEECCCCCCHHHHHCCCCCEE
TVTSFGGH
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA