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The map label for this gene is dctB [H]

Identifier: 186474995

GI number: 186474995

Start: 249625

End: 251676

Strand: Direct

Name: dctB [H]

Synonym: Bphy_0226

Alternate gene names: 186474995

Gene position: 249625-251676 (Clockwise)

Preceding gene: 186474994

Following gene: 186474996

Centisome position: 7.17

GC content: 65.4

Gene sequence:

>2052_bases
ATGAAGGCGGCGGCGCGGCAACATGGCGCGTCGCCGCACGCTACGCAAGCAACGGCGGCGCCCGGTGAGACGGGCCAAGC
GCACGCTGGCCCCGAAGGATTCGACGACGAGCGATATGCCACAATAGGCGATCCTCATCGAACGAATCCCGCCATCGTGA
CGCGCCGCCTGCTGATCCTGTTCGCGCTGGTCGCCGGGCTTGTGGCCGCCTGCGGACTCACATGGACCATCACGTGGCAG
CACGGCATCGATACCCTGCGGCGCAACGCTGCAGTGCGCGCCGACCGCACGACGGCCACGCTGAAGAGCACGCTCGAACG
CTACGAGTCGCTGCCTTATCTGCTTGGCGAACATCCCCTCGTACAGGACGTTCTCGTCGATCCTAAGCCGGACAACGTCG
CCCGCGCCAATCAATATCTGACCGACCTGAACCGCCGCGCCCGCGCGAACGTCGCGTACCTCGTCACGGCGGCGGGCCGC
TGCGTGGCCGCGAGCAACTGGGATCAGCCCGACAGCTTCATCGGCCAGGCGTACCTGTTCCGGCCGTACTTCGTCGAAGC
GGTGAAAGGCAAGGTGGGGCGCTTCTTCGGCATCGGCACGACCTCGCTCGATCCCGGTTACTACATTTCGCAGCCGGTGC
GCCGCGACGGCAAGATTGTCGGCGTGGCGGTCGTGAAGCTCAATCTTGAATGGTTTCAGGGCGCCGATGCGTCCGAGCCG
ATGATCGTGACCGACGATCATGGCGTGATTTTTCTCTCCTCGGTGCCAGCGTGGAAGTACCACACGGTCAAGCCGCTCAC
CAGCGACGTGATCGCGTCGATCTACGACACGCGCCAGTACGCGCGCCAGCCGATCGCGCCGCTGCCGATGTCGGTCGTGC
GCACGCTCGAGGGTGGCGCACAGATCGTGCGCATCGGCGGCGGGCGCACCGGAAACTACGCGGCGCCGCGCTTTCTCGCA
TCGCAGCGCACGCTCGGCGAACCGGACTGGCGTCTCATCACGCTGGCGCCCGTCGACCCCGTCAACGCGGACGCACGTTA
CGCGACGATCGTCACGGGCTTCGGCTATGTGTCGCTGTGTCTGTTGCTGTTCTACTGGCGCATGCGGCGCGCGCGCGTGC
GTGAAGTGATGCGCAGCCGCGCGCTGCTGCAGAAAGCCTATGCCGAATTGAATCAGCGCGTGGCTGAGCGCACCGCCGAT
CTGTCCCAGGCCAACGAGCAACTGACGAAAGAAGTCAGCGAGCGCACGCGCGCCGAACAGGAACTGCGCGATGCGCACGA
CGAGCTGATCCAGGCGAGCAAGCTTGCCGCGCTCGGACAGATGGCGGCGGGCATCACGCATGAACTGAATCAGCCGCTTG
CCGCGCTGCGCGGATTCTCCGACAACACGCGCGTGTTTCTCGAGCGCGGGGATCAGGAATCGGCGAAGGAAAATCTCGAA
GCAATTGCCGCGCTCACGGAGCGCATGGGCAAGATCACGAACCAGCTGAAGCTCTTCGTCGGGCGTGCGCGCCCGCGTAA
TGCGTGCGCGGGCGTGGCGCGCGCATTGCGCAACGTGCTGACCCTATTGCAGAAACGCTTGCAGGGTGTGACGGTCGATG
TTTCGTTGAGTGACGAAGGCGCGTCGCCCGTTCGCTTCAATCTCGACATCGACGATCCGAAGCTGGTCGTGCATTGCGAC
GACTTGCGGCTTGAACAGGTGCTGATCAACCTGCTCGGCAATGCGCTCGACGCCGTCGCTGCGACGCCGTCTCCGCGCAT
CGCGATTGGCGTGCAGACGTCGCCGGATGTGCTCACGCTCACCGTGAGCGACAACGGTCCCGGCATTCCCGACGAGGTAT
TGCCGCGGCTTTTTGAGCCCTTCTTTACGACGAAGGAAATGGGCCAGGGGCTCGGCCTCGGCCTCGCGATCTGCTCGTCG
ATCGCCCGCGACTGCGGCGGCTCGCTTGCGGCGCGCAACAACGCGCAGGGCGGCGCCGAGTTCGTGCTGACGCTTCGGCG
CGTGCGCGCGCAGGCAACGGATATTGCGGACTCTGTGACGACGGGATCCTGA

Upstream 100 bases:

>100_bases
GGTTGTCGTGTCGGCGTGGGAAAAGGAACTCGACCGCTCGAAGCTGCGCGCCGCGTTGAGTCGCGATGTGTCCGTCACCG
AGTCGGCTGAGGTCTAAGCG

Downstream 100 bases:

>100_bases
ATCAGCAAGTTTTGACGGCGGTATACGACATGGTGAACAAGGGCTTGCAAGTCCTCTATATCGAAGACGACGAACTCGTG
CGGCGCGCAAGCGTGCAGAG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 683; Mature: 683

Protein sequence:

>683_residues
MKAAARQHGASPHATQATAAPGETGQAHAGPEGFDDERYATIGDPHRTNPAIVTRRLLILFALVAGLVAACGLTWTITWQ
HGIDTLRRNAAVRADRTTATLKSTLERYESLPYLLGEHPLVQDVLVDPKPDNVARANQYLTDLNRRARANVAYLVTAAGR
CVAASNWDQPDSFIGQAYLFRPYFVEAVKGKVGRFFGIGTTSLDPGYYISQPVRRDGKIVGVAVVKLNLEWFQGADASEP
MIVTDDHGVIFLSSVPAWKYHTVKPLTSDVIASIYDTRQYARQPIAPLPMSVVRTLEGGAQIVRIGGGRTGNYAAPRFLA
SQRTLGEPDWRLITLAPVDPVNADARYATIVTGFGYVSLCLLLFYWRMRRARVREVMRSRALLQKAYAELNQRVAERTAD
LSQANEQLTKEVSERTRAEQELRDAHDELIQASKLAALGQMAAGITHELNQPLAALRGFSDNTRVFLERGDQESAKENLE
AIAALTERMGKITNQLKLFVGRARPRNACAGVARALRNVLTLLQKRLQGVTVDVSLSDEGASPVRFNLDIDDPKLVVHCD
DLRLEQVLINLLGNALDAVAATPSPRIAIGVQTSPDVLTLTVSDNGPGIPDEVLPRLFEPFFTTKEMGQGLGLGLAICSS
IARDCGGSLAARNNAQGGAEFVLTLRRVRAQATDIADSVTTGS

Sequences:

>Translated_683_residues
MKAAARQHGASPHATQATAAPGETGQAHAGPEGFDDERYATIGDPHRTNPAIVTRRLLILFALVAGLVAACGLTWTITWQ
HGIDTLRRNAAVRADRTTATLKSTLERYESLPYLLGEHPLVQDVLVDPKPDNVARANQYLTDLNRRARANVAYLVTAAGR
CVAASNWDQPDSFIGQAYLFRPYFVEAVKGKVGRFFGIGTTSLDPGYYISQPVRRDGKIVGVAVVKLNLEWFQGADASEP
MIVTDDHGVIFLSSVPAWKYHTVKPLTSDVIASIYDTRQYARQPIAPLPMSVVRTLEGGAQIVRIGGGRTGNYAAPRFLA
SQRTLGEPDWRLITLAPVDPVNADARYATIVTGFGYVSLCLLLFYWRMRRARVREVMRSRALLQKAYAELNQRVAERTAD
LSQANEQLTKEVSERTRAEQELRDAHDELIQASKLAALGQMAAGITHELNQPLAALRGFSDNTRVFLERGDQESAKENLE
AIAALTERMGKITNQLKLFVGRARPRNACAGVARALRNVLTLLQKRLQGVTVDVSLSDEGASPVRFNLDIDDPKLVVHCD
DLRLEQVLINLLGNALDAVAATPSPRIAIGVQTSPDVLTLTVSDNGPGIPDEVLPRLFEPFFTTKEMGQGLGLGLAICSS
IARDCGGSLAARNNAQGGAEFVLTLRRVRAQATDIADSVTTGS
>Mature_683_residues
MKAAARQHGASPHATQATAAPGETGQAHAGPEGFDDERYATIGDPHRTNPAIVTRRLLILFALVAGLVAACGLTWTITWQ
HGIDTLRRNAAVRADRTTATLKSTLERYESLPYLLGEHPLVQDVLVDPKPDNVARANQYLTDLNRRARANVAYLVTAAGR
CVAASNWDQPDSFIGQAYLFRPYFVEAVKGKVGRFFGIGTTSLDPGYYISQPVRRDGKIVGVAVVKLNLEWFQGADASEP
MIVTDDHGVIFLSSVPAWKYHTVKPLTSDVIASIYDTRQYARQPIAPLPMSVVRTLEGGAQIVRIGGGRTGNYAAPRFLA
SQRTLGEPDWRLITLAPVDPVNADARYATIVTGFGYVSLCLLLFYWRMRRARVREVMRSRALLQKAYAELNQRVAERTAD
LSQANEQLTKEVSERTRAEQELRDAHDELIQASKLAALGQMAAGITHELNQPLAALRGFSDNTRVFLERGDQESAKENLE
AIAALTERMGKITNQLKLFVGRARPRNACAGVARALRNVLTLLQKRLQGVTVDVSLSDEGASPVRFNLDIDDPKLVVHCD
DLRLEQVLINLLGNALDAVAATPSPRIAIGVQTSPDVLTLTVSDNGPGIPDEVLPRLFEPFFTTKEMGQGLGLGLAICSS
IARDCGGSLAARNNAQGGAEFVLTLRRVRAQATDIADSVTTGS

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=29.045643153527, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788549, Length=246, Percent_Identity=29.2682926829268, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786912, Length=278, Percent_Identity=30.5755395683453, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790861, Length=231, Percent_Identity=32.4675324675325, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI145693157, Length=273, Percent_Identity=27.4725274725275, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081816, Length=368, Percent_Identity=27.7173913043478, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=320, Percent_Identity=28.4375, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=26.6949152542373, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1788393, Length=261, Percent_Identity=27.9693486590038, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1789149, Length=285, Percent_Identity=24.2105263157895, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74330; Mature: 74330

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAARQHGASPHATQATAAPGETGQAHAGPEGFDDERYATIGDPHRTNPAIVTRRLLIL
CCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHH
FALVAGLVAACGLTWTITWQHGIDTLRRNAAVRADRTTATLKSTLERYESLPYLLGEHPL
HHHHHHHHHHCCCEEEEEEHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCHHHCCCCC
VQDVLVDPKPDNVARANQYLTDLNRRARANVAYLVTAAGRCVAASNWDQPDSFIGQAYLF
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCEEECCCCCCCHHHHHHHHHH
RPYFVEAVKGKVGRFFGIGTTSLDPGYYISQPVRRDGKIVGVAVVKLNLEWFQGADASEP
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEHHHCCCCCCCC
MIVTDDHGVIFLSSVPAWKYHTVKPLTSDVIASIYDTRQYARQPIAPLPMSVVRTLEGGA
EEEECCCCEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
QIVRIGGGRTGNYAAPRFLASQRTLGEPDWRLITLAPVDPVNADARYATIVTGFGYVSLC
EEEEECCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHHHHH
LLLFYWRMRRARVREVMRSRALLQKAYAELNQRVAERTADLSQANEQLTKEVSERTRAEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRDAHDELIQASKLAALGQMAAGITHELNQPLAALRGFSDNTRVFLERGDQESAKENLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEECCCHHHHHHHHH
AIAALTERMGKITNQLKLFVGRARPRNACAGVARALRNVLTLLQKRLQGVTVDVSLSDEG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
ASPVRFNLDIDDPKLVVHCDDLRLEQVLINLLGNALDAVAATPSPRIAIGVQTSPDVLTL
CCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEE
TVSDNGPGIPDEVLPRLFEPFFTTKEMGQGLGLGLAICSSIARDCGGSLAARNNAQGGAE
EECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHH
FVLTLRRVRAQATDIADSVTTGS
HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKAAARQHGASPHATQATAAPGETGQAHAGPEGFDDERYATIGDPHRTNPAIVTRRLLIL
CCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHH
FALVAGLVAACGLTWTITWQHGIDTLRRNAAVRADRTTATLKSTLERYESLPYLLGEHPL
HHHHHHHHHHCCCEEEEEEHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCHHHCCCCC
VQDVLVDPKPDNVARANQYLTDLNRRARANVAYLVTAAGRCVAASNWDQPDSFIGQAYLF
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCEEECCCCCCCHHHHHHHHHH
RPYFVEAVKGKVGRFFGIGTTSLDPGYYISQPVRRDGKIVGVAVVKLNLEWFQGADASEP
HHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEHHHCCCCCCCC
MIVTDDHGVIFLSSVPAWKYHTVKPLTSDVIASIYDTRQYARQPIAPLPMSVVRTLEGGA
EEEECCCCEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
QIVRIGGGRTGNYAAPRFLASQRTLGEPDWRLITLAPVDPVNADARYATIVTGFGYVSLC
EEEEECCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHHHHH
LLLFYWRMRRARVREVMRSRALLQKAYAELNQRVAERTADLSQANEQLTKEVSERTRAEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRDAHDELIQASKLAALGQMAAGITHELNQPLAALRGFSDNTRVFLERGDQESAKENLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEECCCHHHHHHHHH
AIAALTERMGKITNQLKLFVGRARPRNACAGVARALRNVLTLLQKRLQGVTVDVSLSDEG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
ASPVRFNLDIDDPKLVVHCDDLRLEQVLINLLGNALDAVAATPSPRIAIGVQTSPDVLTL
CCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEE
TVSDNGPGIPDEVLPRLFEPFFTTKEMGQGLGLGLAICSSIARDCGGSLAARNNAQGGAE
EECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHH
FVLTLRRVRAQATDIADSVTTGS
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3671068 [H]