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The map label for this gene is lon [H]

Identifier: 186474874

GI number: 186474874

Start: 113629

End: 114606

Strand: Direct

Name: lon [H]

Synonym: Bphy_0104

Alternate gene names: 186474874

Gene position: 113629-114606 (Clockwise)

Preceding gene: 186474859

Following gene: 186474875

Centisome position: 3.27

GC content: 61.86

Gene sequence:

>978_bases
ATGACAACGGCAATGGTGAAACAGGAAATCGCGGTTGCATCGTTCAGCAAGGTCTACGACCTGGAGCAGGTGGAGACTGC
GCTGAACGAACTGAGCGAAGGCGCGAGCGAGGCACTGCGTTCCACGTACGAAAAAATGCTGAAAGTTGGCAATCTGCGCT
TCTGCGTGAAGCCGAACCGGATGCCGTCCATCGACGATCTGATCGGCTCGCTGCCCAACTTCACCGAGCCGCTGGATGAT
ATCCGCAAGCAGGTCGCGTTGTGCCTCGAAACGGACGACCGCCTCGAACTGATGCCGATCCTGCTGCTCGGCGATCCGGG
TATCGGCAAGACGCATTTTGCGAAGCAGCTCGCGCGTATGCTCGGCACCGCATACCACTATGTGGCGATGAGTTCGCTGA
CGGCGGGGTGGATTCTGTCGGGCGCGTCGTCGCAATGGAAGAACGCAAAGCCGGGCAAGGTGTTCGACGCGCTCGTGCAC
GGCAGCTATGCAAACCCCGTAATCGCCGTCGACGAAATCGACAAGGCGACGGGCGACTCACAATACGATCCGCTCGGCGC
GCTCTACGCGCTGCTCGAACATGACACCGCACAGAGCTTTATCGACGAGTTCGCGGAAATCCCCATCAACGCCAGTCATG
TGATCTGGATCGCGACCGCGAACGACGAGCGCTCGATTCCCGAGCCGATCATGAACCGCATGAACGTCTTCGAGATTCCG
CCGCCCGATCGGGACGGCTCCCGGCGCATCGCGCAGTCGATCTACGACGAAATTCGCTCCGCGCACGGCTGGGGTCAACA
TTTTCCCGCCGAACTGGGCGGCGCAGCGCTCGACGCGCTCGCGCAGGCTTCGCCGCGCGAAATGCGGCGCGCGATCCTGA
ACGGCTTCGGCTCGGCGCGCATTGCGGGCCGCGATCACATCGGCGCGGGCGACATTCGCCTCGACTACAACTCGCGCCGC
AAACCGATCGGTTTCTAG

Upstream 100 bases:

>100_bases
CGTGGCTGCTGGCTTGCATGCGTTTTTCTCGTCGTTACACTGAAATTGAAGCGGCGTCGGGGACGCTGTGGTTGCAAGAA
CAGCTCGACGGGGTGAAGCG

Downstream 100 bases:

>100_bases
CGTTCGACGCGCCGTTGAGGCGAACGGGCGGCGCGCAAGCGCGCTTGTTCATGGGTCCAGTCTGGGAGCTATTTCATAGC
CCTCAGCAGGATCGTTTGTG

Product: ATPase central domain-containing protein

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTTAMVKQEIAVASFSKVYDLEQVETALNELSEGASEALRSTYEKMLKVGNLRFCVKPNRMPSIDDLIGSLPNFTEPLDD
IRKQVALCLETDDRLELMPILLLGDPGIGKTHFAKQLARMLGTAYHYVAMSSLTAGWILSGASSQWKNAKPGKVFDALVH
GSYANPVIAVDEIDKATGDSQYDPLGALYALLEHDTAQSFIDEFAEIPINASHVIWIATANDERSIPEPIMNRMNVFEIP
PPDRDGSRRIAQSIYDEIRSAHGWGQHFPAELGGAALDALAQASPREMRRAILNGFGSARIAGRDHIGAGDIRLDYNSRR
KPIGF

Sequences:

>Translated_325_residues
MTTAMVKQEIAVASFSKVYDLEQVETALNELSEGASEALRSTYEKMLKVGNLRFCVKPNRMPSIDDLIGSLPNFTEPLDD
IRKQVALCLETDDRLELMPILLLGDPGIGKTHFAKQLARMLGTAYHYVAMSSLTAGWILSGASSQWKNAKPGKVFDALVH
GSYANPVIAVDEIDKATGDSQYDPLGALYALLEHDTAQSFIDEFAEIPINASHVIWIATANDERSIPEPIMNRMNVFEIP
PPDRDGSRRIAQSIYDEIRSAHGWGQHFPAELGGAALDALAQASPREMRRAILNGFGSARIAGRDHIGAGDIRLDYNSRR
KPIGF
>Mature_324_residues
TTAMVKQEIAVASFSKVYDLEQVETALNELSEGASEALRSTYEKMLKVGNLRFCVKPNRMPSIDDLIGSLPNFTEPLDDI
RKQVALCLETDDRLELMPILLLGDPGIGKTHFAKQLARMLGTAYHYVAMSSLTAGWILSGASSQWKNAKPGKVFDALVHG
SYANPVIAVDEIDKATGDSQYDPLGALYALLEHDTAQSFIDEFAEIPINASHVIWIATANDERSIPEPIMNRMNVFEIPP
PDRDGSRRIAQSIYDEIRSAHGWGQHFPAELGGAALDALAQASPREMRRAILNGFGSARIAGRDHIGAGDIRLDYNSRRK
PIGF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=140, Percent_Identity=33.5714285714286, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI31377667, Length=143, Percent_Identity=31.4685314685315, Blast_Score=95, Evalue=7e-20,
Organism=Escherichia coli, GI1786643, Length=155, Percent_Identity=30.9677419354839, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17556486, Length=168, Percent_Identity=30.3571428571429, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17505831, Length=137, Percent_Identity=32.8467153284672, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319449, Length=141, Percent_Identity=36.1702127659575, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221513036, Length=136, Percent_Identity=35.2941176470588, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24666867, Length=136, Percent_Identity=35.2941176470588, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 35711; Mature: 35580

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAMVKQEIAVASFSKVYDLEQVETALNELSEGASEALRSTYEKMLKVGNLRFCVKPNR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
MPSIDDLIGSLPNFTEPLDDIRKQVALCLETDDRLELMPILLLGDPGIGKTHFAKQLARM
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHH
LGTAYHYVAMSSLTAGWILSGASSQWKNAKPGKVFDALVHGSYANPVIAVDEIDKATGDS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCHHHCCCC
QYDPLGALYALLEHDTAQSFIDEFAEIPINASHVIWIATANDERSIPEPIMNRMNVFEIP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHCCCEEECC
PPDRDGSRRIAQSIYDEIRSAHGWGQHFPAELGGAALDALAQASPREMRRAILNGFGSAR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCE
IAGRDHIGAGDIRLDYNSRRKPIGF
ECCCCCCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
TTAMVKQEIAVASFSKVYDLEQVETALNELSEGASEALRSTYEKMLKVGNLRFCVKPNR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
MPSIDDLIGSLPNFTEPLDDIRKQVALCLETDDRLELMPILLLGDPGIGKTHFAKQLARM
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHH
LGTAYHYVAMSSLTAGWILSGASSQWKNAKPGKVFDALVHGSYANPVIAVDEIDKATGDS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCHHHCCCC
QYDPLGALYALLEHDTAQSFIDEFAEIPINASHVIWIATANDERSIPEPIMNRMNVFEIP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHCCCEEECC
PPDRDGSRRIAQSIYDEIRSAHGWGQHFPAELGGAALDALAQASPREMRRAILNGFGSAR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCE
IAGRDHIGAGDIRLDYNSRRKPIGF
ECCCCCCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA