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The map label for this gene is nuoG [H]

Identifier: 183222748

GI number: 183222748

Start: 3525979

End: 3527427

Strand: Reverse

Name: nuoG [H]

Synonym: LEPBI_I3406

Alternate gene names: 183222748

Gene position: 3527427-3525979 (Counterclockwise)

Preceding gene: 183222749

Following gene: 183222747

Centisome position: 97.99

GC content: 40.92

Gene sequence:

>1449_bases
TTGGTTAAGATAAAGATAGACGGAGTCGAATACGAAGTCGACGAAAAGAAAAACCTCATTGATGCAACAAAAGAAGTAGG
AGTTGAAATTCCTTACTTCTGTTACCACCCAGCTCTGAGCATTGTCGGAATGTGCCGTATGTGTCTCATTGAAATTGAAG
GGGTGCCTAGGTTACAAGCTGCTTGTAATACTCCTGTAAAAGAGGGAATGGGTATCATCACAAAATCCGATCGTGTGAAA
GAAGCACGAGCTGGTACCATGGAATTCCTTCTCGCCAATCACCCGTTAGACTGTCCAGTTTGTGATAAGGCTGGGGAATG
TCGTTTGCAAGACAATGCCTTTGGATCAGGAACAGGACATTCTCGATTTGAGTTTGAAAAACGAAATATCCCTCAAGAAG
AAATTGGAACTAATCTCATCATCAATCACAATCGATGTATCGTTTGTTATCGATGTGTTAGGTTCGAAGAGGAAAAAGTA
GGGGAATCAAATCTCGGTCTCTTTGAAAGAGGAAATCATTCCATCATCGGACTTGCCAAGTCAGAACCCATAGATCATAA
TTACCAAGGTGCCTTAGCAGACATTTGCCCTGTGGGTGCCCTTCTCAATAACAAAACATTGTTTAAATCACGTGTTTGGT
GGTATAAGTCTCATAAATCGGTATGTCATGGATGTTCCACAGGTTGTAATGTAACAACTAATGTTCGAGACAATAAAATG
TATCGATATATGGTTCGGGAAAATTTTGATCAAGGGATGTTTTTCCTTTGTGACAAAGGTCGATTTGATTTGGATTGGAT
GAATGATAATCGTCTATTCAGTTATTTGGAAAGTGGAAAACCATCCACTTCGCAAGTGGTAATTTCCAAAATCATTGATC
GCTTAAAAGATGCAAAATCAATCGCCGTTCTTGGTGGCGCTCACGAATCCAACGAAACCTTAGAAGCACTCAAACAAAAT
CTGCAAACACTCTCCCGTGAATTAAGTGGGAAATCCATCCAGTGGGAAACACGAGTGACAGATGCCCAAAACAAAGAAAC
AGAACAGGTTGATTTTTTACTCACAAAAGATTACCATCCGAATACCAAAGGGGCAGTGGACTTAGGTCTTACGACACCAT
CTGGAATTTCTGGAATTGTCTCCGCAGTGAAACAAGGGTCGATTGATCTAGTGATCCTTTTGAAAGAATCCATTCCAGAA
GGGATCGATCCAACGCAAGTGATTAGTTTGGATACCAATTTGACTGATGCAGCAAAGAACGCGAGTTTGGCGGCACCGAT
TCAGATTTTCTGTGAAGCCGAAGGAAGTTTTACCAATAAAAATGGCCTAAAACAAACGTTTGAAAAGTCAATGAATCCCA
TCCAAGGATTACAAACTTCCGCAGGTGTTGTGGAACTCATTGTGAAAACCATGACAAAAAAAATGGAGGCATCCGTTGGG
AACCGTTAA

Upstream 100 bases:

>100_bases
ACAGCCATACACGTATCTTTCCGAAGTAAATATAATTTCCAAATGAAGGTTTGACAAAATCAAAAGACCTAAGTCTAATC
AAACCTAGGGGGTCTGTTCT

Downstream 100 bases:

>100_bases
TGTCGTCAACGTAGCCAAAAAACACCAGTTTTCTTGGTATGAAAAATTTTACTTTTGGTCCATTGGCAAAGGCCTTTGGA
TCACCCTCAAACATTTTGTG

Product: NADH-quinone oxidoreductase chain G

Products: NA

Alternate protein names: NADH dehydrogenase I subunit G; NDH-1 subunit G [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MVKIKIDGVEYEVDEKKNLIDATKEVGVEIPYFCYHPALSIVGMCRMCLIEIEGVPRLQAACNTPVKEGMGIITKSDRVK
EARAGTMEFLLANHPLDCPVCDKAGECRLQDNAFGSGTGHSRFEFEKRNIPQEEIGTNLIINHNRCIVCYRCVRFEEEKV
GESNLGLFERGNHSIIGLAKSEPIDHNYQGALADICPVGALLNNKTLFKSRVWWYKSHKSVCHGCSTGCNVTTNVRDNKM
YRYMVRENFDQGMFFLCDKGRFDLDWMNDNRLFSYLESGKPSTSQVVISKIIDRLKDAKSIAVLGGAHESNETLEALKQN
LQTLSRELSGKSIQWETRVTDAQNKETEQVDFLLTKDYHPNTKGAVDLGLTTPSGISGIVSAVKQGSIDLVILLKESIPE
GIDPTQVISLDTNLTDAAKNASLAAPIQIFCEAEGSFTNKNGLKQTFEKSMNPIQGLQTSAGVVELIVKTMTKKMEASVG
NR

Sequences:

>Translated_482_residues
MVKIKIDGVEYEVDEKKNLIDATKEVGVEIPYFCYHPALSIVGMCRMCLIEIEGVPRLQAACNTPVKEGMGIITKSDRVK
EARAGTMEFLLANHPLDCPVCDKAGECRLQDNAFGSGTGHSRFEFEKRNIPQEEIGTNLIINHNRCIVCYRCVRFEEEKV
GESNLGLFERGNHSIIGLAKSEPIDHNYQGALADICPVGALLNNKTLFKSRVWWYKSHKSVCHGCSTGCNVTTNVRDNKM
YRYMVRENFDQGMFFLCDKGRFDLDWMNDNRLFSYLESGKPSTSQVVISKIIDRLKDAKSIAVLGGAHESNETLEALKQN
LQTLSRELSGKSIQWETRVTDAQNKETEQVDFLLTKDYHPNTKGAVDLGLTTPSGISGIVSAVKQGSIDLVILLKESIPE
GIDPTQVISLDTNLTDAAKNASLAAPIQIFCEAEGSFTNKNGLKQTFEKSMNPIQGLQTSAGVVELIVKTMTKKMEASVG
NR
>Mature_482_residues
MVKIKIDGVEYEVDEKKNLIDATKEVGVEIPYFCYHPALSIVGMCRMCLIEIEGVPRLQAACNTPVKEGMGIITKSDRVK
EARAGTMEFLLANHPLDCPVCDKAGECRLQDNAFGSGTGHSRFEFEKRNIPQEEIGTNLIINHNRCIVCYRCVRFEEEKV
GESNLGLFERGNHSIIGLAKSEPIDHNYQGALADICPVGALLNNKTLFKSRVWWYKSHKSVCHGCSTGCNVTTNVRDNKM
YRYMVRENFDQGMFFLCDKGRFDLDWMNDNRLFSYLESGKPSTSQVVISKIIDRLKDAKSIAVLGGAHESNETLEALKQN
LQTLSRELSGKSIQWETRVTDAQNKETEQVDFLLTKDYHPNTKGAVDLGLTTPSGISGIVSAVKQGSIDLVILLKESIPE
GIDPTQVISLDTNLTDAAKNASLAAPIQIFCEAEGSFTNKNGLKQTFEKSMNPIQGLQTSAGVVELIVKTMTKKMEASVG
NR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=328, Percent_Identity=36.890243902439, Blast_Score=221, Evalue=8e-58,
Organism=Escherichia coli, GI145693161, Length=275, Percent_Identity=35.6363636363636, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17565758, Length=336, Percent_Identity=37.797619047619, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI32566231, Length=336, Percent_Identity=37.797619047619, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI193209088, Length=262, Percent_Identity=41.6030534351145, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24640559, Length=279, Percent_Identity=40.1433691756272, Blast_Score=219, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24640557, Length=279, Percent_Identity=40.1433691756272, Blast_Score=219, Evalue=5e-57,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006656
- InterPro:   IPR000283
- InterPro:   IPR010228
- InterPro:   IPR019574
- InterPro:   IPR015405 [H]

Pfam domain/function: PF09326 DUF1982; PF00111 Fer2; PF00384 Molybdopterin; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53447; Mature: 53447

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00641 COMPLEX1_75K_1 ; PS00643 COMPLEX1_75K_3 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIKIDGVEYEVDEKKNLIDATKEVGVEIPYFCYHPALSIVGMCRMCLIEIEGVPRLQA
CEEEEECCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ACNTPVKEGMGIITKSDRVKEARAGTMEFLLANHPLDCPVCDKAGECRLQDNAFGSGTGH
HCCCCHHHCCCEEECCCHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCCC
SRFEFEKRNIPQEEIGTNLIINHNRCIVCYRCVRFEEEKVGESNLGLFERGNHSIIGLAK
CCEEEHHHCCCHHHHCCEEEEECCCEEEEEEEHHCCHHHCCCCCCCCEECCCCCEEEEEC
SEPIDHNYQGALADICPVGALLNNKTLFKSRVWWYKSHKSVCHGCSTGCNVTTNVRDNKM
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHEEECCHHHHHHCCCCCCEEEECCCCCHH
YRYMVRENFDQGMFFLCDKGRFDLDWMNDNRLFSYLESGKPSTSQVVISKIIDRLKDAKS
HHHHHHCCCCCCEEEEECCCCEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCE
IAVLGGAHESNETLEALKQNLQTLSRELSGKSIQWETRVTDAQNKETEQVDFLLTKDYHP
EEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCC
NTKGAVDLGLTTPSGISGIVSAVKQGSIDLVILLKESIPEGIDPTQVISLDTNLTDAAKN
CCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHCC
ASLAAPIQIFCEAEGSFTNKNGLKQTFEKSMNPIQGLQTSAGVVELIVKTMTKKMEASVG
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCC
NR
CC
>Mature Secondary Structure
MVKIKIDGVEYEVDEKKNLIDATKEVGVEIPYFCYHPALSIVGMCRMCLIEIEGVPRLQA
CEEEEECCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ACNTPVKEGMGIITKSDRVKEARAGTMEFLLANHPLDCPVCDKAGECRLQDNAFGSGTGH
HCCCCHHHCCCEEECCCHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCCC
SRFEFEKRNIPQEEIGTNLIINHNRCIVCYRCVRFEEEKVGESNLGLFERGNHSIIGLAK
CCEEEHHHCCCHHHHCCEEEEECCCEEEEEEEHHCCHHHCCCCCCCCEECCCCCEEEEEC
SEPIDHNYQGALADICPVGALLNNKTLFKSRVWWYKSHKSVCHGCSTGCNVTTNVRDNKM
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHEEECCHHHHHHCCCCCCEEEECCCCCHH
YRYMVRENFDQGMFFLCDKGRFDLDWMNDNRLFSYLESGKPSTSQVVISKIIDRLKDAKS
HHHHHHCCCCCCEEEEECCCCEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCE
IAVLGGAHESNETLEALKQNLQTLSRELSGKSIQWETRVTDAQNKETEQVDFLLTKDYHP
EEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCC
NTKGAVDLGLTTPSGISGIVSAVKQGSIDLVILLKESIPEGIDPTQVISLDTNLTDAAKN
CCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHCC
ASLAAPIQIFCEAEGSFTNKNGLKQTFEKSMNPIQGLQTSAGVVELIVKTMTKKMEASVG
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCC
NR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]