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The map label for this gene is thyX [H]

Identifier: 183222645

GI number: 183222645

Start: 3413132

End: 3414055

Strand: Reverse

Name: thyX [H]

Synonym: LEPBI_I3300

Alternate gene names: 183222645

Gene position: 3414055-3413132 (Counterclockwise)

Preceding gene: 183222647

Following gene: 183222644

Centisome position: 94.84

GC content: 43.07

Gene sequence:

>924_bases
ATGCAACAATCTGATTTCGAATCCATTTCAAGAGTATCCGTTCCCGAATTAGACTCCATTTTAGGAAAACCATTCCCAAT
TCTAGATGATGGATTTGTCAGACTCGTTGATTATATGGGTTCAGATGAATCCATCGTTCAGGCGGCACGCGTTTCGTACG
GAAAAGGAACAAAAAAGGTAAATGAAGACCGAGGACTGATTCGGTATTTAATGCGCCACAGACACAGTACTCCCTTTGAA
ATGTGCGAACTCAAGCTACACGTACGAGTACCAATGGATACTTGGCGCCAATGGATTCGCCACCGCATGGCAAATGTCAA
TGAATACTCTACGCGTTATTCCGTAGCCATTGACTCTGCACAAACGACATTACCGGGTGAATGGCGTGTGCAATCAGTTG
GCAACAAACAAGGAAGTGATGGATACTTAGAATCATCTAAAGGCGACCACCTAACAAAGAGAGAAACAGAGTTCCAAAAA
TTTGCCAATGATATTTACAATGAACGTTTGGAAATGGGAGTGGCACGCGAACAGGCAAGAAAAGACCTCCCACTTGCCAC
ATATACAGAAGCTTATTGGAAAATTGACCTGCACAATTTACTTCATTTTTTAGCACTGCGAATGGATGACCATGCTCAAT
TGGAAATCCGTTTGTTTGCGAAAACCATTGGTGAACAAATCGTACAAAAATGGGTGCCTCATACTTGGGAAGCTTTTGTG
GATTACCGATTGAGTGCCCTCCACCTCACCAAATATGATACTGAAATCATCGCAGCACTGAATGTTTCGGGAAAAGAGGG
AGCAATTAAAAAAGCGATCCAACTTGGAATGTTGGACGACCAAGGCACAACCGCTAAAAAAAGCCGAGAACGTGAGGAAT
TGGAGTACAAATTGTCTCAGTTGGGATTTTCCATCCCTTGGTAG

Upstream 100 bases:

>100_bases
AAGTGCCATTTAGCATCCTTTCTATTTATCTGCCGTTACTGTCCGCTATAACTCTATTTTCGACTTTTCATATGCCTGTG
AACTAAAAAATAAAGCTAAT

Downstream 100 bases:

>100_bases
GGTCTTTGCTTCTCCCTCCCATTTTAGTTTTTGATTGATAATTTATTTCCACATGGTTGTTAGAGTGATTATGAGCCTCA
AAATCCCTCTAACCATCCTT

Product: thymidylate synthase ThyX

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MQQSDFESISRVSVPELDSILGKPFPILDDGFVRLVDYMGSDESIVQAARVSYGKGTKKVNEDRGLIRYLMRHRHSTPFE
MCELKLHVRVPMDTWRQWIRHRMANVNEYSTRYSVAIDSAQTTLPGEWRVQSVGNKQGSDGYLESSKGDHLTKRETEFQK
FANDIYNERLEMGVAREQARKDLPLATYTEAYWKIDLHNLLHFLALRMDDHAQLEIRLFAKTIGEQIVQKWVPHTWEAFV
DYRLSALHLTKYDTEIIAALNVSGKEGAIKKAIQLGMLDDQGTTAKKSREREELEYKLSQLGFSIPW

Sequences:

>Translated_307_residues
MQQSDFESISRVSVPELDSILGKPFPILDDGFVRLVDYMGSDESIVQAARVSYGKGTKKVNEDRGLIRYLMRHRHSTPFE
MCELKLHVRVPMDTWRQWIRHRMANVNEYSTRYSVAIDSAQTTLPGEWRVQSVGNKQGSDGYLESSKGDHLTKRETEFQK
FANDIYNERLEMGVAREQARKDLPLATYTEAYWKIDLHNLLHFLALRMDDHAQLEIRLFAKTIGEQIVQKWVPHTWEAFV
DYRLSALHLTKYDTEIIAALNVSGKEGAIKKAIQLGMLDDQGTTAKKSREREELEYKLSQLGFSIPW
>Mature_307_residues
MQQSDFESISRVSVPELDSILGKPFPILDDGFVRLVDYMGSDESIVQAARVSYGKGTKKVNEDRGLIRYLMRHRHSTPFE
MCELKLHVRVPMDTWRQWIRHRMANVNEYSTRYSVAIDSAQTTLPGEWRVQSVGNKQGSDGYLESSKGDHLTKRETEFQK
FANDIYNERLEMGVAREQARKDLPLATYTEAYWKIDLHNLLHFLALRMDDHAQLEIRLFAKTIGEQIVQKWVPHTWEAFV
DYRLSALHLTKYDTEIIAALNVSGKEGAIKKAIQLGMLDDQGTTAKKSREREELEYKLSQLGFSIPW

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 35514; Mature: 35514

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQSDFESISRVSVPELDSILGKPFPILDDGFVRLVDYMGSDESIVQAARVSYGKGTKKV
CCCCHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCC
NEDRGLIRYLMRHRHSTPFEMCELKLHVRVPMDTWRQWIRHRMANVNEYSTRYSVAIDSA
CHHHHHHHHHHHHCCCCCHHHHEEEEEEECCHHHHHHHHHHHHCCCHHHCCEEEEEECCC
QTTLPGEWRVQSVGNKQGSDGYLESSKGDHLTKRETEFQKFANDIYNERLEMGVAREQAR
CCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDLPLATYTEAYWKIDLHNLLHFLALRMDDHAQLEIRLFAKTIGEQIVQKWVPHTWEAFV
CCCCCHHHHHHHHEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
DYRLSALHLTKYDTEIIAALNVSGKEGAIKKAIQLGMLDDQGTTAKKSREREELEYKLSQ
HHHHHHHEEEHHCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
LGFSIPW
CCCCCCC
>Mature Secondary Structure
MQQSDFESISRVSVPELDSILGKPFPILDDGFVRLVDYMGSDESIVQAARVSYGKGTKKV
CCCCHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCC
NEDRGLIRYLMRHRHSTPFEMCELKLHVRVPMDTWRQWIRHRMANVNEYSTRYSVAIDSA
CHHHHHHHHHHHHCCCCCHHHHEEEEEEECCHHHHHHHHHHHHCCCHHHCCEEEEEECCC
QTTLPGEWRVQSVGNKQGSDGYLESSKGDHLTKRETEFQKFANDIYNERLEMGVAREQAR
CCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDLPLATYTEAYWKIDLHNLLHFLALRMDDHAQLEIRLFAKTIGEQIVQKWVPHTWEAFV
CCCCCHHHHHHHHEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
DYRLSALHLTKYDTEIIAALNVSGKEGAIKKAIQLGMLDDQGTTAKKSREREELEYKLSQ
HHHHHHHEEEHHCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
LGFSIPW
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA