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The map label for this gene is dsbD [H]

Identifier: 183222642

GI number: 183222642

Start: 3409651

End: 3410961

Strand: Reverse

Name: dsbD [H]

Synonym: LEPBI_I3297

Alternate gene names: 183222642

Gene position: 3410961-3409651 (Counterclockwise)

Preceding gene: 183222643

Following gene: 183222639

Centisome position: 94.76

GC content: 37.68

Gene sequence:

>1311_bases
ATGTTTTCTGAAATCCAAACCTTCATTGAATCCCAATTGTCCTCGGGGCATTTTTCCATTGCGACTGTATTCTTTTTAGC
TCTCGGTGGGTTATTGTCGGGGTTACTCCCTTGTGTGTACCCATTGTATCCCATCACTGCTGGCATTTTAAAAACACGTG
TTGCCAAACACAAATGGGCCCATCCGCTTGTGTATTATTTTGGCCTGGCTCTCATGTATGCCATTTTCGGATTGATTGCG
GGTGTGAGCGGAGGTGTATTCAATTCCTTTTTACGTTATCCAGAAACTCAATTGGTGCTTTCGATTTTGTTATTTGTTTT
GGGGCTTAGTGTTGCCGAGTATCTATACTTTCCATTTTTTTCTGGAGACTTGAAAAATTCAGTTAACGTCAATTATGCGA
ATACATTCTTTTTAGGAATGGGAGCGGGATTACTATCATCCCCATGTGTGGGACCCGTTGTTGTCTCCATTTTGGTACAA
TTGGTCACCTACCAAACGGAAGGCTTTAAAATCGTACCAATTTTATTTACCTCATTTAAAATGTTTGTTTTTGGAATGGG
TCTTGGCATTCCCTTTTTGATGATTGGAGTCTTTGGACTTTCCTTACCAAAATCTGGGAAATGGATGAAGTATGTTCAAT
GGGTTCTTGCCATACTCATCTTTTATTTTTCCTATACGTATCTGGAAAAAGCCTTCCTCTTATGGGGATTTGATTCTGGC
CTAAGTGCAAAAGTTTACTTCTTATGGACCACTTCCTTAGTCTTTTTATACCTTCTCAATAAAGAAGGTACCCATAGCGA
AAGGATGAAACATTCTCTGTTTCAAATTTTTGCCATCACTGGATTTCTCTTTTTATTCTTAATCCTAACCCATTCCATTC
TCAAATTGGGACCTGGAATTTCGATGGGGAATCGAATGAGCGAATCAACAATCCAAAAAGAAGAGCATGGGAATTTAGTT
TGGTACCGTAACAAAAACGATGCGTTTCAATTAGCTCAAGATAAGAATCTGCCCATCTTTATTGATTTTTATGCGGATTG
GTGTACCAATTGTAAGGAATTTCAAAAGCTGACTCTCTCCCATCAGGAATTGAATCAGACGTTTCAAAATGTTGTTTTAT
GGAAGGTGTATGATACTGATCCCATCTTCGAGGAATTTGTGAACGATCCAAATTATCCTGAATTAAAGATAGGATTACCT
TTCTTTTTGATCCTAAGTCCAAACGGAAAAATGTTATATAAATCCAATGATTATTTGGATACCAAAGGAATGATCGAAAC
CATTCGAAAATTGCAAAAAAATAATGAATGA

Upstream 100 bases:

>100_bases
GAACAGTTTTCAAAACCAGTGGCATTTCCCATCTCCGAATTTGGACGATTGGATCGAAGCATTGTTTTGAAGGCCACAGC
CACGTTCTAAGTTAGAGTTT

Downstream 100 bases:

>100_bases
GTAAAAAAATGCGAATCTTTATTTAAATAAGATTCGCATTACATTTGTTTAGCGAATTTAGCGAGGAAGTGAATTGATTG
TATTTAGGTATTCGTTCGCA

Product: thiol:disulfide interchange protein DsbD

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MFSEIQTFIESQLSSGHFSIATVFFLALGGLLSGLLPCVYPLYPITAGILKTRVAKHKWAHPLVYYFGLALMYAIFGLIA
GVSGGVFNSFLRYPETQLVLSILLFVLGLSVAEYLYFPFFSGDLKNSVNVNYANTFFLGMGAGLLSSPCVGPVVVSILVQ
LVTYQTEGFKIVPILFTSFKMFVFGMGLGIPFLMIGVFGLSLPKSGKWMKYVQWVLAILIFYFSYTYLEKAFLLWGFDSG
LSAKVYFLWTTSLVFLYLLNKEGTHSERMKHSLFQIFAITGFLFLFLILTHSILKLGPGISMGNRMSESTIQKEEHGNLV
WYRNKNDAFQLAQDKNLPIFIDFYADWCTNCKEFQKLTLSHQELNQTFQNVVLWKVYDTDPIFEEFVNDPNYPELKIGLP
FFLILSPNGKMLYKSNDYLDTKGMIETIRKLQKNNE

Sequences:

>Translated_436_residues
MFSEIQTFIESQLSSGHFSIATVFFLALGGLLSGLLPCVYPLYPITAGILKTRVAKHKWAHPLVYYFGLALMYAIFGLIA
GVSGGVFNSFLRYPETQLVLSILLFVLGLSVAEYLYFPFFSGDLKNSVNVNYANTFFLGMGAGLLSSPCVGPVVVSILVQ
LVTYQTEGFKIVPILFTSFKMFVFGMGLGIPFLMIGVFGLSLPKSGKWMKYVQWVLAILIFYFSYTYLEKAFLLWGFDSG
LSAKVYFLWTTSLVFLYLLNKEGTHSERMKHSLFQIFAITGFLFLFLILTHSILKLGPGISMGNRMSESTIQKEEHGNLV
WYRNKNDAFQLAQDKNLPIFIDFYADWCTNCKEFQKLTLSHQELNQTFQNVVLWKVYDTDPIFEEFVNDPNYPELKIGLP
FFLILSPNGKMLYKSNDYLDTKGMIETIRKLQKNNE
>Mature_436_residues
MFSEIQTFIESQLSSGHFSIATVFFLALGGLLSGLLPCVYPLYPITAGILKTRVAKHKWAHPLVYYFGLALMYAIFGLIA
GVSGGVFNSFLRYPETQLVLSILLFVLGLSVAEYLYFPFFSGDLKNSVNVNYANTFFLGMGAGLLSSPCVGPVVVSILVQ
LVTYQTEGFKIVPILFTSFKMFVFGMGLGIPFLMIGVFGLSLPKSGKWMKYVQWVLAILIFYFSYTYLEKAFLLWGFDSG
LSAKVYFLWTTSLVFLYLLNKEGTHSERMKHSLFQIFAITGFLFLFLILTHSILKLGPGISMGNRMSESTIQKEEHGNLV
WYRNKNDAFQLAQDKNLPIFIDFYADWCTNCKEFQKLTLSHQELNQTFQNVVLWKVYDTDPIFEEFVNDPNYPELKIGLP
FFLILSPNGKMLYKSNDYLDTKGMIETIRKLQKNNE

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=380, Percent_Identity=26.5789473684211, Blast_Score=112, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 49604; Mature: 49604

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA