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The map label for this gene is ggtB [H]

Identifier: 183222523

GI number: 183222523

Start: 3290324

End: 3292075

Strand: Reverse

Name: ggtB [H]

Synonym: LEPBI_I3178

Alternate gene names: 183222523

Gene position: 3292075-3290324 (Counterclockwise)

Preceding gene: 183222525

Following gene: 183222522

Centisome position: 91.45

GC content: 40.87

Gene sequence:

>1752_bases
TTGAGAGATGTGAGTGTTGGGAAAAAGTTTATGGTAGCAACAGGAAATCCTCTCGCTACAAAGGCAGCCATTAAAGTATT
GGAAGAGGGAGGGAATGCAATTGATGCTGCAGTTGCCGCCTTACTTGTATTAAATGTAACAAATGGAGAAGCCGCTAGTT
TTCCTTCCGTTGCTCCGACTTTGGTCTACGATAAAAAAACAGGACAAGTTAAAAGTTACATCGGTGCAGGATCGGCGCCC
AAAAAAGCATCCATCCAATGGTTCAAAGAAAAAGGATATGATGTGATGCCAAAAAATTCTATTTTGTCACAGTTGTTACC
TGCTTCGCCAGATGTCATCGTACGTTTGTTACAAGATCATGGTACCAAATCATTTTCGGAATTGGTTGCACCAGCCATTC
AGACAGCGGAAGAAGGTTTCCCAGCAAACCGCATTCTTGTTAAAAATTTAGATTTACCTTTGTATAAACGATTAGGGTTC
ACAATTTTGATGCCTTATAATTCTGAAGTATATTTAGAAAAAAAATGGTGGTACAATATCCGAGAAGGTGAGTTAACCAA
ACGTTTGGATTTGGCAAAAACTTGGAAGTTGATGGCCGATGAAGAAACGTTGGCAATTAAAAAAGGAAGATCCAGGAAAC
AAGCGTTAGAAGCAGTCCGAGATTATTTTTACAAAGGACCTGTCTCAGATCTTATCGTCAAACTTCATGAAGAAAAAGGT
GGTCTTATCACAAAAGAAGATTTGAGCCAGTATGCTGGAGGTTGGGAAAAACCAGTTTTGGGGGAATACCGTGATTACCA
AATTCTATCGAACCAAACTTGGACTCAAGGACCCGTTGTTCCAATGGTATTGCAACTGTTAGATGGAATTGATTTAAAAT
CAATGGGCCATAGTTCACCCGAATACATTCATACGGTTTCTCAAGCGATTGAATTAGTGATTGCCGATCGTGAAACATAT
TTTGGAGATCCAAAGTTTGTCGATGTGCCCTTAGATGGTTTATTATCCAAAAAATATTCTGACGTAAGACGGAAACTCTT
CCAAAAGGAAGCCTTCGGCAAAACTCCACCAAATGGAAATCCTTGGGCCTTTTCCTCTAGAAAACCAAAATCAAATTTTG
TGCCAGCTAACAATCACGAGGAACAATCGGTAAGTGAAATTAAGTATGGAAAAGACACAACGTATGTAAGTATTGTTGAT
GCTTCTGGGAATGCAGTTTCTCTCACTCCTAGCGATTTTCCACAATCACCAATGGTTCCAGGCACAGGTCTCACACTTGG
CATTCGGATGACGCAGTTCCGTTTAGATCCAACGCATCCATCTTCCCTCGCACCAGGAAAACGTCCGCGGATCACACCTA
ATCCTGGTATGGTGTTAAAAAATGGTAAATTATGGATGAGTTTCGGAACACCAGGGGGCGACGTCCAAAGTCAAGCAATG
ATCCAATTCTTTTTGAACATAGTTGTGTTTGGAATGGACCCACAAAAGGCAGTGGAAGCACCTAGATTTCGTTCGGTGAA
CTGGCCTGATAGTTTTTCTCCACATGCCTATCGTCCGGGTGGAATTGAATTGGAATCGTCTTTATTTGAGATCGTTTCCG
ATGAACTCAAAGCAAAAGGTTATAAAGTTTACAAAAAAGGTCATTTAGACAATGATTTTGGTGCCGTATGTGCTGTGTTA
AATGATTCAAAGAACAAACGACTCCTTGGAGTTGCTGACCCAAGAGAAGAGTCATCGGCAGAAGGTAGGTAA

Upstream 100 bases:

>100_bases
TTTTCAAACTTAGTATCACTATCTTAATTACTGTAATTTTTTTCCATTGTTTAGGAAGTCGTAGGCCAATCGTGTCCGGG
TATGTTGACCCACAGGTAGT

Downstream 100 bases:

>100_bases
TGAAGAATTTGAATCTGTTCGGTAATATAGTAACCCTAGCGAATTCTGGAGACAAAATGGAAAATCATTTTAGAAACCAA
AACAAACTTCAATTGAATCG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MRDVSVGKKFMVATGNPLATKAAIKVLEEGGNAIDAAVAALLVLNVTNGEAASFPSVAPTLVYDKKTGQVKSYIGAGSAP
KKASIQWFKEKGYDVMPKNSILSQLLPASPDVIVRLLQDHGTKSFSELVAPAIQTAEEGFPANRILVKNLDLPLYKRLGF
TILMPYNSEVYLEKKWWYNIREGELTKRLDLAKTWKLMADEETLAIKKGRSRKQALEAVRDYFYKGPVSDLIVKLHEEKG
GLITKEDLSQYAGGWEKPVLGEYRDYQILSNQTWTQGPVVPMVLQLLDGIDLKSMGHSSPEYIHTVSQAIELVIADRETY
FGDPKFVDVPLDGLLSKKYSDVRRKLFQKEAFGKTPPNGNPWAFSSRKPKSNFVPANNHEEQSVSEIKYGKDTTYVSIVD
ASGNAVSLTPSDFPQSPMVPGTGLTLGIRMTQFRLDPTHPSSLAPGKRPRITPNPGMVLKNGKLWMSFGTPGGDVQSQAM
IQFFLNIVVFGMDPQKAVEAPRFRSVNWPDSFSPHAYRPGGIELESSLFEIVSDELKAKGYKVYKKGHLDNDFGAVCAVL
NDSKNKRLLGVADPREESSAEGR

Sequences:

>Translated_583_residues
MRDVSVGKKFMVATGNPLATKAAIKVLEEGGNAIDAAVAALLVLNVTNGEAASFPSVAPTLVYDKKTGQVKSYIGAGSAP
KKASIQWFKEKGYDVMPKNSILSQLLPASPDVIVRLLQDHGTKSFSELVAPAIQTAEEGFPANRILVKNLDLPLYKRLGF
TILMPYNSEVYLEKKWWYNIREGELTKRLDLAKTWKLMADEETLAIKKGRSRKQALEAVRDYFYKGPVSDLIVKLHEEKG
GLITKEDLSQYAGGWEKPVLGEYRDYQILSNQTWTQGPVVPMVLQLLDGIDLKSMGHSSPEYIHTVSQAIELVIADRETY
FGDPKFVDVPLDGLLSKKYSDVRRKLFQKEAFGKTPPNGNPWAFSSRKPKSNFVPANNHEEQSVSEIKYGKDTTYVSIVD
ASGNAVSLTPSDFPQSPMVPGTGLTLGIRMTQFRLDPTHPSSLAPGKRPRITPNPGMVLKNGKLWMSFGTPGGDVQSQAM
IQFFLNIVVFGMDPQKAVEAPRFRSVNWPDSFSPHAYRPGGIELESSLFEIVSDELKAKGYKVYKKGHLDNDFGAVCAVL
NDSKNKRLLGVADPREESSAEGR
>Mature_583_residues
MRDVSVGKKFMVATGNPLATKAAIKVLEEGGNAIDAAVAALLVLNVTNGEAASFPSVAPTLVYDKKTGQVKSYIGAGSAP
KKASIQWFKEKGYDVMPKNSILSQLLPASPDVIVRLLQDHGTKSFSELVAPAIQTAEEGFPANRILVKNLDLPLYKRLGF
TILMPYNSEVYLEKKWWYNIREGELTKRLDLAKTWKLMADEETLAIKKGRSRKQALEAVRDYFYKGPVSDLIVKLHEEKG
GLITKEDLSQYAGGWEKPVLGEYRDYQILSNQTWTQGPVVPMVLQLLDGIDLKSMGHSSPEYIHTVSQAIELVIADRETY
FGDPKFVDVPLDGLLSKKYSDVRRKLFQKEAFGKTPPNGNPWAFSSRKPKSNFVPANNHEEQSVSEIKYGKDTTYVSIVD
ASGNAVSLTPSDFPQSPMVPGTGLTLGIRMTQFRLDPTHPSSLAPGKRPRITPNPGMVLKNGKLWMSFGTPGGDVQSQAM
IQFFLNIVVFGMDPQKAVEAPRFRSVNWPDSFSPHAYRPGGIELESSLFEIVSDELKAKGYKVYKKGHLDNDFGAVCAVL
NDSKNKRLLGVADPREESSAEGR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=531, Percent_Identity=25.9887005649718, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI73915090, Length=531, Percent_Identity=25.9887005649718, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI73915096, Length=531, Percent_Identity=25.9887005649718, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI73915094, Length=531, Percent_Identity=25.9887005649718, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI113429324, Length=518, Percent_Identity=25.2895752895753, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI113429326, Length=510, Percent_Identity=25.4901960784314, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI109148539, Length=602, Percent_Identity=22.4252491694352, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1789856, Length=585, Percent_Identity=27.6923076923077, Blast_Score=196, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI193208245, Length=537, Percent_Identity=25.512104283054, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI193208247, Length=537, Percent_Identity=25.512104283054, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17506189, Length=545, Percent_Identity=23.1192660550459, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI212646519, Length=535, Percent_Identity=22.803738317757, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI72000294, Length=535, Percent_Identity=22.803738317757, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI161077878, Length=525, Percent_Identity=23.047619047619, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24642670, Length=525, Percent_Identity=23.047619047619, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24642666, Length=525, Percent_Identity=23.047619047619, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI161077880, Length=525, Percent_Identity=23.047619047619, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551474, Length=525, Percent_Identity=23.047619047619, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI161077496, Length=539, Percent_Identity=22.0779220779221, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI18859893, Length=563, Percent_Identity=22.202486678508, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 64405; Mature: 64405

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDVSVGKKFMVATGNPLATKAAIKVLEEGGNAIDAAVAALLVLNVTNGEAASFPSVAPT
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCE
LVYDKKTGQVKSYIGAGSAPKKASIQWFKEKGYDVMPKNSILSQLLPASPDVIVRLLQDH
EEEECCCCCHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHC
GTKSFSELVAPAIQTAEEGFPANRILVKNLDLPLYKRLGFTILMPYNSEVYLEKKWWYNI
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHCCCEEEEECCCCEEEEEEEEEEC
REGELTKRLDLAKTWKLMADEETLAIKKGRSRKQALEAVRDYFYKGPVSDLIVKLHEEKG
CCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
GLITKEDLSQYAGGWEKPVLGEYRDYQILSNQTWTQGPVVPMVLQLLDGIDLKSMGHSSP
CEEEHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCHHHCCCCCH
EYIHTVSQAIELVIADRETYFGDPKFVDVPLDGLLSKKYSDVRRKLFQKEAFGKTPPNGN
HHHHHHHHHHHEEEECCHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PWAFSSRKPKSNFVPANNHEEQSVSEIKYGKDTTYVSIVDASGNAVSLTPSDFPQSPMVP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCCCCCCCCC
GTGLTLGIRMTQFRLDPTHPSSLAPGKRPRITPNPGMVLKNGKLWMSFGTPGGDVQSQAM
CCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCHHHHHH
IQFFLNIVVFGMDPQKAVEAPRFRSVNWPDSFSPHAYRPGGIELESSLFEIVSDELKAKG
HHHHHHHHEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
YKVYKKGHLDNDFGAVCAVLNDSKNKRLLGVADPREESSAEGR
EEEEECCCCCCCHHHEEEEEECCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRDVSVGKKFMVATGNPLATKAAIKVLEEGGNAIDAAVAALLVLNVTNGEAASFPSVAPT
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCE
LVYDKKTGQVKSYIGAGSAPKKASIQWFKEKGYDVMPKNSILSQLLPASPDVIVRLLQDH
EEEECCCCCHHHHHCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHC
GTKSFSELVAPAIQTAEEGFPANRILVKNLDLPLYKRLGFTILMPYNSEVYLEKKWWYNI
CCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHCCCEEEEECCCCEEEEEEEEEEC
REGELTKRLDLAKTWKLMADEETLAIKKGRSRKQALEAVRDYFYKGPVSDLIVKLHEEKG
CCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
GLITKEDLSQYAGGWEKPVLGEYRDYQILSNQTWTQGPVVPMVLQLLDGIDLKSMGHSSP
CEEEHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCHHHCCCCCH
EYIHTVSQAIELVIADRETYFGDPKFVDVPLDGLLSKKYSDVRRKLFQKEAFGKTPPNGN
HHHHHHHHHHHEEEECCHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PWAFSSRKPKSNFVPANNHEEQSVSEIKYGKDTTYVSIVDASGNAVSLTPSDFPQSPMVP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCCCCCCCCC
GTGLTLGIRMTQFRLDPTHPSSLAPGKRPRITPNPGMVLKNGKLWMSFGTPGGDVQSQAM
CCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCHHHHHH
IQFFLNIVVFGMDPQKAVEAPRFRSVNWPDSFSPHAYRPGGIELESSLFEIVSDELKAKG
HHHHHHHHEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
YKVYKKGHLDNDFGAVCAVLNDSKNKRLLGVADPREESSAEGR
EEEEECCCCCCCHHHEEEEEECCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]