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The map label for this gene is luxQ [H]

Identifier: 183222354

GI number: 183222354

Start: 3119168

End: 3121543

Strand: Direct

Name: luxQ [H]

Synonym: LEPBI_I3007

Alternate gene names: 183222354

Gene position: 3119168-3121543 (Clockwise)

Preceding gene: 183222353

Following gene: 183222358

Centisome position: 86.65

GC content: 34.93

Gene sequence:

>2376_bases
ATGCCGACTGATCCCTCCCTCGAAATTCAGATTCTATCCGATTTTGAGGACATTGTATTTTCAATTGGATACCCGAAATT
AGAAATTCTGTATACGAGTCGATCGATCCAAACTTTGACAGGTTATGACAGCCAGTATTTTTTAGAAAATAAAACATCCT
GGCAGAAATTCATTTATAAGGAAGATCGAAACTTAATCAAACATGCGTTAATTGCAATCCAAAACAATCAAAAATTTCGA
CTCCGCTTAAGAATCATAACAAAAAATCAAAACATCAAGTACATTGAATGCCGAGGTAGATTGATTCATAATCAATCAAA
TGGTTCGTACAGAATTGATGGGATTGTTACTGACATTTCTGACTTACTTCCTCTTTATCATTTATTTCAAGATGAATCCG
TTGATATCAAACATTTGTTAATTGAAAACAATATGATTTTTAATGGATCACAAGATTCCATGTTTTTAATCGAAGTAAAA
GATGATGATCAATATGTGATCCGTAGGATTAACTTAGCTTATGAAAGATCCACGGGAATCAAACTATCAATGATCCAAGG
AAAAACTCCTATAGAGTTATTGGGTGAAGAACTTGGTGGAACAGTAATCAATAATTTCAAAAAGGCGATCCAATCTAAAA
AAACTATCTCTTATGAAGAAAGTTTCACAATGCCCGCTGGAACAAAAATTTGGATTACGGAACTGACTCCTATTGAAGTA
GAGGGCAAATATAAATACATTGTCGGTGCAAGTAAGGATATCACCGAACAAAAATTAGCCGAAAATGCACTTAAAGAATA
TAATGAACGATATGCTTTGATTTTGGAAGCTAGCTCTGATGGTTGGTTTGATTGGGACTTAGTAAACAATACAGTGATTT
ATTCCAGACGATGGTGGTTAGAATTTGGAAACGATGAAAAACCAGAAAATGTTCCCATTGATTACTGGCAAAGTTTAATC
CATCCAGATGATGTTGGATGGGTCAGTGAATTTTTAGAAACTATTTTAGCCTCACAACGTGAAACCTTTGAATTTACGTT
CCAGATGAAAAAAAGAAAAGGTAATTTTGCACATGTATTGTCAAAATGTTACATCCAAAGGGATGCCTCGGGCAACAAAA
TTCGTTTACTTGGTTCAAATACAGATTTAACTGAAACAAAAAAAATCGAGTATACCCTTCGTTATGCAAAAGAATTAGCA
GAAGCCGCAAACATTGCAAAGGGAAACTTTTTAGCAAATATGAGTCACGAAATTCGGACTCCATTAAATGGCATCATTGG
ATTCACCGAACTTTTATTAAACTCTCCTTTACAAGAAGAACAAAAAGAATATTTGAAAAACATTTTCTTTTCAGGAAAAA
GTTTATTAGAATTGGTGAATCAAATCTTAGACTTCTCTAAGATCGATTCTGGAAAACTTGAATTTGAATCGATTAACACT
AATTTAATTGATTTGGTGCAATCAACCTTAGATTTGTTTCAAGTATCAGCGGCATCCAAAGGAATCGCATTACATATACA
AATTGATCCAAATCTGCCAAAATATGTTTCGCTCGATCCACTTAGGATCAGACAGATTCTATCAAATTTAATCGGGAATG
CCATTAAGTTCACCCATGAAGGATCCGTAAAAGTCTCTTTACAACAAATGGAGCGTAACGGTGATTATGTGACAATTTCA
TTTGAGGTATCTGATACTGGAATTGGTATTGATATGAATGTAGGTTCTAGGCTATTCGATTCTTTTTCTCAAGCAGATAC
TTCGATCACGAGAAAGTACGGTGGATCAGGACTTGGGCTCACGATCACAAATGAACTATTATTAAAAATGAATTCTAAAT
TGACGATCCAAAGTGAACTAGGAAAGGGAAGCCAGTTTAGTTTTCCTTTGACACTGGAAGTCAAATCATCAGGCGAAAAT
GCATCTTCTATTTTTGATGATAAACCTACTCAGAACCTCGAAACTAACTTAGTGCAAATTCCTGAGATCCAATCAGACAT
TCTCATCGTTGAAGATAATGATTTGAATCGAAAACTTTTGACGAAACTGTTACAAAAAAAATATCCGAATTTAAAGTTAC
GTTATGCGATTGATGGAATAGAAGCACTTGCGCAATTCCAATTTAAAGTTCCAGATTTGATCATAATGGATTTGCAAATG
CCGATTATGGATGGATACACAGCAACCATTGAAATTCGAAGATTGGAAACCAATTCAAATAAAAAAACACCAATTGTCGC
TTTGACAGCTGGTGCTTTTTATGCTGTAAAGGATTCTGCGATGGAATCGGGAATGGACGATTTTTTAACCAAACCCATTT
CCGCATCCCATCTGTATGCGACTGTAGAAAAGTGGCTTCGGTTAGGCCGCGTGTAG

Upstream 100 bases:

>100_bases
GTTTTTTACCATCGTTTGCTCTCCCATTTCTCATCCAAAATCGATCGGTTGGATTGTAAAACGCCAGTTTTCTTAACAAT
TTTTTCGTCGCATGGAGGGT

Downstream 100 bases:

>100_bases
TAGATATTCAAAAGCGCTGATTGCCGCCTTTGCCCCTTCTCCCATTGCAATGATAATTTGTTTGTAAGGTGTATTTGTCA
CATCCCCACAAGCAAAGATT

Product: putative sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 791; Mature: 790

Protein sequence:

>791_residues
MPTDPSLEIQILSDFEDIVFSIGYPKLEILYTSRSIQTLTGYDSQYFLENKTSWQKFIYKEDRNLIKHALIAIQNNQKFR
LRLRIITKNQNIKYIECRGRLIHNQSNGSYRIDGIVTDISDLLPLYHLFQDESVDIKHLLIENNMIFNGSQDSMFLIEVK
DDDQYVIRRINLAYERSTGIKLSMIQGKTPIELLGEELGGTVINNFKKAIQSKKTISYEESFTMPAGTKIWITELTPIEV
EGKYKYIVGASKDITEQKLAENALKEYNERYALILEASSDGWFDWDLVNNTVIYSRRWWLEFGNDEKPENVPIDYWQSLI
HPDDVGWVSEFLETILASQRETFEFTFQMKKRKGNFAHVLSKCYIQRDASGNKIRLLGSNTDLTETKKIEYTLRYAKELA
EAANIAKGNFLANMSHEIRTPLNGIIGFTELLLNSPLQEEQKEYLKNIFFSGKSLLELVNQILDFSKIDSGKLEFESINT
NLIDLVQSTLDLFQVSAASKGIALHIQIDPNLPKYVSLDPLRIRQILSNLIGNAIKFTHEGSVKVSLQQMERNGDYVTIS
FEVSDTGIGIDMNVGSRLFDSFSQADTSITRKYGGSGLGLTITNELLLKMNSKLTIQSELGKGSQFSFPLTLEVKSSGEN
ASSIFDDKPTQNLETNLVQIPEIQSDILIVEDNDLNRKLLTKLLQKKYPNLKLRYAIDGIEALAQFQFKVPDLIIMDLQM
PIMDGYTATIEIRRLETNSNKKTPIVALTAGAFYAVKDSAMESGMDDFLTKPISASHLYATVEKWLRLGRV

Sequences:

>Translated_791_residues
MPTDPSLEIQILSDFEDIVFSIGYPKLEILYTSRSIQTLTGYDSQYFLENKTSWQKFIYKEDRNLIKHALIAIQNNQKFR
LRLRIITKNQNIKYIECRGRLIHNQSNGSYRIDGIVTDISDLLPLYHLFQDESVDIKHLLIENNMIFNGSQDSMFLIEVK
DDDQYVIRRINLAYERSTGIKLSMIQGKTPIELLGEELGGTVINNFKKAIQSKKTISYEESFTMPAGTKIWITELTPIEV
EGKYKYIVGASKDITEQKLAENALKEYNERYALILEASSDGWFDWDLVNNTVIYSRRWWLEFGNDEKPENVPIDYWQSLI
HPDDVGWVSEFLETILASQRETFEFTFQMKKRKGNFAHVLSKCYIQRDASGNKIRLLGSNTDLTETKKIEYTLRYAKELA
EAANIAKGNFLANMSHEIRTPLNGIIGFTELLLNSPLQEEQKEYLKNIFFSGKSLLELVNQILDFSKIDSGKLEFESINT
NLIDLVQSTLDLFQVSAASKGIALHIQIDPNLPKYVSLDPLRIRQILSNLIGNAIKFTHEGSVKVSLQQMERNGDYVTIS
FEVSDTGIGIDMNVGSRLFDSFSQADTSITRKYGGSGLGLTITNELLLKMNSKLTIQSELGKGSQFSFPLTLEVKSSGEN
ASSIFDDKPTQNLETNLVQIPEIQSDILIVEDNDLNRKLLTKLLQKKYPNLKLRYAIDGIEALAQFQFKVPDLIIMDLQM
PIMDGYTATIEIRRLETNSNKKTPIVALTAGAFYAVKDSAMESGMDDFLTKPISASHLYATVEKWLRLGRV
>Mature_790_residues
PTDPSLEIQILSDFEDIVFSIGYPKLEILYTSRSIQTLTGYDSQYFLENKTSWQKFIYKEDRNLIKHALIAIQNNQKFRL
RLRIITKNQNIKYIECRGRLIHNQSNGSYRIDGIVTDISDLLPLYHLFQDESVDIKHLLIENNMIFNGSQDSMFLIEVKD
DDQYVIRRINLAYERSTGIKLSMIQGKTPIELLGEELGGTVINNFKKAIQSKKTISYEESFTMPAGTKIWITELTPIEVE
GKYKYIVGASKDITEQKLAENALKEYNERYALILEASSDGWFDWDLVNNTVIYSRRWWLEFGNDEKPENVPIDYWQSLIH
PDDVGWVSEFLETILASQRETFEFTFQMKKRKGNFAHVLSKCYIQRDASGNKIRLLGSNTDLTETKKIEYTLRYAKELAE
AANIAKGNFLANMSHEIRTPLNGIIGFTELLLNSPLQEEQKEYLKNIFFSGKSLLELVNQILDFSKIDSGKLEFESINTN
LIDLVQSTLDLFQVSAASKGIALHIQIDPNLPKYVSLDPLRIRQILSNLIGNAIKFTHEGSVKVSLQQMERNGDYVTISF
EVSDTGIGIDMNVGSRLFDSFSQADTSITRKYGGSGLGLTITNELLLKMNSKLTIQSELGKGSQFSFPLTLEVKSSGENA
SSIFDDKPTQNLETNLVQIPEIQSDILIVEDNDLNRKLLTKLLQKKYPNLKLRYAIDGIEALAQFQFKVPDLIIMDLQMP
IMDGYTATIEIRRLETNSNKKTPIVALTAGAFYAVKDSAMESGMDDFLTKPISASHLYATVEKWLRLGRV

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=437, Percent_Identity=35.4691075514874, Blast_Score=215, Evalue=1e-56,
Organism=Escherichia coli, GI48994928, Length=419, Percent_Identity=32.9355608591885, Blast_Score=202, Evalue=8e-53,
Organism=Escherichia coli, GI1789149, Length=279, Percent_Identity=41.2186379928315, Blast_Score=202, Evalue=9e-53,
Organism=Escherichia coli, GI145693157, Length=252, Percent_Identity=36.1111111111111, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87081816, Length=342, Percent_Identity=33.0409356725146, Blast_Score=155, Evalue=9e-39,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=31.5555555555556, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1786783, Length=259, Percent_Identity=28.1853281853282, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1788549, Length=312, Percent_Identity=24.0384615384615, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=26.1061946902655, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=28.0172413793103, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=240, Percent_Identity=27.9166666666667, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=27.6785714285714, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=74, Percent_Identity=44.5945945945946, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322000, Length=121, Percent_Identity=30.5785123966942, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 90123; Mature: 89992

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTDPSLEIQILSDFEDIVFSIGYPKLEILYTSRSIQTLTGYDSQYFLENKTSWQKFIYK
CCCCCCEEEEEECCHHHHHHCCCCCEEEEEEECCCEEEEECCCCEEEECCCCHHHHHHHH
EDRNLIKHALIAIQNNQKFRLRLRIITKNQNIKYIECRGRLIHNQSNGSYRIDGIVTDIS
HHHHHHHHHHEEEECCCEEEEEEEEEECCCCEEEEEECCEEEEECCCCCEEEEEEHHHHH
DLLPLYHLFQDESVDIKHLLIENNMIFNGSQDSMFLIEVKDDDQYVIRRINLAYERSTGI
HHHHHHHHHCCCCCCEEEEEEECCEEEECCCCCEEEEEECCCCCEEHHHHHHEEECCCCE
KLSMIQGKTPIELLGEELGGTVINNFKKAIQSKKTISYEESFTMPAGTKIWITELTPIEV
EEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCEEEE
EGKYKYIVGASKDITEQKLAENALKEYNERYALILEASSDGWFDWDLVNNTVIYSRRWWL
CCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCEEEEEEEEEE
EFGNDEKPENVPIDYWQSLIHPDDVGWVSEFLETILASQRETFEFTFQMKKRKGNFAHVL
EECCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHH
SKCYIQRDASGNKIRLLGSNTDLTETKKIEYTLRYAKELAEAANIAKGNFLANMSHEIRT
HHHHHEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHCC
PLNGIIGFTELLLNSPLQEEQKEYLKNIFFSGKSLLELVNQILDFSKIDSGKLEFESINT
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCC
NLIDLVQSTLDLFQVSAASKGIALHIQIDPNLPKYVSLDPLRIRQILSNLIGNAIKFTHE
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCHHHHHHHHHHHCCCCEEEEEC
GSVKVSLQQMERNGDYVTISFEVSDTGIGIDMNVGSRLFDSFSQADTSITRKYGGSGLGL
CCEEEEEEHHHCCCCEEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEE
TITNELLLKMNSKLTIQSELGKGSQFSFPLTLEVKSSGENASSIFDDKPTQNLETNLVQI
EEECHHHHCCCCCEEEEHHCCCCCCCCCEEEEEEECCCCCCHHCCCCCCCCCCCCCEEEC
PEIQSDILIVEDNDLNRKLLTKLLQKKYPNLKLRYAIDGIEALAQFQFKVPDLIIMDLQM
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCEEEEEEEC
PIMDGYTATIEIRRLETNSNKKTPIVALTAGAFYAVKDSAMESGMDDFLTKPISASHLYA
CCCCCEEEEEEEEEEECCCCCCCCEEEEECCEEEEEEHHHHHCCCHHHHCCCCCHHHHHH
TVEKWLRLGRV
HHHHHHHHCCC
>Mature Secondary Structure 
PTDPSLEIQILSDFEDIVFSIGYPKLEILYTSRSIQTLTGYDSQYFLENKTSWQKFIYK
CCCCCEEEEEECCHHHHHHCCCCCEEEEEEECCCEEEEECCCCEEEECCCCHHHHHHHH
EDRNLIKHALIAIQNNQKFRLRLRIITKNQNIKYIECRGRLIHNQSNGSYRIDGIVTDIS
HHHHHHHHHHEEEECCCEEEEEEEEEECCCCEEEEEECCEEEEECCCCCEEEEEEHHHHH
DLLPLYHLFQDESVDIKHLLIENNMIFNGSQDSMFLIEVKDDDQYVIRRINLAYERSTGI
HHHHHHHHHCCCCCCEEEEEEECCEEEECCCCCEEEEEECCCCCEEHHHHHHEEECCCCE
KLSMIQGKTPIELLGEELGGTVINNFKKAIQSKKTISYEESFTMPAGTKIWITELTPIEV
EEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCEEEE
EGKYKYIVGASKDITEQKLAENALKEYNERYALILEASSDGWFDWDLVNNTVIYSRRWWL
CCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCEEEEEEEEEE
EFGNDEKPENVPIDYWQSLIHPDDVGWVSEFLETILASQRETFEFTFQMKKRKGNFAHVL
EECCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHH
SKCYIQRDASGNKIRLLGSNTDLTETKKIEYTLRYAKELAEAANIAKGNFLANMSHEIRT
HHHHHEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHCC
PLNGIIGFTELLLNSPLQEEQKEYLKNIFFSGKSLLELVNQILDFSKIDSGKLEFESINT
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCC
NLIDLVQSTLDLFQVSAASKGIALHIQIDPNLPKYVSLDPLRIRQILSNLIGNAIKFTHE
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCHHHHHHHHHHHCCCCEEEEEC
GSVKVSLQQMERNGDYVTISFEVSDTGIGIDMNVGSRLFDSFSQADTSITRKYGGSGLGL
CCEEEEEEHHHCCCCEEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEE
TITNELLLKMNSKLTIQSELGKGSQFSFPLTLEVKSSGENASSIFDDKPTQNLETNLVQI
EEECHHHHCCCCCEEEEHHCCCCCCCCCEEEEEEECCCCCCHHCCCCCCCCCCCCCEEEC
PEIQSDILIVEDNDLNRKLLTKLLQKKYPNLKLRYAIDGIEALAQFQFKVPDLIIMDLQM
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCEEEEEEEC
PIMDGYTATIEIRRLETNSNKKTPIVALTAGAFYAVKDSAMESGMDDFLTKPISASHLYA
CCCCCEEEEEEEEEEECCCCCCCCEEEEECCEEEEEEHHHHHCCCHHHHCCCCCHHHHHH
TVEKWLRLGRV
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]