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The map label for this gene is yegE [H]

Identifier: 183222324

GI number: 183222324

Start: 3078927

End: 3080426

Strand: Direct

Name: yegE [H]

Synonym: LEPBI_I2976

Alternate gene names: 183222324

Gene position: 3078927-3080426 (Clockwise)

Preceding gene: 183222322

Following gene: 183222325

Centisome position: 85.53

GC content: 38.33

Gene sequence:

>1500_bases
GTGCCACTTCCAGATTCGGAGATATTGCAGTTATTAACCTCGATTAGCCGAGAATTAGTATGCTTACATGAAACGGATGG
AACTTACATTTATGTCAGTCCCAATTCCGATACCGTGATTGGATACCAACCGGAGGAATTGTTGGGAAAAAATCCTTATG
ATTTTTTTCATCCAGATGATCGACGATTGATTTTTGAAAGATCTCACCAACCCCTATTACATGGGGCAGAAAATATCAAT
CCCACATTTCGTTTTCTACATAAGAATGGATCTTATATTTGGTTACAGAGTGACAACCGGTTGACCACCCATCCCACAAC
AGGAAAACAATATTTACATACATCTTCTCGTGACATCTCGGAAAAAATAGAATCCGATGCAAACTTAGCTCTTTCGGAAC
GAAAGTTCAAAACATTATTCCGCGACTCACCAATTGGTCTTGTACTTTCCAGCAAACAGGGTTATATCGATGATGTGAAC
GAAGCCTTCGCAAAATTTTTAGGATATGAAACTTTTGAACTGCTAGGAAAACATTTTTCTGAGATCAGTTCACTTGGAGA
ACTCGAAGAAAATCTCCGTTACAGAGATTCTGTCCAAAAAGGAATGATCGATCATTATTCCATTGAAAAACAATATTTCC
ACAAAGCAGGGCATTTGGTATGGGCATACATCACAGTGACAGTGTTACGTGATGAGATGGGCCAACCCATATACTATTTG
GCGCAAATCATCGATATTGACGAAAGGAAAAAAACGGAAAACCTACTTTTAGAAAATAATGAACACCTAAAGGCGACAAA
AAATTCCCTTCTCATCCAAAACAAACAATTACAATCATACAACCAAATCATCTCTCATCATTTACGTGCTCCTGTCAGTA
ACCTAAGGAGTTTGGTAGACCTTTTAAAGGTCACAGATGCAGCCGAAGAAAAAATCGAACTCCAAAATCATTTGGACGAA
GTGACTGAAGATTTAGAAACCATACTTTCTGAACTCATCACCACTTTAAAAATCCAAAGTTTGGAACATTACCATCCGGA
ATGGATTTCCATTAAAGATACATTTTCAAAAGTACAAAAATTGATGGAAGGGGAATTATTGGAAAAAAAGGTACAGATCG
ACCTCAATGTGACAGAAAAGGAAAAGGTCTTTGTTTCAAAGGATTATTTAGAAACCGTACTCTTACAACTCCTGAGCAAT
TCCCTACAATTTGCTGACCCTTCCCGAGTTTTGAGGATCGTGATTGAATCCTTTGCCATTGGCACAGAAACCATCATTTC
TTTCTCCGACAACGGTTCTGGGATCGATTTATCTCGCTATGGTGACCAAATTTTTCAGTTAAAAAAGACTTTTCATCGTC
ATATGAGTGGCAAAGGCCTCGGCTTGTTTTTAATGAAATACACGATGGAATCATTGGGTGGAAGGATCGAAGTGAAATCG
AAACCAGGTGAAGGAGCTACTTTTTTACTCTACTTCCCATTCGGGAGTACAAATCTATGA

Upstream 100 bases:

>100_bases
AGGGATGGTAAAAAAAATTTGGTTACCACCCGTTTTTATAATTAGAAAAAAACTCTGATTTGGGATGGACAAGTGAGTCC
GATTCTTATTGAATAAGGGT

Downstream 100 bases:

>100_bases
ACCCCAGAATTTGTATCATTGATGATGATAAAATCTATCAATTCACTACGAAAAAGATCATCGCAAATGCAGGGATCACA
GTAGAAGTACTGATTTTTTC

Product: putative two-component sensor and regulator

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MPLPDSEILQLLTSISRELVCLHETDGTYIYVSPNSDTVIGYQPEELLGKNPYDFFHPDDRRLIFERSHQPLLHGAENIN
PTFRFLHKNGSYIWLQSDNRLTTHPTTGKQYLHTSSRDISEKIESDANLALSERKFKTLFRDSPIGLVLSSKQGYIDDVN
EAFAKFLGYETFELLGKHFSEISSLGELEENLRYRDSVQKGMIDHYSIEKQYFHKAGHLVWAYITVTVLRDEMGQPIYYL
AQIIDIDERKKTENLLLENNEHLKATKNSLLIQNKQLQSYNQIISHHLRAPVSNLRSLVDLLKVTDAAEEKIELQNHLDE
VTEDLETILSELITTLKIQSLEHYHPEWISIKDTFSKVQKLMEGELLEKKVQIDLNVTEKEKVFVSKDYLETVLLQLLSN
SLQFADPSRVLRIVIESFAIGTETIISFSDNGSGIDLSRYGDQIFQLKKTFHRHMSGKGLGLFLMKYTMESLGGRIEVKS
KPGEGATFLLYFPFGSTNL

Sequences:

>Translated_499_residues
MPLPDSEILQLLTSISRELVCLHETDGTYIYVSPNSDTVIGYQPEELLGKNPYDFFHPDDRRLIFERSHQPLLHGAENIN
PTFRFLHKNGSYIWLQSDNRLTTHPTTGKQYLHTSSRDISEKIESDANLALSERKFKTLFRDSPIGLVLSSKQGYIDDVN
EAFAKFLGYETFELLGKHFSEISSLGELEENLRYRDSVQKGMIDHYSIEKQYFHKAGHLVWAYITVTVLRDEMGQPIYYL
AQIIDIDERKKTENLLLENNEHLKATKNSLLIQNKQLQSYNQIISHHLRAPVSNLRSLVDLLKVTDAAEEKIELQNHLDE
VTEDLETILSELITTLKIQSLEHYHPEWISIKDTFSKVQKLMEGELLEKKVQIDLNVTEKEKVFVSKDYLETVLLQLLSN
SLQFADPSRVLRIVIESFAIGTETIISFSDNGSGIDLSRYGDQIFQLKKTFHRHMSGKGLGLFLMKYTMESLGGRIEVKS
KPGEGATFLLYFPFGSTNL
>Mature_498_residues
PLPDSEILQLLTSISRELVCLHETDGTYIYVSPNSDTVIGYQPEELLGKNPYDFFHPDDRRLIFERSHQPLLHGAENINP
TFRFLHKNGSYIWLQSDNRLTTHPTTGKQYLHTSSRDISEKIESDANLALSERKFKTLFRDSPIGLVLSSKQGYIDDVNE
AFAKFLGYETFELLGKHFSEISSLGELEENLRYRDSVQKGMIDHYSIEKQYFHKAGHLVWAYITVTVLRDEMGQPIYYLA
QIIDIDERKKTENLLLENNEHLKATKNSLLIQNKQLQSYNQIISHHLRAPVSNLRSLVDLLKVTDAAEEKIELQNHLDEV
TEDLETILSELITTLKIQSLEHYHPEWISIKDTFSKVQKLMEGELLEKKVQIDLNVTEKEKVFVSKDYLETVLLQLLSNS
LQFADPSRVLRIVIESFAIGTETIISFSDNGSGIDLSRYGDQIFQLKKTFHRHMSGKGLGLFLMKYTMESLGGRIEVKSK
PGEGATFLLYFPFGSTNL

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=124, Percent_Identity=36.2903225806452, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788549, Length=383, Percent_Identity=25.3263707571802, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788713, Length=267, Percent_Identity=25.4681647940075, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=261, Percent_Identity=24.5210727969349, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=25, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 57325; Mature: 57194

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPDSEILQLLTSISRELVCLHETDGTYIYVSPNSDTVIGYQPEELLGKNPYDFFHPDD
CCCCHHHHHHHHHHHHHCEEEEEECCCCEEEEECCCCEEECCCCHHHHCCCCCCCCCCCC
RRLIFERSHQPLLHGAENINPTFRFLHKNGSYIWLQSDNRLTTHPTTGKQYLHTSSRDIS
CEEEEECCCCCHHCCCCCCCHHEEEEECCCCEEEEECCCEEEECCCCCHHHHCCCCHHHH
EKIESDANLALSERKFKTLFRDSPIGLVLSSKQGYIDDVNEAFAKFLGYETFELLGKHFS
HHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHH
EISSLGELEENLRYRDSVQKGMIDHYSIEKQYFHKAGHLVWAYITVTVLRDEMGQPIYYL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCHHHHH
AQIIDIDERKKTENLLLENNEHLKATKNSLLIQNKQLQSYNQIISHHLRAPVSNLRSLVD
HHHHCCHHHHHHHHHHCCCCCCHHHHHHHHEEEHHHHHHHHHHHHHHHHCCHHHHHHHHH
LLKVTDAAEEKIELQNHLDEVTEDLETILSELITTLKIQSLEHYHPEWISIKDTFSKVQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
LMEGELLEKKVQIDLNVTEKEKVFVSKDYLETVLLQLLSNSLQFADPSRVLRIVIESFAI
HHHHHHHHHHEEEEEEECCCHHEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
GTETIISFSDNGSGIDLSRYGDQIFQLKKTFHRHMSGKGLGLFLMKYTMESLGGRIEVKS
CCHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEC
KPGEGATFLLYFPFGSTNL
CCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
PLPDSEILQLLTSISRELVCLHETDGTYIYVSPNSDTVIGYQPEELLGKNPYDFFHPDD
CCCHHHHHHHHHHHHHCEEEEEECCCCEEEEECCCCEEECCCCHHHHCCCCCCCCCCCC
RRLIFERSHQPLLHGAENINPTFRFLHKNGSYIWLQSDNRLTTHPTTGKQYLHTSSRDIS
CEEEEECCCCCHHCCCCCCCHHEEEEECCCCEEEEECCCEEEECCCCCHHHHCCCCHHHH
EKIESDANLALSERKFKTLFRDSPIGLVLSSKQGYIDDVNEAFAKFLGYETFELLGKHFS
HHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHH
EISSLGELEENLRYRDSVQKGMIDHYSIEKQYFHKAGHLVWAYITVTVLRDEMGQPIYYL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCHHHHH
AQIIDIDERKKTENLLLENNEHLKATKNSLLIQNKQLQSYNQIISHHLRAPVSNLRSLVD
HHHHCCHHHHHHHHHHCCCCCCHHHHHHHHEEEHHHHHHHHHHHHHHHHCCHHHHHHHHH
LLKVTDAAEEKIELQNHLDEVTEDLETILSELITTLKIQSLEHYHPEWISIKDTFSKVQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
LMEGELLEKKVQIDLNVTEKEKVFVSKDYLETVLLQLLSNSLQFADPSRVLRIVIESFAI
HHHHHHHHHHEEEEEEECCCHHEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
GTETIISFSDNGSGIDLSRYGDQIFQLKKTFHRHMSGKGLGLFLMKYTMESLGGRIEVKS
CCHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEC
KPGEGATFLLYFPFGSTNL
CCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]