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The map label for this gene is ctaB [H]

Identifier: 183222045

GI number: 183222045

Start: 2784279

End: 2785136

Strand: Direct

Name: ctaB [H]

Synonym: LEPBI_I2687

Alternate gene names: 183222045

Gene position: 2784279-2785136 (Clockwise)

Preceding gene: 183222044

Following gene: 183222046

Centisome position: 77.35

GC content: 41.49

Gene sequence:

>858_bases
TTGATGTTCCGCTTATGGAACCAACTCACAAAACCTAGGGTCACAGTGCTTGTATTGGCCACTGTACTGCCTGGAATGTA
CCTTGGAACCACAGGATACCCGAGCTTAACTGTCATCTCCATCACTTTATTTGGGACTTATCTTATGAGTTCTGCTTCTT
TTATCCTCAACCAATACATTGAGAGAGAAAGAGATGCTGTCATGTACAGAACCAAACAAAGACCAATCCCTGCAGGTGAA
ATTTCTCCCACATTTGCGTTATTACTGGGAATTGTAGTCGCAATCGTTTCGTTTGGAATCCTCACTTATTTCATCAACCT
GCTAACGGCCGTTTGTGCACTTGCGGCACTTTTACTCTATGTATTTTTATACACCATCTGGTTAAAACCTAGAACAGAAC
AAAACATTGTGATTGGTGGAATCTCAGGTTGTATCGGACCACTCATCGGGTATGCTGCCATGGCGAATGCACTTCCGATG
CAAGCGTGGGTCATGTTCCTCATGATCTTTCTTTGGACACCAGCTCATTTTTGGGCCCTTGCGATTTTCCTAAAAGATGA
TTATGAATTTGCAGGGATCCCAATGATGCCTGTTGTCTCTGGAATAGAAAAAACGGTGAACCAAATTTTTCTGTATGCCA
TTGCGTATTCATTGTCTGTGATTGGGTTTTATTTTGTCGATGACCGTATGGGCTATTTATTTTTACTTTCTGCGATTGTC
CTAACGGTTCTCATCCTTGGATTTGCCTATCGATTAAAACTATCGATGGACAAAGTGCTTGCGAAGCGATTTTTCTTTTT
TAGCATTTTACACTTATTCCTCGTGAGCATTGCCATCGTCATCGATTCCAAAATTTAG

Upstream 100 bases:

>100_bases
AACTTGTGACTGGCCTCCATACCTTAAATGGGGTTTTAGTTTTTTTGTTTTGTTATATGGCCGCATTTTACCATTTTCGT
TCTGACAAAAAGGGTGTTCG

Downstream 100 bases:

>100_bases
GTTTTTTGATTGATTTGGGTAAGGAATTCTGTTTTCCTTTTGCCCATGAGTGTACTTGCGCGTTATTTCTCAAAATCTGA
TTTAGATGAAATCAAATCTG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MMFRLWNQLTKPRVTVLVLATVLPGMYLGTTGYPSLTVISITLFGTYLMSSASFILNQYIERERDAVMYRTKQRPIPAGE
ISPTFALLLGIVVAIVSFGILTYFINLLTAVCALAALLLYVFLYTIWLKPRTEQNIVIGGISGCIGPLIGYAAMANALPM
QAWVMFLMIFLWTPAHFWALAIFLKDDYEFAGIPMMPVVSGIEKTVNQIFLYAIAYSLSVIGFYFVDDRMGYLFLLSAIV
LTVLILGFAYRLKLSMDKVLAKRFFFFSILHLFLVSIAIVIDSKI

Sequences:

>Translated_285_residues
MMFRLWNQLTKPRVTVLVLATVLPGMYLGTTGYPSLTVISITLFGTYLMSSASFILNQYIERERDAVMYRTKQRPIPAGE
ISPTFALLLGIVVAIVSFGILTYFINLLTAVCALAALLLYVFLYTIWLKPRTEQNIVIGGISGCIGPLIGYAAMANALPM
QAWVMFLMIFLWTPAHFWALAIFLKDDYEFAGIPMMPVVSGIEKTVNQIFLYAIAYSLSVIGFYFVDDRMGYLFLLSAIV
LTVLILGFAYRLKLSMDKVLAKRFFFFSILHLFLVSIAIVIDSKI
>Mature_285_residues
MMFRLWNQLTKPRVTVLVLATVLPGMYLGTTGYPSLTVISITLFGTYLMSSASFILNQYIERERDAVMYRTKQRPIPAGE
ISPTFALLLGIVVAIVSFGILTYFINLLTAVCALAALLLYVFLYTIWLKPRTEQNIVIGGISGCIGPLIGYAAMANALPM
QAWVMFLMIFLWTPAHFWALAIFLKDDYEFAGIPMMPVVSGIEKTVNQIFLYAIAYSLSVIGFYFVDDRMGYLFLLSAIV
LTVLILGFAYRLKLSMDKVLAKRFFFFSILHLFLVSIAIVIDSKI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=263, Percent_Identity=30.0380228136882, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786631, Length=283, Percent_Identity=32.1554770318021, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1790473, Length=257, Percent_Identity=26.4591439688716, Blast_Score=78, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71998235, Length=270, Percent_Identity=27.4074074074074, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6325085, Length=297, Percent_Identity=25.5892255892256, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI19921064, Length=271, Percent_Identity=31.7343173431734, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32022; Mature: 32022

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA