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The map label for this gene is gabT [H]

Identifier: 183222014

GI number: 183222014

Start: 2751728

End: 2753017

Strand: Direct

Name: gabT [H]

Synonym: LEPBI_I2655

Alternate gene names: 183222014

Gene position: 2751728-2753017 (Clockwise)

Preceding gene: 183222013

Following gene: 183222015

Centisome position: 76.44

GC content: 45.58

Gene sequence:

>1290_bases
ATGACGGGCAATCAAAAACAAACCAACAAAACTCTATGGGAAAGAAGGCTTAAAAACGTTCCGAGAGGGGTCACTACCGC
CTATCCTGTGTTTGCCGAAAAAGCTACCAATGCAGAAATTTGGGACATTGAAGGAAAACGTTTCATCGATTTTGGTGGTG
GGATTGGTGTACAAAACACGGGGCATTGCCACCCAAAGGTGGTGGCAGCCATTCACAAACAAGTGGACAAGGTGCTCCAT
ACGGCTTTCCAAATTATGCCCTACGAACCTTATATTGATCTTTGCGAGAAACTGAACGCCAAAGCACCGATCGACGGGGA
AGCCAAAACCATTTTATTTTCCTCTGGTGCCGAAGCCCTCGAAAATGCAGTGAAAATTGCAAGAGCTGCGACTGGCAGAC
CAGGGATCATCAGTTTTCTCGGTGGATTCCACGGTCGTACCATGATGGCACTGGCTCTCACAGGAAAGGTCATTCCTTAT
AAAAAAGGCTTTGGTCCATTTGCAAGTGATGTCTACCACATCCCTTTCCCCATGGAATACCATGGCGTGACAGAAGAGGA
TTCGATTAAGGCATTACATAATTTATTCAAAGCAGACATTGACCCAGGCCGAGTGGCGGCCATCGCCATCGAACCCGTGC
AAGGCGAAGGTGGGTTTTACATTGCATCCCCAAGTTTCTTAAAAAAACTGAGAGCCATTTGTGATGAACATGGGATTTTA
CTGATTGCCGATGAAGTACAATCTGGATTTGCAAGGACAGGGAAACTGTTTGCCATCGAACATTCCGGAGTGAAACCAGA
CCTCATTGCAACTGCCAAATCACTCGCGGCAGGGATGCCACTTTCTGCTGTGATTGGAAAAACTTCGATCATGGATTCAG
TGGAACCAGGTGGACTTGGCGGAACTTATGCGGGAAACCCAGTGGCGTGTGCGGCAGGGATTGCCGTGATGGATCTCATC
GAAGAAGAAGGCATCCTTCAGAAATCAGTGAATCTTGGCAAACTTCTCATCCAGGAACTGAATGAAATCAAAAAAACCAA
TCCCAATATCGGCGAAATACGCGGATTAGGTGGAATGGTTGCCTTTGAGCTTGTGGAAAACGGAGATCCGAACAAACCAT
CTGCCGATATGGCAAAAAAATTAACGGCAAAAGCGTTAGAACATGGGCTTGTTTTACTTTCTTGTGGTGTGTATGGAAAC
GTCATTCGGATTTTAGTTCCCATCACAGCAGAAGATGCGATTGTAAAAGAAGGTCTAAACATCATTACAAAATCATTAAA
GGAAATCTAA

Upstream 100 bases:

>100_bases
CTTTTGGCGGAGTCAAATTTTCAGGAATGGGAAGAGAAGGCTCCAAATACGGTCTCGATGATTATACGGTAACCAAATAT
CTCTGCCTCGGAGGAATCAA

Downstream 100 bases:

>100_bases
CCCAAGTATGAAACAGTATAAACTTTGGATTGATGGAAAGTGGACAAACACATCCGGCGGAAAACCAATGGACATCGAAG
ACCCTGCCACTGGCAAAAAA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTGNQKQTNKTLWERRLKNVPRGVTTAYPVFAEKATNAEIWDIEGKRFIDFGGGIGVQNTGHCHPKVVAAIHKQVDKVLH
TAFQIMPYEPYIDLCEKLNAKAPIDGEAKTILFSSGAEALENAVKIARAATGRPGIISFLGGFHGRTMMALALTGKVIPY
KKGFGPFASDVYHIPFPMEYHGVTEEDSIKALHNLFKADIDPGRVAAIAIEPVQGEGGFYIASPSFLKKLRAICDEHGIL
LIADEVQSGFARTGKLFAIEHSGVKPDLIATAKSLAAGMPLSAVIGKTSIMDSVEPGGLGGTYAGNPVACAAGIAVMDLI
EEEGILQKSVNLGKLLIQELNEIKKTNPNIGEIRGLGGMVAFELVENGDPNKPSADMAKKLTAKALEHGLVLLSCGVYGN
VIRILVPITAEDAIVKEGLNIITKSLKEI

Sequences:

>Translated_429_residues
MTGNQKQTNKTLWERRLKNVPRGVTTAYPVFAEKATNAEIWDIEGKRFIDFGGGIGVQNTGHCHPKVVAAIHKQVDKVLH
TAFQIMPYEPYIDLCEKLNAKAPIDGEAKTILFSSGAEALENAVKIARAATGRPGIISFLGGFHGRTMMALALTGKVIPY
KKGFGPFASDVYHIPFPMEYHGVTEEDSIKALHNLFKADIDPGRVAAIAIEPVQGEGGFYIASPSFLKKLRAICDEHGIL
LIADEVQSGFARTGKLFAIEHSGVKPDLIATAKSLAAGMPLSAVIGKTSIMDSVEPGGLGGTYAGNPVACAAGIAVMDLI
EEEGILQKSVNLGKLLIQELNEIKKTNPNIGEIRGLGGMVAFELVENGDPNKPSADMAKKLTAKALEHGLVLLSCGVYGN
VIRILVPITAEDAIVKEGLNIITKSLKEI
>Mature_428_residues
TGNQKQTNKTLWERRLKNVPRGVTTAYPVFAEKATNAEIWDIEGKRFIDFGGGIGVQNTGHCHPKVVAAIHKQVDKVLHT
AFQIMPYEPYIDLCEKLNAKAPIDGEAKTILFSSGAEALENAVKIARAATGRPGIISFLGGFHGRTMMALALTGKVIPYK
KGFGPFASDVYHIPFPMEYHGVTEEDSIKALHNLFKADIDPGRVAAIAIEPVQGEGGFYIASPSFLKKLRAICDEHGILL
IADEVQSGFARTGKLFAIEHSGVKPDLIATAKSLAAGMPLSAVIGKTSIMDSVEPGGLGGTYAGNPVACAAGIAVMDLIE
EEGILQKSVNLGKLLIQELNEIKKTNPNIGEIRGLGGMVAFELVENGDPNKPSADMAKKLTAKALEHGLVLLSCGVYGNV
IRILVPITAEDAIVKEGLNIITKSLKEI

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=412, Percent_Identity=32.0388349514563, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI284507298, Length=323, Percent_Identity=32.1981424148607, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI13994255, Length=411, Percent_Identity=29.683698296837, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=29.5238095238095, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI24119277, Length=426, Percent_Identity=25.8215962441315, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI226442709, Length=372, Percent_Identity=30.9139784946237, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI226442705, Length=404, Percent_Identity=28.960396039604, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI188536080, Length=436, Percent_Identity=26.605504587156, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI38679950, Length=436, Percent_Identity=26.605504587156, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI38679946, Length=436, Percent_Identity=26.605504587156, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=54.8693586698337, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI1787560, Length=423, Percent_Identity=54.3735224586288, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=33.9950372208437, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1788044, Length=398, Percent_Identity=34.1708542713568, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI145693181, Length=337, Percent_Identity=35.9050445103858, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1786991, Length=371, Percent_Identity=30.9973045822102, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1786349, Length=319, Percent_Identity=32.6018808777429, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25144271, Length=415, Percent_Identity=29.8795180722892, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI32564660, Length=445, Percent_Identity=33.9325842696629, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71992977, Length=425, Percent_Identity=29.6470588235294, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25144274, Length=288, Percent_Identity=31.25, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17541228, Length=427, Percent_Identity=24.5901639344262, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=26.7080745341615, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324432, Length=409, Percent_Identity=32.518337408313, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=31.566265060241, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324386, Length=357, Percent_Identity=23.8095238095238, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321456, Length=438, Percent_Identity=23.972602739726, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=32.2815533980583, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI28574759, Length=417, Percent_Identity=32.6139088729017, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI161085790, Length=416, Percent_Identity=32.2115384615385, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI21356575, Length=390, Percent_Identity=30.2564102564103, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI281366494, Length=389, Percent_Identity=26.4781491002571, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24667139, Length=389, Percent_Identity=26.4781491002571, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24667143, Length=389, Percent_Identity=26.4781491002571, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45829; Mature: 45698

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGNQKQTNKTLWERRLKNVPRGVTTAYPVFAEKATNAEIWDIEGKRFIDFGGGIGVQNT
CCCCCHHHHHHHHHHHHHHCCCCCCHHCHHHHHCCCCCEEEECCCCEEEEECCCCCCCCC
GHCHPKVVAAIHKQVDKVLHTAFQIMPYEPYIDLCEKLNAKAPIDGEAKTILFSSGAEAL
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCHHHH
ENAVKIARAATGRPGIISFLGGFHGRTMMALALTGKVIPYKKGFGPFASDVYHIPFPMEY
HHHHHHHHHCCCCCHHHHHHCCCCCHHEEEHHHHCCCCCCCCCCCCCCCCEEECCCCCCC
HGVTEEDSIKALHNLFKADIDPGRVAAIAIEPVQGEGGFYIASPSFLKKLRAICDEHGIL
CCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCEEEECHHHHHHHHHHHCCCCEE
LIADEVQSGFARTGKLFAIEHSGVKPDLIATAKSLAAGMPLSAVIGKTSIMDSVEPGGLG
EEEHHHHCCHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHCCHHHHCCCCCCCCC
GTYAGNPVACAAGIAVMDLIEEEGILQKSVNLGKLLIQELNEIKKTNPNIGEIRGLGGMV
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHH
AFELVENGDPNKPSADMAKKLTAKALEHGLVLLSCGVYGNVIRILVPITAEDAIVKEGLN
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHCEEEEEEECCCCHHHHHHHHH
IITKSLKEI
HHHHHHHCC
>Mature Secondary Structure 
TGNQKQTNKTLWERRLKNVPRGVTTAYPVFAEKATNAEIWDIEGKRFIDFGGGIGVQNT
CCCCHHHHHHHHHHHHHHCCCCCCHHCHHHHHCCCCCEEEECCCCEEEEECCCCCCCCC
GHCHPKVVAAIHKQVDKVLHTAFQIMPYEPYIDLCEKLNAKAPIDGEAKTILFSSGAEAL
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCHHHH
ENAVKIARAATGRPGIISFLGGFHGRTMMALALTGKVIPYKKGFGPFASDVYHIPFPMEY
HHHHHHHHHCCCCCHHHHHHCCCCCHHEEEHHHHCCCCCCCCCCCCCCCCEEECCCCCCC
HGVTEEDSIKALHNLFKADIDPGRVAAIAIEPVQGEGGFYIASPSFLKKLRAICDEHGIL
CCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCEEEECHHHHHHHHHHHCCCCEE
LIADEVQSGFARTGKLFAIEHSGVKPDLIATAKSLAAGMPLSAVIGKTSIMDSVEPGGLG
EEEHHHHCCHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHCCHHHHCCCCCCCCC
GTYAGNPVACAAGIAVMDLIEEEGILQKSVNLGKLLIQELNEIKKTNPNIGEIRGLGGMV
CCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHH
AFELVENGDPNKPSADMAKKLTAKALEHGLVLLSCGVYGNVIRILVPITAEDAIVKEGLN
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHCEEEEEEECCCCHHHHHHHHH
IITKSLKEI
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]