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The map label for this gene is evgS [H]

Identifier: 183222001

GI number: 183222001

Start: 2734984

End: 2736765

Strand: Reverse

Name: evgS [H]

Synonym: LEPBI_I2642

Alternate gene names: 183222001

Gene position: 2736765-2734984 (Counterclockwise)

Preceding gene: 183222002

Following gene: 183222000

Centisome position: 76.03

GC content: 35.86

Gene sequence:

>1782_bases
TTGTGGCAATACCATCCTTATAGTGTTCTCCTTTTTCTAGCATTTAGCTTCAATCTTGGATTGGGGCTTTTCGTTCTTAA
ATCTTTTCGCCTCAATTTAGTTAAATATTTATTGATCCTTGTATTTGGGTCCATGTTATGGACCGGATTCTACGGGATTG
ATTTTATATACATCACCACTACATTTCACCGAACATTCATTAGTTTACTCTATATGGGTGTAGCCATTTCGAACGTGGGT
ATGGTTCTTGTATCCATTGAATTCACAAACAATCGCCAACTGTTAACCAAACGATTTTGGGTTATTCTTGCTCTCCAACC
ATTATTTACTTTGGCAGTTTGTGTTTTGGACCCATTATTTAAAACATTAACATTGGATACATATCTCACAAGTATTGATG
GTAGGGTACAATGGATCCAAGAAACAAATATAGGTGGGTTCATTGCATCGTATTTGATTTCCTTTTTTTGGTCAGTTTTT
GTTGCGATTCTATTATTTCGTGGGATTCTTAAATCCAAGTCAACAGAACGGAATCGTTATTTACTCATCTTAATTTCTTT
TTTGTTCATTTGGGTAGCCGCTATTTTACACAAGGTTGGAATCCGGCCTCTTCCAGGAATGAATATAACTGCAGTTATGT
GTACTATGCAGGCAATCATGATTTTTTTTGCCATTGGTTATTACCGAATGTTCGATTTGGTGCCATTGGTTCGAGGCGAG
ATTGTTGATGAACTAGACGAAGCAGTTGTCATTCTTGATTTTAACAATCGGGTTGTGGATTGGAATAGTTCTGCCGAGAA
TTTATTTTCCATTAAGGACAAAAGTGTTGCGTTACTTCCGCATGATATTTTTTTTCAGAACACTCCAGAGTTAATTTCTA
AATTAGATCATTTATCTGATAAACGAACCATCTCCAAATGGTCTTGGGAAAAAGAGCAGAAGTTTTGGGAAGTAACAGCA
AAACAAATTAGAGATTCCAATCGAAAAAAAATAGGTATGGTTCTTGTATTTCGAGACAATACGGAGCAAAGAAATCTCGA
AAAACAAATGGCAAATGTGAACAGAGAGCTTCTTGTTGCCAATGGAACCAAAGATAGGTTTTTATCAATCATTTCACATG
ATTTGCGTGGTCCTCTTGCTGGGATCAAAATGTTACTCAAAGTGCTCAATGAAGATATGAAAAAAAAGGAAGATGCTTTA
GCTGGGATGACCCAATCATTAGTTGATGCAACGGAATCTGTTTTTTCCTTATTAGAAAACTTATTAGAATGGTCTAAATT
ACAACGAGGCCAAGAGGAATTTAGGCCAAATTATTATCGGTTGGATTCGATTGTTTTGGAATGTGTGGAATTGTTTTCAT
TGAGTGCCAAAAATAAAGGAATCAGTTTTGAGATCAATATTCCAAATCACGCAATGGTATATTGTGACGATCGAATGATC
ATTACAGTCATTCGCAATTTAATTTCCAATGCTTTGAAATTTAGTCATCAATGCAGTAAAATTGAAGTCTCTGCCATTGA
TACTGGTTATCACTGGTTAGTATCGATTCGTGATTTTGGAGTCGGTATGTCCAAAACTACAATTGATAAATTATTTAGAG
CTGGTGAAGTCATAAAGTCAATTGGTACTCAAGGTGAAACTGGCAATGGAATTGGATTGTTGTTATGTTCAGAGTTTGTG
ACAGTGAATGGTGGAACACTTTCTGCAGACAGTGATGGAGCCTCAGGTTCTGTATTTCAATTTAGCATCCCCAAAAAACA
AAACGAGGAAGTTTTTATATGA

Upstream 100 bases:

>100_bases
GGAAAGGTACAGGGAAACATTCGAACAGCAAAATTACAAATCGCAGATGGAGTTGTCTTTGACGGAAACTGTGAAATGTT
AAGCAGCGACGAGCCTTAGT

Downstream 100 bases:

>100_bases
GTCAAACTATTTTAATCACAGGCGCAACAGACGGAATTGGAAGAGTTTGTGCTCATTCCTTTGCGAAATCAAAAAACGAA
CTCATATTAGTTGGAAGAAA

Product: putative signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MWQYHPYSVLLFLAFSFNLGLGLFVLKSFRLNLVKYLLILVFGSMLWTGFYGIDFIYITTTFHRTFISLLYMGVAISNVG
MVLVSIEFTNNRQLLTKRFWVILALQPLFTLAVCVLDPLFKTLTLDTYLTSIDGRVQWIQETNIGGFIASYLISFFWSVF
VAILLFRGILKSKSTERNRYLLILISFLFIWVAAILHKVGIRPLPGMNITAVMCTMQAIMIFFAIGYYRMFDLVPLVRGE
IVDELDEAVVILDFNNRVVDWNSSAENLFSIKDKSVALLPHDIFFQNTPELISKLDHLSDKRTISKWSWEKEQKFWEVTA
KQIRDSNRKKIGMVLVFRDNTEQRNLEKQMANVNRELLVANGTKDRFLSIISHDLRGPLAGIKMLLKVLNEDMKKKEDAL
AGMTQSLVDATESVFSLLENLLEWSKLQRGQEEFRPNYYRLDSIVLECVELFSLSAKNKGISFEINIPNHAMVYCDDRMI
ITVIRNLISNALKFSHQCSKIEVSAIDTGYHWLVSIRDFGVGMSKTTIDKLFRAGEVIKSIGTQGETGNGIGLLLCSEFV
TVNGGTLSADSDGASGSVFQFSIPKKQNEEVFI

Sequences:

>Translated_593_residues
MWQYHPYSVLLFLAFSFNLGLGLFVLKSFRLNLVKYLLILVFGSMLWTGFYGIDFIYITTTFHRTFISLLYMGVAISNVG
MVLVSIEFTNNRQLLTKRFWVILALQPLFTLAVCVLDPLFKTLTLDTYLTSIDGRVQWIQETNIGGFIASYLISFFWSVF
VAILLFRGILKSKSTERNRYLLILISFLFIWVAAILHKVGIRPLPGMNITAVMCTMQAIMIFFAIGYYRMFDLVPLVRGE
IVDELDEAVVILDFNNRVVDWNSSAENLFSIKDKSVALLPHDIFFQNTPELISKLDHLSDKRTISKWSWEKEQKFWEVTA
KQIRDSNRKKIGMVLVFRDNTEQRNLEKQMANVNRELLVANGTKDRFLSIISHDLRGPLAGIKMLLKVLNEDMKKKEDAL
AGMTQSLVDATESVFSLLENLLEWSKLQRGQEEFRPNYYRLDSIVLECVELFSLSAKNKGISFEINIPNHAMVYCDDRMI
ITVIRNLISNALKFSHQCSKIEVSAIDTGYHWLVSIRDFGVGMSKTTIDKLFRAGEVIKSIGTQGETGNGIGLLLCSEFV
TVNGGTLSADSDGASGSVFQFSIPKKQNEEVFI
>Mature_593_residues
MWQYHPYSVLLFLAFSFNLGLGLFVLKSFRLNLVKYLLILVFGSMLWTGFYGIDFIYITTTFHRTFISLLYMGVAISNVG
MVLVSIEFTNNRQLLTKRFWVILALQPLFTLAVCVLDPLFKTLTLDTYLTSIDGRVQWIQETNIGGFIASYLISFFWSVF
VAILLFRGILKSKSTERNRYLLILISFLFIWVAAILHKVGIRPLPGMNITAVMCTMQAIMIFFAIGYYRMFDLVPLVRGE
IVDELDEAVVILDFNNRVVDWNSSAENLFSIKDKSVALLPHDIFFQNTPELISKLDHLSDKRTISKWSWEKEQKFWEVTA
KQIRDSNRKKIGMVLVFRDNTEQRNLEKQMANVNRELLVANGTKDRFLSIISHDLRGPLAGIKMLLKVLNEDMKKKEDAL
AGMTQSLVDATESVFSLLENLLEWSKLQRGQEEFRPNYYRLDSIVLECVELFSLSAKNKGISFEINIPNHAMVYCDDRMI
ITVIRNLISNALKFSHQCSKIEVSAIDTGYHWLVSIRDFGVGMSKTTIDKLFRAGEVIKSIGTQGETGNGIGLLLCSEFV
TVNGGTLSADSDGASGSVFQFSIPKKQNEEVFI

Specific function: Member of the two-component regulatory system evgS/evgA. Phosphorylates evgA via a four-step phosphorelay in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=376, Percent_Identity=26.3297872340426, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=30.0847457627119, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI48994928, Length=322, Percent_Identity=26.0869565217391, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1789149, Length=272, Percent_Identity=27.9411764705882, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI145693157, Length=257, Percent_Identity=24.5136186770428, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=23.8297872340426, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788549, Length=352, Percent_Identity=21.0227272727273, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=24.5833333333333, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786600, Length=261, Percent_Identity=23.7547892720307, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67604; Mature: 67604

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWQYHPYSVLLFLAFSFNLGLGLFVLKSFRLNLVKYLLILVFGSMLWTGFYGIDFIYITT
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEH
TFHRTFISLLYMGVAISNVGMVLVSIEFTNNRQLLTKRFWVILALQPLFTLAVCVLDPLF
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTLTLDTYLTSIDGRVQWIQETNIGGFIASYLISFFWSVFVAILLFRGILKSKSTERNRY
HHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LLILISFLFIWVAAILHKVGIRPLPGMNITAVMCTMQAIMIFFAIGYYRMFDLVPLVRGE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVDELDEAVVILDFNNRVVDWNSSAENLFSIKDKSVALLPHDIFFQNTPELISKLDHLSD
HHHHHCCEEEEEECCCEEEECCCCHHHHEEECCCCEEECCHHHHHCCCHHHHHHHHHCCC
KRTISKWSWEKEQKFWEVTAKQIRDSNRKKIGMVLVFRDNTEQRNLEKQMANVNRELLVA
CCHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEEE
NGTKDRFLSIISHDLRGPLAGIKMLLKVLNEDMKKKEDALAGMTQSLVDATESVFSLLEN
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLEWSKLQRGQEEFRPNYYRLDSIVLECVELFSLSAKNKGISFEINIPNHAMVYCDDRMI
HHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCHH
ITVIRNLISNALKFSHQCSKIEVSAIDTGYHWLVSIRDFGVGMSKTTIDKLFRAGEVIKS
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHHH
IGTQGETGNGIGLLLCSEFVTVNGGTLSADSDGASGSVFQFSIPKKQNEEVFI
HCCCCCCCCCEEEEEEHHHHEECCCEEECCCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MWQYHPYSVLLFLAFSFNLGLGLFVLKSFRLNLVKYLLILVFGSMLWTGFYGIDFIYITT
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEH
TFHRTFISLLYMGVAISNVGMVLVSIEFTNNRQLLTKRFWVILALQPLFTLAVCVLDPLF
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTLTLDTYLTSIDGRVQWIQETNIGGFIASYLISFFWSVFVAILLFRGILKSKSTERNRY
HHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LLILISFLFIWVAAILHKVGIRPLPGMNITAVMCTMQAIMIFFAIGYYRMFDLVPLVRGE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVDELDEAVVILDFNNRVVDWNSSAENLFSIKDKSVALLPHDIFFQNTPELISKLDHLSD
HHHHHCCEEEEEECCCEEEECCCCHHHHEEECCCCEEECCHHHHHCCCHHHHHHHHHCCC
KRTISKWSWEKEQKFWEVTAKQIRDSNRKKIGMVLVFRDNTEQRNLEKQMANVNRELLVA
CCHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEEE
NGTKDRFLSIISHDLRGPLAGIKMLLKVLNEDMKKKEDALAGMTQSLVDATESVFSLLEN
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLEWSKLQRGQEEFRPNYYRLDSIVLECVELFSLSAKNKGISFEINIPNHAMVYCDDRMI
HHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCHH
ITVIRNLISNALKFSHQCSKIEVSAIDTGYHWLVSIRDFGVGMSKTTIDKLFRAGEVIKS
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHHH
IGTQGETGNGIGLLLCSEFVTVNGGTLSADSDGASGSVFQFSIPKKQNEEVFI
HCCCCCCCCCEEEEEEHHHHEECCCEEECCCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]