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The map label for this gene is msrA2 [H]

Identifier: 183221992

GI number: 183221992

Start: 2724376

End: 2725059

Strand: Direct

Name: msrA2 [H]

Synonym: LEPBI_I2633

Alternate gene names: 183221992

Gene position: 2724376-2725059 (Clockwise)

Preceding gene: 183221991

Following gene: 183221995

Centisome position: 75.68

GC content: 37.57

Gene sequence:

>684_bases
ATGATCGGTTTGGATTGTCTGTTCGGCAAAAAATTAGTTCCTTTGGCCATTTTCGGTTTGGCCTTTGTCCTCTTCCCATT
TTGTGGACCTGTCACCCAAATTTCGAAACAAGAATCCTTACCTCTCGTTCCAAAATCAGGGCAAAAAATAGCCGTGTTTG
CAGAAGGTTGTTTTTGGTGTTCAGAACATATCTTTGAATCCATTCCGGGTGTGATAGATGTTGTGTCTGGATATGCAGGT
GGGCATACGGAAAATCCAACGTATGAATCAGTCAATACGGAAATGACAGGACATGCAGAATCAGTTTATATTGTTTATGA
TCCAACTAAAATAAGTTATGCGGAACTCTGCAGAATCTTTTTTCTTTCGCATGATCCAACCACAAAAGACAGACAAGGAC
CTGACATTGGTTCTTCGTATCGTTCGATTTTGTTTTATGCAGATGAAGAGGAATTCAAAATTGCAAATACAATCAAAAAA
GAAATCCAAACACAAAACATTTGGAATGGAACGATTGTGACCGAATTCCAAAAATTAAAACATTTTTACAAAGCGGAAGG
ATACCACCAGGATTTTATCAAAAACAATCCGTCTCAATCCTACGTCTTAGCAGTTTCTATTCCGAGATTCAAAGAGTTTC
AAAATCGTTACAATGAATTTAAAACGCGGAAAACTGTTCCTTAA

Upstream 100 bases:

>100_bases
GACGTCCAAACGAAAAGGACGTCACCCCTCCCTAAACTCGGACGATTCCTCAAACTAGTAGAAATTCTAACCAAATCCGT
ACGGGAACAATCTAATTGGT

Downstream 100 bases:

>100_bases
TTTTTGTTCTAAAAGAATCGAATTCAGCCTTAGATTGAAATTTACAAACTTTCAAAATTTCCATCGGGATTTCAGAAGAT
TTTGCTTCTTTTGAATTGAT

Product: peptide methionine sulfoxide reductase MsrA

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MIGLDCLFGKKLVPLAIFGLAFVLFPFCGPVTQISKQESLPLVPKSGQKIAVFAEGCFWCSEHIFESIPGVIDVVSGYAG
GHTENPTYESVNTEMTGHAESVYIVYDPTKISYAELCRIFFLSHDPTTKDRQGPDIGSSYRSILFYADEEEFKIANTIKK
EIQTQNIWNGTIVTEFQKLKHFYKAEGYHQDFIKNNPSQSYVLAVSIPRFKEFQNRYNEFKTRKTVP

Sequences:

>Translated_227_residues
MIGLDCLFGKKLVPLAIFGLAFVLFPFCGPVTQISKQESLPLVPKSGQKIAVFAEGCFWCSEHIFESIPGVIDVVSGYAG
GHTENPTYESVNTEMTGHAESVYIVYDPTKISYAELCRIFFLSHDPTTKDRQGPDIGSSYRSILFYADEEEFKIANTIKK
EIQTQNIWNGTIVTEFQKLKHFYKAEGYHQDFIKNNPSQSYVLAVSIPRFKEFQNRYNEFKTRKTVP
>Mature_227_residues
MIGLDCLFGKKLVPLAIFGLAFVLFPFCGPVTQISKQESLPLVPKSGQKIAVFAEGCFWCSEHIFESIPGVIDVVSGYAG
GHTENPTYESVNTEMTGHAESVYIVYDPTKISYAELCRIFFLSHDPTTKDRQGPDIGSSYRSILFYADEEEFKIANTIKK
EIQTQNIWNGTIVTEFQKLKHFYKAEGYHQDFIKNNPSQSYVLAVSIPRFKEFQNRYNEFKTRKTVP

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=40.9090909090909, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI208609995, Length=154, Percent_Identity=40.9090909090909, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=38.3177570093458, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1790665, Length=162, Percent_Identity=41.9753086419753, Blast_Score=127, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=31.6901408450704, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=37.3417721518987, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=37.2413793103448, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=37.1428571428571, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=35.8620689655172, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 25793; Mature: 25793

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGLDCLFGKKLVPLAIFGLAFVLFPFCGPVTQISKQESLPLVPKSGQKIAVFAEGCFWC
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCEEEEEECCHHHH
SEHIFESIPGVIDVVSGYAGGHTENPTYESVNTEMTGHAESVYIVYDPTKISYAELCRIF
HHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHH
FLSHDPTTKDRQGPDIGSSYRSILFYADEEEFKIANTIKKEIQTQNIWNGTIVTEFQKLK
HCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
HFYKAEGYHQDFIKNNPSQSYVLAVSIPRFKEFQNRYNEFKTRKTVP
HHHHCCCCHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIGLDCLFGKKLVPLAIFGLAFVLFPFCGPVTQISKQESLPLVPKSGQKIAVFAEGCFWC
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCEEEEEECCHHHH
SEHIFESIPGVIDVVSGYAGGHTENPTYESVNTEMTGHAESVYIVYDPTKISYAELCRIF
HHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHH
FLSHDPTTKDRQGPDIGSSYRSILFYADEEEFKIANTIKKEIQTQNIWNGTIVTEFQKLK
HCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
HFYKAEGYHQDFIKNNPSQSYVLAVSIPRFKEFQNRYNEFKTRKTVP
HHHHCCCCHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]