Click here to switch to the map view.

The map label for this gene is rnc [H]

Identifier: 183221945

GI number: 183221945

Start: 2671343

End: 2672071

Strand: Reverse

Name: rnc [H]

Synonym: LEPBI_I2584

Alternate gene names: 183221945

Gene position: 2672071-2671343 (Counterclockwise)

Preceding gene: 183221946

Following gene: 183221944

Centisome position: 74.23

GC content: 41.15

Gene sequence:

>729_bases
TTGTCCCACTCCATTCGCATCAAACTCACTCCCGAAAGAATCACCTCTCTCCAAGAACTACAATCCATCACAGATACAAG
TTTTAAGGATATTTCTCTCCTCCACCTAGCTTTTGTTCATAGGTCCTTTGCCAATGAGGATTCGGATCGTTATCTTTCTG
ATAATGAACGATTGGAATTTTTAGGAGACTCCGTCCTTGGCATATTGGCCGCAGAATACCTTTACAAATCGCTCCCTAAG
GGCAAGGAAGGGATCCTTGCGAAACTCAAGAGCAAAATGGTCTCAGCACCCGCCATTGCCAAACTGGCACGTTTCTATCG
ATTCCCTGATTTTTTACTTTTGGGAAAAGGAGAAAAAGAAAAGGGGGAAGCCAATTTGAACTTACAGGCTGATTGTTTTG
AAGCTTTTCTTGGTGCCTTGTATCTCGACCAAGGGCTAAACAGTTGTCGGATATTTCTCACACCCCATTTCCAAACCATG
GAGAAAGGTGTAGAATCGGCGGAAGAGACAAAAGATTATAAAACCATTTTGCAGGAATATTGCCAAAAAAAATGGAAAAA
ATTGCCTGAATATATTCTCTTGAAAGAAGAGGGACCAGACCACGACAAAGATTTTTCTGTATCCGTTTCTTGTGAAAATT
ACTTTCAATCGAATGGCGATGGGAAAAATAAACGGAGAGCAGAACAAATGGCTGCGAAAGCTGCCCTTCGAATTTTGAAA
TTATTATGA

Upstream 100 bases:

>100_bases
AAACCGTAGGCGATGTAATTAAATTCATCGATAAACTTAAGGGGTAATTCCCAATCCAAAAACCGGGTTCCCCGAATAGA
GGAACCCGGATCTTTTTCCC

Downstream 100 bases:

>100_bases
TCGATTTTTTATTAAAATCAAAATCTATGCGAGTCCGAGTGGCCGCTCTCATCCAAGATCCCAAGGGAAAAATTTTACTC
GTCCAACAACAGAAAAAACA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MSHSIRIKLTPERITSLQELQSITDTSFKDISLLHLAFVHRSFANEDSDRYLSDNERLEFLGDSVLGILAAEYLYKSLPK
GKEGILAKLKSKMVSAPAIAKLARFYRFPDFLLLGKGEKEKGEANLNLQADCFEAFLGALYLDQGLNSCRIFLTPHFQTM
EKGVESAEETKDYKTILQEYCQKKWKKLPEYILLKEEGPDHDKDFSVSVSCENYFQSNGDGKNKRRAEQMAAKAALRILK
LL

Sequences:

>Translated_242_residues
MSHSIRIKLTPERITSLQELQSITDTSFKDISLLHLAFVHRSFANEDSDRYLSDNERLEFLGDSVLGILAAEYLYKSLPK
GKEGILAKLKSKMVSAPAIAKLARFYRFPDFLLLGKGEKEKGEANLNLQADCFEAFLGALYLDQGLNSCRIFLTPHFQTM
EKGVESAEETKDYKTILQEYCQKKWKKLPEYILLKEEGPDHDKDFSVSVSCENYFQSNGDGKNKRRAEQMAAKAALRILK
LL
>Mature_241_residues
SHSIRIKLTPERITSLQELQSITDTSFKDISLLHLAFVHRSFANEDSDRYLSDNERLEFLGDSVLGILAAEYLYKSLPKG
KEGILAKLKSKMVSAPAIAKLARFYRFPDFLLLGKGEKEKGEANLNLQADCFEAFLGALYLDQGLNSCRIFLTPHFQTME
KGVESAEETKDYKTILQEYCQKKWKKLPEYILLKEEGPDHDKDFSVSVSCENYFQSNGDGKNKRRAEQMAAKAALRILKL
L

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=228, Percent_Identity=28.9473684210526, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI155030234, Length=228, Percent_Identity=28.9473684210526, Blast_Score=87, Evalue=9e-18,
Organism=Escherichia coli, GI1788920, Length=227, Percent_Identity=33.0396475770925, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17506883, Length=234, Percent_Identity=31.1965811965812, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193202651, Length=234, Percent_Identity=31.1965811965812, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137682, Length=237, Percent_Identity=32.4894514767932, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27556; Mature: 27425

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSIRIKLTPERITSLQELQSITDTSFKDISLLHLAFVHRSFANEDSDRYLSDNERLEF
CCCCEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
LGDSVLGILAAEYLYKSLPKGKEGILAKLKSKMVSAPAIAKLARFYRFPDFLLLGKGEKE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCC
KGEANLNLQADCFEAFLGALYLDQGLNSCRIFLTPHFQTMEKGVESAEETKDYKTILQEY
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
CQKKWKKLPEYILLKEEGPDHDKDFSVSVSCENYFQSNGDGKNKRRAEQMAAKAALRILK
HHHHHHHCCCEEEEECCCCCCCCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LL
HC
>Mature Secondary Structure 
SHSIRIKLTPERITSLQELQSITDTSFKDISLLHLAFVHRSFANEDSDRYLSDNERLEF
CCCEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
LGDSVLGILAAEYLYKSLPKGKEGILAKLKSKMVSAPAIAKLARFYRFPDFLLLGKGEKE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCC
KGEANLNLQADCFEAFLGALYLDQGLNSCRIFLTPHFQTMEKGVESAEETKDYKTILQEY
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
CQKKWKKLPEYILLKEEGPDHDKDFSVSVSCENYFQSNGDGKNKRRAEQMAAKAALRILK
HHHHHHHCCCEEEEECCCCCCCCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LL
HC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA