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The map label for this gene is phr [H]

Identifier: 183221779

GI number: 183221779

Start: 2481168

End: 2482658

Strand: Direct

Name: phr [H]

Synonym: LEPBI_I2409

Alternate gene names: 183221779

Gene position: 2481168-2482658 (Clockwise)

Preceding gene: 183221776

Following gene: 183221780

Centisome position: 68.93

GC content: 37.36

Gene sequence:

>1491_bases
GTGAAATCCGATCGAATCCGAGTCTGTAATGAAAAACCCATCCAATTAGAAAAATCCTATGTACTTTATTGGATGCAAGC
TTACAGGCGTTTTGATGCCAACCACGCTTTTAATCATGCCGTCAACTTAGCGAAAGAATTAAACAAAGAACTAATTGTTT
ATGAAGGGCTCCGAATGGATTACCCTTGGAATTCCGAACGAATCCATCAGTTTATCCTAGAAGGAATGATAGAGAACCAA
ACAAGAGCAGACGAACTTGAGATCAAATATTGGCCCTTTGTGGAAACACCAAAAAATCTTGGGAAAGGACTTCTCAAAGA
GATTTCAGAGAATGCCTCTGTGGTGGTAACGGATGATTTTCCTTGTTTTATCATTCCGGAACAAACTGAAAAATTAGCCA
AAAAAATCCATTGTCAACTTCTCGCCATTGATGGGAACTCCCTCATCCCCTTCTCACGATTTGCAAAACAAGCAAGTGCT
GCTCGCATCCTTCGATTATGGATCCACAAAGAACTGAACCGAGAGTTTCCAAAAATGAATACGATCATTTGGAAGAATGA
AGATCTTTCAAAACTCAATGGAAAAACAAATCCACCAGAACGAATTGGACTTCCAAAATCAATTGATGGTATTTTAAAAC
TCATTCCCTTCCAAAATATAGTTTCTCCAGTGAAAGGTGTAAAAGGAGGTAGAAACGAAGCATTACGTTTGTTAAATGAT
TTTTTGAAACACAAATTAGATTTATATCTTACCAAAAGGTCGGAACCAAACCGACCAGAACTCACAGCAACAAGTGGGCT
TTCCCCTTATTTACATTTTGGTTGGATTGGCCTTGATGAAATATTTGTTGCGGTATTAAAACATAGTGCTAAAGGAAAAT
GGAATCCAGAACGAATGAGTCATGAGAAACCAGGAGATCGAGAACATTTTTATTCTCCATCAGTTTCGGCTAACCATTTT
TTGGACGAACTCATTACTTGGCGAGATATTGGGTATTTATTTTTTTGGAAGGACAAACCAAAACAAATCAATTTGAGCCA
CTTACCTGATTGGGTAAAAACTAATTTTCAAAAACACCAAAATGACCATAGAGAGTATGTTTATACCTTAGAACAATTTG
AATCCGCCAAAACCCATGATGAACTTTGGAATGCAGCCCAGACAGAACTGGTCAAAACAGGAAAAATCCATAATTATATG
CGAATGTTATGGGGGAAAAAAGTCATCGAATGGTCAAAAACCTATGAGGAAGCATTTTTCATCTTAGAACATCTTAATAA
CAAGTATGCGTATGATGGTAGGAATCCAAATTCCTACACAGGAATCTTATGGTGTTTTGGACTCTTTGATCGGCCTTGGT
TTCCCGAACGAAATGTATTTGGAAATGTACGTTTTATGTCTTCCGATTCAACAAAAAAGAAGTTTAAACTGAATTCCTAT
TTGGAGTATATTGGTGAACTGAGTGGCAAATCCAACTCACTCTTCCCATGA

Upstream 100 bases:

>100_bases
ATGCGAAACAGATAGCTTAATGAGTAAGCATTTCGCTCCTTCGTTTACTAGACATGAAAAAATTCCAAGGCAAGGAAACC
TCAGTCCCCCTCTAATAGGA

Downstream 100 bases:

>100_bases
CAGACCCGACAAAACCCATATTTGAAGAAGAAACAAGTTTAAAAACGGATTCGGTTTATTCCTATTTTGTCATTTTATTC
AATGATTCAATCCATGAATT

Product: deoxyribodipyrimidine photo-lyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MKSDRIRVCNEKPIQLEKSYVLYWMQAYRRFDANHAFNHAVNLAKELNKELIVYEGLRMDYPWNSERIHQFILEGMIENQ
TRADELEIKYWPFVETPKNLGKGLLKEISENASVVVTDDFPCFIIPEQTEKLAKKIHCQLLAIDGNSLIPFSRFAKQASA
ARILRLWIHKELNREFPKMNTIIWKNEDLSKLNGKTNPPERIGLPKSIDGILKLIPFQNIVSPVKGVKGGRNEALRLLND
FLKHKLDLYLTKRSEPNRPELTATSGLSPYLHFGWIGLDEIFVAVLKHSAKGKWNPERMSHEKPGDREHFYSPSVSANHF
LDELITWRDIGYLFFWKDKPKQINLSHLPDWVKTNFQKHQNDHREYVYTLEQFESAKTHDELWNAAQTELVKTGKIHNYM
RMLWGKKVIEWSKTYEEAFFILEHLNNKYAYDGRNPNSYTGILWCFGLFDRPWFPERNVFGNVRFMSSDSTKKKFKLNSY
LEYIGELSGKSNSLFP

Sequences:

>Translated_496_residues
MKSDRIRVCNEKPIQLEKSYVLYWMQAYRRFDANHAFNHAVNLAKELNKELIVYEGLRMDYPWNSERIHQFILEGMIENQ
TRADELEIKYWPFVETPKNLGKGLLKEISENASVVVTDDFPCFIIPEQTEKLAKKIHCQLLAIDGNSLIPFSRFAKQASA
ARILRLWIHKELNREFPKMNTIIWKNEDLSKLNGKTNPPERIGLPKSIDGILKLIPFQNIVSPVKGVKGGRNEALRLLND
FLKHKLDLYLTKRSEPNRPELTATSGLSPYLHFGWIGLDEIFVAVLKHSAKGKWNPERMSHEKPGDREHFYSPSVSANHF
LDELITWRDIGYLFFWKDKPKQINLSHLPDWVKTNFQKHQNDHREYVYTLEQFESAKTHDELWNAAQTELVKTGKIHNYM
RMLWGKKVIEWSKTYEEAFFILEHLNNKYAYDGRNPNSYTGILWCFGLFDRPWFPERNVFGNVRFMSSDSTKKKFKLNSY
LEYIGELSGKSNSLFP
>Mature_496_residues
MKSDRIRVCNEKPIQLEKSYVLYWMQAYRRFDANHAFNHAVNLAKELNKELIVYEGLRMDYPWNSERIHQFILEGMIENQ
TRADELEIKYWPFVETPKNLGKGLLKEISENASVVVTDDFPCFIIPEQTEKLAKKIHCQLLAIDGNSLIPFSRFAKQASA
ARILRLWIHKELNREFPKMNTIIWKNEDLSKLNGKTNPPERIGLPKSIDGILKLIPFQNIVSPVKGVKGGRNEALRLLND
FLKHKLDLYLTKRSEPNRPELTATSGLSPYLHFGWIGLDEIFVAVLKHSAKGKWNPERMSHEKPGDREHFYSPSVSANHF
LDELITWRDIGYLFFWKDKPKQINLSHLPDWVKTNFQKHQNDHREYVYTLEQFESAKTHDELWNAAQTELVKTGKIHNYM
RMLWGKKVIEWSKTYEEAFFILEHLNNKYAYDGRNPNSYTGILWCFGLFDRPWFPERNVFGNVRFMSSDSTKKKFKLNSY
LEYIGELSGKSNSLFP

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=500, Percent_Identity=28, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24586398, Length=500, Percent_Identity=28, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24586404, Length=148, Percent_Identity=39.1891891891892, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 58280; Mature: 58280

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDRIRVCNEKPIQLEKSYVLYWMQAYRRFDANHAFNHAVNLAKELNKELIVYEGLRMD
CCCCCEEECCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECEECC
YPWNSERIHQFILEGMIENQTRADELEIKYWPFVETPKNLGKGLLKEISENASVVVTDDF
CCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCC
PCFIIPEQTEKLAKKIHCQLLAIDGNSLIPFSRFAKQASAARILRLWIHKELNREFPKMN
CEEEECHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TIIWKNEDLSKLNGKTNPPERIGLPKSIDGILKLIPFQNIVSPVKGVKGGRNEALRLLND
EEEECCCCHHHHCCCCCCHHHCCCCHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHH
FLKHKLDLYLTKRSEPNRPELTATSGLSPYLHFGWIGLDEIFVAVLKHSAKGKWNPERMS
HHHHHHHEEEECCCCCCCCCEEECCCCCCCHHCCCCCHHHHHHHHHHHCCCCCCCHHHHC
HEKPGDREHFYSPSVSANHFLDELITWRDIGYLFFWKDKPKQINLSHLPDWVKTNFQKHQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCEECHHHCCHHHHHHHHHHC
NDHREYVYTLEQFESAKTHDELWNAAQTELVKTGKIHNYMRMLWGKKVIEWSKTYEEAFF
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILEHLNNKYAYDGRNPNSYTGILWCFGLFDRPWFPERNVFGNVRFMSSDSTKKKFKLNSY
HHHHHCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHH
LEYIGELSGKSNSLFP
HHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKSDRIRVCNEKPIQLEKSYVLYWMQAYRRFDANHAFNHAVNLAKELNKELIVYEGLRMD
CCCCCEEECCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECEECC
YPWNSERIHQFILEGMIENQTRADELEIKYWPFVETPKNLGKGLLKEISENASVVVTDDF
CCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCC
PCFIIPEQTEKLAKKIHCQLLAIDGNSLIPFSRFAKQASAARILRLWIHKELNREFPKMN
CEEEECHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TIIWKNEDLSKLNGKTNPPERIGLPKSIDGILKLIPFQNIVSPVKGVKGGRNEALRLLND
EEEECCCCHHHHCCCCCCHHHCCCCHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHH
FLKHKLDLYLTKRSEPNRPELTATSGLSPYLHFGWIGLDEIFVAVLKHSAKGKWNPERMS
HHHHHHHEEEECCCCCCCCCEEECCCCCCCHHCCCCCHHHHHHHHHHHCCCCCCCHHHHC
HEKPGDREHFYSPSVSANHFLDELITWRDIGYLFFWKDKPKQINLSHLPDWVKTNFQKHQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCEECHHHCCHHHHHHHHHHC
NDHREYVYTLEQFESAKTHDELWNAAQTELVKTGKIHNYMRMLWGKKVIEWSKTYEEAFF
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILEHLNNKYAYDGRNPNSYTGILWCFGLFDRPWFPERNVFGNVRFMSSDSTKKKFKLNSY
HHHHHCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHH
LEYIGELSGKSNSLFP
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]