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The map label for this gene is serC

Identifier: 183221737

GI number: 183221737

Start: 2437972

End: 2439069

Strand: Direct

Name: serC

Synonym: LEPBI_I2366

Alternate gene names: 183221737

Gene position: 2437972-2439069 (Clockwise)

Preceding gene: 183221734

Following gene: 183221738

Centisome position: 67.73

GC content: 39.62

Gene sequence:

>1098_bases
ATGCCTACGTTTACACACAGAATCTACAATTTTAATGCAGGTCCCGCCATGTTACCCACCGAGGTCATGGAGGAAGCGAA
GAGTGAGTTCCTCAATTTTAGGGGAACTGGTATGTCTGTCATGGAAATGAGCCACAGAGAAAAACATTTCCAATCCATTT
TGGACGAATCCATCTCAGACCTTCGGGAACTTTTAAATTTACCATCTCGTTATGCGGTAGTTTATTTCCCTGGTGGAGCC
ACATTACAATTTTCTGCCATCCCTTTTAATTATTTATCATCTGGAGATTCTTGTGACTTTGCCCTAACAGGCGTTTGGGC
AAAGAAAGCCTTTGAAGAAGCAAAAAAATTCTATCCCAATGTAAAATCAATTTTTAATGGAGCAGATTCCAAGTATATGG
AACTTCCCACCATCACTGATGAATCAGTCAACGATGGAGCCAAATATATGTACATCACTTCCAATAACACCATTTATGGA
ACAAGGTACAAAACATTTCCGAAACTAAAAAAAGCGCCACTGATTGCTGATATGACAAGTGAACTTCTCAGTCGGAAGCT
ACCGATCGAAGATTTTTCAGTGATTTTTGCTGGGGCTCAAAAAAACATAGGCCCCTCAGGCCTAACTCTTGTGATTTATG
ATAAGGAAAAATTACCCGAGGTTTCCCATCCCATTCCCAATTTGATGAACTTTGCTTTGATGGAAAAAAATGGATCTCTT
TACAATACACCTCCCACTTACTCAATCTACATTGCGGGTTTGGTTTTTAAATACCTAAAACGGAAAGGTGGATTAGCGGT
GATGGAGGAAACAAACGAAAGAAAGGCAAAAAAATTGTATGATGCCATTGATTCTTCCTCTCTTTTTTATGCACCAGTAC
CTGTACCATTCCGTTCCGCAATGAATGTTGTCTTCCGTAGCCATAATGATGGTTTGGATTCAAAATTTTTGTCTCTTGCC
GAAGAACAAGGATTTGCTGGTTTGAAAGGATATAGAGAAGTAGGTGGGTTTAGAGCCAGTATCTACAATGCGATGCCAGA
AGAAGGTGTGGATGCTCTCATTTCATTTATGAAAGAATTTGAAAGGTCCAATGGTTAA

Upstream 100 bases:

>100_bases
TCAGATGCCCACAAGATTAACAACCTTTCCGATTCTGCAAAGCAAGTTTTCGAATAAAAATCTATTTACCAGGGGGGAGA
TTTTAAAATTCTGTGGGAGA

Downstream 100 bases:

>100_bases
ACCATCGTTTCCATTCCTAATTGGCTTAATTGTCACAGGGATTCATTCTCATTCTGTTTGGATCCCAGAAGGTAACTTTG
CTTGGGAAGTTGCGAACAAA

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MPTFTHRIYNFNAGPAMLPTEVMEEAKSEFLNFRGTGMSVMEMSHREKHFQSILDESISDLRELLNLPSRYAVVYFPGGA
TLQFSAIPFNYLSSGDSCDFALTGVWAKKAFEEAKKFYPNVKSIFNGADSKYMELPTITDESVNDGAKYMYITSNNTIYG
TRYKTFPKLKKAPLIADMTSELLSRKLPIEDFSVIFAGAQKNIGPSGLTLVIYDKEKLPEVSHPIPNLMNFALMEKNGSL
YNTPPTYSIYIAGLVFKYLKRKGGLAVMEETNERKAKKLYDAIDSSSLFYAPVPVPFRSAMNVVFRSHNDGLDSKFLSLA
EEQGFAGLKGYREVGGFRASIYNAMPEEGVDALISFMKEFERSNG

Sequences:

>Translated_365_residues
MPTFTHRIYNFNAGPAMLPTEVMEEAKSEFLNFRGTGMSVMEMSHREKHFQSILDESISDLRELLNLPSRYAVVYFPGGA
TLQFSAIPFNYLSSGDSCDFALTGVWAKKAFEEAKKFYPNVKSIFNGADSKYMELPTITDESVNDGAKYMYITSNNTIYG
TRYKTFPKLKKAPLIADMTSELLSRKLPIEDFSVIFAGAQKNIGPSGLTLVIYDKEKLPEVSHPIPNLMNFALMEKNGSL
YNTPPTYSIYIAGLVFKYLKRKGGLAVMEETNERKAKKLYDAIDSSSLFYAPVPVPFRSAMNVVFRSHNDGLDSKFLSLA
EEQGFAGLKGYREVGGFRASIYNAMPEEGVDALISFMKEFERSNG
>Mature_364_residues
PTFTHRIYNFNAGPAMLPTEVMEEAKSEFLNFRGTGMSVMEMSHREKHFQSILDESISDLRELLNLPSRYAVVYFPGGAT
LQFSAIPFNYLSSGDSCDFALTGVWAKKAFEEAKKFYPNVKSIFNGADSKYMELPTITDESVNDGAKYMYITSNNTIYGT
RYKTFPKLKKAPLIADMTSELLSRKLPIEDFSVIFAGAQKNIGPSGLTLVIYDKEKLPEVSHPIPNLMNFALMEKNGSLY
NTPPTYSIYIAGLVFKYLKRKGGLAVMEETNERKAKKLYDAIDSSSLFYAPVPVPFRSAMNVVFRSHNDGLDSKFLSLAE
EQGFAGLKGYREVGGFRASIYNAMPEEGVDALISFMKEFERSNG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=362, Percent_Identity=41.1602209944751, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI10863955, Length=357, Percent_Identity=36.9747899159664, Blast_Score=247, Evalue=2e-65,
Organism=Escherichia coli, GI1787136, Length=361, Percent_Identity=43.4903047091413, Blast_Score=303, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17506897, Length=362, Percent_Identity=42.2651933701657, Blast_Score=287, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=40.2597402597403, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI21356589, Length=363, Percent_Identity=42.9752066115703, Blast_Score=299, Evalue=2e-81,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_LEPBA (B0SCE2)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001963367.1
- ProteinModelPortal:   B0SCE2
- SMR:   B0SCE2
- GeneID:   6388184
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_2298
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   LBIF355278:LBF_2298-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR022278
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40912; Mature: 40781

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 46-46 BINDING 106-106 BINDING 157-157 BINDING 177-177 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTFTHRIYNFNAGPAMLPTEVMEEAKSEFLNFRGTGMSVMEMSHREKHFQSILDESISD
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRELLNLPSRYAVVYFPGGATLQFSAIPFNYLSSGDSCDFALTGVWAKKAFEEAKKFYPN
HHHHHCCCCCEEEEEECCCCEEEEECCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHCCC
VKSIFNGADSKYMELPTITDESVNDGAKYMYITSNNTIYGTRYKTFPKLKKAPLIADMTS
HHHHHCCCCCCEEECCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCHHHHCCHHHHHHH
ELLSRKLPIEDFSVIFAGAQKNIGPSGLTLVIYDKEKLPEVSHPIPNLMNFALMEKNGSL
HHHHCCCCCCHHHEEEECCCCCCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHCCCCCCC
YNTPPTYSIYIAGLVFKYLKRKGGLAVMEETNERKAKKLYDAIDSSSLFYAPVPVPFRSA
CCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCEEEECCCCCHHHH
MNVVFRSHNDGLDSKFLSLAEEQGFAGLKGYREVGGFRASIYNAMPEEGVDALISFMKEF
HHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHH
ERSNG
HHCCC
>Mature Secondary Structure 
PTFTHRIYNFNAGPAMLPTEVMEEAKSEFLNFRGTGMSVMEMSHREKHFQSILDESISD
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRELLNLPSRYAVVYFPGGATLQFSAIPFNYLSSGDSCDFALTGVWAKKAFEEAKKFYPN
HHHHHCCCCCEEEEEECCCCEEEEECCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHCCC
VKSIFNGADSKYMELPTITDESVNDGAKYMYITSNNTIYGTRYKTFPKLKKAPLIADMTS
HHHHHCCCCCCEEECCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCHHHHCCHHHHHHH
ELLSRKLPIEDFSVIFAGAQKNIGPSGLTLVIYDKEKLPEVSHPIPNLMNFALMEKNGSL
HHHHCCCCCCHHHEEEECCCCCCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHCCCCCCC
YNTPPTYSIYIAGLVFKYLKRKGGLAVMEETNERKAKKLYDAIDSSSLFYAPVPVPFRSA
CCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCEEEECCCCCHHHH
MNVVFRSHNDGLDSKFLSLAEEQGFAGLKGYREVGGFRASIYNAMPEEGVDALISFMKEF
HHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHH
ERSNG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA