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The map label for this gene is uvrC

Identifier: 183221458

GI number: 183221458

Start: 2168050

End: 2169894

Strand: Reverse

Name: uvrC

Synonym: LEPBI_I2076

Alternate gene names: 183221458

Gene position: 2169894-2168050 (Counterclockwise)

Preceding gene: 183221461

Following gene: 183221457

Centisome position: 60.28

GC content: 40.43

Gene sequence:

>1845_bases
ATGAAAGACTCACTTGTACTAAAAACCATCCAAGAAAAAATTAAAAATTTAGGTAGTTTACCTGGTTGTTATCTTTGGAA
AAATGAACTGGGACAAGTGATTTATGTGGGTAAAGCACTCAAACTCCAATCGCGAGTTAGGTCCTATCTCAATCCCAACC
AAAAAGACAGAAAAACTCGAGCTCTTTTTGTCGAATTATATGACCTAGATTGGATAGCCACAGGAACCGAAAAAGAAGCA
CTTCTCCTCGAAGCCACTCTCATTAAAAAATACAATCCAAAGTTTAATGTTAGGTTAAAAGACGATAAAAAATATCCCTT
CTTATGTGTTTCCACAAGTGAAGATTATCCGATGGTATTTCTGACAAGAAAGGTCAAAGACAATGGAGACAGATACTTTG
GTCCCTTTACCGATGTGAAAGCCGCACGAGATACACTCGAGCTAATACACCGGATTTTTCCCATTCGCAAAACAAAATTA
AAACTCCCTCTCCCAAAACCACAAAGACCATGTCTCAATTTTCATATGGGTCGGTGTCTCGGTCCATGCCAAGGGAATGT
CACGAAGGATACCTATTCAGAGTTAGTGGATGAGATTTTACGATTTTTAGAAGGGAAAAAGGAACGACTTGTCGCTGATT
TAAAAAAAGCAATGATGGATGCCTCATCCAAAATGGAATATGAAAGGGCAGGATTTCTCAAACAAAGGATTGAAAAAATC
AACCAACTCCGAGAGAAACAAACAGTTGTGAGTATGGATGGGGGAGATGAAGACATTCTTGGGATCAGCAAACGAGAGGA
TGAAGGCCAAATTTTGATCCTGGAAGTCAGAGGAGGGAGACTCGAAGGGAAAAAATCATTTCCGCTCACTGGACTTTCTT
TTTCGGATGATGAAGAAGCTTTTACTTCCTTTCTAAGAGATTATTATTTAAATGTGACTGTCTTACCGAGTGTTGTGTAT
TTGCCCACATCGGCAAAAGGGAACTATGATGTTTTTTTAGAAGCAATCTTAGAAAAATTTGGCACTTCCATCAAACTCAA
ATTTCCAGAGATGGGTCCCAAAAAATCCCTCCTCCGACTCGCAGAAAAAAACGCAGATCTTAGTTTAACAGAAAGGATCC
TTGCCACAAAACTCCGTGACCAAACGGTTGCGATGAAAGAACTCCAAGAGAAATTAAACCTTCCGACTTTGCCAAGGACC
ATTGAATGTTATGATATCTCTCATTTCCAAGGTAGTTTGCCTGTCGCCAGTGGTGTGATGTTTGTAGAGGGAAAACCATA
CAAACCTGGGTATCGGCATTACAAAATGCGTGGCTACGAAGGGATCAATGACCCAGGAATGATCCATGAAGTCATTGCAA
GGAGACTCAGCCATCTTGTAAATGAAGAGGAACCACTCCCAGATCTCATTGTGATTGATGGAGGTCTCACTCAATTGTCG
CGAGCGGCGGAGGCAGCGAATGCATTGGACTTGGGTCACATACCTATGGTAGGCCTTGCGAAAAAACGAGAGGAGATCTA
TTTCCCAGGTGAAAAACACCCCTATAGTTTCGATCAACATTCGCCTATGATGCGTCTCCTTCGGAATTTAAGAGATGAAG
CACACAGATTTGGTGTTACTTTCCAAAGGTTACAAAGGAAGAAAAAAGCACTCAAATCCATTTTGGATGATATTCCAGAC
ATTGGTGCGAGCCGAAGGAAAAGTATCCTCATGTACTTCCAAGCGAAAAAAAAAGTAACAGATGCGACACGACAAGAATT
GGAAAAAGTCCAAGGCATTGGTCCCGTGTTAGCTGAAAAAATTTTTACAAATATACAAAACCTAAAAAAAATCGAACCGA
AATAA

Upstream 100 bases:

>100_bases
AGACCAAAAATTATAAATTTGATCATTTTCCGTATGTCCATACCATAGGGATACAGATTGTCTAAGAATTGTAAACGTAA
AATTCCTGAATCAACTCTTT

Downstream 100 bases:

>100_bases
GGATTTTTCACCACACCACTTGGGAGTGGCAACGTGAATCCTTTCAGACTTTTTTTTATCGTTTTTGTTCTGTCTTGTCA
CACAAAAGGAAACCATCCTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MKDSLVLKTIQEKIKNLGSLPGCYLWKNELGQVIYVGKALKLQSRVRSYLNPNQKDRKTRALFVELYDLDWIATGTEKEA
LLLEATLIKKYNPKFNVRLKDDKKYPFLCVSTSEDYPMVFLTRKVKDNGDRYFGPFTDVKAARDTLELIHRIFPIRKTKL
KLPLPKPQRPCLNFHMGRCLGPCQGNVTKDTYSELVDEILRFLEGKKERLVADLKKAMMDASSKMEYERAGFLKQRIEKI
NQLREKQTVVSMDGGDEDILGISKREDEGQILILEVRGGRLEGKKSFPLTGLSFSDDEEAFTSFLRDYYLNVTVLPSVVY
LPTSAKGNYDVFLEAILEKFGTSIKLKFPEMGPKKSLLRLAEKNADLSLTERILATKLRDQTVAMKELQEKLNLPTLPRT
IECYDISHFQGSLPVASGVMFVEGKPYKPGYRHYKMRGYEGINDPGMIHEVIARRLSHLVNEEEPLPDLIVIDGGLTQLS
RAAEAANALDLGHIPMVGLAKKREEIYFPGEKHPYSFDQHSPMMRLLRNLRDEAHRFGVTFQRLQRKKKALKSILDDIPD
IGASRRKSILMYFQAKKKVTDATRQELEKVQGIGPVLAEKIFTNIQNLKKIEPK

Sequences:

>Translated_614_residues
MKDSLVLKTIQEKIKNLGSLPGCYLWKNELGQVIYVGKALKLQSRVRSYLNPNQKDRKTRALFVELYDLDWIATGTEKEA
LLLEATLIKKYNPKFNVRLKDDKKYPFLCVSTSEDYPMVFLTRKVKDNGDRYFGPFTDVKAARDTLELIHRIFPIRKTKL
KLPLPKPQRPCLNFHMGRCLGPCQGNVTKDTYSELVDEILRFLEGKKERLVADLKKAMMDASSKMEYERAGFLKQRIEKI
NQLREKQTVVSMDGGDEDILGISKREDEGQILILEVRGGRLEGKKSFPLTGLSFSDDEEAFTSFLRDYYLNVTVLPSVVY
LPTSAKGNYDVFLEAILEKFGTSIKLKFPEMGPKKSLLRLAEKNADLSLTERILATKLRDQTVAMKELQEKLNLPTLPRT
IECYDISHFQGSLPVASGVMFVEGKPYKPGYRHYKMRGYEGINDPGMIHEVIARRLSHLVNEEEPLPDLIVIDGGLTQLS
RAAEAANALDLGHIPMVGLAKKREEIYFPGEKHPYSFDQHSPMMRLLRNLRDEAHRFGVTFQRLQRKKKALKSILDDIPD
IGASRRKSILMYFQAKKKVTDATRQELEKVQGIGPVLAEKIFTNIQNLKKIEPK
>Mature_614_residues
MKDSLVLKTIQEKIKNLGSLPGCYLWKNELGQVIYVGKALKLQSRVRSYLNPNQKDRKTRALFVELYDLDWIATGTEKEA
LLLEATLIKKYNPKFNVRLKDDKKYPFLCVSTSEDYPMVFLTRKVKDNGDRYFGPFTDVKAARDTLELIHRIFPIRKTKL
KLPLPKPQRPCLNFHMGRCLGPCQGNVTKDTYSELVDEILRFLEGKKERLVADLKKAMMDASSKMEYERAGFLKQRIEKI
NQLREKQTVVSMDGGDEDILGISKREDEGQILILEVRGGRLEGKKSFPLTGLSFSDDEEAFTSFLRDYYLNVTVLPSVVY
LPTSAKGNYDVFLEAILEKFGTSIKLKFPEMGPKKSLLRLAEKNADLSLTERILATKLRDQTVAMKELQEKLNLPTLPRT
IECYDISHFQGSLPVASGVMFVEGKPYKPGYRHYKMRGYEGINDPGMIHEVIARRLSHLVNEEEPLPDLIVIDGGLTQLS
RAAEAANALDLGHIPMVGLAKKREEIYFPGEKHPYSFDQHSPMMRLLRNLRDEAHRFGVTFQRLQRKKKALKSILDDIPD
IGASRRKSILMYFQAKKKVTDATRQELEKVQGIGPVLAEKIFTNIQNLKKIEPK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=611, Percent_Identity=33.2242225859247, Blast_Score=318, Evalue=5e-88,
Organism=Escherichia coli, GI1788037, Length=184, Percent_Identity=29.8913043478261, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_LEPBA (B0SB16)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001963100.1
- ProteinModelPortal:   B0SB16
- GeneID:   6388632
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_2022
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   LBIF355278:LBF_2022-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70252; Mature: 70252

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDSLVLKTIQEKIKNLGSLPGCYLWKNELGQVIYVGKALKLQSRVRSYLNPNQKDRKTR
CCCHHHHHHHHHHHHHHCCCCCEEEEHHHCCCEEEECHHHHHHHHHHHHCCCCCCHHHHH
ALFVELYDLDWIATGTEKEALLLEATLIKKYNPKFNVRLKDDKKYPFLCVSTSEDYPMVF
EEEEEEECCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCEEE
LTRKVKDNGDRYFGPFTDVKAARDTLELIHRIFPIRKTKLKLPLPKPQRPCLNFHMGRCL
EEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHCC
GPCQGNVTKDTYSELVDEILRFLEGKKERLVADLKKAMMDASSKMEYERAGFLKQRIEKI
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQLREKQTVVSMDGGDEDILGISKREDEGQILILEVRGGRLEGKKSFPLTGLSFSDDEEA
HHHHHHHHEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHH
FTSFLRDYYLNVTVLPSVVYLPTSAKGNYDVFLEAILEKFGTSIKLKFPEMGPKKSLLRL
HHHHHHHHHCCEEEECEEEEECCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHH
AEKNADLSLTERILATKLRDQTVAMKELQEKLNLPTLPRTIECYDISHFQGSLPVASGVM
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHCCEE
FVEGKPYKPGYRHYKMRGYEGINDPGMIHEVIARRLSHLVNEEEPLPDLIVIDGGLTQLS
EECCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHH
RAAEAANALDLGHIPMVGLAKKREEIYFPGEKHPYSFDQHSPMMRLLRNLRDEAHRFGVT
HHHHHHCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FQRLQRKKKALKSILDDIPDIGASRRKSILMYFQAKKKVTDATRQELEKVQGIGPVLAEK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHH
IFTNIQNLKKIEPK
HHHHHHHHHCCCCC
>Mature Secondary Structure
MKDSLVLKTIQEKIKNLGSLPGCYLWKNELGQVIYVGKALKLQSRVRSYLNPNQKDRKTR
CCCHHHHHHHHHHHHHHCCCCCEEEEHHHCCCEEEECHHHHHHHHHHHHCCCCCCHHHHH
ALFVELYDLDWIATGTEKEALLLEATLIKKYNPKFNVRLKDDKKYPFLCVSTSEDYPMVF
EEEEEEECCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCEEE
LTRKVKDNGDRYFGPFTDVKAARDTLELIHRIFPIRKTKLKLPLPKPQRPCLNFHMGRCL
EEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHCC
GPCQGNVTKDTYSELVDEILRFLEGKKERLVADLKKAMMDASSKMEYERAGFLKQRIEKI
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQLREKQTVVSMDGGDEDILGISKREDEGQILILEVRGGRLEGKKSFPLTGLSFSDDEEA
HHHHHHHHEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHH
FTSFLRDYYLNVTVLPSVVYLPTSAKGNYDVFLEAILEKFGTSIKLKFPEMGPKKSLLRL
HHHHHHHHHCCEEEECEEEEECCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHH
AEKNADLSLTERILATKLRDQTVAMKELQEKLNLPTLPRTIECYDISHFQGSLPVASGVM
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHCCEE
FVEGKPYKPGYRHYKMRGYEGINDPGMIHEVIARRLSHLVNEEEPLPDLIVIDGGLTQLS
EECCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHH
RAAEAANALDLGHIPMVGLAKKREEIYFPGEKHPYSFDQHSPMMRLLRNLRDEAHRFGVT
HHHHHHCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FQRLQRKKKALKSILDDIPDIGASRRKSILMYFQAKKKVTDATRQELEKVQGIGPVLAEK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHH
IFTNIQNLKKIEPK
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA