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The map label for this gene is rmlA [H]

Identifier: 183221422

GI number: 183221422

Start: 2121275

End: 2122159

Strand: Reverse

Name: rmlA [H]

Synonym: LEPBI_I2040

Alternate gene names: 183221422

Gene position: 2122159-2121275 (Counterclockwise)

Preceding gene: 183221423

Following gene: 183221421

Centisome position: 58.95

GC content: 38.98

Gene sequence:

>885_bases
TTGAAAGGGATTATTTTGGCAGGCGGGTCTGGAACAAGATTGTATCCACTCACCAGGGGAGTCGTTAAACAACTACTCCC
CGTGTATGACAAACCGATGATCTATTATCCATTGTCTGTCCTCATGCTTGCAGGGATCAGGGAAATATTGATTATATCCA
CTCCGAATGATACGAAACGATTCGAGGATCTTTTTGGGGATGGAAGCGATTTAGGCTTAAAAATTCAATACATAATACAA
CCTTCTCCAGATGGTCTAGCGCAAGCTTTTTTATTAGGAGAAGATTTTATAGGCAATGATGACGCATGCCTCGTATTAGG
TGATAATATCTTTTACGGAGACGGTTTGATTCAGATGTTATCTGATACTATTTTGGAAGTAAAAGAGTCCCAAAAAGCAG
TCGTATACGGATATACGGTAAAGGATCCAGAACGATATGGGGTTGCAGAATTGGATTCTGAAATGAATGTTTTGTCAATA
GAAGAAAAACCTCTGAAGCCTAAAAGTAATGTCGCTGTAGTTGGTTTGTATTTTTATCCGCAGGATGTAATCAAACTGGC
AAAACATGTAGTTCCATCGCCAAGAGGGGAGCTAGAGATCACATCTCTCAACCAATTGTATTTAGAACAATCGCGACTTA
AATGTAAACTTTTGGGGCGGGGGTACGCTTGGCTCGACACAGGAACTTACGATAGTTTGTTGGAAGCATCTAATTTCATT
GAGGTGATTGAAAAAAGACAAGGTTTGAAAATTGCCTGTTTAGAAGAAATCGCATTTCGTAAAGGTTTTATCGGTTTGGA
AACTTTAAAAAAACATGCGACACTGAATCAAAAAAATCAGTACGGTGTCTATCTGCAAGAAATTGTGAATTCGGTGATGA
GATAA

Upstream 100 bases:

>100_bases
AGGCTAGAATGACCCTTCATTTTTATGAAATCAAAAAAAGGGAATATGAGGAACTTCGTGCGGAAGTGGAAAAGTTAGGG
GAAAGTGTGGAGGGTTTGGG

Downstream 100 bases:

>100_bases
ATGGAATTCAAGAATGTTTTGGTGACAGGGAGTGCCGGATTCATTGGATCCAATTTTGTTCCTTACTTTTTGGAAACACA
TCCCCATGTTCATGTTGTCA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKGIILAGGSGTRLYPLTRGVVKQLLPVYDKPMIYYPLSVLMLAGIREILIISTPNDTKRFEDLFGDGSDLGLKIQYIIQ
PSPDGLAQAFLLGEDFIGNDDACLVLGDNIFYGDGLIQMLSDTILEVKESQKAVVYGYTVKDPERYGVAELDSEMNVLSI
EEKPLKPKSNVAVVGLYFYPQDVIKLAKHVVPSPRGELEITSLNQLYLEQSRLKCKLLGRGYAWLDTGTYDSLLEASNFI
EVIEKRQGLKIACLEEIAFRKGFIGLETLKKHATLNQKNQYGVYLQEIVNSVMR

Sequences:

>Translated_294_residues
MKGIILAGGSGTRLYPLTRGVVKQLLPVYDKPMIYYPLSVLMLAGIREILIISTPNDTKRFEDLFGDGSDLGLKIQYIIQ
PSPDGLAQAFLLGEDFIGNDDACLVLGDNIFYGDGLIQMLSDTILEVKESQKAVVYGYTVKDPERYGVAELDSEMNVLSI
EEKPLKPKSNVAVVGLYFYPQDVIKLAKHVVPSPRGELEITSLNQLYLEQSRLKCKLLGRGYAWLDTGTYDSLLEASNFI
EVIEKRQGLKIACLEEIAFRKGFIGLETLKKHATLNQKNQYGVYLQEIVNSVMR
>Mature_294_residues
MKGIILAGGSGTRLYPLTRGVVKQLLPVYDKPMIYYPLSVLMLAGIREILIISTPNDTKRFEDLFGDGSDLGLKIQYIIQ
PSPDGLAQAFLLGEDFIGNDDACLVLGDNIFYGDGLIQMLSDTILEVKESQKAVVYGYTVKDPERYGVAELDSEMNVLSI
EEKPLKPKSNVAVVGLYFYPQDVIKLAKHVVPSPRGELEITSLNQLYLEQSRLKCKLLGRGYAWLDTGTYDSLLEASNFI
EVIEKRQGLKIACLEEIAFRKGFIGLETLKKHATLNQKNQYGVYLQEIVNSVMR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=64.5833333333333, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1790224, Length=294, Percent_Identity=60.8843537414966, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1787488, Length=295, Percent_Identity=24.406779661017, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788355, Length=259, Percent_Identity=26.2548262548263, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=260, Percent_Identity=27.3076923076923, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32837; Mature: 32837

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPLTRGVVKQLLPVYDKPMIYYPLSVLMLAGIREILIISTPNDTKR
CCCEEEECCCCCEEEHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCEEEEEECCCHHHH
FEDLFGDGSDLGLKIQYIIQPSPDGLAQAFLLGEDFIGNDDACLVLGDNIFYGDGLIQML
HHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCEEECCHHHHHH
SDTILEVKESQKAVVYGYTVKDPERYGVAELDSEMNVLSIEEKPLKPKSNVAVVGLYFYP
HHHHHHHHCCCCEEEEEEEECCCHHCCHHHHCCCCCEEEECCCCCCCCCCEEEEEEEECC
QDVIKLAKHVVPSPRGELEITSLNQLYLEQSRLKCKLLGRGYAWLDTGTYDSLLEASNFI
HHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCEEEEECCCEEEEECCCHHHHHHHHHHH
EVIEKRQGLKIACLEEIAFRKGFIGLETLKKHATLNQKNQYGVYLQEIVNSVMR
HHHHHCCCCEEEHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPLTRGVVKQLLPVYDKPMIYYPLSVLMLAGIREILIISTPNDTKR
CCCEEEECCCCCEEEHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCEEEEEECCCHHHH
FEDLFGDGSDLGLKIQYIIQPSPDGLAQAFLLGEDFIGNDDACLVLGDNIFYGDGLIQML
HHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCEEECCHHHHHH
SDTILEVKESQKAVVYGYTVKDPERYGVAELDSEMNVLSIEEKPLKPKSNVAVVGLYFYP
HHHHHHHHCCCCEEEEEEEECCCHHCCHHHHCCCCCEEEECCCCCCCCCCEEEEEEEECC
QDVIKLAKHVVPSPRGELEITSLNQLYLEQSRLKCKLLGRGYAWLDTGTYDSLLEASNFI
HHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCEEEEECCCEEEEECCCHHHHHHHHHHH
EVIEKRQGLKIACLEEIAFRKGFIGLETLKKHATLNQKNQYGVYLQEIVNSVMR
HHHHHCCCCEEEHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]