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The map label for this gene is hemL [H]

Identifier: 183221415

GI number: 183221415

Start: 2113563

End: 2115590

Strand: Reverse

Name: hemL [H]

Synonym: LEPBI_I2033

Alternate gene names: 183221415

Gene position: 2115590-2113563 (Counterclockwise)

Preceding gene: 183221416

Following gene: 183221414

Centisome position: 58.77

GC content: 38.02

Gene sequence:

>2028_bases
ATGAAAGTAATTGCTATTATCCAGGCAAGATTGGGATCCACAAGGTTACCGAAAAAGGTAATGAAGGAAGTAAATGGAAA
ACCATTAATTGAGATTTTATTGTCTCGATTGTCAAAATCCAAAAAAATCAATCAGATAATACTTGCTACATCAACTAAAG
AAGAAAATGACCCTCTTCAGAATCTTGTAGAGAAACTCGGGTATACTGTCTATCGTGGAAGTGAACAGAATGTGTTAGAA
CGATATTACTTCGCCGCAAAGGAAGCTGGGGCAGAGGTAGTGATTCGTGTCACTGGTGATTGTCCACTCATCGATCCCAA
CGTTGTCGATGAAGTAATTTCCGAATTTTTGAAAGGTGGCATTGATTATTGTTCAAACATTAATCCTCCTACTTATCCAG
ATGGACTAGATACAGAAGTTTTTTCTTTTGCAGCTTTGGAAAGAGCATACAGGGAAGCCACTTTGGATAGAGAACGCGAA
CACGTAACACCTTATATTCGTGAATCAGATTCGTTTAAAAAATCAAATCTAGTTTTTTCTGAGGATCATTCAACAGAACG
TTGGACTGTAGACGAGCCTGCTGACTTTCAATTGATCTCAAAGATATTTAACCATTTTCATCCTAAATTAGATTTTAGTT
GGTTAGATGTTTTAAAGCTTAAAACAAAATATCCTGATTTATTTTTAATGAATAACAAAATCATTCGCAATGAGGGGCAA
AATTTGGGGACGGGACAAAAGCTTTGGAAAAGGGCAAAACATATTATTCCTGGTGGAAACATGTTACTTTCGAAACGATC
AGAGATGTTTTTACCTGACCAATGGCCCTCTTACTTTAGTAAGGCGAAGGGCTGCTCCGTTTGGGATTTGGATGGAAAAG
AATACATCGACATGTCTATTATGGGGATTGGAACTAATACATTAGGATATGGACACCCAGAGGTAGATGAGGCTGTTAAA
AAGAATATTGAGAATGGTAACATGGCCACCTTCAATTGTCCTGAAGAAGTTTATCTTGCTGAGAAGTTAATTGAGATCCA
TCCATGGGCAGATATGGTTCGGCTTGCAAGAACTGGTGGTGAAGCAAATGCAATCGCTATTAGAATTGCTCGCGCGGCAT
CAGGGAAAGATAAAATAGCTATTTGTGGGTATCATGGATGGCATGATTGGTATCTTTCTGCAAATTTATCGGAGGATGAC
GGATTGTCTGGCCACCTACTGCCAGGTCTTGATCCGAAAGGAGTTCCTAAGAACCTAACAGGTACAGTTTTTCCTTTCAA
TTACAACCAATTTCAAGAATTAGAGACTCTTGTAAATAACCAAGATATCGGTGTGATCGTGATGGAAGTATCTAGAAATC
ATGGTCCAGAGGATCAGTTTCTTGAAAAAGTTAGGAAATTAGCCACTATCAGAAACATTGTTTTGGTATTTGACGAGTGT
ACATCTGGATTTCGCCAAAACTTCGGTGGACTTCATAAAATATACGGAGTTGAACCTGATATTGCAATGTTTGGAAAAGC
CATAGGAAATGGATATGCGATTACAGCAGTGATTGGGAGGCGTGAAGTAATGGAGTCAGCTCAATCAACATTTATCAGCA
GTACTTTTTGGACGGAACGTATTGGACCAACGGCAGCGTTAAAAACTTTAGAAGTTATGGAAAAGGAAAAATCTTGGGAG
TATATAACGAATATGGGTATCCATATCAGAGACCGATGGTTGGCTTTGGCAAAAAAGTATAATGTTAATCTTTCAGTATG
GGGAATGCCAGCCCTTTCTGGATTTACGATCAATAGCAAAAATACTTTAGAATACAAAACATTGATTACTCAAGAGATGT
TGAAAAAAGGATATTTAGCAGCAAATTCCGTTTACGTTTGTATGGAACACAAACAAACAGTTGTTGATGGTTATTTTGAA
ACCATTGATCCAATATTTAAGCTGATAGGGGAATGTGAAAATGGGCGTGATGTTATTTCCCTACTTGATGGTCCGGTTTG
TCATACAGGATTTAAACGGCTCAATTGA

Upstream 100 bases:

>100_bases
GAGTGCTTCTTGGGCTTACCCGTGAAGATTATAAACTCAAACGTTTATAATCTTCAATAAATAGATTGTGCACTTATATT
AAATACGATTCAGGAAATTT

Downstream 100 bases:

>100_bases
TTCTAATTTTTTCTGAAGCACTTTTGACAACGGGCCTTGGTCATTTAGGAAGATGCACTGCGCTAGCTGAAATACTTTTG
GAAAAAGGAAATGTCGATGT

Product: putative glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MKVIAIIQARLGSTRLPKKVMKEVNGKPLIEILLSRLSKSKKINQIILATSTKEENDPLQNLVEKLGYTVYRGSEQNVLE
RYYFAAKEAGAEVVIRVTGDCPLIDPNVVDEVISEFLKGGIDYCSNINPPTYPDGLDTEVFSFAALERAYREATLDRERE
HVTPYIRESDSFKKSNLVFSEDHSTERWTVDEPADFQLISKIFNHFHPKLDFSWLDVLKLKTKYPDLFLMNNKIIRNEGQ
NLGTGQKLWKRAKHIIPGGNMLLSKRSEMFLPDQWPSYFSKAKGCSVWDLDGKEYIDMSIMGIGTNTLGYGHPEVDEAVK
KNIENGNMATFNCPEEVYLAEKLIEIHPWADMVRLARTGGEANAIAIRIARAASGKDKIAICGYHGWHDWYLSANLSEDD
GLSGHLLPGLDPKGVPKNLTGTVFPFNYNQFQELETLVNNQDIGVIVMEVSRNHGPEDQFLEKVRKLATIRNIVLVFDEC
TSGFRQNFGGLHKIYGVEPDIAMFGKAIGNGYAITAVIGRREVMESAQSTFISSTFWTERIGPTAALKTLEVMEKEKSWE
YITNMGIHIRDRWLALAKKYNVNLSVWGMPALSGFTINSKNTLEYKTLITQEMLKKGYLAANSVYVCMEHKQTVVDGYFE
TIDPIFKLIGECENGRDVISLLDGPVCHTGFKRLN

Sequences:

>Translated_675_residues
MKVIAIIQARLGSTRLPKKVMKEVNGKPLIEILLSRLSKSKKINQIILATSTKEENDPLQNLVEKLGYTVYRGSEQNVLE
RYYFAAKEAGAEVVIRVTGDCPLIDPNVVDEVISEFLKGGIDYCSNINPPTYPDGLDTEVFSFAALERAYREATLDRERE
HVTPYIRESDSFKKSNLVFSEDHSTERWTVDEPADFQLISKIFNHFHPKLDFSWLDVLKLKTKYPDLFLMNNKIIRNEGQ
NLGTGQKLWKRAKHIIPGGNMLLSKRSEMFLPDQWPSYFSKAKGCSVWDLDGKEYIDMSIMGIGTNTLGYGHPEVDEAVK
KNIENGNMATFNCPEEVYLAEKLIEIHPWADMVRLARTGGEANAIAIRIARAASGKDKIAICGYHGWHDWYLSANLSEDD
GLSGHLLPGLDPKGVPKNLTGTVFPFNYNQFQELETLVNNQDIGVIVMEVSRNHGPEDQFLEKVRKLATIRNIVLVFDEC
TSGFRQNFGGLHKIYGVEPDIAMFGKAIGNGYAITAVIGRREVMESAQSTFISSTFWTERIGPTAALKTLEVMEKEKSWE
YITNMGIHIRDRWLALAKKYNVNLSVWGMPALSGFTINSKNTLEYKTLITQEMLKKGYLAANSVYVCMEHKQTVVDGYFE
TIDPIFKLIGECENGRDVISLLDGPVCHTGFKRLN
>Mature_675_residues
MKVIAIIQARLGSTRLPKKVMKEVNGKPLIEILLSRLSKSKKINQIILATSTKEENDPLQNLVEKLGYTVYRGSEQNVLE
RYYFAAKEAGAEVVIRVTGDCPLIDPNVVDEVISEFLKGGIDYCSNINPPTYPDGLDTEVFSFAALERAYREATLDRERE
HVTPYIRESDSFKKSNLVFSEDHSTERWTVDEPADFQLISKIFNHFHPKLDFSWLDVLKLKTKYPDLFLMNNKIIRNEGQ
NLGTGQKLWKRAKHIIPGGNMLLSKRSEMFLPDQWPSYFSKAKGCSVWDLDGKEYIDMSIMGIGTNTLGYGHPEVDEAVK
KNIENGNMATFNCPEEVYLAEKLIEIHPWADMVRLARTGGEANAIAIRIARAASGKDKIAICGYHGWHDWYLSANLSEDD
GLSGHLLPGLDPKGVPKNLTGTVFPFNYNQFQELETLVNNQDIGVIVMEVSRNHGPEDQFLEKVRKLATIRNIVLVFDEC
TSGFRQNFGGLHKIYGVEPDIAMFGKAIGNGYAITAVIGRREVMESAQSTFISSTFWTERIGPTAALKTLEVMEKEKSWE
YITNMGIHIRDRWLALAKKYNVNLSVWGMPALSGFTINSKNTLEYKTLITQEMLKKGYLAANSVYVCMEHKQTVVDGYFE
TIDPIFKLIGECENGRDVISLLDGPVCHTGFKRLN

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=325, Percent_Identity=26.4615384615385, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1786349, Length=384, Percent_Identity=29.1666666666667, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1789016, Length=360, Percent_Identity=28.6111111111111, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788044, Length=370, Percent_Identity=26.7567567567568, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789759, Length=356, Percent_Identity=26.123595505618, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787560, Length=378, Percent_Identity=21.957671957672, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357415, Length=349, Percent_Identity=25.5014326647564, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 76200; Mature: 76200

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIAIIQARLGSTRLPKKVMKEVNGKPLIEILLSRLSKSKKINQIILATSTKEENDPLQ
CEEEEEEHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHH
NLVEKLGYTVYRGSEQNVLERYYFAAKEAGAEVVIRVTGDCPLIDPNVVDEVISEFLKGG
HHHHHCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCC
IDYCSNINPPTYPDGLDTEVFSFAALERAYREATLDREREHVTPYIRESDSFKKSNLVFS
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCCCCCCCCCEEE
EDHSTERWTVDEPADFQLISKIFNHFHPKLDFSWLDVLKLKTKYPDLFLMNNKIIRNEGQ
CCCCCCCEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCEEEECCCC
NLGTGQKLWKRAKHIIPGGNMLLSKRSEMFLPDQWPSYFSKAKGCSVWDLDGKEYIDMSI
CCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHCCCCEEEECCCCCEEEEEE
MGIGTNTLGYGHPEVDEAVKKNIENGNMATFNCPEEVYLAEKLIEIHPWADMVRLARTGG
EEECCCCCCCCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCC
EANAIAIRIARAASGKDKIAICGYHGWHDWYLSANLSEDDGLSGHLLPGLDPKGVPKNLT
CCCEEEEEEEECCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
GTVFPFNYNQFQELETLVNNQDIGVIVMEVSRNHGPEDQFLEKVRKLATIRNIVLVFDEC
CCEEECCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEHHHH
TSGFRQNFGGLHKIYGVEPDIAMFGKAIGNGYAITAVIGRREVMESAQSTFISSTFWTER
HHHHHHCCCCHHHHCCCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
IGPTAALKTLEVMEKEKSWEYITNMGIHIRDRWLALAKKYNVNLSVWGMPALSGFTINSK
CCHHHHHHHHHHHHHHCCHHHHHCCCCEEHHHHHHHHHHHCCCEEEECCCCCCCEEECCC
NTLEYKTLITQEMLKKGYLAANSVYVCMEHKQTVVDGYFETIDPIFKLIGECENGRDVIS
CCCHHHHHHHHHHHHCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LLDGPVCHTGFKRLN
HHCCCHHHHHHHHCC
>Mature Secondary Structure
MKVIAIIQARLGSTRLPKKVMKEVNGKPLIEILLSRLSKSKKINQIILATSTKEENDPLQ
CEEEEEEHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHH
NLVEKLGYTVYRGSEQNVLERYYFAAKEAGAEVVIRVTGDCPLIDPNVVDEVISEFLKGG
HHHHHCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCC
IDYCSNINPPTYPDGLDTEVFSFAALERAYREATLDREREHVTPYIRESDSFKKSNLVFS
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHCCCCCCCCCCEEE
EDHSTERWTVDEPADFQLISKIFNHFHPKLDFSWLDVLKLKTKYPDLFLMNNKIIRNEGQ
CCCCCCCEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCEEEECCCC
NLGTGQKLWKRAKHIIPGGNMLLSKRSEMFLPDQWPSYFSKAKGCSVWDLDGKEYIDMSI
CCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHCCCCEEEECCCCCEEEEEE
MGIGTNTLGYGHPEVDEAVKKNIENGNMATFNCPEEVYLAEKLIEIHPWADMVRLARTGG
EEECCCCCCCCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCC
EANAIAIRIARAASGKDKIAICGYHGWHDWYLSANLSEDDGLSGHLLPGLDPKGVPKNLT
CCCEEEEEEEECCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
GTVFPFNYNQFQELETLVNNQDIGVIVMEVSRNHGPEDQFLEKVRKLATIRNIVLVFDEC
CCEEECCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEHHHH
TSGFRQNFGGLHKIYGVEPDIAMFGKAIGNGYAITAVIGRREVMESAQSTFISSTFWTER
HHHHHHCCCCHHHHCCCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
IGPTAALKTLEVMEKEKSWEYITNMGIHIRDRWLALAKKYNVNLSVWGMPALSGFTINSK
CCHHHHHHHHHHHHHHCCHHHHHCCCCEEHHHHHHHHHHHCCCEEEECCCCCCCEEECCC
NTLEYKTLITQEMLKKGYLAANSVYVCMEHKQTVVDGYFETIDPIFKLIGECENGRDVIS
CCCHHHHHHHHHHHHCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LLDGPVCHTGFKRLN
HHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA