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The map label for this gene is serA1 [H]

Identifier: 183221387

GI number: 183221387

Start: 2086594

End: 2087580

Strand: Reverse

Name: serA1 [H]

Synonym: LEPBI_I2005

Alternate gene names: 183221387

Gene position: 2087580-2086594 (Counterclockwise)

Preceding gene: 183221388

Following gene: 183221386

Centisome position: 57.99

GC content: 37.18

Gene sequence:

>987_bases
GTGAATATTTTTATCTCTACCTATCCCTTTGGAAAATACGATCCGCGACCTATTGATCTTTTAAGGAAAAGCGGGATTCG
TTTTACAATCAATCCACTTGGTAGAAAGCTAACTGCAGAGGAAATATTAGAATTTGCAAAAGATTCTGATGGAATCATTG
CAGGTACTGAAAATTTAGATTTACTCGTAAATGAATCGAGAAATTTAAAAATGATTTCTCGTGTCGGAATTGGATTGGAT
TCGGTGCCTTTAAAAATGTGCAAAGGGAAAGGAATTCGCGTATCCTATACACCTGATGCTGTGACACTTGCTGTCGCAGA
ATTAGTCGTTGGAATGATGGTTACCTTACCTAGGCAAGTGGTATATGCTGATCGAGAATTGCGAAGGGAAGGTTGGTCCC
GGCCTGTCGGTTTGAGTATTCAATCCTCGACAATAGGCATTGTTGGATTTGGGAGAGTGGGTCAAAAAATTGTACGAATA
TTAAGTAGTTTTAAACCCAGAAAGATTTTTATACATGATATCGTTGATAAGACTAGTGAGATCTCTGAGTTAAGAAAACT
TGCCTTAGATATCGAACAAGTTTCCTTTCAAAAATTGCTTAAAAGTTCTGATCTTGTTAGTCTCCATGTACCTTTAACAC
CGCAAACAAGAAATTTAATTAGCAATCCGGAATTGAAAAAGATGAACCAAGCTGCATACTTATTCAATTTCGCAAGAGGA
GGGATTGTAAATGAAGAGGACGTTTATCAGTATTTAAAAAAAGGACATCTTGCAGGTATGGCTATTGATGTTTACGAAAA
AGAACCATACAAAGGTAAGCTGACTGAGCTTGAAAATGTAGTTCTCACACAACATATGGGATCCTGTTCTTTTGATTGTC
GATTGGAAATGGAAACTCAGGCAACAGAAGAGTTAATTCGTTATTTTCGAAACCAACCTTTACTCAGTGAAGTACCATAT
TTCGAAGTCGAGAATTCGCATCAGTGA

Upstream 100 bases:

>100_bases
TTATCACACTGGAAAGACATATTGGAAATTTTGATAATAGAGTATTTTCGATTTTATGATGAGCCGAAAAATTGTTTAAG
AATAATGATGGAATAGAATC

Downstream 100 bases:

>100_bases
AAAACTTAAATCTTAATAAACATTACTATACGAACCTACTTCCTTCATCAATGCTTAGAAATATTTTTCGACATTCCTAT
TTTATTCTTTTATTCGTTTT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MNIFISTYPFGKYDPRPIDLLRKSGIRFTINPLGRKLTAEEILEFAKDSDGIIAGTENLDLLVNESRNLKMISRVGIGLD
SVPLKMCKGKGIRVSYTPDAVTLAVAELVVGMMVTLPRQVVYADRELRREGWSRPVGLSIQSSTIGIVGFGRVGQKIVRI
LSSFKPRKIFIHDIVDKTSEISELRKLALDIEQVSFQKLLKSSDLVSLHVPLTPQTRNLISNPELKKMNQAAYLFNFARG
GIVNEEDVYQYLKKGHLAGMAIDVYEKEPYKGKLTELENVVLTQHMGSCSFDCRLEMETQATEELIRYFRNQPLLSEVPY
FEVENSHQ

Sequences:

>Translated_328_residues
MNIFISTYPFGKYDPRPIDLLRKSGIRFTINPLGRKLTAEEILEFAKDSDGIIAGTENLDLLVNESRNLKMISRVGIGLD
SVPLKMCKGKGIRVSYTPDAVTLAVAELVVGMMVTLPRQVVYADRELRREGWSRPVGLSIQSSTIGIVGFGRVGQKIVRI
LSSFKPRKIFIHDIVDKTSEISELRKLALDIEQVSFQKLLKSSDLVSLHVPLTPQTRNLISNPELKKMNQAAYLFNFARG
GIVNEEDVYQYLKKGHLAGMAIDVYEKEPYKGKLTELENVVLTQHMGSCSFDCRLEMETQATEELIRYFRNQPLLSEVPY
FEVENSHQ
>Mature_328_residues
MNIFISTYPFGKYDPRPIDLLRKSGIRFTINPLGRKLTAEEILEFAKDSDGIIAGTENLDLLVNESRNLKMISRVGIGLD
SVPLKMCKGKGIRVSYTPDAVTLAVAELVVGMMVTLPRQVVYADRELRREGWSRPVGLSIQSSTIGIVGFGRVGQKIVRI
LSSFKPRKIFIHDIVDKTSEISELRKLALDIEQVSFQKLLKSSDLVSLHVPLTPQTRNLISNPELKKMNQAAYLFNFARG
GIVNEEDVYQYLKKGHLAGMAIDVYEKEPYKGKLTELENVVLTQHMGSCSFDCRLEMETQATEELIRYFRNQPLLSEVPY
FEVENSHQ

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=290, Percent_Identity=32.7586206896552, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI23308577, Length=308, Percent_Identity=28.8961038961039, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI145580578, Length=254, Percent_Identity=32.2834645669291, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4557499, Length=254, Percent_Identity=32.2834645669291, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4557497, Length=254, Percent_Identity=31.496062992126, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI61743967, Length=254, Percent_Identity=31.496062992126, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI145580575, Length=254, Percent_Identity=32.2834645669291, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1789279, Length=297, Percent_Identity=30.6397306397306, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87082289, Length=310, Percent_Identity=25.1612903225806, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787645, Length=202, Percent_Identity=29.2079207920792, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=299, Percent_Identity=30.4347826086957, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=231, Percent_Identity=26.8398268398268, Blast_Score=88, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=305, Percent_Identity=29.1803278688525, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=305, Percent_Identity=28.1967213114754, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324055, Length=262, Percent_Identity=28.6259541984733, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=221, Percent_Identity=28.9592760180996, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=139, Percent_Identity=32.3741007194245, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585514, Length=311, Percent_Identity=32.1543408360129, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574282, Length=311, Percent_Identity=32.1543408360129, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574284, Length=311, Percent_Identity=32.1543408360129, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45551003, Length=311, Percent_Identity=32.1543408360129, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45552429, Length=311, Percent_Identity=32.1543408360129, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19921140, Length=309, Percent_Identity=28.4789644012945, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28574286, Length=286, Percent_Identity=30.0699300699301, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28571528, Length=318, Percent_Identity=28.6163522012579, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=28.2051282051282, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646446, Length=258, Percent_Identity=30.2325581395349, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646448, Length=258, Percent_Identity=30.2325581395349, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646452, Length=258, Percent_Identity=30.2325581395349, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646450, Length=258, Percent_Identity=30.2325581395349, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI62472511, Length=258, Percent_Identity=30.2325581395349, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37071; Mature: 37071

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00551 MOLYBDOPTERIN_PROK_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFISTYPFGKYDPRPIDLLRKSGIRFTINPLGRKLTAEEILEFAKDSDGIIAGTENLD
CEEEEEECCCCCCCCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCCCEEECCCCCE
LLVNESRNLKMISRVGIGLDSVPLKMCKGKGIRVSYTPDAVTLAVAELVVGMMVTLPRQV
EEEECCCCEEEHHHHCCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
VYADRELRREGWSRPVGLSIQSSTIGIVGFGRVGQKIVRILSSFKPRKIFIHDIVDKTSE
HHHHHHHHHHCCCCCCCEEEECCEEEEEECHHHHHHHHHHHHCCCCCEEEHHHHHCCHHH
ISELRKLALDIEQVSFQKLLKSSDLVSLHVPLTPQTRNLISNPELKKMNQAAYLFNFARG
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHCC
GIVNEEDVYQYLKKGHLAGMAIDVYEKEPYKGKLTELENVVLTQHMGSCSFDCRLEMETQ
CCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHH
ATEELIRYFRNQPLLSEVPYFEVENSHQ
HHHHHHHHHCCCCCHHHCCEEEECCCCC
>Mature Secondary Structure
MNIFISTYPFGKYDPRPIDLLRKSGIRFTINPLGRKLTAEEILEFAKDSDGIIAGTENLD
CEEEEEECCCCCCCCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCCCCEEECCCCCE
LLVNESRNLKMISRVGIGLDSVPLKMCKGKGIRVSYTPDAVTLAVAELVVGMMVTLPRQV
EEEECCCCEEEHHHHCCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
VYADRELRREGWSRPVGLSIQSSTIGIVGFGRVGQKIVRILSSFKPRKIFIHDIVDKTSE
HHHHHHHHHHCCCCCCCEEEECCEEEEEECHHHHHHHHHHHHCCCCCEEEHHHHHCCHHH
ISELRKLALDIEQVSFQKLLKSSDLVSLHVPLTPQTRNLISNPELKKMNQAAYLFNFARG
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHCC
GIVNEEDVYQYLKKGHLAGMAIDVYEKEPYKGKLTELENVVLTQHMGSCSFDCRLEMETQ
CCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHH
ATEELIRYFRNQPLLSEVPYFEVENSHQ
HHHHHHHHHCCCCCHHHCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]