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The map label for this gene is guaB [H]

Identifier: 183220663

GI number: 183220663

Start: 1318180

End: 1319706

Strand: Direct

Name: guaB [H]

Synonym: LEPBI_I1272

Alternate gene names: 183220663

Gene position: 1318180-1319706 (Clockwise)

Preceding gene: 183220661

Following gene: 183220664

Centisome position: 36.62

GC content: 43.48

Gene sequence:

>1527_bases
ATGTCAAATCACCCCCTACCAGGAACTGAGCTTCTCGACGGAGTCAGTGGACAAGAGCTCTTCTCGGTCAACATGGGACT
CACGTATCGAGATTTTTTAGTACTACCTGGCTATATAGACTTCAATCCAAGCGATGTGGAACTAGAAACAAAACTTTCCA
AAAATATTTCACTCAAAAGACCACTCATGAGTTCTCCCATGGACACTGTGACTGAGTCTGAAATGGCGATTGCACAGGCG
CTTATGGGTGGAATTGGAATCATACATTATAATAATACGATAGAGGAACAAGTGGATCTCGTTCGTAAGGTGAAACGATT
CGAAAACGGATTCATCAAAGATCCTATCTTACTTTCTCCAGAACATACGGTTGCTGATTTAGATGCAGTCAAAGAAAAAT
ATGGATTCAGTGGGATTCCCATTACCGAAAACGGAACCGCTAATTCCAAGTTAGTTGGGATAGTTACAAACCGTGATGTG
GACTTTGAAAAAGACAGAAATATCAAACTCGGTAAGGTGATGACGACAGAACTTATTACTGCCAATGTGGGGATCAGTTT
ACTCGAAGCGAATGATATCCTTCGCACAAGTAAAAAAGGTAAACTCCCCATCGTAGACAAACAAGGAAAACTTGTGGCAC
TCATTTGCCGTAGTGACCTGAAAAAAAATAAAGAATTCCCTCAATCATCCAAAGATGACCAAAAAAGATTACGTGTTGGT
GCAGCCCTTTCCACCTTACCTGAGTCACGCGATCGTATGGCAGCTCTTGCAGGAGTCGGCGTTGATGCCATCATCATCGA
TTCTGCCCAAGGGAATTCCAGTTACCAAATTGAAATGATCCAATGGATCAAATCCAATTTTCCTAATATTGATGTGATTG
GGGGAAATGTTGTCACTAAAGCACAAGCTGCCAATCTCATAGGGGCCGGTGCCGATGGCCTTCGCATTGGAATGGGACCT
GGTTCCATTTGTATCACCCAAGATACGATGGCTGTGGGACGAGCGCAAGCCACAGCTGTTTTTAAAACAGCGGAGTATGC
ACAAGCGCATGGAGTGCCAGTGATTGCTGATGGAGGTATCTCCAATATCGGGGACATTGCTAACGCACTCGCCATTGGAG
CTTCGATGTGTATGATGGGTTCCATGTTTGCTGGAACAAAAGAAGCACCAGGTGAGTATTTTTATGAAAATGGAATTCGT
CTAAAGAAGTATAGAGGAATGGCAAGTTTAGAAGCGATGAGCAAAGGTGGAGACAAACGGTACTTCTCTGAATCACAAAA
GATCAAAGTGGCACAAGGTGTCTCTGGTTATGTGGTTGATAAAGGATCTGTTCTGAACCTCATTCCTTATCTCGTGCAAG
GACTCAGACAAAGTTTCCAAGATATGGGATACCGTAATATCCCAGATTTACACAAAGCGTTACGAGAAGGGAAACTTCGG
TTTGAACGTAGGACAGAGTCAGCACAAGCGCAAGGGAGTGTTCACGGATTGTATTCCTATACCAAACCTTCTATGAGGGC
AGAATAA

Upstream 100 bases:

>100_bases
CATAAAAGGTCGTGGTACTCACTATTATCGGTCAATTTTCTCCTGAAATTCTCTTGCACGCAGAGTTTTCTTACCTAAAG
TAGAAAAAGGAAGGATAATT

Downstream 100 bases:

>100_bases
AGAAATTACATGCGAAAACTTTGGATTTTATTTTTATTCATTTCGTTTGTGTCGTTAGAGGCACAAACGCCTGAAGCAAG
TTTGTCGGCACAAGAACTTC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSNHPLPGTELLDGVSGQELFSVNMGLTYRDFLVLPGYIDFNPSDVELETKLSKNISLKRPLMSSPMDTVTESEMAIAQA
LMGGIGIIHYNNTIEEQVDLVRKVKRFENGFIKDPILLSPEHTVADLDAVKEKYGFSGIPITENGTANSKLVGIVTNRDV
DFEKDRNIKLGKVMTTELITANVGISLLEANDILRTSKKGKLPIVDKQGKLVALICRSDLKKNKEFPQSSKDDQKRLRVG
AALSTLPESRDRMAALAGVGVDAIIIDSAQGNSSYQIEMIQWIKSNFPNIDVIGGNVVTKAQAANLIGAGADGLRIGMGP
GSICITQDTMAVGRAQATAVFKTAEYAQAHGVPVIADGGISNIGDIANALAIGASMCMMGSMFAGTKEAPGEYFYENGIR
LKKYRGMASLEAMSKGGDKRYFSESQKIKVAQGVSGYVVDKGSVLNLIPYLVQGLRQSFQDMGYRNIPDLHKALREGKLR
FERRTESAQAQGSVHGLYSYTKPSMRAE

Sequences:

>Translated_508_residues
MSNHPLPGTELLDGVSGQELFSVNMGLTYRDFLVLPGYIDFNPSDVELETKLSKNISLKRPLMSSPMDTVTESEMAIAQA
LMGGIGIIHYNNTIEEQVDLVRKVKRFENGFIKDPILLSPEHTVADLDAVKEKYGFSGIPITENGTANSKLVGIVTNRDV
DFEKDRNIKLGKVMTTELITANVGISLLEANDILRTSKKGKLPIVDKQGKLVALICRSDLKKNKEFPQSSKDDQKRLRVG
AALSTLPESRDRMAALAGVGVDAIIIDSAQGNSSYQIEMIQWIKSNFPNIDVIGGNVVTKAQAANLIGAGADGLRIGMGP
GSICITQDTMAVGRAQATAVFKTAEYAQAHGVPVIADGGISNIGDIANALAIGASMCMMGSMFAGTKEAPGEYFYENGIR
LKKYRGMASLEAMSKGGDKRYFSESQKIKVAQGVSGYVVDKGSVLNLIPYLVQGLRQSFQDMGYRNIPDLHKALREGKLR
FERRTESAQAQGSVHGLYSYTKPSMRAE
>Mature_507_residues
SNHPLPGTELLDGVSGQELFSVNMGLTYRDFLVLPGYIDFNPSDVELETKLSKNISLKRPLMSSPMDTVTESEMAIAQAL
MGGIGIIHYNNTIEEQVDLVRKVKRFENGFIKDPILLSPEHTVADLDAVKEKYGFSGIPITENGTANSKLVGIVTNRDVD
FEKDRNIKLGKVMTTELITANVGISLLEANDILRTSKKGKLPIVDKQGKLVALICRSDLKKNKEFPQSSKDDQKRLRVGA
ALSTLPESRDRMAALAGVGVDAIIIDSAQGNSSYQIEMIQWIKSNFPNIDVIGGNVVTKAQAANLIGAGADGLRIGMGPG
SICITQDTMAVGRAQATAVFKTAEYAQAHGVPVIADGGISNIGDIANALAIGASMCMMGSMFAGTKEAPGEYFYENGIRL
KKYRGMASLEAMSKGGDKRYFSESQKIKVAQGVSGYVVDKGSVLNLIPYLVQGLRQSFQDMGYRNIPDLHKALREGKLRF
ERRTESAQAQGSVHGLYSYTKPSMRAE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=496, Percent_Identity=58.6693548387097, Blast_Score=598, Evalue=1e-171,
Organism=Homo sapiens, GI34328930, Length=496, Percent_Identity=58.6693548387097, Blast_Score=598, Evalue=1e-171,
Organism=Homo sapiens, GI34328928, Length=496, Percent_Identity=58.6693548387097, Blast_Score=597, Evalue=1e-171,
Organism=Homo sapiens, GI156616279, Length=496, Percent_Identity=58.6693548387097, Blast_Score=597, Evalue=1e-171,
Organism=Homo sapiens, GI217035148, Length=496, Percent_Identity=57.6612903225806, Blast_Score=584, Evalue=1e-167,
Organism=Homo sapiens, GI66933016, Length=496, Percent_Identity=57.0564516129032, Blast_Score=579, Evalue=1e-165,
Organism=Homo sapiens, GI217035152, Length=478, Percent_Identity=58.9958158995816, Blast_Score=579, Evalue=1e-165,
Organism=Homo sapiens, GI217035150, Length=496, Percent_Identity=55.241935483871, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI156104880, Length=214, Percent_Identity=35.981308411215, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI50541954, Length=242, Percent_Identity=31.404958677686, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI50541952, Length=242, Percent_Identity=31.404958677686, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI50541948, Length=242, Percent_Identity=31.404958677686, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI50541956, Length=242, Percent_Identity=31.404958677686, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=39.3004115226337, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI1786293, Length=212, Percent_Identity=32.0754716981132, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71994385, Length=516, Percent_Identity=47.8682170542636, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71994389, Length=436, Percent_Identity=48.8532110091743, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17560440, Length=222, Percent_Identity=31.5315315315315, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322012, Length=499, Percent_Identity=54.5090180360721, Blast_Score=564, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6323585, Length=499, Percent_Identity=54.3086172344689, Blast_Score=554, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6323464, Length=500, Percent_Identity=55.6, Blast_Score=552, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6319352, Length=351, Percent_Identity=53.5612535612536, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319353, Length=148, Percent_Identity=56.0810810810811, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24641071, Length=500, Percent_Identity=58.2, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24641073, Length=500, Percent_Identity=58.2, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=58.4650112866817, Blast_Score=515, Evalue=1e-146,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 55069; Mature: 54938

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHPLPGTELLDGVSGQELFSVNMGLTYRDFLVLPGYIDFNPSDVELETKLSKNISLKR
CCCCCCCCHHHHCCCCCCEEEEEECCCEEEHEEEECCEECCCCCCEEEEEHHCCCCCCCC
PLMSSPMDTVTESEMAIAQALMGGIGIIHYNNTIEEQVDLVRKVKRFENGFIKDPILLSP
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECC
EHTVADLDAVKEKYGFSGIPITENGTANSKLVGIVTNRDVDFEKDRNIKLGKVMTTELIT
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEECCEEEEHHEE
ANVGISLLEANDILRTSKKGKLPIVDKQGKLVALICRSDLKKNKEFPQSSKDDQKRLRVG
ECCCEEEEECCHHHHCCCCCCCCEECCCCCEEEEEEHHHHHHCCCCCCCCCCHHHHHHHH
AALSTLPESRDRMAALAGVGVDAIIIDSAQGNSSYQIEMIQWIKSNFPNIDVIGGNVVTK
HHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEHHHHHHHHCCCCCEEEECCCEEEH
AQAANLIGAGADGLRIGMGPGSICITQDTMAVGRAQATAVFKTAEYAQAHGVPVIADGGI
HHHHHHEECCCCCEEEECCCCCEEEECCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCC
SNIGDIANALAIGASMCMMGSMFAGTKEAPGEYFYENGIRLKKYRGMASLEAMSKGGDKR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEECCCCHHHHHHHCCCCCH
YFSESQKIKVAQGVSGYVVDKGSVLNLIPYLVQGLRQSFQDMGYRNIPDLHKALREGKLR
HHCCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHH
FERRTESAQAQGSVHGLYSYTKPSMRAE
HHHHHHHHHHCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
SNHPLPGTELLDGVSGQELFSVNMGLTYRDFLVLPGYIDFNPSDVELETKLSKNISLKR
CCCCCCCHHHHCCCCCCEEEEEECCCEEEHEEEECCEECCCCCCEEEEEHHCCCCCCCC
PLMSSPMDTVTESEMAIAQALMGGIGIIHYNNTIEEQVDLVRKVKRFENGFIKDPILLSP
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECC
EHTVADLDAVKEKYGFSGIPITENGTANSKLVGIVTNRDVDFEKDRNIKLGKVMTTELIT
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEECCEEEEHHEE
ANVGISLLEANDILRTSKKGKLPIVDKQGKLVALICRSDLKKNKEFPQSSKDDQKRLRVG
ECCCEEEEECCHHHHCCCCCCCCEECCCCCEEEEEEHHHHHHCCCCCCCCCCHHHHHHHH
AALSTLPESRDRMAALAGVGVDAIIIDSAQGNSSYQIEMIQWIKSNFPNIDVIGGNVVTK
HHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEHHHHHHHHCCCCCEEEECCCEEEH
AQAANLIGAGADGLRIGMGPGSICITQDTMAVGRAQATAVFKTAEYAQAHGVPVIADGGI
HHHHHHEECCCCCEEEECCCCCEEEECCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCC
SNIGDIANALAIGASMCMMGSMFAGTKEAPGEYFYENGIRLKKYRGMASLEAMSKGGDKR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEECCCCHHHHHHHCCCCCH
YFSESQKIKVAQGVSGYVVDKGSVLNLIPYLVQGLRQSFQDMGYRNIPDLHKALREGKLR
HHCCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHH
FERRTESAQAQGSVHGLYSYTKPSMRAE
HHHHHHHHHHCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]