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The map label for this gene is mntB [H]

Identifier: 183220656

GI number: 183220656

Start: 1310238

End: 1310891

Strand: Direct

Name: mntB [H]

Synonym: LEPBI_I1265

Alternate gene names: 183220656

Gene position: 1310238-1310891 (Clockwise)

Preceding gene: 183220655

Following gene: 183220657

Centisome position: 36.4

GC content: 42.66

Gene sequence:

>654_bases
TTGTCCGTGGGTTACAGGAAAGAATTCCCGGTTGTGACTGACATCCACCTTCATATTGAGGCGGGCAAAACCTACGCTCT
CGTGGGTGGCAATGGAGCAGGGAAAACCACACTCTTTCGCACACTTACCGATTTACTCCCACCACTTTCGGGTTCCATTC
AGTTTTCCAATGAAATCTCTACTTCCTATGTGCCTCAGGCAAAAAAAATGGCACTCGATTTCCCCTTACGTGTGGAAGAT
GTCCTCCTCATGCCAAAAAATATTGGATTTAGTTTTTTACCCAAAAAAAGATTTTCCGAAGAGGATCTGGCACTCATTGA
AAAAACAGGTGTTAGTTCTTACTTAAAAAAACAAATCTCCCTATGTAGCGGGGGGCAGTTACAAAAGGTTCTGATTTTAC
GATCTCTACTCACGAAAGCCAATTTGATATTTTTAGATGAACCAATGGATTCTTTGGACCATAATGCCAGAGAACTCTTC
CAATCCATTTTATCAGAATACCTCAAACTAGGGAACCGGTCCTTGTTTTTTATCACCCATAGCCTCGAACACGATTGGGG
GTTTGGATTTGATGAAGTGTTTGAGATTGATGAAGGAAAGTTGTACAACATCACGAGAGGAGAAAGGCCACCAAACTGCC
ACCACCATGACTAG

Upstream 100 bases:

>100_bases
TATGAAGATGCCTTACGGATGAGTTTACAAAAAATACGTGATGCAAGCGACAAAACCAAATAGTCTTTCCACTCCTTCCA
CCTTCATCCATGCGGACCAT

Downstream 100 bases:

>100_bases
TCTCCTCTCCAGTTGGAATTTATTTTTACCACAAGTGTTAGTGGGTAGCCTTGTCGGGGCATTACTCTCAGTACTTGGGA
TCCTCATTGTACTCAGAGGG

Product: ABC transporter ATPase

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MSVGYRKEFPVVTDIHLHIEAGKTYALVGGNGAGKTTLFRTLTDLLPPLSGSIQFSNEISTSYVPQAKKMALDFPLRVED
VLLMPKNIGFSFLPKKRFSEEDLALIEKTGVSSYLKKQISLCSGGQLQKVLILRSLLTKANLIFLDEPMDSLDHNARELF
QSILSEYLKLGNRSLFFITHSLEHDWGFGFDEVFEIDEGKLYNITRGERPPNCHHHD

Sequences:

>Translated_217_residues
MSVGYRKEFPVVTDIHLHIEAGKTYALVGGNGAGKTTLFRTLTDLLPPLSGSIQFSNEISTSYVPQAKKMALDFPLRVED
VLLMPKNIGFSFLPKKRFSEEDLALIEKTGVSSYLKKQISLCSGGQLQKVLILRSLLTKANLIFLDEPMDSLDHNARELF
QSILSEYLKLGNRSLFFITHSLEHDWGFGFDEVFEIDEGKLYNITRGERPPNCHHHD
>Mature_216_residues
SVGYRKEFPVVTDIHLHIEAGKTYALVGGNGAGKTTLFRTLTDLLPPLSGSIQFSNEISTSYVPQAKKMALDFPLRVEDV
LLMPKNIGFSFLPKKRFSEEDLALIEKTGVSSYLKKQISLCSGGQLQKVLILRSLLTKANLIFLDEPMDSLDHNARELFQ
SILSEYLKLGNRSLFFITHSLEHDWGFGFDEVFEIDEGKLYNITRGERPPNCHHHD

Specific function: This protein is probably a component of a manganese permease, a binding protein-dependent, ATP-driven transport system. Probably responsible for energy coupling to the transport system [H]

COG id: COG1121

COG function: function code P; ABC-type Mn/Zn transport systems, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27881501, Length=188, Percent_Identity=29.2553191489362, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI30795238, Length=188, Percent_Identity=29.2553191489362, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI31657092, Length=219, Percent_Identity=28.310502283105, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI105990541, Length=199, Percent_Identity=27.1356783919598, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI66529005, Length=199, Percent_Identity=29.1457286432161, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1788165, Length=197, Percent_Identity=27.9187817258883, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI87081791, Length=206, Percent_Identity=27.1844660194175, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1786563, Length=185, Percent_Identity=29.7297297297297, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI87081709, Length=206, Percent_Identity=27.6699029126214, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787164, Length=196, Percent_Identity=27.5510204081633, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1789962, Length=183, Percent_Identity=28.4153005464481, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788506, Length=207, Percent_Identity=30.4347826086957, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1786253, Length=172, Percent_Identity=26.7441860465116, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1787041, Length=180, Percent_Identity=28.3333333333333, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787112, Length=203, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081834, Length=203, Percent_Identity=26.1083743842365, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1786803, Length=215, Percent_Identity=26.046511627907, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1787370, Length=193, Percent_Identity=26.4248704663212, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1788761, Length=212, Percent_Identity=27.3584905660377, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1786698, Length=185, Percent_Identity=23.2432432432432, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789032, Length=208, Percent_Identity=25.4807692307692, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1786975, Length=151, Percent_Identity=29.1390728476821, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1790467, Length=208, Percent_Identity=24.5192307692308, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787712, Length=179, Percent_Identity=25.1396648044693, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789891, Length=213, Percent_Identity=26.2910798122066, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787143, Length=224, Percent_Identity=25.8928571428571, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786703, Length=194, Percent_Identity=26.8041237113402, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788210, Length=198, Percent_Identity=29.7979797979798, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786872, Length=206, Percent_Identity=26.2135922330097, Blast_Score=61, Evalue=4e-11,
Organism=Escherichia coli, GI1788450, Length=183, Percent_Identity=24.5901639344262, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI48995001, Length=197, Percent_Identity=28.9340101522843, Blast_Score=60, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17510237, Length=182, Percent_Identity=29.1208791208791, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115533608, Length=196, Percent_Identity=29.0816326530612, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569081, Length=180, Percent_Identity=29.4444444444444, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71983516, Length=182, Percent_Identity=28.021978021978, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71983510, Length=182, Percent_Identity=28.021978021978, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71983523, Length=182, Percent_Identity=28.021978021978, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71992285, Length=199, Percent_Identity=28.643216080402, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=192, Percent_Identity=26.0416666666667, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17558664, Length=193, Percent_Identity=25.3886010362694, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=218, Percent_Identity=24.7706422018349, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221474134, Length=190, Percent_Identity=31.0526315789474, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574259, Length=178, Percent_Identity=28.0898876404494, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 24502; Mature: 24371

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVGYRKEFPVVTDIHLHIEAGKTYALVGGNGAGKTTLFRTLTDLLPPLSGSIQFSNEIS
CCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCCC
TSYVPQAKKMALDFPLRVEDVLLMPKNIGFSFLPKKRFSEEDLALIEKTGVSSYLKKQIS
CCCCCCHHHHEECCCCCEEHEEEECCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
LCSGGQLQKVLILRSLLTKANLIFLDEPMDSLDHNARELFQSILSEYLKLGNRSLFFITH
HCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEEE
SLEHDWGFGFDEVFEIDEGKLYNITRGERPPNCHHHD
CCCCCCCCCHHHHEECCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SVGYRKEFPVVTDIHLHIEAGKTYALVGGNGAGKTTLFRTLTDLLPPLSGSIQFSNEIS
CCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCCC
TSYVPQAKKMALDFPLRVEDVLLMPKNIGFSFLPKKRFSEEDLALIEKTGVSSYLKKQIS
CCCCCCHHHHEECCCCCEEHEEEECCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
LCSGGQLQKVLILRSLLTKANLIFLDEPMDSLDHNARELFQSILSEYLKLGNRSLFFITH
HCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEEE
SLEHDWGFGFDEVFEIDEGKLYNITRGERPPNCHHHD
CCCCCCCCCHHHHEECCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10760146 [H]