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The map label for this gene is cobA1 [H]

Identifier: 183220575

GI number: 183220575

Start: 1225731

End: 1226543

Strand: Reverse

Name: cobA1 [H]

Synonym: LEPBI_I1179

Alternate gene names: 183220575

Gene position: 1226543-1225731 (Counterclockwise)

Preceding gene: 183220578

Following gene: 183220574

Centisome position: 34.07

GC content: 47.11

Gene sequence:

>813_bases
TTGCAAGGTATAACAGATATGTCCTCCAATAAGACAGAACAGGGTTTTGTGAGTTTCGTGAGCGGTGGTCCAGGCCCCGT
TGACCTACTGACCCTCCGTGGAAAATCTCGCATTGAAAGAGCAGAGGTGATTCTGTATGACGCCTTACTCGATCCCAGTT
TTTTAGAGATCTTCCCTGAGTCTGCCCAAATCCTTTACGTGGGCAAACGAGCCAAAGAACACTACCGCACCCAAACAGAA
ATCAATGCTCTCCTCGTCGAGTTTGCCCATCAGGGAAAAAAAGTGGTCCGCCTCAAAGGTGGTGACGCTTCGATCTTTGG
TCGTTTGTCAGAAGAAATCCAAAGCTTAGAAGCCGCTGGGATTCCTTATGAAGTGATACCAGGAGTAAGCTCCGTGACAG
CAGGTGCTGCAGACCTTGGTCTCTCGCTTACCGTGCGCGGACTTTCTCGCCAAATCATCATCCTGGATGGGCATACCATT
TTGGAAGATGAACGCAGTTGGATGGGAATGGAAAATTTTCCAGGGACCATTGCGATCCTAATGGGAAGCCAAAAAACCAA
GGAACTTTCCGAAAGACTCATCCAAAAAGGTGTCCTCCCAACTACCCCCATTGTCCTTTTAGAAAATGCCGGAAATCCCA
ATGCCACATATACAGTCTCCACTCTCGCCAATACGATGTTAGAGGGAATGGGAAAACAAACAAAAGGTCCAGGGATTTTG
TATGTGGGAGAAGCACTTCGTCCCCTTTTGGAAAATACAAAAACCATTCAAAACGTGATCCACTCCGCTTCCTCTTTTTT
GGAATCCTTATGA

Upstream 100 bases:

>100_bases
TTATAAATTGAATCTTTTCCTGGGGTTCGAGACGAGTAAACCAAAAAAATGGAGATTTTGTAGAAATTATTGGCCAATCA
CTTGACTATTTCTAGCAGGA

Downstream 100 bases:

>100_bases
CAGTCAAAAAATATCCAATCTTTCTCAATTTGGAAGGAAGGAACATCCTCGTTGTTGGTGGTGGTAATGCTTGTTTAGAA
AAATTGATGGGCCTTGAACA

Product: uroporphyrin-III C/tetrapyrrole methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MQGITDMSSNKTEQGFVSFVSGGPGPVDLLTLRGKSRIERAEVILYDALLDPSFLEIFPESAQILYVGKRAKEHYRTQTE
INALLVEFAHQGKKVVRLKGGDASIFGRLSEEIQSLEAAGIPYEVIPGVSSVTAGAADLGLSLTVRGLSRQIIILDGHTI
LEDERSWMGMENFPGTIAILMGSQKTKELSERLIQKGVLPTTPIVLLENAGNPNATYTVSTLANTMLEGMGKQTKGPGIL
YVGEALRPLLENTKTIQNVIHSASSFLESL

Sequences:

>Translated_270_residues
MQGITDMSSNKTEQGFVSFVSGGPGPVDLLTLRGKSRIERAEVILYDALLDPSFLEIFPESAQILYVGKRAKEHYRTQTE
INALLVEFAHQGKKVVRLKGGDASIFGRLSEEIQSLEAAGIPYEVIPGVSSVTAGAADLGLSLTVRGLSRQIIILDGHTI
LEDERSWMGMENFPGTIAILMGSQKTKELSERLIQKGVLPTTPIVLLENAGNPNATYTVSTLANTMLEGMGKQTKGPGIL
YVGEALRPLLENTKTIQNVIHSASSFLESL
>Mature_270_residues
MQGITDMSSNKTEQGFVSFVSGGPGPVDLLTLRGKSRIERAEVILYDALLDPSFLEIFPESAQILYVGKRAKEHYRTQTE
INALLVEFAHQGKKVVRLKGGDASIFGRLSEEIQSLEAAGIPYEVIPGVSSVTAGAADLGLSLTVRGLSRQIIILDGHTI
LEDERSWMGMENFPGTIAILMGSQKTKELSERLIQKGVLPTTPIVLLENAGNPNATYTVSTLANTMLEGMGKQTKGPGIL
YVGEALRPLLENTKTIQNVIHSASSFLESL

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=234, Percent_Identity=33.7606837606838, Blast_Score=144, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6322922, Length=246, Percent_Identity=30.0813008130081, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 29184; Mature: 29184

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGITDMSSNKTEQGFVSFVSGGPGPVDLLTLRGKSRIERAEVILYDALLDPSFLEIFPE
CCCCCCCCCCCCHHHHHHEECCCCCCEEEEEECCCHHHHHHHEEEEHHHCCCHHHHHCCC
SAQILYVGKRAKEHYRTQTEINALLVEFAHQGKKVVRLKGGDASIFGRLSEEIQSLEAAG
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCC
IPYEVIPGVSSVTAGAADLGLSLTVRGLSRQIIILDGHTILEDERSWMGMENFPGTIAIL
CCHHHCCCCHHHHCCHHHCCCEEEEECCCEEEEEEECCEEECCHHHHCCCCCCCCEEEEE
MGSQKTKELSERLIQKGVLPTTPIVLLENAGNPNATYTVSTLANTMLEGMGKQTKGPGIL
ECCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHCCCCCCCCCEE
YVGEALRPLLENTKTIQNVIHSASSFLESL
EECHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQGITDMSSNKTEQGFVSFVSGGPGPVDLLTLRGKSRIERAEVILYDALLDPSFLEIFPE
CCCCCCCCCCCCHHHHHHEECCCCCCEEEEEECCCHHHHHHHEEEEHHHCCCHHHHHCCC
SAQILYVGKRAKEHYRTQTEINALLVEFAHQGKKVVRLKGGDASIFGRLSEEIQSLEAAG
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCC
IPYEVIPGVSSVTAGAADLGLSLTVRGLSRQIIILDGHTILEDERSWMGMENFPGTIAIL
CCHHHCCCCHHHHCCHHHCCCEEEEECCCEEEEEEECCEEECCHHHHCCCCCCCCEEEEE
MGSQKTKELSERLIQKGVLPTTPIVLLENAGNPNATYTVSTLANTMLEGMGKQTKGPGIL
ECCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHCCCCCCCCCEE
YVGEALRPLLENTKTIQNVIHSASSFLESL
EECHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA