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The map label for this gene is fusA [H]

Identifier: 183220549

GI number: 183220549

Start: 1199542

End: 1201662

Strand: Reverse

Name: fusA [H]

Synonym: LEPBI_I1153

Alternate gene names: 183220549

Gene position: 1201662-1199542 (Counterclockwise)

Preceding gene: 183220555

Following gene: 183220548

Centisome position: 33.38

GC content: 45.12

Gene sequence:

>2121_bases
ATGACCTCTGCGACGCAAGCAACCAAACGTGATCCAAAATTGGAAAGAATCCGTAACATCGGGATTTCCGCACACATTGA
CTCTGGGAAAACAACCCTTACAGAACGTATCTTATTTTATACGAACAAAATCCATGCCATCCACGAAGTACGTGGAAAAG
ACGGTGTGGGTGCTACGATGGATAGTATGGACCTCGAACGAGAAAGAGGGATCACAATCCAATCCGCAGCAACGTATGCG
ACATGGAAAGACATCACCATCAACATCATTGACACTCCGGGCCACGTTGACTTCACGATCGAAGTAGAACGTTCCCTTCG
TGTCCTTGACTCTGCGATTATGGTCCTTTGTGGGGTTGCGGGTGTTCAGTCCCAGTCCATTACAGTTGACCGCCAGATGA
AACGTTATAGTGTTCCGCGTGTTGCCTTTATCAACAAACTTGATAGAACAGGTGCGAACCCATGGCGCGTCATCGAACAA
CTTCGTGAAAAACTCCACCTCAACGCACATGCAGTACAACTTCCCATCGGACTCGAAAACGACCTGAAAGGGATCGTTGA
CCTTGTGGAGATGAAGGCATATTATTTTGAAGGTCCAAACGGACAAGACATCAAAATCACTGATATCCCAGATGAGTTAA
AAGACCAAGCCAACGAAAAACGTGAGGCACTTCTGGATGCAGTTTCCCTTTTCAGTGACGAACTCACAGAAGAGATGTTG
GAAGGAACTCCTTCTGAAGCGCGAGTGAAAGAAGCGATCCGTCGTGGAGTACTCGCACTGAAATTTGTTCCTGTATTTAT
GGGTTCCGCGTTTAAAAACAAAGGGGTACAAAGACTCCTTGATGGCGTTGCAGATTACCTCGCATCTCCATACGATGTGG
AAAACAAAGCAAAAGAAATTGGAAACGAAGAAAACGAATTCAATTTGGAATCCGATCCAGAAAAACCACTCGTTTGCCTT
GCCTTCAAATTAGAAGACGGGCGATACGGTCAGTTAACTTACGTTCGTGTTTACCAAGGTAGACTCGAAAAAGGGATGAC
GATCTATAACTCCTCAAACAACAAACGCCATAACATTGGACGTCTGGTTCGTATGCACTCAAACGATATGGAAGATATCG
CAAAAGCAGAAGCAGGTGACATTGTTGCTCTATTTGGTATTGATTGTGCCTCTGGGGATACCTTCACTGATGGAAAAGCA
AAAGTGACGATGGAGTCTATGTTTGTTCCAAACCCGGTGATTTCACTTACCATCGAATGTAAAGAATCCAAACAACTTCC
AAACCTTGCGAAAGCTCTCAACCGATTCACAAAGGAAGACCCAACTTTCCAAACAGAAATCGACAAAGAGTCGGGACAAA
CCATCATCAAAGGGATGGGAGAACTCCACCTCGAAGTGTACATCGAACGTATGAAACGGGAATACGGAGTGGATTTAGTC
ACAGGAGCTCCGCAAGTTGCTTACCGTGAAACCATCACTAAGGCTGCCGATTTCGACTACACACACAAAAAACAAACGGG
TGGTCAAGGTCAGTTCTCTCGAGTGGCAGGTTTTATCGAACCAATCCCCCAAGAAGAAGGAAAAGACTACGAATTCGTGG
ATAAAATTGTGGGTGGATCCATCCCTCGCGAATACATCGGTTCTTGCGATAAGGGTTTTCGCTCTTGTTTAGAGAGAGGA
TCTCTCATTGGATTCCCTATCATTGGAGTTCGTTGTGTGATCAATGACGGTGCTTACCATGATGTGGATTCATCGGATAT
GGCCTTCCAAATTGGTGCTCGTTACGGATTCCGCCAAGGATTCTCGAAAGCAGCTCCGATCATTCTTGAGCCAATCATGA
GAGTGGAAGTGGAAGGACCGACAGAATTCCAAGGAGCCATCCTTGCCTCTGTGAACCAAAGACGTGGTATGATCTTAAAC
ACGACAGAAGAGAACGGTTATGCGAAAATTGAAGCAGAAGTTCCTCTTGCTGATATGTTTGGGTATTCGACTGTATTACG
TTCGTCGACACAAGGAAAGGCTGAGTTTGCGATGGAATTCTCCAAGTATGCTCCTGTTCCAAGAAACGTAGCAGACGAGC
TCATGAAAAAATACAAAGTCAATAACAAAGACGAAGAATAA

Upstream 100 bases:

>100_bases
GATTTTCCCTCTAACCAAAAATCCCAAGTACTTTACAAACGCAGTCCATTTCAGATTTTGGTAGAATCAATTCAACTTTA
ACCTTATTTTTGAGGAAAAT

Downstream 100 bases:

>100_bases
ATCTTCGTTTTTACAACCAATTGATTTTGGAAAAGGCGGGTCCTCCCGCCTTTTTTATTGCCCTCTCCCTTTTTCCTGTC
GATACTTCCCTTAGGGATTT

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MTSATQATKRDPKLERIRNIGISAHIDSGKTTLTERILFYTNKIHAIHEVRGKDGVGATMDSMDLERERGITIQSAATYA
TWKDITINIIDTPGHVDFTIEVERSLRVLDSAIMVLCGVAGVQSQSITVDRQMKRYSVPRVAFINKLDRTGANPWRVIEQ
LREKLHLNAHAVQLPIGLENDLKGIVDLVEMKAYYFEGPNGQDIKITDIPDELKDQANEKREALLDAVSLFSDELTEEML
EGTPSEARVKEAIRRGVLALKFVPVFMGSAFKNKGVQRLLDGVADYLASPYDVENKAKEIGNEENEFNLESDPEKPLVCL
AFKLEDGRYGQLTYVRVYQGRLEKGMTIYNSSNNKRHNIGRLVRMHSNDMEDIAKAEAGDIVALFGIDCASGDTFTDGKA
KVTMESMFVPNPVISLTIECKESKQLPNLAKALNRFTKEDPTFQTEIDKESGQTIIKGMGELHLEVYIERMKREYGVDLV
TGAPQVAYRETITKAADFDYTHKKQTGGQGQFSRVAGFIEPIPQEEGKDYEFVDKIVGGSIPREYIGSCDKGFRSCLERG
SLIGFPIIGVRCVINDGAYHDVDSSDMAFQIGARYGFRQGFSKAAPIILEPIMRVEVEGPTEFQGAILASVNQRRGMILN
TTEENGYAKIEAEVPLADMFGYSTVLRSSTQGKAEFAMEFSKYAPVPRNVADELMKKYKVNNKDEE

Sequences:

>Translated_706_residues
MTSATQATKRDPKLERIRNIGISAHIDSGKTTLTERILFYTNKIHAIHEVRGKDGVGATMDSMDLERERGITIQSAATYA
TWKDITINIIDTPGHVDFTIEVERSLRVLDSAIMVLCGVAGVQSQSITVDRQMKRYSVPRVAFINKLDRTGANPWRVIEQ
LREKLHLNAHAVQLPIGLENDLKGIVDLVEMKAYYFEGPNGQDIKITDIPDELKDQANEKREALLDAVSLFSDELTEEML
EGTPSEARVKEAIRRGVLALKFVPVFMGSAFKNKGVQRLLDGVADYLASPYDVENKAKEIGNEENEFNLESDPEKPLVCL
AFKLEDGRYGQLTYVRVYQGRLEKGMTIYNSSNNKRHNIGRLVRMHSNDMEDIAKAEAGDIVALFGIDCASGDTFTDGKA
KVTMESMFVPNPVISLTIECKESKQLPNLAKALNRFTKEDPTFQTEIDKESGQTIIKGMGELHLEVYIERMKREYGVDLV
TGAPQVAYRETITKAADFDYTHKKQTGGQGQFSRVAGFIEPIPQEEGKDYEFVDKIVGGSIPREYIGSCDKGFRSCLERG
SLIGFPIIGVRCVINDGAYHDVDSSDMAFQIGARYGFRQGFSKAAPIILEPIMRVEVEGPTEFQGAILASVNQRRGMILN
TTEENGYAKIEAEVPLADMFGYSTVLRSSTQGKAEFAMEFSKYAPVPRNVADELMKKYKVNNKDEE
>Mature_705_residues
TSATQATKRDPKLERIRNIGISAHIDSGKTTLTERILFYTNKIHAIHEVRGKDGVGATMDSMDLERERGITIQSAATYAT
WKDITINIIDTPGHVDFTIEVERSLRVLDSAIMVLCGVAGVQSQSITVDRQMKRYSVPRVAFINKLDRTGANPWRVIEQL
REKLHLNAHAVQLPIGLENDLKGIVDLVEMKAYYFEGPNGQDIKITDIPDELKDQANEKREALLDAVSLFSDELTEEMLE
GTPSEARVKEAIRRGVLALKFVPVFMGSAFKNKGVQRLLDGVADYLASPYDVENKAKEIGNEENEFNLESDPEKPLVCLA
FKLEDGRYGQLTYVRVYQGRLEKGMTIYNSSNNKRHNIGRLVRMHSNDMEDIAKAEAGDIVALFGIDCASGDTFTDGKAK
VTMESMFVPNPVISLTIECKESKQLPNLAKALNRFTKEDPTFQTEIDKESGQTIIKGMGELHLEVYIERMKREYGVDLVT
GAPQVAYRETITKAADFDYTHKKQTGGQGQFSRVAGFIEPIPQEEGKDYEFVDKIVGGSIPREYIGSCDKGFRSCLERGS
LIGFPIIGVRCVINDGAYHDVDSSDMAFQIGARYGFRQGFSKAAPIILEPIMRVEVEGPTEFQGAILASVNQRRGMILNT
TEENGYAKIEAEVPLADMFGYSTVLRSSTQGKAEFAMEFSKYAPVPRNVADELMKKYKVNNKDEE

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=694, Percent_Identity=53.314121037464, Blast_Score=755, Evalue=0.0,
Organism=Homo sapiens, GI19923640, Length=718, Percent_Identity=36.3509749303621, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI25306283, Length=401, Percent_Identity=41.1471321695761, Blast_Score=260, Evalue=3e-69,
Organism=Homo sapiens, GI25306287, Length=294, Percent_Identity=46.2585034013605, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI4503483, Length=480, Percent_Identity=24.5833333333333, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI157426893, Length=195, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI94966754, Length=137, Percent_Identity=43.0656934306569, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI310132016, Length=113, Percent_Identity=42.4778761061947, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI310110807, Length=113, Percent_Identity=42.4778761061947, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI310123363, Length=113, Percent_Identity=42.4778761061947, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789738, Length=702, Percent_Identity=48.4330484330484, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI1790835, Length=489, Percent_Identity=26.9938650306748, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI48994988, Length=178, Percent_Identity=39.8876404494382, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1788922, Length=161, Percent_Identity=36.6459627329193, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17533571, Length=693, Percent_Identity=50.6493506493506, Blast_Score=705, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17556745, Length=725, Percent_Identity=28.4137931034483, Blast_Score=275, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI17506493, Length=479, Percent_Identity=25.678496868476, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17557151, Length=195, Percent_Identity=33.8461538461538, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=201, Percent_Identity=30.8457711442786, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71988811, Length=201, Percent_Identity=30.8457711442786, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323098, Length=694, Percent_Identity=54.6109510086455, Blast_Score=781, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322359, Length=783, Percent_Identity=29.6296296296296, Blast_Score=300, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6324707, Length=476, Percent_Identity=25.4201680672269, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320593, Length=476, Percent_Identity=25.4201680672269, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323320, Length=168, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324166, Length=155, Percent_Identity=33.5483870967742, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24582462, Length=704, Percent_Identity=53.9772727272727, Blast_Score=778, Evalue=0.0,
Organism=Drosophila melanogaster, GI221458488, Length=724, Percent_Identity=30.3867403314917, Blast_Score=301, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24585711, Length=821, Percent_Identity=24.9695493300853, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24585713, Length=821, Percent_Identity=24.9695493300853, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24585709, Length=821, Percent_Identity=24.9695493300853, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI78706572, Length=153, Percent_Identity=38.562091503268, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574573, Length=144, Percent_Identity=37.5, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 78809; Mature: 78677

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSATQATKRDPKLERIRNIGISAHIDSGKTTLTERILFYTNKIHAIHEVRGKDGVGATM
CCCCCCCCCCCCHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
DSMDLERERGITIQSAATYATWKDITINIIDTPGHVDFTIEVERSLRVLDSAIMVLCGVA
HHHCHHHHCCCEEECCCCEEEECCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHC
GVQSQSITVDRQMKRYSVPRVAFINKLDRTGANPWRVIEQLREKLHLNAHAVQLPIGLEN
CCCCCCEEHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCH
DLKGIVDLVEMKAYYFEGPNGQDIKITDIPDELKDQANEKREALLDAVSLFSDELTEEML
HHHHHHHHHHHHHHEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGTPSEARVKEAIRRGVLALKFVPVFMGSAFKNKGVQRLLDGVADYLASPYDVENKAKEI
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHC
GNEENEFNLESDPEKPLVCLAFKLEDGRYGQLTYVRVYQGRLEKGMTIYNSSNNKRHNIG
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHHCCEEEEECCCCCHHHHH
RLVRMHSNDMEDIAKAEAGDIVALFGIDCASGDTFTDGKAKVTMESMFVPNPVISLTIEC
HHHHHCCCCHHHHHHCCCCCEEEEEEEEECCCCCCCCCCEEEEEHHHCCCCCEEEEEEEE
KESKQLPNLAKALNRFTKEDPTFQTEIDKESGQTIIKGMGELHLEVYIERMKREYGVDLV
CCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEE
TGAPQVAYRETITKAADFDYTHKKQTGGQGQFSRVAGFIEPIPQEEGKDYEFVDKIVGGS
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCC
IPREYIGSCDKGFRSCLERGSLIGFPIIGVRCVINDGAYHDVDSSDMAFQIGARYGFRQG
CCHHHHCCHHHHHHHHHHCCCEECCCEEEEEEEEECCCCCCCCCCCCEEEECCHHHHHHC
FSKAAPIILEPIMRVEVEGPTEFQGAILASVNQRRGMILNTTEENGYAKIEAEVPLADMF
CCCCCCHHHCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCCHHHHH
GYSTVLRSSTQGKAEFAMEFSKYAPVPRNVADELMKKYKVNNKDEE
HHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TSATQATKRDPKLERIRNIGISAHIDSGKTTLTERILFYTNKIHAIHEVRGKDGVGATM
CCCCCCCCCCCHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
DSMDLERERGITIQSAATYATWKDITINIIDTPGHVDFTIEVERSLRVLDSAIMVLCGVA
HHHCHHHHCCCEEECCCCEEEECCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHC
GVQSQSITVDRQMKRYSVPRVAFINKLDRTGANPWRVIEQLREKLHLNAHAVQLPIGLEN
CCCCCCEEHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCH
DLKGIVDLVEMKAYYFEGPNGQDIKITDIPDELKDQANEKREALLDAVSLFSDELTEEML
HHHHHHHHHHHHHHEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGTPSEARVKEAIRRGVLALKFVPVFMGSAFKNKGVQRLLDGVADYLASPYDVENKAKEI
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHC
GNEENEFNLESDPEKPLVCLAFKLEDGRYGQLTYVRVYQGRLEKGMTIYNSSNNKRHNIG
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHHCCEEEEECCCCCHHHHH
RLVRMHSNDMEDIAKAEAGDIVALFGIDCASGDTFTDGKAKVTMESMFVPNPVISLTIEC
HHHHHCCCCHHHHHHCCCCCEEEEEEEEECCCCCCCCCCEEEEEHHHCCCCCEEEEEEEE
KESKQLPNLAKALNRFTKEDPTFQTEIDKESGQTIIKGMGELHLEVYIERMKREYGVDLV
CCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEE
TGAPQVAYRETITKAADFDYTHKKQTGGQGQFSRVAGFIEPIPQEEGKDYEFVDKIVGGS
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCC
IPREYIGSCDKGFRSCLERGSLIGFPIIGVRCVINDGAYHDVDSSDMAFQIGARYGFRQG
CCHHHHCCHHHHHHHHHHCCCEECCCEEEEEEEEECCCCCCCCCCCCEEEECCHHHHHHC
FSKAAPIILEPIMRVEVEGPTEFQGAILASVNQRRGMILNTTEENGYAKIEAEVPLADMF
CCCCCCHHHCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCCHHHHH
GYSTVLRSSTQGKAEFAMEFSKYAPVPRNVADELMKKYKVNNKDEE
HHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA