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The map label for this gene is etfA [H]

Identifier: 183220530

GI number: 183220530

Start: 1180091

End: 1181050

Strand: Reverse

Name: etfA [H]

Synonym: LEPBI_I1132

Alternate gene names: 183220530

Gene position: 1181050-1180091 (Counterclockwise)

Preceding gene: 183220531

Following gene: 183220529

Centisome position: 32.81

GC content: 44.17

Gene sequence:

>960_bases
ATGGCTGATGTTTTAGTAGTTGGTGAATTAAAAAACGGCGAACTTAAAAAAATCTCAAAAGAACTCACTTCGGCAGCTCG
CAAAATTGCGGATGCCATTGGTGGTAAAGTTCATACTCTCATCATCACTGACAACGTTGACGCGTTTGCTGGTGATTTAA
AAGCAGTTGGTGCGGATGCAGTGATTGGTGCAAACCTTGGTGAATTTTCACCAGAAGGTTATGCAAACGGAATTTTTGCC
GTGATCCAAGAGAAAAAACCGGCAGTGGTTCTTATGCCTCACTCTGCTCAAGGAAAAGAATACTCTGCAAGAGTGGCGAT
CAAAGCAAATGCTGGAATCGTTGCGGATGCAGTGGCTCTTTCTGTTGACGGTGGTAAAGTGGTAGCAAAAAAACCAATTT
ACTCTGGTAAAGCGTACGCAAACTTTAAAGTTTCTTCTGACATCCAAATGTTCACTGTGCGTGCAAACTCACAAGAAGTG
ACTCCAAAAGACGGAGCGGGTGCTGTTGAAAAATCAGGAGCTTCTGTTGGTGAAGTGAGAACAAAATCACTTTCCAAAGA
CCTTTCCGGTGGAAACAAAGTGCAATTAGCGGATGCTTCTATCATCGTATCTGGTGGTCGTGGAATCAAAGGACCAGAAA
ACTGGCCTATCATCCAAGACTTAGCAGACACACTTGGTGCTGCTCTTGGTGCTTCCCGTGCCACTGTAGATGCTGGATGG
ATTTCTCACTCACACCAAGTGGGTCAAACAGGGAAAACTGTCTCCCCTAACTGTTACATCGCTTGTGGAATTTCCGGAGC
GATCCAACACTTAGCGGGTATGGGATCTTCTAAATACATCGTTGCGATCAACAAAGACGGAGATGCTCCTATTTTCAAAG
TAGCAACTTACGGTGTTGTCGCTGATTTGTTTGAAGTGGTGCCTGCACTCACTTCTGAATTCAAAAAAGTATTGGGTTAA

Upstream 100 bases:

>100_bases
ATCGCTGGTCGAAAACTGGAAGCAGCAGATGCACAAGGTTTTGCATCTCAACTTGTAAAAGCTCTTCGCGAAGAAGCGAA
GGTCATCTAAGGAGACGAAC

Downstream 100 bases:

>100_bases
TTCCCAATACGAACCATCTCACTTTGAGGAATTTCCTTCTCAAAATCCAGATTGTTCTCCTTTTCTCTGTCCAAATGGGT
TCCCTTTGGGCAGAGGATGG

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MADVLVVGELKNGELKKISKELTSAARKIADAIGGKVHTLIITDNVDAFAGDLKAVGADAVIGANLGEFSPEGYANGIFA
VIQEKKPAVVLMPHSAQGKEYSARVAIKANAGIVADAVALSVDGGKVVAKKPIYSGKAYANFKVSSDIQMFTVRANSQEV
TPKDGAGAVEKSGASVGEVRTKSLSKDLSGGNKVQLADASIIVSGGRGIKGPENWPIIQDLADTLGAALGASRATVDAGW
ISHSHQVGQTGKTVSPNCYIACGISGAIQHLAGMGSSKYIVAINKDGDAPIFKVATYGVVADLFEVVPALTSEFKKVLG

Sequences:

>Translated_319_residues
MADVLVVGELKNGELKKISKELTSAARKIADAIGGKVHTLIITDNVDAFAGDLKAVGADAVIGANLGEFSPEGYANGIFA
VIQEKKPAVVLMPHSAQGKEYSARVAIKANAGIVADAVALSVDGGKVVAKKPIYSGKAYANFKVSSDIQMFTVRANSQEV
TPKDGAGAVEKSGASVGEVRTKSLSKDLSGGNKVQLADASIIVSGGRGIKGPENWPIIQDLADTLGAALGASRATVDAGW
ISHSHQVGQTGKTVSPNCYIACGISGAIQHLAGMGSSKYIVAINKDGDAPIFKVATYGVVADLFEVVPALTSEFKKVLG
>Mature_318_residues
ADVLVVGELKNGELKKISKELTSAARKIADAIGGKVHTLIITDNVDAFAGDLKAVGADAVIGANLGEFSPEGYANGIFAV
IQEKKPAVVLMPHSAQGKEYSARVAIKANAGIVADAVALSVDGGKVVAKKPIYSGKAYANFKVSSDIQMFTVRANSQEVT
PKDGAGAVEKSGASVGEVRTKSLSKDLSGGNKVQLADASIIVSGGRGIKGPENWPIIQDLADTLGAALGASRATVDAGWI
SHSHQVGQTGKTVSPNCYIACGISGAIQHLAGMGSSKYIVAINKDGDAPIFKVATYGVVADLFEVVPALTSEFKKVLG

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=317, Percent_Identity=40.6940063091483, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI189181759, Length=223, Percent_Identity=47.085201793722, Blast_Score=188, Evalue=5e-48,
Organism=Escherichia coli, GI1787990, Length=248, Percent_Identity=33.0645161290323, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786226, Length=297, Percent_Identity=31.6498316498317, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87082157, Length=240, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17506929, Length=318, Percent_Identity=40.5660377358491, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6325261, Length=193, Percent_Identity=39.8963730569948, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17136898, Length=316, Percent_Identity=40.8227848101266, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24652801, Length=316, Percent_Identity=40.8227848101266, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 32719; Mature: 32588

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVLVVGELKNGELKKISKELTSAARKIADAIGGKVHTLIITDNVDAFAGDLKAVGADA
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHCCHHHCCCCE
VIGANLGEFSPEGYANGIFAVIQEKKPAVVLMPHSAQGKEYSARVAIKANAGIVADAVAL
EEECCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEEEECCCEEEEEEEE
SVDGGKVVAKKPIYSGKAYANFKVSSDIQMFTVRANSQEVTPKDGAGAVEKSGASVGEVR
EECCCEEEEECCCCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCCCCHHHCCCCHHHHH
TKSLSKDLSGGNKVQLADASIIVSGGRGIKGPENWPIIQDLADTLGAALGASRATVDAGW
HHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHH
ISHSHQVGQTGKTVSPNCYIACGISGAIQHLAGMGSSKYIVAINKDGDAPIFKVATYGVV
CCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCEEEEEECCCCCCEEEHHHHHHH
ADLFEVVPALTSEFKKVLG
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADVLVVGELKNGELKKISKELTSAARKIADAIGGKVHTLIITDNVDAFAGDLKAVGADA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHCCHHHCCCCE
VIGANLGEFSPEGYANGIFAVIQEKKPAVVLMPHSAQGKEYSARVAIKANAGIVADAVAL
EEECCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEEEECCCEEEEEEEE
SVDGGKVVAKKPIYSGKAYANFKVSSDIQMFTVRANSQEVTPKDGAGAVEKSGASVGEVR
EECCCEEEEECCCCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCCCCHHHCCCCHHHHH
TKSLSKDLSGGNKVQLADASIIVSGGRGIKGPENWPIIQDLADTLGAALGASRATVDAGW
HHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHH
ISHSHQVGQTGKTVSPNCYIACGISGAIQHLAGMGSSKYIVAINKDGDAPIFKVATYGVV
CCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCEEEEEECCCCCCEEEHHHHHHH
ADLFEVVPALTSEFKKVLG
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]