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The map label for this gene is fabG6 [H]

Identifier: 183219975

GI number: 183219975

Start: 556255

End: 557697

Strand: Direct

Name: fabG6 [H]

Synonym: LEPBI_I0557

Alternate gene names: 183219975

Gene position: 556255-557697 (Clockwise)

Preceding gene: 183219973

Following gene: 183219976

Centisome position: 15.45

GC content: 41.58

Gene sequence:

>1443_bases
ATGAAGCCGATCCAAAAAATACTCATCGCCAATCGTGGTGAAATTGCTGTTCGAGTCATTCGCACTGCCAAAAAAATGGG
GATCAGAACAGTCGCTGTTTATTCTGATCCCGATTCTCAAAGTTTGTTCGTTTTAAGTGCTGATGAAGCGTATCCACTCG
GTGGAACCGATGCTCGTTCCTCGTATTTAAATGTAGATAAGGTGATTGAAGCCTGTTTGGCAACGGGTGCCGATGCAGTG
CACCCAGGTTATGGATTTTTATCAGAAAATACTGACTTCGCAAAAAAATTAGAACAACATGGAATTTCTTTTATCGGTCC
AAAACCTCATTCAATTGAGGCGATGGGTGACAAGATCGGCTCACGCATATTAGTTGCCAAAAGTGGTGTACCAGTTGTCC
CAGGTTACGAAGGGGAATCCCAAGAGATGTCTGTTTTCAAAAAAGAAGCGGATAAAATTGGATACCCGGTGATGGCAAAA
GCAAGTGCTGGTGGTGGTGGCAAAGGGATGCGACGTATCAATTCCTCTGACGAACTGGAAGCTGGCATTTTATCGGCAAA
ACGAGAAGCTATGTCAGCTTTTGGAGATGATCGAATTCTATTAGAAAAGTACATTGTGAACCCAAGGCATGTGGAATTTC
AAATCTTTGGTGACACACAAGGAAACATCATCCATTTGCATGAACGCGATTGTTCCTTACAAAGACGCCACCAAAAGGTA
GTGGAAGAAACACCCGCTCCCAATTTTCCATCTTCTTTGAAATCTAAGATGGCAGAAGCTGCTGTGATGGCAGGTAAAGC
CGTTCAATATGAAGGAGCTGGTACCGTAGAATTTATATTAGGTGAGAATGGTGAATTTTACTTTTTGGAGATGAACACTC
GATTACAAGTAGAACATCCTGTCACTGAAATGACAACGGGACTAGATTTGGTCGAATGGCAAATCCGAGTTTGCCAAGGG
GAACCTCTTCCGAACTTACAAACACCCAAACAAAATGGTCATGCCATCGAAGTGCGAATTTATGCCGAAGATCCAAAAGA
AGGATTTTTACCTTCCATCGGAAAAATCCATCATTTATCTTTTCCAACAAGAGAAGACCTACGAATTGATTCCGGTGTGG
TTACAGGTTCTGAAATTACAATGTATTACGATCCGATGATAGCAAAACTCATTGTATGGGGTGAAGATCGACAAACTGCA
ATTCAGCGACTCATCGAATGTTTATCAGAGACAATTGTGTTTGGTCCCAAAACCAATTTGCAGTTCTTACAAAAATTAGT
ATCCACTGACCAATTTGCAAAAGGAACTGTTTCGACTCACTTCATCGCAGATCATGAAGATTTACTATTAAAAGAGAATA
CGAAGGAAGAACTTAAATATGCCTTCGCAGGACTCTTTTTTTCCTCGAAACAAACCCTGGATCCTTGGAGCCCAATTAGG
TAA

Upstream 100 bases:

>100_bases
ACCATAAAAAAAAGAATTGGTTAGTCTTTGGGATGGTCAATTCACTTACGATCTTTCAGTTGATTTATTTTCGCTATTCT
CCAATTTTGAACCTACTCAC

Downstream 100 bases:

>100_bases
TCAGATATGGATTTTTTATTCGAAACAAAATCAAAACCTGCCTCGGTCCACGTGAATGGAAATACCATTCGCGTACGATT
GGACAATGAATCCTTTTCTT

Product: biotin carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase A [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MKPIQKILIANRGEIAVRVIRTAKKMGIRTVAVYSDPDSQSLFVLSADEAYPLGGTDARSSYLNVDKVIEACLATGADAV
HPGYGFLSENTDFAKKLEQHGISFIGPKPHSIEAMGDKIGSRILVAKSGVPVVPGYEGESQEMSVFKKEADKIGYPVMAK
ASAGGGGKGMRRINSSDELEAGILSAKREAMSAFGDDRILLEKYIVNPRHVEFQIFGDTQGNIIHLHERDCSLQRRHQKV
VEETPAPNFPSSLKSKMAEAAVMAGKAVQYEGAGTVEFILGENGEFYFLEMNTRLQVEHPVTEMTTGLDLVEWQIRVCQG
EPLPNLQTPKQNGHAIEVRIYAEDPKEGFLPSIGKIHHLSFPTREDLRIDSGVVTGSEITMYYDPMIAKLIVWGEDRQTA
IQRLIECLSETIVFGPKTNLQFLQKLVSTDQFAKGTVSTHFIADHEDLLLKENTKEELKYAFAGLFFSSKQTLDPWSPIR

Sequences:

>Translated_480_residues
MKPIQKILIANRGEIAVRVIRTAKKMGIRTVAVYSDPDSQSLFVLSADEAYPLGGTDARSSYLNVDKVIEACLATGADAV
HPGYGFLSENTDFAKKLEQHGISFIGPKPHSIEAMGDKIGSRILVAKSGVPVVPGYEGESQEMSVFKKEADKIGYPVMAK
ASAGGGGKGMRRINSSDELEAGILSAKREAMSAFGDDRILLEKYIVNPRHVEFQIFGDTQGNIIHLHERDCSLQRRHQKV
VEETPAPNFPSSLKSKMAEAAVMAGKAVQYEGAGTVEFILGENGEFYFLEMNTRLQVEHPVTEMTTGLDLVEWQIRVCQG
EPLPNLQTPKQNGHAIEVRIYAEDPKEGFLPSIGKIHHLSFPTREDLRIDSGVVTGSEITMYYDPMIAKLIVWGEDRQTA
IQRLIECLSETIVFGPKTNLQFLQKLVSTDQFAKGTVSTHFIADHEDLLLKENTKEELKYAFAGLFFSSKQTLDPWSPIR
>Mature_480_residues
MKPIQKILIANRGEIAVRVIRTAKKMGIRTVAVYSDPDSQSLFVLSADEAYPLGGTDARSSYLNVDKVIEACLATGADAV
HPGYGFLSENTDFAKKLEQHGISFIGPKPHSIEAMGDKIGSRILVAKSGVPVVPGYEGESQEMSVFKKEADKIGYPVMAK
ASAGGGGKGMRRINSSDELEAGILSAKREAMSAFGDDRILLEKYIVNPRHVEFQIFGDTQGNIIHLHERDCSLQRRHQKV
VEETPAPNFPSSLKSKMAEAAVMAGKAVQYEGAGTVEFILGENGEFYFLEMNTRLQVEHPVTEMTTGLDLVEWQIRVCQG
EPLPNLQTPKQNGHAIEVRIYAEDPKEGFLPSIGKIHHLSFPTREDLRIDSGVVTGSEITMYYDPMIAKLIVWGEDRQTA
IQRLIECLSETIVFGPKTNLQFLQKLVSTDQFAKGTVSTHFIADHEDLLLKENTKEELKYAFAGLFFSSKQTLDPWSPIR

Specific function: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=481, Percent_Identity=51.5592515592516, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI189095269, Length=476, Percent_Identity=48.9495798319328, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI65506442, Length=475, Percent_Identity=49.0526315789474, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=475, Percent_Identity=49.0526315789474, Blast_Score=441, Evalue=1e-123,
Organism=Homo sapiens, GI106049528, Length=454, Percent_Identity=43.8325991189427, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=454, Percent_Identity=43.8325991189427, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=454, Percent_Identity=43.8325991189427, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI38679974, Length=517, Percent_Identity=31.7214700193424, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI38679960, Length=517, Percent_Identity=31.7214700193424, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI38679977, Length=517, Percent_Identity=31.7214700193424, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI38679967, Length=517, Percent_Identity=31.7214700193424, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI38679971, Length=517, Percent_Identity=31.7214700193424, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI134142062, Length=516, Percent_Identity=31.3953488372093, Blast_Score=253, Evalue=4e-67,
Organism=Escherichia coli, GI1789654, Length=441, Percent_Identity=48.5260770975057, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71987519, Length=455, Percent_Identity=54.0659340659341, Blast_Score=493, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=51.0204081632653, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17562816, Length=457, Percent_Identity=41.7943107221007, Blast_Score=355, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=30.9664694280079, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71997168, Length=507, Percent_Identity=30.9664694280079, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI133931226, Length=487, Percent_Identity=30.5954825462012, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=48.0812641083521, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319695, Length=472, Percent_Identity=38.3474576271186, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6321376, Length=453, Percent_Identity=39.7350993377483, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6324343, Length=524, Percent_Identity=31.4885496183206, Blast_Score=249, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6323863, Length=472, Percent_Identity=32.4152542372881, Blast_Score=247, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6322331, Length=311, Percent_Identity=21.8649517684887, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24651757, Length=453, Percent_Identity=50.9933774834437, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=49.3857493857494, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI281363050, Length=454, Percent_Identity=43.8325991189427, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=454, Percent_Identity=43.8325991189427, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=454, Percent_Identity=43.8325991189427, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=454, Percent_Identity=43.8325991189427, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=454, Percent_Identity=43.8325991189427, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=454, Percent_Identity=43.8325991189427, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652210, Length=454, Percent_Identity=43.8325991189427, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652214, Length=454, Percent_Identity=43.8325991189427, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19921944, Length=454, Percent_Identity=43.8325991189427, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652216, Length=454, Percent_Identity=43.8325991189427, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24586458, Length=527, Percent_Identity=31.4990512333966, Blast_Score=261, Evalue=6e-70,
Organism=Drosophila melanogaster, GI161076407, Length=527, Percent_Identity=31.4990512333966, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI24586460, Length=527, Percent_Identity=31.4990512333966, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI161076409, Length=527, Percent_Identity=31.4990512333966, Blast_Score=261, Evalue=7e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 53089; Mature: 53089

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIQKILIANRGEIAVRVIRTAKKMGIRTVAVYSDPDSQSLFVLSADEAYPLGGTDARS
CCHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCHH
SYLNVDKVIEACLATGADAVHPGYGFLSENTDFAKKLEQHGISFIGPKPHSIEAMGDKIG
HHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCHHHHHHHCC
SRILVAKSGVPVVPGYEGESQEMSVFKKEADKIGYPVMAKASAGGGGKGMRRINSSDELE
CEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHCCCCCHHH
AGILSAKREAMSAFGDDRILLEKYIVNPRHVEFQIFGDTQGNIIHLHERDCSLQRRHQKV
HHHHHHHHHHHHHCCCCCEEHHHHCCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHH
VEETPAPNFPSSLKSKMAEAAVMAGKAVQYEGAGTVEFILGENGEFYFLEMNTRLQVEHP
HHHCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCCEEEEEECCEEEECCC
VTEMTTGLDLVEWQIRVCQGEPLPNLQTPKQNGHAIEVRIYAEDPKEGFLPSIGKIHHLS
HHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEECC
FPTREDLRIDSGVVTGSEITMYYDPMIAKLIVWGEDRQTAIQRLIECLSETIVFGPKTNL
CCCCCCCEECCCEEECCEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHEEECCCCCH
QFLQKLVSTDQFAKGTVSTHFIADHEDLLLKENTKEELKYAFAGLFFSSKQTLDPWSPIR
HHHHHHHCCCHHCCCCCEEEEEECCCHHEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKPIQKILIANRGEIAVRVIRTAKKMGIRTVAVYSDPDSQSLFVLSADEAYPLGGTDARS
CCHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCHH
SYLNVDKVIEACLATGADAVHPGYGFLSENTDFAKKLEQHGISFIGPKPHSIEAMGDKIG
HHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCHHHHHHHCC
SRILVAKSGVPVVPGYEGESQEMSVFKKEADKIGYPVMAKASAGGGGKGMRRINSSDELE
CEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHCCCCCHHH
AGILSAKREAMSAFGDDRILLEKYIVNPRHVEFQIFGDTQGNIIHLHERDCSLQRRHQKV
HHHHHHHHHHHHHCCCCCEEHHHHCCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHH
VEETPAPNFPSSLKSKMAEAAVMAGKAVQYEGAGTVEFILGENGEFYFLEMNTRLQVEHP
HHHCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCCEEEEEECCEEEECCC
VTEMTTGLDLVEWQIRVCQGEPLPNLQTPKQNGHAIEVRIYAEDPKEGFLPSIGKIHHLS
HHHHHCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEECC
FPTREDLRIDSGVVTGSEITMYYDPMIAKLIVWGEDRQTAIQRLIECLSETIVFGPKTNL
CCCCCCCEECCCEEECCEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHEEECCCCCH
QFLQKLVSTDQFAKGTVSTHFIADHEDLLLKENTKEELKYAFAGLFFSSKQTLDPWSPIR
HHHHHHHCCCHHCCCCCEEEEEECCCHHEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463; 9478969 [H]