| Definition | Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_010602 |
| Length | 3,599,677 |
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The map label for this gene is pbpC [H]
Identifier: 183219952
GI number: 183219952
Start: 529657
End: 531774
Strand: Direct
Name: pbpC [H]
Synonym: LEPBI_I0534
Alternate gene names: 183219952
Gene position: 529657-531774 (Clockwise)
Preceding gene: 183219951
Following gene: 183219953
Centisome position: 14.71
GC content: 39.85
Gene sequence:
>2118_bases TTGATTCCAATCCAAAATCGATTTTCTATCGTTTTCGATTGGAAACGTTTACTTTGTTTATTTTACGTATTTCTTTTTCC AACAATCCTTTTTGCTTTTCCCACTTACAAGGAAGTGAAATCAAACTACTTACCTTCCGATATTCGTTTTTATGATCGAG AGGGGGAACTCATCCAAAGGCTTCGGGTACGAAAAGAGTATCGGTCGGAAGAATGGGTTGAGTACAAAGAGTTTCCCAAA TTTCTAATTGATGCTGTTGTGCATGCGGAAGACAAACGGTTCTTTGAACACAACGGTGTGGATGGCAATGCCATCGTCGC CTCTTTTTGGAACAGTTTGAAAGGTTCTGCTCTTCGTGGTGGATCGACGATCACCATGCAACTGGTCACAATCCTTGATC CCGAGTTACAACCAAAACCAAAGGAGCGAAAGTCAATCTTCCAGAAGATCAAACAAATACATCGGGCCACTGAGTTAGAA TCGTCATGGTCGAAGGAAGAAATTTTTACAGCTTATCTGAACTTAATTTATTTTCGAGGGGAACTGAGAGGGATCGCTTC CGCCACAAAAGGATTATTCCATAAATCCGTGAGTTCCATCACACCCAATGAAGCCTATTTACTTGCCGCCCTCATTCGTT CTCCCCAGAGCTCCATTCAAAAAATATCGAAACGCGTGTGTTTACTCAAATTCGACAAGGATGGCGATTCGTTTGATTGT GAAGACATCTCTCGTTTTGTGCGAGAGGTTTTGTTACGGAATTTGAATTACCCACAGCAACCGTCAATCGTGCCTTTATT TGCAAAATCAATTTTAGAATTAGGTGAGTATGGTCCTAACTATCATTTAACAATTGATACATCTATTTCCATTTCATATC AAAAAAAAGTAGAGGAAATATTAAAACGAAATATCAAAACGTTAGAAAATCGAAACGTGAAAGACGGAGCCGTTGTGGTA TTGGAAAACAAAACCGGACATGTACTCGTTTATGTTTCCAATATCGGAAAAGAGAGTTCCGTTTCACAATTAGATCTGAT TCGAACCAAACGACAAGTAGGGTCCACTCTCAAACCATTCGTGTATGCGATGAATTTCCAACAAAAGAAACTCACACCGA GTTCGATCCTTTCCGATTCACCAATTGGTATTTCTGTTTACCAAGGCATCTATCGACCCTTAAATTATGATAAATCTTAC AAGGGTAATGTCACCGTTCGGGAAAGTTTAGCATCCTCACTCAATATCCCTGCTATCAGGGCTTTATCATTTTTAGATGT GAACGAATTTGTATCCTTATTAGAAGATCTAGGAATCCAAGGTCTGTTGTATCCCGAATATTATGGACCTTCATTGGCAC TTGGGGCCGCGGACATTAGTTTATTAGAACTTACCAATGCATATCGCATGTTTGCCAATGGTGGAATCTACTCAAAAATC CAATGGAGGAAAGACAAAGGAAACCAGATCCAGACTGTCATTTTTTCTCCCGAGGTCAGTTATATGATTTCAGATATACT ATCAGACCGCGAAGCAAGGTCATTGGGATTTGGTTGGGATAATTTTTTATCCACTTCGTATTATACAGCAGTCAAAACAG GGACAAGCCAAGACATGAGAGACAATTGGTGTATTGGTTATTCCGAACATTATACAGTGGGAGTGTGGGTAGGCAATCCG ACTGGAAGTCCTATGTTAGATGTCTCAGGGATCACTGGTGCTGCGCCTGTTTGGCGAGAAACCATGGATTTGTTGCATGA ATCGCTTGGTTCCAAGTTGAAACCTTTGGAGAAGGGGGCTTTCAAGGATGAGGAAGTACCAAATCTTGAAGTGGAAACTT CGAATCAAAACAGTTTCGAAAAAACCAAATCGTTTCGAATTTTGACTCCCGTGAGTGGAAGTATTTTCGCATTGGATCCA GATATTCCGAATGGTAGACAAAAAATCCTCTTTACAATCAGTTCCTACGATGTTTCGTATTCTTATCATTTAAACGATTT ATTTTTAGCGAGAGCAAGTGAACCGTATCTCTGGGAACCAAAAAAAGGGGAATATCGTTTGGAAATCAAAGACAAAGACA ACAAAGTAGTTTCTTTCTCTTTATTCGAAGTTCGATAA
Upstream 100 bases:
>100_bases GGAAGCCATTTGATTATCGAAACAGGTTATGAGTCAAAAGAAATTTTGCCAGAATGAGACCATTCATTCTTCCCTACACA TAGAATTTGTTTCGTTCGTA
Downstream 100 bases:
>100_bases TACAAATGTCAAAACCATCTAAATACAAACACAAATTCATCCAACAAGTTGTCTGGGGAGAGATGGATGCTTTTGGTCAT GTCAATAATGTAACATATGT
Product: penicillin-binding protein
Products: NA
Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]
Number of amino acids: Translated: 705; Mature: 705
Protein sequence:
>705_residues MIPIQNRFSIVFDWKRLLCLFYVFLFPTILFAFPTYKEVKSNYLPSDIRFYDREGELIQRLRVRKEYRSEEWVEYKEFPK FLIDAVVHAEDKRFFEHNGVDGNAIVASFWNSLKGSALRGGSTITMQLVTILDPELQPKPKERKSIFQKIKQIHRATELE SSWSKEEIFTAYLNLIYFRGELRGIASATKGLFHKSVSSITPNEAYLLAALIRSPQSSIQKISKRVCLLKFDKDGDSFDC EDISRFVREVLLRNLNYPQQPSIVPLFAKSILELGEYGPNYHLTIDTSISISYQKKVEEILKRNIKTLENRNVKDGAVVV LENKTGHVLVYVSNIGKESSVSQLDLIRTKRQVGSTLKPFVYAMNFQQKKLTPSSILSDSPIGISVYQGIYRPLNYDKSY KGNVTVRESLASSLNIPAIRALSFLDVNEFVSLLEDLGIQGLLYPEYYGPSLALGAADISLLELTNAYRMFANGGIYSKI QWRKDKGNQIQTVIFSPEVSYMISDILSDREARSLGFGWDNFLSTSYYTAVKTGTSQDMRDNWCIGYSEHYTVGVWVGNP TGSPMLDVSGITGAAPVWRETMDLLHESLGSKLKPLEKGAFKDEEVPNLEVETSNQNSFEKTKSFRILTPVSGSIFALDP DIPNGRQKILFTISSYDVSYSYHLNDLFLARASEPYLWEPKKGEYRLEIKDKDNKVVSFSLFEVR
Sequences:
>Translated_705_residues MIPIQNRFSIVFDWKRLLCLFYVFLFPTILFAFPTYKEVKSNYLPSDIRFYDREGELIQRLRVRKEYRSEEWVEYKEFPK FLIDAVVHAEDKRFFEHNGVDGNAIVASFWNSLKGSALRGGSTITMQLVTILDPELQPKPKERKSIFQKIKQIHRATELE SSWSKEEIFTAYLNLIYFRGELRGIASATKGLFHKSVSSITPNEAYLLAALIRSPQSSIQKISKRVCLLKFDKDGDSFDC EDISRFVREVLLRNLNYPQQPSIVPLFAKSILELGEYGPNYHLTIDTSISISYQKKVEEILKRNIKTLENRNVKDGAVVV LENKTGHVLVYVSNIGKESSVSQLDLIRTKRQVGSTLKPFVYAMNFQQKKLTPSSILSDSPIGISVYQGIYRPLNYDKSY KGNVTVRESLASSLNIPAIRALSFLDVNEFVSLLEDLGIQGLLYPEYYGPSLALGAADISLLELTNAYRMFANGGIYSKI QWRKDKGNQIQTVIFSPEVSYMISDILSDREARSLGFGWDNFLSTSYYTAVKTGTSQDMRDNWCIGYSEHYTVGVWVGNP TGSPMLDVSGITGAAPVWRETMDLLHESLGSKLKPLEKGAFKDEEVPNLEVETSNQNSFEKTKSFRILTPVSGSIFALDP DIPNGRQKILFTISSYDVSYSYHLNDLFLARASEPYLWEPKKGEYRLEIKDKDNKVVSFSLFEVR >Mature_705_residues MIPIQNRFSIVFDWKRLLCLFYVFLFPTILFAFPTYKEVKSNYLPSDIRFYDREGELIQRLRVRKEYRSEEWVEYKEFPK FLIDAVVHAEDKRFFEHNGVDGNAIVASFWNSLKGSALRGGSTITMQLVTILDPELQPKPKERKSIFQKIKQIHRATELE SSWSKEEIFTAYLNLIYFRGELRGIASATKGLFHKSVSSITPNEAYLLAALIRSPQSSIQKISKRVCLLKFDKDGDSFDC EDISRFVREVLLRNLNYPQQPSIVPLFAKSILELGEYGPNYHLTIDTSISISYQKKVEEILKRNIKTLENRNVKDGAVVV LENKTGHVLVYVSNIGKESSVSQLDLIRTKRQVGSTLKPFVYAMNFQQKKLTPSSILSDSPIGISVYQGIYRPLNYDKSY KGNVTVRESLASSLNIPAIRALSFLDVNEFVSLLEDLGIQGLLYPEYYGPSLALGAADISLLELTNAYRMFANGGIYSKI QWRKDKGNQIQTVIFSPEVSYMISDILSDREARSLGFGWDNFLSTSYYTAVKTGTSQDMRDNWCIGYSEHYTVGVWVGNP TGSPMLDVSGITGAAPVWRETMDLLHESLGSKLKPLEKGAFKDEEVPNLEVETSNQNSFEKTKSFRILTPVSGSIFALDP DIPNGRQKILFTISSYDVSYSYHLNDLFLARASEPYLWEPKKGEYRLEIKDKDNKVVSFSLFEVR
Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]
COG id: COG4953
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1788867, Length=524, Percent_Identity=29.7709923664122, Blast_Score=219, Evalue=4e-58, Organism=Escherichia coli, GI1786343, Length=550, Percent_Identity=23.0909090909091, Blast_Score=110, Evalue=5e-25, Organism=Escherichia coli, GI87082258, Length=303, Percent_Identity=25.4125412541254, Blast_Score=89, Evalue=9e-19, Organism=Escherichia coli, GI1789601, Length=146, Percent_Identity=32.1917808219178, Blast_Score=67, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011815 - InterPro: IPR009647 - InterPro: IPR001460 [H]
Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-
Molecular weight: Translated: 80382; Mature: 80382
Theoretical pI: Translated: 8.60; Mature: 8.60
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.7 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIPIQNRFSIVFDWKRLLCLFYVFLFPTILFAFPTYKEVKSNYLPSDIRFYDREGELIQR CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEECCCHHHHHH LRVRKEYRSEEWVEYKEFPKFLIDAVVHAEDKRFFEHNGVDGNAIVASFWNSLKGSALRG HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC GSTITMQLVTILDPELQPKPKERKSIFQKIKQIHRATELESSWSKEEIFTAYLNLIYFRG CCEEEEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH ELRGIASATKGLFHKSVSSITPNEAYLLAALIRSPQSSIQKISKRVCLLKFDKDGDSFDC HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHCEEEEEECCCCCCCCH EDISRFVREVLLRNLNYPQQPSIVPLFAKSILELGEYGPNYHLTIDTSISISYQKKVEEI HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECEEEEHHHHHHHHH LKRNIKTLENRNVKDGAVVVLENKTGHVLVYVSNIGKESSVSQLDLIRTKRQVGSTLKPF HHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHH VYAMNFQQKKLTPSSILSDSPIGISVYQGIYRPLNYDKSYKGNVTVRESLASSLNIPAIR HEEECCCHHCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHCCCCHHH ALSFLDVNEFVSLLEDLGIQGLLYPEYYGPSLALGAADISLLELTNAYRMFANGGIYSKI HHHHCCHHHHHHHHHHCCCCEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEEE QWRKDKGNQIQTVIFSPEVSYMISDILSDREARSLGFGWDNFLSTSYYTAVKTGTSQDMR EEECCCCCEEEEEEECCCHHHHHHHHHCCCHHHHCCCCHHHHHCCCEEEEEECCCCCCCC DNWCIGYSEHYTVGVWVGNPTGSPMLDVSGITGAAPVWRETMDLLHESLGSKLKPLEKGA CCEEECCCCCEEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCC FKDEEVPNLEVETSNQNSFEKTKSFRILTPVSGSIFALDPDIPNGRQKILFTISSYDVSY CCCCCCCCCEEECCCCCCHHHHCCEEEEECCCCCEEEECCCCCCCCEEEEEEEECCEEEE SYHLNDLFLARASEPYLWEPKKGEYRLEIKDKDNKVVSFSLFEVR EEECCEEEEEECCCCCEECCCCCCEEEEEECCCCEEEEEEEEEEC >Mature Secondary Structure MIPIQNRFSIVFDWKRLLCLFYVFLFPTILFAFPTYKEVKSNYLPSDIRFYDREGELIQR CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEECCCHHHHHH LRVRKEYRSEEWVEYKEFPKFLIDAVVHAEDKRFFEHNGVDGNAIVASFWNSLKGSALRG HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC GSTITMQLVTILDPELQPKPKERKSIFQKIKQIHRATELESSWSKEEIFTAYLNLIYFRG CCEEEEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH ELRGIASATKGLFHKSVSSITPNEAYLLAALIRSPQSSIQKISKRVCLLKFDKDGDSFDC HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHCEEEEEECCCCCCCCH EDISRFVREVLLRNLNYPQQPSIVPLFAKSILELGEYGPNYHLTIDTSISISYQKKVEEI HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECEEEEHHHHHHHHH LKRNIKTLENRNVKDGAVVVLENKTGHVLVYVSNIGKESSVSQLDLIRTKRQVGSTLKPF HHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHH VYAMNFQQKKLTPSSILSDSPIGISVYQGIYRPLNYDKSYKGNVTVRESLASSLNIPAIR HEEECCCHHCCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHCCCCHHH ALSFLDVNEFVSLLEDLGIQGLLYPEYYGPSLALGAADISLLELTNAYRMFANGGIYSKI HHHHCCHHHHHHHHHHCCCCEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEEE QWRKDKGNQIQTVIFSPEVSYMISDILSDREARSLGFGWDNFLSTSYYTAVKTGTSQDMR EEECCCCCEEEEEEECCCHHHHHHHHHCCCHHHHCCCCHHHHHCCCEEEEEECCCCCCCC DNWCIGYSEHYTVGVWVGNPTGSPMLDVSGITGAAPVWRETMDLLHESLGSKLKPLEKGA CCEEECCCCCEEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCC FKDEEVPNLEVETSNQNSFEKTKSFRILTPVSGSIFALDPDIPNGRQKILFTISSYDVSY CCCCCCCCCEEECCCCCCHHHHCCEEEEECCCCCEEEECCCCCCCCEEEEEEEECCEEEE SYHLNDLFLARASEPYLWEPKKGEYRLEIKDKDNKVVSFSLFEVR EEECCEEEEEECCCCCEECCCCCCEEEEEECCCCEEEEEEEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10542235; 9205837; 9278503; 9841666 [H]