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The map label for this gene is yngE [H]

Identifier: 183219938

GI number: 183219938

Start: 519107

End: 520708

Strand: Direct

Name: yngE [H]

Synonym: LEPBI_I0520

Alternate gene names: 183219938

Gene position: 519107-520708 (Clockwise)

Preceding gene: 183219937

Following gene: 183219939

Centisome position: 14.42

GC content: 41.57

Gene sequence:

>1602_bases
ATGGAAAGGCTGATCTCAAAAATAAACCCGTTATCATCTGATTTTATTTCAAATCGAACTACATACTTAGAAACTCTTGT
TCCCATACGAAAAACCATCGAAAAAGTTAAGTTAGGTGGTGGCAAAAAGGCCTTGGAAAAACATAAGTCGCGAGGCAAAC
TCACTGCAAGGGAACGAATTGCAGAACTCATCGATTCCAATACAGAATTTATGGAAATCTGTGGACTTGCCGCAGAAGGT
GTGTACAACGATCCAGTGCCATCCGCCGGTATCATCACAGGAATTGGAAAAGTGGAAGGTGTTGACTGTATGATTGTTGC
CAATGATGCAACAGTCAAAGGTGGAACGTATTATCCATTGACCGTCAAAAAACATGTTCGTGCTCAAGAGATCGCCGAAA
ACAATTCACTCCCTTGTGTTTATTTAGTGGATTCTGGTGGAGCATTTTTGCCCATGCAAGACGAAGTTTTTCCTGACAAA
GATCATTTTGGTAGGATCTTTTTTAACCAAGCTCGGATGAGTGCAAAAGGAATTTCTCAAATAGCGGTTGTTATGGGTTC
TTGCACTGCGGGTGGTGCTTATATCCCTGCTATGTCTGACGAATCCGTGATTGTAAAGGGGAATGGGACAATTTTTCTTG
GAGGACCACCTCTAGTCAAAGCGGCTACAGGAGAAGTTGTCACTGGTGAAGAGTTAGGTGGCGCAGATGTTCATTGCCGT
ATTTCGGGTGTCACTGATCATTATGCAGAAGACGATTACCATGCTTTGGAAATTACAAGATCCATTATCAAAAATTTAAA
TGTAAAAAATTTCACAACTCCAAAAGAAACTGAAGATCCTTTATATCCAACAGAAGAAATTTATGGAATCATCGAAAGAG
ATTCTCGTAAATCCTATGATCCAAGAGAGATCATCGCAAGGTTAGTGGATGGTTCTAGGTTTCATGAATTTAAAAAACTA
TATGCCACGACGATCGTAACGGGGTTTGCCGAAATTTATGGTCACCCCGTCGGCATTATCGCCAATCATGGGGTTTTGTT
TTCAGAGTCGGCTCTGAAAGCTTCACACTTTATAGAACTCTGTGACCAAAGGCGAATCCCTTTGCTTTTCCTCCAAAACA
TCACTGGTTTTATGGTTGGGAAAAAATATGAAAACAATGGGATTGCCCGTGATGGTGCCAAAATGGTCAATGCGGTCTCA
ACAACGACTGTCCCCAAACTAACCATTGTTACGGGAGGATCTTATGGGGCTGGTAATTATGGAATGTGTGGTCGTGCCTT
TGCTCCCGAATTTTTATGGATGTGGCCAAATGCTCGGATCTCTGTTATGGGTGGAGAACAAGCTGCCAATGTTTTATGGA
CGGTAAAAAAAGACCAAAAAGAAGCCCAAGGGGAAACCATTTTACCTGATGAAGAAACAACTTTCAAAAAACCAATTTTA
GATGATTATGAAAAAAAATCCTCTGCTGTGTATAGCTCCGCTCGGCTTTGGGATGATGGAATCATAGACCCGGCAGACAC
TCGCAATATTTTAGGAAGGGCATTGTCCATCCTCAGTAGAAGGAAAGAAGAAAGAAAACCGTTCGGTGTCTTTCGAATGT
AA

Upstream 100 bases:

>100_bases
TGCCCAACCGTTGTTTATGAAAAACTACATTATTTTGTAGATAGTTTTTCTCACAAAAAAACCAAAACATTCCACTTTAA
CAAACAAAATAAGGACTAGT

Downstream 100 bases:

>100_bases
TTTTTTTCCTTTTCATTTCTTTTTATGGTGCAAACTTAAATCAAATGGTCATTCGCGAAACGTCTTCGAATCAGGTAGTT
GTCATCACCATTGAAGGTGA

Product: acetyl-coenzyme A carboxyltransferase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MERLISKINPLSSDFISNRTTYLETLVPIRKTIEKVKLGGGKKALEKHKSRGKLTARERIAELIDSNTEFMEICGLAAEG
VYNDPVPSAGIITGIGKVEGVDCMIVANDATVKGGTYYPLTVKKHVRAQEIAENNSLPCVYLVDSGGAFLPMQDEVFPDK
DHFGRIFFNQARMSAKGISQIAVVMGSCTAGGAYIPAMSDESVIVKGNGTIFLGGPPLVKAATGEVVTGEELGGADVHCR
ISGVTDHYAEDDYHALEITRSIIKNLNVKNFTTPKETEDPLYPTEEIYGIIERDSRKSYDPREIIARLVDGSRFHEFKKL
YATTIVTGFAEIYGHPVGIIANHGVLFSESALKASHFIELCDQRRIPLLFLQNITGFMVGKKYENNGIARDGAKMVNAVS
TTTVPKLTIVTGGSYGAGNYGMCGRAFAPEFLWMWPNARISVMGGEQAANVLWTVKKDQKEAQGETILPDEETTFKKPIL
DDYEKKSSAVYSSARLWDDGIIDPADTRNILGRALSILSRRKEERKPFGVFRM

Sequences:

>Translated_533_residues
MERLISKINPLSSDFISNRTTYLETLVPIRKTIEKVKLGGGKKALEKHKSRGKLTARERIAELIDSNTEFMEICGLAAEG
VYNDPVPSAGIITGIGKVEGVDCMIVANDATVKGGTYYPLTVKKHVRAQEIAENNSLPCVYLVDSGGAFLPMQDEVFPDK
DHFGRIFFNQARMSAKGISQIAVVMGSCTAGGAYIPAMSDESVIVKGNGTIFLGGPPLVKAATGEVVTGEELGGADVHCR
ISGVTDHYAEDDYHALEITRSIIKNLNVKNFTTPKETEDPLYPTEEIYGIIERDSRKSYDPREIIARLVDGSRFHEFKKL
YATTIVTGFAEIYGHPVGIIANHGVLFSESALKASHFIELCDQRRIPLLFLQNITGFMVGKKYENNGIARDGAKMVNAVS
TTTVPKLTIVTGGSYGAGNYGMCGRAFAPEFLWMWPNARISVMGGEQAANVLWTVKKDQKEAQGETILPDEETTFKKPIL
DDYEKKSSAVYSSARLWDDGIIDPADTRNILGRALSILSRRKEERKPFGVFRM
>Mature_533_residues
MERLISKINPLSSDFISNRTTYLETLVPIRKTIEKVKLGGGKKALEKHKSRGKLTARERIAELIDSNTEFMEICGLAAEG
VYNDPVPSAGIITGIGKVEGVDCMIVANDATVKGGTYYPLTVKKHVRAQEIAENNSLPCVYLVDSGGAFLPMQDEVFPDK
DHFGRIFFNQARMSAKGISQIAVVMGSCTAGGAYIPAMSDESVIVKGNGTIFLGGPPLVKAATGEVVTGEELGGADVHCR
ISGVTDHYAEDDYHALEITRSIIKNLNVKNFTTPKETEDPLYPTEEIYGIIERDSRKSYDPREIIARLVDGSRFHEFKKL
YATTIVTGFAEIYGHPVGIIANHGVLFSESALKASHFIELCDQRRIPLLFLQNITGFMVGKKYENNGIARDGAKMVNAVS
TTTVPKLTIVTGGSYGAGNYGMCGRAFAPEFLWMWPNARISVMGGEQAANVLWTVKKDQKEAQGETILPDEETTFKKPIL
DDYEKKSSAVYSSARLWDDGIIDPADTRNILGRALSILSRRKEERKPFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=527, Percent_Identity=60.9108159392789, Blast_Score=664, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=542, Percent_Identity=31.7343173431734, Blast_Score=235, Evalue=9e-62,
Organism=Homo sapiens, GI295821216, Length=562, Percent_Identity=30.7829181494662, Blast_Score=225, Evalue=8e-59,
Organism=Homo sapiens, GI310133460, Length=118, Percent_Identity=59.3220338983051, Blast_Score=127, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17552936, Length=532, Percent_Identity=59.2105263157895, Blast_Score=655, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=32.741617357002, Blast_Score=241, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=32.741617357002, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24586065, Length=549, Percent_Identity=59.1985428051002, Blast_Score=678, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 58540; Mature: 58540

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLISKINPLSSDFISNRTTYLETLVPIRKTIEKVKLGGGKKALEKHKSRGKLTARERI
CHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
AELIDSNTEFMEICGLAAEGVYNDPVPSAGIITGIGKVEGVDCMIVANDATVKGGTYYPL
HHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCEEEEEEECCCEECCCEEEEE
TVKKHVRAQEIAENNSLPCVYLVDSGGAFLPMQDEVFPDKDHFGRIFFNQARMSAKGISQ
EHHHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHH
IAVVMGSCTAGGAYIPAMSDESVIVKGNGTIFLGGPPLVKAATGEVVTGEELGGADVHCR
HHHHHHCCCCCCEEEECCCCCEEEEECCCEEEECCCCEEEECCCCEEECCCCCCCCEEEE
ISGVTDHYAEDDYHALEITRSIIKNLNVKNFTTPKETEDPLYPTEEIYGIIERDSRKSYD
EECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
PREIIARLVDGSRFHEFKKLYATTIVTGFAEIYGHPVGIIANHGVLFSESALKASHFIEL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCHHHHHHHHHHH
CDQRRIPLLFLQNITGFMVGKKYENNGIARDGAKMVNAVSTTTVPKLTIVTGGSYGAGNY
HHCCCCCEEEECCCHHHEECCEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
GMCGRAFAPEFLWMWPNARISVMGGEQAANVLWTVKKDQKEAQGETILPDEETTFKKPIL
CCCCCCCCCCEEEECCCCEEEEECCCCCCCEEEEEECCHHHCCCCCCCCCCCCHHCCCCH
DDYEKKSSAVYSSARLWDDGIIDPADTRNILGRALSILSRRKEERKPFGVFRM
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MERLISKINPLSSDFISNRTTYLETLVPIRKTIEKVKLGGGKKALEKHKSRGKLTARERI
CHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
AELIDSNTEFMEICGLAAEGVYNDPVPSAGIITGIGKVEGVDCMIVANDATVKGGTYYPL
HHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCEEEEEEECCCEECCCEEEEE
TVKKHVRAQEIAENNSLPCVYLVDSGGAFLPMQDEVFPDKDHFGRIFFNQARMSAKGISQ
EHHHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHH
IAVVMGSCTAGGAYIPAMSDESVIVKGNGTIFLGGPPLVKAATGEVVTGEELGGADVHCR
HHHHHHCCCCCCEEEECCCCCEEEEECCCEEEECCCCEEEECCCCEEECCCCCCCCEEEE
ISGVTDHYAEDDYHALEITRSIIKNLNVKNFTTPKETEDPLYPTEEIYGIIERDSRKSYD
EECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
PREIIARLVDGSRFHEFKKLYATTIVTGFAEIYGHPVGIIANHGVLFSESALKASHFIEL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCHHHHHHHHHHH
CDQRRIPLLFLQNITGFMVGKKYENNGIARDGAKMVNAVSTTTVPKLTIVTGGSYGAGNY
HHCCCCCEEEECCCHHHEECCEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
GMCGRAFAPEFLWMWPNARISVMGGEQAANVLWTVKKDQKEAQGETILPDEETTFKKPIL
CCCCCCCCCCEEEECCCCEEEEECCCCCCCEEEEEECCHHHCCCCCCCCCCCCHHCCCCH
DDYEKKSSAVYSSARLWDDGIIDPADTRNILGRALSILSRRKEERKPFGVFRM
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]