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The map label for this gene is kefC [H]

Identifier: 183219625

GI number: 183219625

Start: 192884

End: 194596

Strand: Reverse

Name: kefC [H]

Synonym: LEPBI_I0200

Alternate gene names: 183219625

Gene position: 194596-192884 (Counterclockwise)

Preceding gene: 183219626

Following gene: 183219617

Centisome position: 5.41

GC content: 42.5

Gene sequence:

>1713_bases
ATGCACGGGGAAGAGTCACTTTTACAAGACATTGGTCTGAGTATCATTTTCGCAACAGTATTGAGTCATATTGCAAGGGT
TCTCAAACAGCCGTTAATCTTAGGTTATATTATCGGTGGGGCAATGCTTGGAAAAGAAATGGGATTCGAACTTGTGACAA
ACGAAGCGAGTATCGAACTCATATCCGAAATTGGACTCATCCTCTTACTCTTCATCATCGGTCTTGAAATCAATCTCGCC
GAACTCGCCAAGATGGGAAAGGCGATGTTCACTCTCGGTATCTTACAATTCACACTTTCTGTTGCCTTTGTTTATTCCGT
GTTTCCATTTTTTGGCCTTTCGATTGGTTCGGAAAAATTTGATCTTCTTTATATCGCCGTCGCACTCTCTTTGAGTTCTA
CACTCATTGTTGTGAAACTCTTACAGGACAAAGTAGAGATCAACACTCTCTCAGGAAAATTGACCGTGGGAGTATTAGTA
TTCCAAGACATTTGGGCCATTTTGTTTATGGGGGTCCAACCAAACCTAAACAACCCTGAAATCTTAAAAATCCTCACTTC
TGTTGGGATCATTGTATTACTCATCGCCTTTAGTTTCAGTGTCAGTCGTTACGTACTCGCCAAATTATACAAAGCCTGTG
CGAGTAGCCCTGAGTTAATCCTTCTTACTTCGATTATGTGGTGTTTTTTGGTTTGTGGAATCGCAGGAGAAGCTGGTCTT
TCCAAAGAAATGGGTGCTCTCGTTGCGGGTATGAGCATTGCGGCATTTCCTTATGGTGCGGATGTGATTTCCAAACTCAT
CGGAATCCGAGACTTCTTTGTCACCCTCTTCTTTGTGGCACTTGGTCTTAAAGTCCCCCTCCCAAGTTTAGAAGTCATTG
GGCTTTCTGCAGCGATCATTGCACTTATGTTATTTGTTCGGATGATTACCATTGCCCCTGTCATCATCAAACTCAATAAG
GGAGTTCGTAATGGATTCCTTACAGCTCTGAACCTTGCGCAAATTTCTGAATTTTCTCTTGTGATCCTTGCATTAGGTGC
TGGTTTTGAACACATCACTCCTAAACTACAAGCAGTCATCTTAACTTCCACGATCATTGCTTCTGTGTTATCAACTTACA
TCATCATGTTCAACCATAACATTGCCGCTACCTTAGAACGTTTGTTAGCAAGAGTAGGAATCACTGACCAAACAGAGGAA
TCAGGATCGGCCGATCCATCTGGGCAAAGTGGTCATGGAGGGCATGGTGGAGATGGGATGGTGCGAGACATCATTGTTCT
CGGTTATTTCCGAATCGCTCGTGCCTTTGTGGAATACTTGGAGGACTTATCACCATCTCTTATCAAACGGATCATCATCG
CTGACTACAATCCTGCCTTTAAAGAGGAACTCACAAACAAAGGATTCCAGTGGGCCTATGCGGACTTGGCACATCCTGAT
TCCCTATCCCACATTGGATTACATGACGCATCCATGGTGATTTGTACCATCTCTGATTCTTTTCTCAAAGGAACAAATAA
CAATCGTTTGCTGTCTACTCTTAGTAAACTCGCACCCAATGCCAAAATCATTTTGACGAGCGATGAACCTGGAGAAGCAA
AAAAATTAGTAGCGGATGGAGCTCAAAAAGTGATCATTCCTGGTGTGATTACAGGTGAATTTTTATACGACTACATTTCT
CGAGGGATGAGAAATAATGAAAGAGAAGTGTAA

Upstream 100 bases:

>100_bases
TACAAAATTCTCCCACTCCATAGTCGTAAATCTTCTGTAGAAAAAAAAACGACTTTCACATCTCAAGGAATTCCTAAACT
TTTCCCTAAAGAAGGTATCT

Downstream 100 bases:

>100_bases
TCATTACAAATTAATTCAGACGAAACTAAGACAGAATCAAACTATCTGAAACAAAGTTGAAATAAAAATACAAAACATTT
TAGAACCTTAATTCTAACAA

Product: putative sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MHGEESLLQDIGLSIIFATVLSHIARVLKQPLILGYIIGGAMLGKEMGFELVTNEASIELISEIGLILLLFIIGLEINLA
ELAKMGKAMFTLGILQFTLSVAFVYSVFPFFGLSIGSEKFDLLYIAVALSLSSTLIVVKLLQDKVEINTLSGKLTVGVLV
FQDIWAILFMGVQPNLNNPEILKILTSVGIIVLLIAFSFSVSRYVLAKLYKACASSPELILLTSIMWCFLVCGIAGEAGL
SKEMGALVAGMSIAAFPYGADVISKLIGIRDFFVTLFFVALGLKVPLPSLEVIGLSAAIIALMLFVRMITIAPVIIKLNK
GVRNGFLTALNLAQISEFSLVILALGAGFEHITPKLQAVILTSTIIASVLSTYIIMFNHNIAATLERLLARVGITDQTEE
SGSADPSGQSGHGGHGGDGMVRDIIVLGYFRIARAFVEYLEDLSPSLIKRIIIADYNPAFKEELTNKGFQWAYADLAHPD
SLSHIGLHDASMVICTISDSFLKGTNNNRLLSTLSKLAPNAKIILTSDEPGEAKKLVADGAQKVIIPGVITGEFLYDYIS
RGMRNNEREV

Sequences:

>Translated_570_residues
MHGEESLLQDIGLSIIFATVLSHIARVLKQPLILGYIIGGAMLGKEMGFELVTNEASIELISEIGLILLLFIIGLEINLA
ELAKMGKAMFTLGILQFTLSVAFVYSVFPFFGLSIGSEKFDLLYIAVALSLSSTLIVVKLLQDKVEINTLSGKLTVGVLV
FQDIWAILFMGVQPNLNNPEILKILTSVGIIVLLIAFSFSVSRYVLAKLYKACASSPELILLTSIMWCFLVCGIAGEAGL
SKEMGALVAGMSIAAFPYGADVISKLIGIRDFFVTLFFVALGLKVPLPSLEVIGLSAAIIALMLFVRMITIAPVIIKLNK
GVRNGFLTALNLAQISEFSLVILALGAGFEHITPKLQAVILTSTIIASVLSTYIIMFNHNIAATLERLLARVGITDQTEE
SGSADPSGQSGHGGHGGDGMVRDIIVLGYFRIARAFVEYLEDLSPSLIKRIIIADYNPAFKEELTNKGFQWAYADLAHPD
SLSHIGLHDASMVICTISDSFLKGTNNNRLLSTLSKLAPNAKIILTSDEPGEAKKLVADGAQKVIIPGVITGEFLYDYIS
RGMRNNEREV
>Mature_570_residues
MHGEESLLQDIGLSIIFATVLSHIARVLKQPLILGYIIGGAMLGKEMGFELVTNEASIELISEIGLILLLFIIGLEINLA
ELAKMGKAMFTLGILQFTLSVAFVYSVFPFFGLSIGSEKFDLLYIAVALSLSSTLIVVKLLQDKVEINTLSGKLTVGVLV
FQDIWAILFMGVQPNLNNPEILKILTSVGIIVLLIAFSFSVSRYVLAKLYKACASSPELILLTSIMWCFLVCGIAGEAGL
SKEMGALVAGMSIAAFPYGADVISKLIGIRDFFVTLFFVALGLKVPLPSLEVIGLSAAIIALMLFVRMITIAPVIIKLNK
GVRNGFLTALNLAQISEFSLVILALGAGFEHITPKLQAVILTSTIIASVLSTYIIMFNHNIAATLERLLARVGITDQTEE
SGSADPSGQSGHGGHGGDGMVRDIIVLGYFRIARAFVEYLEDLSPSLIKRIIIADYNPAFKEELTNKGFQWAYADLAHPD
SLSHIGLHDASMVICTISDSFLKGTNNNRLLSTLSKLAPNAKIILTSDEPGEAKKLVADGAQKVIIPGVITGEFLYDYIS
RGMRNNEREV

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=349, Percent_Identity=25.7879656160458, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786232, Length=525, Percent_Identity=27.047619047619, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1786685, Length=568, Percent_Identity=21.3028169014084, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789749, Length=557, Percent_Identity=22.9802513464991, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 61533; Mature: 61533

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGEESLLQDIGLSIIFATVLSHIARVLKQPLILGYIIGGAMLGKEMGFELVTNEASIEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEECCHHHHH
ISEIGLILLLFIIGLEINLAELAKMGKAMFTLGILQFTLSVAFVYSVFPFFGLSIGSEKF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLLYIAVALSLSSTLIVVKLLQDKVEINTLSGKLTVGVLVFQDIWAILFMGVQPNLNNPE
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHH
ILKILTSVGIIVLLIAFSFSVSRYVLAKLYKACASSPELILLTSIMWCFLVCGIAGEAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
SKEMGALVAGMSIAAFPYGADVISKLIGIRDFFVTLFFVALGLKVPLPSLEVIGLSAAII
HHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
ALMLFVRMITIAPVIIKLNKGVRNGFLTALNLAQISEFSLVILALGAGFEHITPKLQAVI
HHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHHH
LTSTIIASVLSTYIIMFNHNIAATLERLLARVGITDQTEESGSADPSGQSGHGGHGGDGM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
VRDIIVLGYFRIARAFVEYLEDLSPSLIKRIIIADYNPAFKEELTNKGFQWAYADLAHPD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCCCCCC
SLSHIGLHDASMVICTISDSFLKGTNNNRLLSTLSKLAPNAKIILTSDEPGEAKKLVADG
CCCCCCCCCCCEEEEEECHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCC
AQKVIIPGVITGEFLYDYISRGMRNNEREV
CCEEEECCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHGEESLLQDIGLSIIFATVLSHIARVLKQPLILGYIIGGAMLGKEMGFELVTNEASIEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEECCHHHHH
ISEIGLILLLFIIGLEINLAELAKMGKAMFTLGILQFTLSVAFVYSVFPFFGLSIGSEKF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLLYIAVALSLSSTLIVVKLLQDKVEINTLSGKLTVGVLVFQDIWAILFMGVQPNLNNPE
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHH
ILKILTSVGIIVLLIAFSFSVSRYVLAKLYKACASSPELILLTSIMWCFLVCGIAGEAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
SKEMGALVAGMSIAAFPYGADVISKLIGIRDFFVTLFFVALGLKVPLPSLEVIGLSAAII
HHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
ALMLFVRMITIAPVIIKLNKGVRNGFLTALNLAQISEFSLVILALGAGFEHITPKLQAVI
HHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHHH
LTSTIIASVLSTYIIMFNHNIAATLERLLARVGITDQTEESGSADPSGQSGHGGHGGDGM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
VRDIIVLGYFRIARAFVEYLEDLSPSLIKRIIIADYNPAFKEELTNKGFQWAYADLAHPD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCCCCCC
SLSHIGLHDASMVICTISDSFLKGTNNNRLLSTLSKLAPNAKIILTSDEPGEAKKLVADG
CCCCCCCCCCCEEEEEECHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCC
AQKVIIPGVITGEFLYDYISRGMRNNEREV
CCEEEECCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA