Click here to switch to the map view.

The map label for this gene is lysC [H]

Identifier: 183219612

GI number: 183219612

Start: 182925

End: 184139

Strand: Reverse

Name: lysC [H]

Synonym: LEPBI_I0187

Alternate gene names: 183219612

Gene position: 184139-182925 (Counterclockwise)

Preceding gene: 183219614

Following gene: 183219611

Centisome position: 5.12

GC content: 42.96

Gene sequence:

>1215_bases
ATGTCATCGAAAATCGTTGTCCAAAAATACGGTGGAACCTCAGTTGGTGACACCACTAAAATTAAAAACGTGGCCAAACG
CATCAAACGTTACCACGACGAAGGCCAAAAGGTTGCCGTTGTTGTTTCTGCAATGGGACATACTACTGACGAACTCGTAG
ACCTTGCTGACCAAATCTCAAAAAATCCTCCGAAACGTGAAATGGATATGTTACTCTCTACGGGAGAACAAGTTTCGATC
GCATTACTTGCCATCGCTCTCAATGAGTTAGGAGTCCCAGCCCAATCCTTTACTGGATCCCAATTAAAAATCTTAACCGA
TGGCAACTTTTCCAATGGAAAAATTGAAATGATCGACCGTTCTAGGATCGACGAAGCGTTTAACAAGGGAAAGGTGGTAA
TCGTTGCAGGATTTCAAGGAATCGACAAAGACGAAAATATTGTCACCTTAGGACGGGGGGGAAGTGATACTTCGGCTGTA
GCACTCGCAGCGGCTCTCGGTGCTGACGAATGTGAAATTTATACCGATGTGGATGGCGTGTATACAGCAGACCCAAGAAA
AATCCCAACGGCAAAAATGCACAAACAAATCACTTACGAAGAGATGTTAGAACTCGCAAGCCTTGGAGCTGGAGTCCTTC
ATTCACGTAGTGTTGAATTAGGAATGAATTACAACGTGGTAATCCACGTACGATCTAGTTTCCATGACAAACCGGGAACA
TTAGTAATGAGTGAGGATAAAATTATGGAAAAAATGAAAGTGAGCGGAGTGACAGCGAAAGGGGACCAAGCGCGTGTTAC
CATTGCAGATGTAAAAGACAAACCAGGGATCGCAGCCGACCTTTTCACCCAATTATCCAACAAGGATGTCATCGTTGATG
TCATAGTCCAATCCTCACCAAGAGATGGAATCAATACCATTTCCTTTACCATCGCAAAAAAAGATATCACGGCCGCAAAA
CCAATCATAGAAGCTTATGCGAAAGAACACGGCAACGGCAAAGCAGAAATCGACGAAAACATTTCGATTGTTTCGGCTGT
GGGTGTTGGAATGAAATCACATGTTGGGGTTGCCGCAAAGATGTTCCAATCTTTAGCAGAAAAAAATATCAACATTGAAA
TGATTTCGACTTCTGAGATCAAAATTTCTTGTGTCATCAAACAAAACCAAGCGGAAGACGCAGTAAAAGCTTTACACACT
ACCTTTATCGGGTAG

Upstream 100 bases:

>100_bases
AATAACCTATACTCATTGGAGTCTTCCGAGCTCGATTGGTTGCAAAAAAATTCATTCTACTTGATTCCCGATTTGCCTCT
CCTACCCTGTCCATAAACCC

Downstream 100 bases:

>100_bases
ATTTATGACCGTATGCAAAAGAGACCTCGATTCCAACGTTATTTCGTTTTCATTTTTGCTGCGGTTGTTAGCGTTTCCCT
CACCGTCCCTACAAATCCAC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSSKIVVQKYGGTSVGDTTKIKNVAKRIKRYHDEGQKVAVVVSAMGHTTDELVDLADQISKNPPKREMDMLLSTGEQVSI
ALLAIALNELGVPAQSFTGSQLKILTDGNFSNGKIEMIDRSRIDEAFNKGKVVIVAGFQGIDKDENIVTLGRGGSDTSAV
ALAAALGADECEIYTDVDGVYTADPRKIPTAKMHKQITYEEMLELASLGAGVLHSRSVELGMNYNVVIHVRSSFHDKPGT
LVMSEDKIMEKMKVSGVTAKGDQARVTIADVKDKPGIAADLFTQLSNKDVIVDVIVQSSPRDGINTISFTIAKKDITAAK
PIIEAYAKEHGNGKAEIDENISIVSAVGVGMKSHVGVAAKMFQSLAEKNINIEMISTSEIKISCVIKQNQAEDAVKALHT
TFIG

Sequences:

>Translated_404_residues
MSSKIVVQKYGGTSVGDTTKIKNVAKRIKRYHDEGQKVAVVVSAMGHTTDELVDLADQISKNPPKREMDMLLSTGEQVSI
ALLAIALNELGVPAQSFTGSQLKILTDGNFSNGKIEMIDRSRIDEAFNKGKVVIVAGFQGIDKDENIVTLGRGGSDTSAV
ALAAALGADECEIYTDVDGVYTADPRKIPTAKMHKQITYEEMLELASLGAGVLHSRSVELGMNYNVVIHVRSSFHDKPGT
LVMSEDKIMEKMKVSGVTAKGDQARVTIADVKDKPGIAADLFTQLSNKDVIVDVIVQSSPRDGINTISFTIAKKDITAAK
PIIEAYAKEHGNGKAEIDENISIVSAVGVGMKSHVGVAAKMFQSLAEKNINIEMISTSEIKISCVIKQNQAEDAVKALHT
TFIG
>Mature_403_residues
SSKIVVQKYGGTSVGDTTKIKNVAKRIKRYHDEGQKVAVVVSAMGHTTDELVDLADQISKNPPKREMDMLLSTGEQVSIA
LLAIALNELGVPAQSFTGSQLKILTDGNFSNGKIEMIDRSRIDEAFNKGKVVIVAGFQGIDKDENIVTLGRGGSDTSAVA
LAAALGADECEIYTDVDGVYTADPRKIPTAKMHKQITYEEMLELASLGAGVLHSRSVELGMNYNVVIHVRSSFHDKPGTL
VMSEDKIMEKMKVSGVTAKGDQARVTIADVKDKPGIAADLFTQLSNKDVIVDVIVQSSPRDGINTISFTIAKKDITAAKP
IIEAYAKEHGNGKAEIDENISIVSAVGVGMKSHVGVAAKMFQSLAEKNINIEMISTSEIKISCVIKQNQAEDAVKALHTT
FIG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=341, Percent_Identity=33.7243401759531, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1790455, Length=459, Percent_Identity=25.4901960784314, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790376, Length=464, Percent_Identity=22.8448275862069, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320893, Length=501, Percent_Identity=26.7465069860279, Blast_Score=143, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43331; Mature: 43200

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKIVVQKYGGTSVGDTTKIKNVAKRIKRYHDEGQKVAVVVSAMGHTTDELVDLADQIS
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHH
KNPPKREMDMLLSTGEQVSIALLAIALNELGVPAQSFTGSQLKILTDGNFSNGKIEMIDR
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEH
SRIDEAFNKGKVVIVAGFQGIDKDENIVTLGRGGSDTSAVALAAALGADECEIYTDVDGV
HHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCE
YTADPRKIPTAKMHKQITYEEMLELASLGAGVLHSRSVELGMNYNVVIHVRSSFHDKPGT
EECCCCCCCHHHHHHCCCHHHHHHHHHCCCCHHCCCCEEECCCEEEEEEEECCCCCCCCE
LVMSEDKIMEKMKVSGVTAKGDQARVTIADVKDKPGIAADLFTQLSNKDVIVDVIVQSSP
EEEEHHHHHHHHHHCCCEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCC
RDGINTISFTIAKKDITAAKPIIEAYAKEHGNGKAEIDENISIVSAVGVGMKSHVGVAAK
CCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCEEEEEHHCCCCHHHHHHHHH
MFQSLAEKNINIEMISTSEIKISCVIKQNQAEDAVKALHTTFIG
HHHHHHHCCCEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSKIVVQKYGGTSVGDTTKIKNVAKRIKRYHDEGQKVAVVVSAMGHTTDELVDLADQIS
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHH
KNPPKREMDMLLSTGEQVSIALLAIALNELGVPAQSFTGSQLKILTDGNFSNGKIEMIDR
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEH
SRIDEAFNKGKVVIVAGFQGIDKDENIVTLGRGGSDTSAVALAAALGADECEIYTDVDGV
HHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCE
YTADPRKIPTAKMHKQITYEEMLELASLGAGVLHSRSVELGMNYNVVIHVRSSFHDKPGT
EECCCCCCCHHHHHHCCCHHHHHHHHHCCCCHHCCCCEEECCCEEEEEEEECCCCCCCCE
LVMSEDKIMEKMKVSGVTAKGDQARVTIADVKDKPGIAADLFTQLSNKDVIVDVIVQSSP
EEEEHHHHHHHHHHCCCEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCC
RDGINTISFTIAKKDITAAKPIIEAYAKEHGNGKAEIDENISIVSAVGVGMKSHVGVAAK
CCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCEEECCCEEEEEHHCCCCHHHHHHHHH
MFQSLAEKNINIEMISTSEIKISCVIKQNQAEDAVKALHTTFIG
HHHHHHHCCCEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]