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The map label for this gene is nadC [H]

Identifier: 182680392

GI number: 182680392

Start: 3968919

End: 3969788

Strand: Reverse

Name: nadC [H]

Synonym: Bind_3492

Alternate gene names: 182680392

Gene position: 3969788-3968919 (Counterclockwise)

Preceding gene: 182680393

Following gene: 182680391

Centisome position: 95.2

GC content: 64.37

Gene sequence:

>870_bases
ATGACGAGCGCGCCCGCTCCTATCTCCCCGCAATTACCTCGTCTCCTGGTTGAGCCCCTGGTGCGTGCCGCGCTCCTCGA
AGATCTCGGCCGGGCGGGCGATATTACGAGCGATGCCATCGTCCCCGCGCATCAGCAGGCGCGCATGGCGCTCAACGCCC
GCCAGCCAGGCATTGTCAGTGGACTATCCGCCGCCAAGCTCGCGTTCGAACTGATCGATCCCGCCATTGCCGTCACGGTT
CATCACCCCGATGGAACGCGGATCAAGCCGGGCGACGTCATCGCCCATATTGCTGGGCCGGCACGCAGTATCCTGACCGC
GGAGCGTGTGGCGCTGAATTTCCTCGGCCATTTGAGCGGGGTCGCGAGCGCGACCGCCACTTTGGTGGCCGCTGTTGCCT
ATACACGCGCGCAAATCGTCTGCACGCGCAAGACGACGCCGGGCCTGCGCAGCCTGGAAAAGCTGGCGGTGCGCCATGGC
GGCGGCGGCAACCATCGCTTCGGCCTCGACGATGCCATGCTGATCAAGGATAATCACGTGGCTTTGGCGGGCGGCATCAC
GGAAGCCCTGCGGCGGGCGAAACAGGGAGCCGGCCATCTCGTGAAAATCGAGCTGGAAGTGGACACGCTCGCCCAATTGG
AAGAGGCGCTCGCCGAAGGCGTCGATGCCGTCCTACTCGATAATATGACCCCCGAGCTTCTTTCCCAGGCCGTGGTCATG
GTCGCGGGCCGCGCCATTACCGAAGCCTCGGGCCGAGTGACGCCGGAGACGGCGACGGCCATTGCCGAGAGTGGCGTTGA
TCTGATTTCGGTCGGTTGGGTGACGCATAGCGCCGCTGTTCTGGATATTGGCCTCGATTTTTGCCCGTGA

Upstream 100 bases:

>100_bases
CGCCTCCGAAGCCAGGCGCACGAGCCTGTGTCTTGAGGATGCTTTGGCGCAAGCGCGTGAAAATTTGCCGGAACCCGTCG
TTTAATCCCAGGACCAATCC

Downstream 100 bases:

>100_bases
TACGGAAGCCAAGCCGCGCTTGCGCCTTGCCGAACGGCTGGTCTAGATCGTAAACTCCAAAGTGCAGCCTGTTTGGAATC
AGGCGTTCCCGGGGCTTTGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTSAPAPISPQLPRLLVEPLVRAALLEDLGRAGDITSDAIVPAHQQARMALNARQPGIVSGLSAAKLAFELIDPAIAVTV
HHPDGTRIKPGDVIAHIAGPARSILTAERVALNFLGHLSGVASATATLVAAVAYTRAQIVCTRKTTPGLRSLEKLAVRHG
GGGNHRFGLDDAMLIKDNHVALAGGITEALRRAKQGAGHLVKIELEVDTLAQLEEALAEGVDAVLLDNMTPELLSQAVVM
VAGRAITEASGRVTPETATAIAESGVDLISVGWVTHSAAVLDIGLDFCP

Sequences:

>Translated_289_residues
MTSAPAPISPQLPRLLVEPLVRAALLEDLGRAGDITSDAIVPAHQQARMALNARQPGIVSGLSAAKLAFELIDPAIAVTV
HHPDGTRIKPGDVIAHIAGPARSILTAERVALNFLGHLSGVASATATLVAAVAYTRAQIVCTRKTTPGLRSLEKLAVRHG
GGGNHRFGLDDAMLIKDNHVALAGGITEALRRAKQGAGHLVKIELEVDTLAQLEEALAEGVDAVLLDNMTPELLSQAVVM
VAGRAITEASGRVTPETATAIAESGVDLISVGWVTHSAAVLDIGLDFCP
>Mature_288_residues
TSAPAPISPQLPRLLVEPLVRAALLEDLGRAGDITSDAIVPAHQQARMALNARQPGIVSGLSAAKLAFELIDPAIAVTVH
HPDGTRIKPGDVIAHIAGPARSILTAERVALNFLGHLSGVASATATLVAAVAYTRAQIVCTRKTTPGLRSLEKLAVRHGG
GGNHRFGLDDAMLIKDNHVALAGGITEALRRAKQGAGHLVKIELEVDTLAQLEEALAEGVDAVLLDNMTPELLSQAVVMV
AGRAITEASGRVTPETATAIAESGVDLISVGWVTHSAAVLDIGLDFCP

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=280, Percent_Identity=34.6428571428571, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786299, Length=271, Percent_Identity=39.1143911439114, Blast_Score=162, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=249, Percent_Identity=31.3253012048193, Blast_Score=122, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29940; Mature: 29809

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAPAPISPQLPRLLVEPLVRAALLEDLGRAGDITSDAIVPAHQQARMALNARQPGIVS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHH
GLSAAKLAFELIDPAIAVTVHHPDGTRIKPGDVIAHIAGPARSILTAERVALNFLGHLSG
CHHHHHHHHHHHCCEEEEEEECCCCCEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
VASATATLVAAVAYTRAQIVCTRKTTPGLRSLEKLAVRHGGGGNHRFGLDDAMLIKDNHV
HHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCE
ALAGGITEALRRAKQGAGHLVKIELEVDTLAQLEEALAEGVDAVLLDNMTPELLSQAVVM
EEECCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHH
VAGRAITEASGRVTPETATAIAESGVDLISVGWVTHSAAVLDIGLDFCP
HHCHHHHCCCCCCCCHHHHHHHHCCCCEEEECHHHHCCEEEEECCCCCC
>Mature Secondary Structure 
TSAPAPISPQLPRLLVEPLVRAALLEDLGRAGDITSDAIVPAHQQARMALNARQPGIVS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHH
GLSAAKLAFELIDPAIAVTVHHPDGTRIKPGDVIAHIAGPARSILTAERVALNFLGHLSG
CHHHHHHHHHHHCCEEEEEEECCCCCEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
VASATATLVAAVAYTRAQIVCTRKTTPGLRSLEKLAVRHGGGGNHRFGLDDAMLIKDNHV
HHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCE
ALAGGITEALRRAKQGAGHLVKIELEVDTLAQLEEALAEGVDAVLLDNMTPELLSQAVVM
EEECCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHH
VAGRAITEASGRVTPETATAIAESGVDLISVGWVTHSAAVLDIGLDFCP
HHCHHHHCCCCCCCCHHHHHHHHCCCCEEEECHHHHCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]