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The map label for this gene is dctA3 [H]

Identifier: 182680360

GI number: 182680360

Start: 3926339

End: 3927658

Strand: Reverse

Name: dctA3 [H]

Synonym: Bind_3460

Alternate gene names: 182680360

Gene position: 3927658-3926339 (Counterclockwise)

Preceding gene: 182680366

Following gene: 182680356

Centisome position: 94.18

GC content: 56.59

Gene sequence:

>1320_bases
TTGAGTCTCTTTAAGCATCTTTACATCCAGGTCATCGTAGCCGTCCTTTGCGGTGCGATCCTCGGTTTCGTATGGCCATC
ATTTGCTTCTGGATTGAAACCCCTCAGCGACGTCTTCATTAACCTGATCAGAATGGTTCTCCTCCCCGTGATTTTCGGCA
CGGTCGTGCTTGGCATCGCGCGCATGGAGAATATGCGTGAGCTCGGAAGAGTCGGTGCCAAGGCTCTGGCCTATTTCGAA
ATTGCTTCGACTCTGGCCCTTATTATCGGGATGGTGGTGGTCAATATCGTCAGGCCAGGCACAGGCATTCATGCTGATCC
TCTTACGCTCGATGCGGAGTCCATCAGCCAATATACCAAGGCCGTCGCCGAACATGCGGGGCTTGTAGACTTCCTCGTTC
ACATCGTTCCCTCCAACATCGTGGAGAGTTTCGCCAGCGGCAACATCCTGCAGGTGTTGTTCTTTAGCCTGTTGCTCGGG
ATCGCTTTGGCCAAGGCGGGTGACGCTGCGCGTCCCTTTGTTTGCACGCTCGAAAGTCTGCTTGATGGTATATTTCATAT
CGTCAGCATGGTCATGCGCTTCGCCCCGCTTGGCGCACTGGGAGCAATGGCATTCACGATCTCGAAATACGGTTTGGGAA
GCCTAGCTTCCATGGGGCTCGTGCTTGTATGCGTCTATGCGACCTGTTTGCTCTTCGCGATCCTTTCCTTTGGATTGATC
GCGCGTCTGGTCGGTTTCTCCGCCTTCCGTTTTCTCCGCTACATACGCGACGAGATCGTCACGGTCTTTGGAACCTGTTC
TTCTGAATCAGTGCTGCCGCGCCTGATGCAGAAATTGGAGATGGCGGGCGTCCCAAGAACAGTTGTGGGTCTCGTCCTGC
CGGGCGGTCTCACATTCAACGCCTGTGGCAGCGCGATCTATTTCACGATTGGTGCTCTGTTTATCGCCCAAGCCACCGAC
ACGTCCCTCTCGATGGTTGACCAACTCGCGATCCTGGGCGTTCTCATGCTGACCAGCAAGGGATCGGCGGGCGTCGCGGG
CGCCGGCTTCGTGACCCTTGCCGCGACGTTGGGCGCCCTCCACAAGATCCCGGTTTCCGGTCTTGTTCTGCTGCTGGGCG
TTGATCGCTTCATGGCTGAAGCGCGGTCAGTCACCAATACGATCAGCAACGCTTTCGGTGCCGTCGCTGTTGCTGCATGG
GAAGGTGTCCTCGACCGAGAAAAGCTCGCGGCGGCCCTGCGCGGCGAGCTGGAACCCGAAGTCCTGACGACGACGGAATT
GGTCGATCACCCTGTCACACCCATCACAATCGTTCAGTGA

Upstream 100 bases:

>100_bases
ATCGATTTTGAGCATTAGCCCCGATCCGGCGCCAGCGTTAGCGTCCTCAAGGTTCCAAAAGACGGGCGTTGCGAGCCCGC
GAAAGGATGGAGGGCCAGCG

Downstream 100 bases:

>100_bases
ATCCAGAGTTCAGTGAATTCCAGCGAAGCCGGGTGCGCTTGTGCTCACCCGGCGCGGATTTTTTAGAGAAACGCGTCCAG
CGCTTCGAGCAGTGCCTCTG

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSLFKHLYIQVIVAVLCGAILGFVWPSFASGLKPLSDVFINLIRMVLLPVIFGTVVLGIARMENMRELGRVGAKALAYFE
IASTLALIIGMVVVNIVRPGTGIHADPLTLDAESISQYTKAVAEHAGLVDFLVHIVPSNIVESFASGNILQVLFFSLLLG
IALAKAGDAARPFVCTLESLLDGIFHIVSMVMRFAPLGALGAMAFTISKYGLGSLASMGLVLVCVYATCLLFAILSFGLI
ARLVGFSAFRFLRYIRDEIVTVFGTCSSESVLPRLMQKLEMAGVPRTVVGLVLPGGLTFNACGSAIYFTIGALFIAQATD
TSLSMVDQLAILGVLMLTSKGSAGVAGAGFVTLAATLGALHKIPVSGLVLLLGVDRFMAEARSVTNTISNAFGAVAVAAW
EGVLDREKLAAALRGELEPEVLTTTELVDHPVTPITIVQ

Sequences:

>Translated_439_residues
MSLFKHLYIQVIVAVLCGAILGFVWPSFASGLKPLSDVFINLIRMVLLPVIFGTVVLGIARMENMRELGRVGAKALAYFE
IASTLALIIGMVVVNIVRPGTGIHADPLTLDAESISQYTKAVAEHAGLVDFLVHIVPSNIVESFASGNILQVLFFSLLLG
IALAKAGDAARPFVCTLESLLDGIFHIVSMVMRFAPLGALGAMAFTISKYGLGSLASMGLVLVCVYATCLLFAILSFGLI
ARLVGFSAFRFLRYIRDEIVTVFGTCSSESVLPRLMQKLEMAGVPRTVVGLVLPGGLTFNACGSAIYFTIGALFIAQATD
TSLSMVDQLAILGVLMLTSKGSAGVAGAGFVTLAATLGALHKIPVSGLVLLLGVDRFMAEARSVTNTISNAFGAVAVAAW
EGVLDREKLAAALRGELEPEVLTTTELVDHPVTPITIVQ
>Mature_438_residues
SLFKHLYIQVIVAVLCGAILGFVWPSFASGLKPLSDVFINLIRMVLLPVIFGTVVLGIARMENMRELGRVGAKALAYFEI
ASTLALIIGMVVVNIVRPGTGIHADPLTLDAESISQYTKAVAEHAGLVDFLVHIVPSNIVESFASGNILQVLFFSLLLGI
ALAKAGDAARPFVCTLESLLDGIFHIVSMVMRFAPLGALGAMAFTISKYGLGSLASMGLVLVCVYATCLLFAILSFGLIA
RLVGFSAFRFLRYIRDEIVTVFGTCSSESVLPRLMQKLEMAGVPRTVVGLVLPGGLTFNACGSAIYFTIGALFIAQATDT
SLSMVDQLAILGVLMLTSKGSAGVAGAGFVTLAATLGALHKIPVSGLVLLLGVDRFMAEARSVTNTISNAFGAVAVAAWE
GVLDREKLAAALRGELEPEVLTTTELVDHPVTPITIVQ

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=429, Percent_Identity=27.039627039627, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI40254478, Length=439, Percent_Identity=25.9681093394077, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI223468564, Length=298, Percent_Identity=30.2013422818792, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI223468566, Length=298, Percent_Identity=30.2013422818792, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI169790839, Length=452, Percent_Identity=25.2212389380531, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI5032093, Length=424, Percent_Identity=27.122641509434, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI194239697, Length=462, Percent_Identity=23.5930735930736, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI66773030, Length=372, Percent_Identity=26.0752688172043, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4827012, Length=381, Percent_Identity=25.4593175853018, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI262359914, Length=409, Percent_Identity=24.6943765281174, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI301601644, Length=175, Percent_Identity=29.7142857142857, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789947, Length=415, Percent_Identity=50.3614457831325, Blast_Score=433, Evalue=1e-123,
Organism=Escherichia coli, GI1790514, Length=386, Percent_Identity=38.860103626943, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1788024, Length=282, Percent_Identity=21.2765957446809, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789473, Length=294, Percent_Identity=25.5102040816327, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=389, Percent_Identity=25.9640102827763, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71983099, Length=466, Percent_Identity=25.9656652360515, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71983106, Length=466, Percent_Identity=25.9656652360515, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193206505, Length=471, Percent_Identity=26.5392781316348, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193206654, Length=455, Percent_Identity=23.7362637362637, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17541374, Length=445, Percent_Identity=24.4943820224719, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71996953, Length=434, Percent_Identity=23.5023041474654, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24583025, Length=460, Percent_Identity=23.0434782608696, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17137668, Length=460, Percent_Identity=23.0434782608696, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24583023, Length=460, Percent_Identity=23.0434782608696, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46307; Mature: 46176

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFKHLYIQVIVAVLCGAILGFVWPSFASGLKPLSDVFINLIRMVLLPVIFGTVVLGIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMENMRELGRVGAKALAYFEIASTLALIIGMVVVNIVRPGTGIHADPLTLDAESISQYTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
AVAEHAGLVDFLVHIVPSNIVESFASGNILQVLFFSLLLGIALAKAGDAARPFVCTLESL
HHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LDGIFHIVSMVMRFAPLGALGAMAFTISKYGLGSLASMGLVLVCVYATCLLFAILSFGLI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLVGFSAFRFLRYIRDEIVTVFGTCSSESVLPRLMQKLEMAGVPRTVVGLVLPGGLTFN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHH
ACGSAIYFTIGALFIAQATDTSLSMVDQLAILGVLMLTSKGSAGVAGAGFVTLAATLGAL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
HKIPVSGLVLLLGVDRFMAEARSVTNTISNAFGAVAVAAWEGVLDREKLAAALRGELEPE
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VLTTTELVDHPVTPITIVQ
HHHHHHHHHCCCCCEEECC
>Mature Secondary Structure 
SLFKHLYIQVIVAVLCGAILGFVWPSFASGLKPLSDVFINLIRMVLLPVIFGTVVLGIA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMENMRELGRVGAKALAYFEIASTLALIIGMVVVNIVRPGTGIHADPLTLDAESISQYTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
AVAEHAGLVDFLVHIVPSNIVESFASGNILQVLFFSLLLGIALAKAGDAARPFVCTLESL
HHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LDGIFHIVSMVMRFAPLGALGAMAFTISKYGLGSLASMGLVLVCVYATCLLFAILSFGLI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLVGFSAFRFLRYIRDEIVTVFGTCSSESVLPRLMQKLEMAGVPRTVVGLVLPGGLTFN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHH
ACGSAIYFTIGALFIAQATDTSLSMVDQLAILGVLMLTSKGSAGVAGAGFVTLAATLGAL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
HKIPVSGLVLLLGVDRFMAEARSVTNTISNAFGAVAVAAWEGVLDREKLAAALRGELEPE
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VLTTTELVDHPVTPITIVQ
HHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]