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The map label for this gene is dcp [H]

Identifier: 182680161

GI number: 182680161

Start: 3707047

End: 3709116

Strand: Reverse

Name: dcp [H]

Synonym: Bind_3258

Alternate gene names: 182680161

Gene position: 3709116-3707047 (Counterclockwise)

Preceding gene: 182680165

Following gene: 182680157

Centisome position: 88.94

GC content: 59.18

Gene sequence:

>2070_bases
ATGGACGCGACGACCGAAAACAATCCCTTGCTGGCCGCCTGGACTGGGCCTTTTGCGGCGCCTCCTTTCGATCGTCTGAA
GCCAGATCATTTCATGCCGGCCTTTACCGAGGCTTTTGTGAGAGCGCGCGCCGAAATCGACGCCATTGCCGCCAATCCCG
AAGAACCGACGTTCGAAAACACGATCGCAGCCTTGGAACGCGCCGGAGAGGATTTGACCCGCGTTTCATTGACGTTCTTC
AATCTGGCTGGCGCTGATACCAACGACGCCCTTGAGGAAGTCGAGCGCGACATTGCGCCGCTTTTGTCCCGCCATCGCAG
CGCGACTTATCTGAATGAGGATTTATTCCGCAGGATCGAGAGCTTGCGAGAGCAGGGTGAAAAGCTCGGCCTCGATGCGG
AACAGGCGCGCGTTCTGGAGCGCTATCATATTGCTTTCAGCCGCAATGGCGGCGGTCTGCCGCAAGAGGCCAAGGCGCGG
CTCGCGGCCATCGCCGAACGGCTAGCAACGCTTGGCACGCAGTTCAGCCAGAATGTCCTGGCGGATGAAAAAGCTTATCG
GCTCGTTCTGGAAACCCCGGAGGATCTTGCGGGCCTGCCGCCTTCCCTTATTGCCGCGGCCGCCGGCACGGCCGCTGAAC
TCGGCCTGCCCGGCAAATATGTGATCACCCTTGCGCGTTCGTCCATCGAGCCTTTCCTGCAATTTTCCGCGCGGCGCGAT
CTGCGCGAGCAGGCTTTCCGCGCCTGGGCCATGCGGGGTGAGAACGGCGGAGCGAGCGATAATCGCGCCATTGCCGCTGA
AATGGTGAAGCTACGCGCGGAGCGGGCGAAACTTTTGGGCTATGAGACTTTCGCCCATTTCAAATTGGCCGATACGATGG
CCAAGACACCCAAGGCGGCGCGCGATCTGTTGCAATCCGTCTGGGAGCCTGCGCGGGCCCGCGCCTTGAAGGAGCAAGCG
GCTTTGCGTGCTCTGGCCGCGAGCGAAGGCGGCAATTTCGAGATTGCGGCGTGGGATTGGCGCTATTATGCCGAGAAACA
GCGCAAGGCCGAATATGATCTCGACGAGGGGGAGACCAAGCCCTATCTCCAGCTTGGAAAGCTGGTCGAAGCGGCCTTCC
ACGCGGCCGAAAAATTGTTCGGCCTCACATTCACCGAGCGTTTCGACATCCCCCTTTATCACAAGGATGCGCGCGCCTGG
ACAGTGAGCCGTGATGGTGCCGAGATTGCCTTATTCATCGGTGATTATTTCGCCCGGCCCTCGAAGCACAGCGGCGCCTG
GATGAGCCTCTATAGGGAACAGCAGAAGCTTGATGGCACGGTCCTGCCGATTGTCGTCAATGTGCTGAATTTCGCACGCG
GCGGGGAAGGGGAAGCCTGCCTGCTCAGTTTCGACGATGCGCGGACTCTGTTTCATGAATTCGGCCATGCCCTGCATGGC
ATGTTGTCGGATGTGACCTATCCGTTGATCTCCGGGACTAGCGTCGCGCGCGATTTCGTCGAATTCCCGTCTCAGCTCTA
TGAACATTGGCTGGAACAGCCGGAAATTCTGCGGCGCTTCGCGGTGCATTATGAGACCGGCGAACCCATGCCGGAGGCCT
TGCTGCAGAAAATTCTGGCGGCGCGGCAGTTCAACCAGGGCTTTGCGACGGTTGAATATACGGCCTCGGCTTTGGTCGAT
CTCGACCTGCACCTCAAGGCTGGCGAGGAGGAGATCGATATTATCTCCTTTGAAGCCGAAACATTGGCCAAGCTCGGCAT
GCCGGAGGCGATCGGCATGCGCCACCGCACGCCGCACTTCCAGCACATCTTTACGGGCGATGGCTATTCAGCCGGTTATT
ACAGCTATCTCTGGTCAGAAATTCTCGATGCCGATGGTTTCGACGCCTTCGAGGAAAAGGGTGATATTTTTGATCCTGAA
CTCGCCAAAAGGCTGCATGATCATGTCTATTCGGCAGGATATAGCCGGGACCCGGAAACAGCCTATGCCGGCTTCCGTGG
CCGCGCGCCGGAGCCGGCAGCACTTTTGCGCAAGCGTGGTCTTCTCGATACGGCCAACGCGCAGGCTTGA

Upstream 100 bases:

>100_bases
TCTCCCCATTCGATTCCCGGCTCTTTTAGACCATTCACCATGGGGATGACAAATCGTCCAGCGGTCCATAAATTGCCTCT
TGTGGCTGAGGAGAACGATT

Downstream 100 bases:

>100_bases
ACGGCACGTTTCTAGGACATAGCCCCTAAAAACGTTAGCCTTTCAAGGGGCTATGTTCCTGTTCGCCGATGTAGTCCCTC
AGGACAATGGCATTGTTGTG

Product: peptidyl-dipeptidase Dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 689; Mature: 689

Protein sequence:

>689_residues
MDATTENNPLLAAWTGPFAAPPFDRLKPDHFMPAFTEAFVRARAEIDAIAANPEEPTFENTIAALERAGEDLTRVSLTFF
NLAGADTNDALEEVERDIAPLLSRHRSATYLNEDLFRRIESLREQGEKLGLDAEQARVLERYHIAFSRNGGGLPQEAKAR
LAAIAERLATLGTQFSQNVLADEKAYRLVLETPEDLAGLPPSLIAAAAGTAAELGLPGKYVITLARSSIEPFLQFSARRD
LREQAFRAWAMRGENGGASDNRAIAAEMVKLRAERAKLLGYETFAHFKLADTMAKTPKAARDLLQSVWEPARARALKEQA
ALRALAASEGGNFEIAAWDWRYYAEKQRKAEYDLDEGETKPYLQLGKLVEAAFHAAEKLFGLTFTERFDIPLYHKDARAW
TVSRDGAEIALFIGDYFARPSKHSGAWMSLYREQQKLDGTVLPIVVNVLNFARGGEGEACLLSFDDARTLFHEFGHALHG
MLSDVTYPLISGTSVARDFVEFPSQLYEHWLEQPEILRRFAVHYETGEPMPEALLQKILAARQFNQGFATVEYTASALVD
LDLHLKAGEEEIDIISFEAETLAKLGMPEAIGMRHRTPHFQHIFTGDGYSAGYYSYLWSEILDADGFDAFEEKGDIFDPE
LAKRLHDHVYSAGYSRDPETAYAGFRGRAPEPAALLRKRGLLDTANAQA

Sequences:

>Translated_689_residues
MDATTENNPLLAAWTGPFAAPPFDRLKPDHFMPAFTEAFVRARAEIDAIAANPEEPTFENTIAALERAGEDLTRVSLTFF
NLAGADTNDALEEVERDIAPLLSRHRSATYLNEDLFRRIESLREQGEKLGLDAEQARVLERYHIAFSRNGGGLPQEAKAR
LAAIAERLATLGTQFSQNVLADEKAYRLVLETPEDLAGLPPSLIAAAAGTAAELGLPGKYVITLARSSIEPFLQFSARRD
LREQAFRAWAMRGENGGASDNRAIAAEMVKLRAERAKLLGYETFAHFKLADTMAKTPKAARDLLQSVWEPARARALKEQA
ALRALAASEGGNFEIAAWDWRYYAEKQRKAEYDLDEGETKPYLQLGKLVEAAFHAAEKLFGLTFTERFDIPLYHKDARAW
TVSRDGAEIALFIGDYFARPSKHSGAWMSLYREQQKLDGTVLPIVVNVLNFARGGEGEACLLSFDDARTLFHEFGHALHG
MLSDVTYPLISGTSVARDFVEFPSQLYEHWLEQPEILRRFAVHYETGEPMPEALLQKILAARQFNQGFATVEYTASALVD
LDLHLKAGEEEIDIISFEAETLAKLGMPEAIGMRHRTPHFQHIFTGDGYSAGYYSYLWSEILDADGFDAFEEKGDIFDPE
LAKRLHDHVYSAGYSRDPETAYAGFRGRAPEPAALLRKRGLLDTANAQA
>Mature_689_residues
MDATTENNPLLAAWTGPFAAPPFDRLKPDHFMPAFTEAFVRARAEIDAIAANPEEPTFENTIAALERAGEDLTRVSLTFF
NLAGADTNDALEEVERDIAPLLSRHRSATYLNEDLFRRIESLREQGEKLGLDAEQARVLERYHIAFSRNGGGLPQEAKAR
LAAIAERLATLGTQFSQNVLADEKAYRLVLETPEDLAGLPPSLIAAAAGTAAELGLPGKYVITLARSSIEPFLQFSARRD
LREQAFRAWAMRGENGGASDNRAIAAEMVKLRAERAKLLGYETFAHFKLADTMAKTPKAARDLLQSVWEPARARALKEQA
ALRALAASEGGNFEIAAWDWRYYAEKQRKAEYDLDEGETKPYLQLGKLVEAAFHAAEKLFGLTFTERFDIPLYHKDARAW
TVSRDGAEIALFIGDYFARPSKHSGAWMSLYREQQKLDGTVLPIVVNVLNFARGGEGEACLLSFDDARTLFHEFGHALHG
MLSDVTYPLISGTSVARDFVEFPSQLYEHWLEQPEILRRFAVHYETGEPMPEALLQKILAARQFNQGFATVEYTASALVD
LDLHLKAGEEEIDIISFEAETLAKLGMPEAIGMRHRTPHFQHIFTGDGYSAGYYSYLWSEILDADGFDAFEEKGDIFDPE
LAKRLHDHVYSAGYSRDPETAYAGFRGRAPEPAALLRKRGLLDTANAQA

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=583, Percent_Identity=30.3602058319039, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI14149738, Length=669, Percent_Identity=27.8026905829596, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI156105687, Length=669, Percent_Identity=24.5142002989537, Blast_Score=153, Evalue=5e-37,
Organism=Escherichia coli, GI1787819, Length=682, Percent_Identity=42.5219941348974, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=35.5685131195335, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI32565901, Length=563, Percent_Identity=23.8010657193606, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71999758, Length=397, Percent_Identity=22.4181360201511, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319793, Length=688, Percent_Identity=24.7093023255814, Blast_Score=180, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322715, Length=431, Percent_Identity=25.2900232018561, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21356111, Length=690, Percent_Identity=22.7536231884058, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI20129717, Length=571, Percent_Identity=23.1173380035026, Blast_Score=134, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 76733; Mature: 76733

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATTENNPLLAAWTGPFAAPPFDRLKPDHFMPAFTEAFVRARAEIDAIAANPEEPTFEN
CCCCCCCCCEEEEECCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHH
TIAALERAGEDLTRVSLTFFNLAGADTNDALEEVERDIAPLLSRHRSATYLNEDLFRRIE
HHHHHHHCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SLREQGEKLGLDAEQARVLERYHIAFSRNGGGLPQEAKARLAAIAERLATLGTQFSQNVL
HHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEKAYRLVLETPEDLAGLPPSLIAAAAGTAAELGLPGKYVITLARSSIEPFLQFSARRD
CCHHHHEEEEECCHHHHCCCHHHHHHHCCCHHHCCCCCHHEEEEHHHHHHHHHHHHHHHH
LREQAFRAWAMRGENGGASDNRAIAAEMVKLRAERAKLLGYETFAHFKLADTMAKTPKAA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
RDLLQSVWEPARARALKEQAALRALAASEGGNFEIAAWDWRYYAEKQRKAEYDLDEGETK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCC
PYLQLGKLVEAAFHAAEKLFGLTFTERFDIPLYHKDARAWTVSRDGAEIALFIGDYFARP
HHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEECCCCEEEEECCCCEEEEEEEHHHCCC
SKHSGAWMSLYREQQKLDGTVLPIVVNVLNFARGGEGEACLLSFDDARTLFHEFGHALHG
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHH
MLSDVTYPLISGTSVARDFVEFPSQLYEHWLEQPEILRRFAVHYETGEPMPEALLQKILA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
ARQFNQGFATVEYTASALVDLDLHLKAGEEEIDIISFEAETLAKLGMPEAIGMRHRTPHF
HHHHCCCCEEHEEHHHHHEEEEEEEECCCCCEEEEEECHHHHHHCCCCHHHCCCCCCCCC
QHIFTGDGYSAGYYSYLWSEILDADGFDAFEEKGDIFDPELAKRLHDHVYSAGYSRDPET
CEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCH
AYAGFRGRAPEPAALLRKRGLLDTANAQA
HHCCCCCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDATTENNPLLAAWTGPFAAPPFDRLKPDHFMPAFTEAFVRARAEIDAIAANPEEPTFEN
CCCCCCCCCEEEEECCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHH
TIAALERAGEDLTRVSLTFFNLAGADTNDALEEVERDIAPLLSRHRSATYLNEDLFRRIE
HHHHHHHCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SLREQGEKLGLDAEQARVLERYHIAFSRNGGGLPQEAKARLAAIAERLATLGTQFSQNVL
HHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEKAYRLVLETPEDLAGLPPSLIAAAAGTAAELGLPGKYVITLARSSIEPFLQFSARRD
CCHHHHEEEEECCHHHHCCCHHHHHHHCCCHHHCCCCCHHEEEEHHHHHHHHHHHHHHHH
LREQAFRAWAMRGENGGASDNRAIAAEMVKLRAERAKLLGYETFAHFKLADTMAKTPKAA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
RDLLQSVWEPARARALKEQAALRALAASEGGNFEIAAWDWRYYAEKQRKAEYDLDEGETK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCC
PYLQLGKLVEAAFHAAEKLFGLTFTERFDIPLYHKDARAWTVSRDGAEIALFIGDYFARP
HHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEECCCCEEEEECCCCEEEEEEEHHHCCC
SKHSGAWMSLYREQQKLDGTVLPIVVNVLNFARGGEGEACLLSFDDARTLFHEFGHALHG
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHH
MLSDVTYPLISGTSVARDFVEFPSQLYEHWLEQPEILRRFAVHYETGEPMPEALLQKILA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
ARQFNQGFATVEYTASALVDLDLHLKAGEEEIDIISFEAETLAKLGMPEAIGMRHRTPHF
HHHHCCCCEEHEEHHHHHEEEEEEEECCCCCEEEEEECHHHHHHCCCCHHHCCCCCCCCC
QHIFTGDGYSAGYYSYLWSEILDADGFDAFEEKGDIFDPELAKRLHDHVYSAGYSRDPET
CEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCH
AYAGFRGRAPEPAALLRKRGLLDTANAQA
HHCCCCCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]