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The map label for this gene is patA [H]

Identifier: 182680118

GI number: 182680118

Start: 3658118

End: 3659551

Strand: Reverse

Name: patA [H]

Synonym: Bind_3215

Alternate gene names: 182680118

Gene position: 3659551-3658118 (Counterclockwise)

Preceding gene: 182680119

Following gene: 182680115

Centisome position: 87.76

GC content: 57.95

Gene sequence:

>1434_bases
ATGAAGAATATCCCGGTGCAGGAGATCAAGCCCGCTGGCAATGGGGAGACCTTCGACATCAAGGCCTTGCTCGCTGCGCG
GGAGCCCGAGCGCTATTCGCTGCATACGCATTATCTGAACGAGATGATGGTCAAGGTTTTGCAAACCATTGGCTATGATG
TTGGTTTCAAAAGCGGGCAAGGACAATATTTGTTCGACCGCAATGATGCGCGCTATCTCGATCTGTTGAGCGGCTGGGGT
GTTTTTGCCATCGGCCGCAATCACCCCCTTCTGCGTGAAACCCTGACAAGTGTCCTGGCGAGTGACCTTCCCAATCTCGT
TCAGATGGACGTTTCCGTGCTGGCTGGATTGCTGGCGGAGCGTCTGCTCGGTTTCGTGCCTTTTCTCGACAAGGTCTTTT
TCTGCAATTCCGGCACTGAGGCGGTCGAAGCGGCGATCAAATTCGCCCGCCGGGCGACGGGGCGGCCCGGCATCGTCTAT
TGCGAACACGCCTTTCATGGTCTGAGCTATGGCTCTTTATCCTTGAACGGAGATCAGATTTTCCGGGAAGGCTTCGGGGA
TACTTTGCCGGGGTGCCATGCGGTTCCCTTCAATGATCTCGCGGCGCTCGAAAAGGCCTTGGCAAAGCATGATATAGCTG
CCTTTATTGTCGAGCCGGTGCAAGGCAAGGGAGTCAATCTTCCCGATGACGGCTATCTCGCCGGCGTGCAGGCGCTCTGC
CGCAAATATGGAACCTTGTTCGTCGCCGACGAGATCCAGACGGGTCTCGGCCGCACCGGAAAATTCCTTGCCATAGAACA
TTGGGGCGTCGAGCCGGATATGGTGCTGGTCGCCAAGGCGCTTTCGGGCGGCCATGTCCCGGTCGGCGCCGTGCTGAGCC
GCAAGGGTATTTTCGAAAAGGTGTTTTCCCGGATGGATCGGGCGGTGGTGCATGGCTCGACCTTCGCCAAGAACGATCTC
GCCATGGCGGCGGGCCTTGCCACCTTGGAAGTGATTGAACGGGAACAACTCGTCGAAAAAGCCGCGCGCAATGGCGAAAG
GTTGCTGACTTTCTTCCAAGGTCTGGCCGATCGCTACGAACTGGTGCGCACGGTGCGCGGCAAGGGCCTGATGATCGGCA
TTGAATTTGGGGCGCCGCGTTCGCTCAAGCTCAAGGCCTCATGGACGCTGCTCGAAACCGTCAACACGGGCCTGTTCTGT
CAGCTTATCACCATCCCCTTGTTCAAGGAGCACAAAATCCTCGTGCAAGTGGCAGGTCACGCGAGCCACACGGTCAAGCT
GCTGCCGACGCTCGTGATTGATGACGGGGATTGCGACTGGATCGAACGCGCGTTTGAAACCGTCATCGCCGATAGTCACA
AGGTTCCCGGAGCTGTCTGGTCGCTTGGCAAGACGCTGGCCGATCATGCGATGAAGGCGCGCGCCGCGAAGTAG

Upstream 100 bases:

>100_bases
GGATTCATCCCTGACAAGGGCCGATTGCGAATCCGGTAATAGGATTTGGCGGGAAACGCAAAGGCGGTCGGTATCACGGT
CGATTGATGAGGCGTGAGGA

Downstream 100 bases:

>100_bases
ACATTGTGGCCAGTCTATCCTGAGGTTTGCGGATAGGAATGCACAGGTAGGACTTTTGAATCTTTTTCCTGATTCTCCGA
GCCCCGAAAAAGCTTGAGAG

Product: class III aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MKNIPVQEIKPAGNGETFDIKALLAAREPERYSLHTHYLNEMMVKVLQTIGYDVGFKSGQGQYLFDRNDARYLDLLSGWG
VFAIGRNHPLLRETLTSVLASDLPNLVQMDVSVLAGLLAERLLGFVPFLDKVFFCNSGTEAVEAAIKFARRATGRPGIVY
CEHAFHGLSYGSLSLNGDQIFREGFGDTLPGCHAVPFNDLAALEKALAKHDIAAFIVEPVQGKGVNLPDDGYLAGVQALC
RKYGTLFVADEIQTGLGRTGKFLAIEHWGVEPDMVLVAKALSGGHVPVGAVLSRKGIFEKVFSRMDRAVVHGSTFAKNDL
AMAAGLATLEVIEREQLVEKAARNGERLLTFFQGLADRYELVRTVRGKGLMIGIEFGAPRSLKLKASWTLLETVNTGLFC
QLITIPLFKEHKILVQVAGHASHTVKLLPTLVIDDGDCDWIERAFETVIADSHKVPGAVWSLGKTLADHAMKARAAK

Sequences:

>Translated_477_residues
MKNIPVQEIKPAGNGETFDIKALLAAREPERYSLHTHYLNEMMVKVLQTIGYDVGFKSGQGQYLFDRNDARYLDLLSGWG
VFAIGRNHPLLRETLTSVLASDLPNLVQMDVSVLAGLLAERLLGFVPFLDKVFFCNSGTEAVEAAIKFARRATGRPGIVY
CEHAFHGLSYGSLSLNGDQIFREGFGDTLPGCHAVPFNDLAALEKALAKHDIAAFIVEPVQGKGVNLPDDGYLAGVQALC
RKYGTLFVADEIQTGLGRTGKFLAIEHWGVEPDMVLVAKALSGGHVPVGAVLSRKGIFEKVFSRMDRAVVHGSTFAKNDL
AMAAGLATLEVIEREQLVEKAARNGERLLTFFQGLADRYELVRTVRGKGLMIGIEFGAPRSLKLKASWTLLETVNTGLFC
QLITIPLFKEHKILVQVAGHASHTVKLLPTLVIDDGDCDWIERAFETVIADSHKVPGAVWSLGKTLADHAMKARAAK
>Mature_477_residues
MKNIPVQEIKPAGNGETFDIKALLAAREPERYSLHTHYLNEMMVKVLQTIGYDVGFKSGQGQYLFDRNDARYLDLLSGWG
VFAIGRNHPLLRETLTSVLASDLPNLVQMDVSVLAGLLAERLLGFVPFLDKVFFCNSGTEAVEAAIKFARRATGRPGIVY
CEHAFHGLSYGSLSLNGDQIFREGFGDTLPGCHAVPFNDLAALEKALAKHDIAAFIVEPVQGKGVNLPDDGYLAGVQALC
RKYGTLFVADEIQTGLGRTGKFLAIEHWGVEPDMVLVAKALSGGHVPVGAVLSRKGIFEKVFSRMDRAVVHGSTFAKNDL
AMAAGLATLEVIEREQLVEKAARNGERLLTFFQGLADRYELVRTVRGKGLMIGIEFGAPRSLKLKASWTLLETVNTGLFC
QLITIPLFKEHKILVQVAGHASHTVKLLPTLVIDDGDCDWIERAFETVIADSHKVPGAVWSLGKTLADHAMKARAAK

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=332, Percent_Identity=37.9518072289157, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI284507298, Length=248, Percent_Identity=42.741935483871, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI13994255, Length=403, Percent_Identity=30.7692307692308, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI24119277, Length=430, Percent_Identity=28.1395348837209, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI37574042, Length=411, Percent_Identity=28.2238442822384, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI226442705, Length=412, Percent_Identity=28.1553398058252, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI226442709, Length=350, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI188536080, Length=467, Percent_Identity=23.3404710920771, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38679950, Length=467, Percent_Identity=23.3404710920771, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI38679946, Length=467, Percent_Identity=23.3404710920771, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI145693181, Length=342, Percent_Identity=40.0584795321637, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1788044, Length=327, Percent_Identity=34.8623853211009, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789759, Length=407, Percent_Identity=31.6953316953317, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1787560, Length=416, Percent_Identity=30.0480769230769, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1789016, Length=336, Percent_Identity=32.7380952380952, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786349, Length=335, Percent_Identity=31.6417910447761, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1786991, Length=326, Percent_Identity=29.7546012269939, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=330, Percent_Identity=37.8787878787879, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI25144274, Length=218, Percent_Identity=44.0366972477064, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=411, Percent_Identity=27.9805352798054, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI32564660, Length=431, Percent_Identity=31.554524361949, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=424, Percent_Identity=25.4716981132075, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=32.4644549763033, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324432, Length=434, Percent_Identity=31.1059907834101, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324386, Length=329, Percent_Identity=27.0516717325228, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21357415, Length=333, Percent_Identity=36.3363363363363, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI161085790, Length=411, Percent_Identity=31.1435523114355, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI28574759, Length=411, Percent_Identity=31.1435523114355, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI21356575, Length=411, Percent_Identity=30.9002433090024, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 52065; Mature: 52065

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIPVQEIKPAGNGETFDIKALLAAREPERYSLHTHYLNEMMVKVLQTIGYDVGFKSGQ
CCCCCHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GQYLFDRNDARYLDLLSGWGVFAIGRNHPLLRETLTSVLASDLPNLVQMDVSVLAGLLAE
CCEEEECCCCHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
RLLGFVPFLDKVFFCNSGTEAVEAAIKFARRATGRPGIVYCEHAFHGLSYGSLSLNGDQI
HHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCCCCEEEEECHHCCCCCCEEECCHHHH
FREGFGDTLPGCHAVPFNDLAALEKALAKHDIAAFIVEPVQGKGVNLPDDGYLAGVQALC
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHH
RKYGTLFVADEIQTGLGRTGKFLAIEHWGVEPDMVLVAKALSGGHVPVGAVLSRKGIFEK
HHHCCEEEEHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
VFSRMDRAVVHGSTFAKNDLAMAAGLATLEVIEREQLVEKAARNGERLLTFFQGLADRYE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LVRTVRGKGLMIGIEFGAPRSLKLKASWTLLETVNTGLFCQLITIPLFKEHKILVQVAGH
HHHHHCCCEEEEEEECCCCCCEEEEEEEHHHHHHCCCCEEEEHHCCCCCCCEEEEEECCC
ASHTVKLLPTLVIDDGDCDWIERAFETVIADSHKVPGAVWSLGKTLADHAMKARAAK
CCCEEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNIPVQEIKPAGNGETFDIKALLAAREPERYSLHTHYLNEMMVKVLQTIGYDVGFKSGQ
CCCCCHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GQYLFDRNDARYLDLLSGWGVFAIGRNHPLLRETLTSVLASDLPNLVQMDVSVLAGLLAE
CCEEEECCCCHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
RLLGFVPFLDKVFFCNSGTEAVEAAIKFARRATGRPGIVYCEHAFHGLSYGSLSLNGDQI
HHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCCCCEEEEECHHCCCCCCEEECCHHHH
FREGFGDTLPGCHAVPFNDLAALEKALAKHDIAAFIVEPVQGKGVNLPDDGYLAGVQALC
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHH
RKYGTLFVADEIQTGLGRTGKFLAIEHWGVEPDMVLVAKALSGGHVPVGAVLSRKGIFEK
HHHCCEEEEHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
VFSRMDRAVVHGSTFAKNDLAMAAGLATLEVIEREQLVEKAARNGERLLTFFQGLADRYE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LVRTVRGKGLMIGIEFGAPRSLKLKASWTLLETVNTGLFCQLITIPLFKEHKILVQVAGH
HHHHHCCCEEEEEEECCCCCCEEEEEEEHHHHHHCCCCEEEEHHCCCCCCCEEEEEECCC
ASHTVKLLPTLVIDDGDCDWIERAFETVIADSHKVPGAVWSLGKTLADHAMKARAAK
CCCEEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA