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The map label for this gene is mro [H]

Identifier: 182679980

GI number: 182679980

Start: 3512645

End: 3513733

Strand: Reverse

Name: mro [H]

Synonym: Bind_3076

Alternate gene names: 182679980

Gene position: 3513733-3512645 (Counterclockwise)

Preceding gene: 182679981

Following gene: 182679979

Centisome position: 84.26

GC content: 59.14

Gene sequence:

>1089_bases
ATGACATACATCGAAACAGTGGGTCCGAACATCGTGCGCGAGCACTTCGGTCATCTGCCGGACGGAGCCACTGTTGAGCG
TGTGCGGCTCTGTGGCAGAAACGGCTTCGAACTCGCCGTCATTACTTTTGGTGCCACTGTCCAATCCCTTCACGTGCCAG
ACCGTACAGGACGTTGCGCCGACATCGTGCTTGGTCATGACGATTTTGCGCCTTATTTCGCGCATCGACGCTATTTCGGC
GCCACTATCGGTCGCTATGCTAACCGTATCGCGCACGGCAGCTTTTTACTCGATGGCCGGCGATTCCAGGTGACGGCCAA
TGATGGGGTGAACAGTCTGCATGGCGGTGTAGCCGGGTTCGACCAGCGGCTATGGTCTATCGAGGCCCTTACGGATGATC
CCGCGCCCTCGATGACATTGGCCTATATCAGCCCCGATGGAGAAGAAGGCTATCCTGGCACACTCAGCGCCCGCGTCACT
TATACCGTGACCGAGGATATTGGGTTCTCCATCGCCTTCGAGGCGATGACCGATCGACCCACCGTCGTCAACCTCACGCA
CCACGGATTCTTCAATCTCGCCGGCGTTGATGCGGCAGAAGATGTGCTCGACCATGAGCTCCTCATGATGGCGGATGCCT
ATCTGCCTGTTGATGAGACCCTGATTCCGCTTGGCGGGCCGGAGCCTGTTGTGGGCACTCCGTTCGATTTCCGTCAGCCG
CAGCGGATTGGCGCGCGCCTACGAAACGGACACGAGCAGCTTCGTCTTGCGCAGGGCTACGACCACAATTTTTGCCTCCA
AGGCGGCCGGACCGAGGCACCGCGGCTCGCCGCCCGAGTCCTGCATCGCGCGTCCGGCAGAGGGATGGAGCTTTTCACCG
ATCAGCCCGGTCTCCAATTCTATTCCGGCAATTTCCTTGACGGGTCGGTGCCGGGAAAACGCGGCCGCCTCTATCGGCAA
GCCGATGCCTTTTGCCTTGAGCCACAAGCTTGGCCTGATGCGCCCAATCGGCTGGACTACTCCTCCGTCAGACTCGATCC
AGGCGAAGTTTACCGGCACCTTTCCTTCTACCGTTTTTACTCAACCTGA

Upstream 100 bases:

>100_bases
CCGGAGGGATGAGCGACGTCGACCTCGTCCCCCTCCAACATGTCGCGGATGCCTTCATGCTGGGCCGCCGCACATTGGTC
GAGCCGTTCGAGGATTGACC

Downstream 100 bases:

>100_bases
ACCGGGGGAGACCACGGATGCAAGGCAACGAACATGACAGCCATTGACGGATGCAGCGACATGGGAAAGGGCAGGTCGAT
CGAACAGGTTGCGGCCACGC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MTYIETVGPNIVREHFGHLPDGATVERVRLCGRNGFELAVITFGATVQSLHVPDRTGRCADIVLGHDDFAPYFAHRRYFG
ATIGRYANRIAHGSFLLDGRRFQVTANDGVNSLHGGVAGFDQRLWSIEALTDDPAPSMTLAYISPDGEEGYPGTLSARVT
YTVTEDIGFSIAFEAMTDRPTVVNLTHHGFFNLAGVDAAEDVLDHELLMMADAYLPVDETLIPLGGPEPVVGTPFDFRQP
QRIGARLRNGHEQLRLAQGYDHNFCLQGGRTEAPRLAARVLHRASGRGMELFTDQPGLQFYSGNFLDGSVPGKRGRLYRQ
ADAFCLEPQAWPDAPNRLDYSSVRLDPGEVYRHLSFYRFYST

Sequences:

>Translated_362_residues
MTYIETVGPNIVREHFGHLPDGATVERVRLCGRNGFELAVITFGATVQSLHVPDRTGRCADIVLGHDDFAPYFAHRRYFG
ATIGRYANRIAHGSFLLDGRRFQVTANDGVNSLHGGVAGFDQRLWSIEALTDDPAPSMTLAYISPDGEEGYPGTLSARVT
YTVTEDIGFSIAFEAMTDRPTVVNLTHHGFFNLAGVDAAEDVLDHELLMMADAYLPVDETLIPLGGPEPVVGTPFDFRQP
QRIGARLRNGHEQLRLAQGYDHNFCLQGGRTEAPRLAARVLHRASGRGMELFTDQPGLQFYSGNFLDGSVPGKRGRLYRQ
ADAFCLEPQAWPDAPNRLDYSSVRLDPGEVYRHLSFYRFYST
>Mature_361_residues
TYIETVGPNIVREHFGHLPDGATVERVRLCGRNGFELAVITFGATVQSLHVPDRTGRCADIVLGHDDFAPYFAHRRYFGA
TIGRYANRIAHGSFLLDGRRFQVTANDGVNSLHGGVAGFDQRLWSIEALTDDPAPSMTLAYISPDGEEGYPGTLSARVTY
TVTEDIGFSIAFEAMTDRPTVVNLTHHGFFNLAGVDAAEDVLDHELLMMADAYLPVDETLIPLGGPEPVVGTPFDFRQPQ
RIGARLRNGHEQLRLAQGYDHNFCLQGGRTEAPRLAARVLHRASGRGMELFTDQPGLQFYSGNFLDGSVPGKRGRLYRQA
DAFCLEPQAWPDAPNRLDYSSVRLDPGEVYRHLSFYRFYST

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=352, Percent_Identity=46.5909090909091, Blast_Score=308, Evalue=3e-84,
Organism=Escherichia coli, GI1786971, Length=342, Percent_Identity=38.0116959064327, Blast_Score=217, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17557428, Length=333, Percent_Identity=31.5315315315315, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI115533334, Length=333, Percent_Identity=31.5315315315315, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319493, Length=333, Percent_Identity=26.7267267267267, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322004, Length=356, Percent_Identity=25.8426966292135, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324399, Length=345, Percent_Identity=24.6376811594203, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24659048, Length=345, Percent_Identity=41.1594202898551, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24668282, Length=346, Percent_Identity=42.485549132948, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24668278, Length=339, Percent_Identity=37.4631268436578, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24583720, Length=339, Percent_Identity=37.1681415929204, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24641876, Length=347, Percent_Identity=36.0230547550432, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 40125; Mature: 39994

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYIETVGPNIVREHFGHLPDGATVERVRLCGRNGFELAVITFGATVQSLHVPDRTGRCA
CCEECCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEEECCEEEEEECCCCCCCEE
DIVLGHDDFAPYFAHRRYFGATIGRYANRIAHGSFLLDGRRFQVTANDGVNSLHGGVAGF
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEEECCCCCHHHCCCHHHH
DQRLWSIEALTDDPAPSMTLAYISPDGEEGYPGTLSARVTYTVTEDIGFSIAFEAMTDRP
HHHHEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCEEEEEEECCCC
TVVNLTHHGFFNLAGVDAAEDVLDHELLMMADAYLPVDETLIPLGGPEPVVGTPFDFRQP
CEEEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCH
QRIGARLRNGHEQLRLAQGYDHNFCLQGGRTEAPRLAARVLHRASGRGMELFTDQPGLQF
HHHHHHHHCCHHHEEECCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEE
YSGNFLDGSVPGKRGRLYRQADAFCLEPQAWPDAPNRLDYSSVRLDPGEVYRHLSFYRFY
ECCCCCCCCCCCCCCCEEECCCCEEECCCCCCCCCCCCCCCCEECCHHHHHHHHHHEEEE
ST
CC
>Mature Secondary Structure 
TYIETVGPNIVREHFGHLPDGATVERVRLCGRNGFELAVITFGATVQSLHVPDRTGRCA
CEECCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEEECCEEEEEECCCCCCCEE
DIVLGHDDFAPYFAHRRYFGATIGRYANRIAHGSFLLDGRRFQVTANDGVNSLHGGVAGF
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEEECCCCCHHHCCCHHHH
DQRLWSIEALTDDPAPSMTLAYISPDGEEGYPGTLSARVTYTVTEDIGFSIAFEAMTDRP
HHHHEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCEEEEEEECCCC
TVVNLTHHGFFNLAGVDAAEDVLDHELLMMADAYLPVDETLIPLGGPEPVVGTPFDFRQP
CEEEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCH
QRIGARLRNGHEQLRLAQGYDHNFCLQGGRTEAPRLAARVLHRASGRGMELFTDQPGLQF
HHHHHHHHCCHHHEEECCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEE
YSGNFLDGSVPGKRGRLYRQADAFCLEPQAWPDAPNRLDYSSVRLDPGEVYRHLSFYRFY
ECCCCCCCCCCCCCCCEEECCCCEEECCCCCCCCCCCCCCCCEECCHHHHHHHHHHEEEE
ST
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]